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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6258-6261

Peripheral but crucial: A hydrophobic pocket (Tyr706, Leu 337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase

(7) Xue, Fengtian a Li, Huiying b Fang, Jianguo a Roman, Linda J c Martásek, Pavel c Poulos, Thomas L b Silverman, Richard B a

a NORTHWESTERN UNIVERSITY (United States)

b UNIVERSITY OF CALIFORNIA (United States)

c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO (United States)

Author keywords

Crystal structure; Nitric oxide synthase; Peripheral hydrophobic pocket; Pi stacking; Selective inhibitor

Indexed keywords

AMINOPYRIDINE; LEUCINE; METHIONINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TYROSINE;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; NONHUMAN; RAT;

ALKYLATION; ANIMALS; CATALYTIC DOMAIN; CATTLE; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; KINETICS; LEUCINE; METHIONINE; MICE; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE TYPE I; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TYROSINE; X-RAY DIFFRACTION;

EID: 77957876680 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.08.096 Document Type: Article

Times cited : (20)

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