Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6526-6537

  Xue, Fengtian ^a   Huang, Jinwen ^a   Ji, Haitao ^a   Fang, Jianguo ^a   Li, Huiying ^b   Martásek, Pavel ^c,d   Roman, Linda J ^c   Poulos, Thomas L ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

cis Pyrrolidine pharmacophore; Enzyme inhibitors; Neurodegenerative therapeutics; Neuronal nitric oxide synthase

Indexed keywords

4 METHYL 6 [[4 [[3' (TRIFLUOROMETHYL)BIPHENYL 4 YL]METHOXY]PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; 6 [[4 (3 PHENOXYPHENOXY)PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; 6 [[4 [(3' CHLORO 4' FLUOROBIPHENYL 4 YL)METHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; 6 [[4 [(3' CHLOROBIPHENYL 4 YL)METHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; 6 [[4 [(3' FLUOROBIPHENYL 4 YL)METHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; 6 [[4 [(4' FLUORO 3' METHYLBIPHENYL 4 YL)METHOXY]PYRROLIDIN 3 YL]METHYL] 4 METHYLPYRIDIN 2 AMINE; 6 [[4 [3 (4 CHLORO 3 FLUOROPHENOXY)PHENOXY]PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; 6 [[4 [3 (4 CHLOROPHENOXY)PHENOXY]PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; 6 [[4 [3 (4 FLUORO 3 METHYLPHENOXY)PHENOXY]PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; 6 [[4 [3 (4 FLUOROPHENOXY)PHENOXY]PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; 6[[4 (BIPHENYL 4 YLOXY)PYRROLIDIN 3 YL]METHYL]PYRIDIN 2 AMINE; BIPHENYL DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; LIPOPHILICITY; MOLECULAR DOCKING; PROTEIN INTERACTION;

ANIMALS; CATTLE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MICE; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE TYPE I; PROTEIN BINDING; PYRROLIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955984231     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.074     Document Type: Article

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