The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow

Experimental Hematology

Volumn 29, Issue 12, 2001, Pages 1439-1447

  Shen, Wei ^a,b   Bendall, Linda J ^a,b   Gottlieb, David J ^a,b   Bradstock, Kenneth F ^a,b  

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIBODY; BETA1 INTEGRIN; CHEMOKINE RECEPTOR CXCR4; FIBRONECTIN; INTEGRIN; LAMININ; PERTUSSIS TOXIN; SCLEROPROTEIN; STROMAL CELL DERIVED FACTOR 1; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 5; WORTMANNIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; IN VITRO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

ANIMALS; ANTIBODIES; B-LYMPHOCYTES; BONE MARROW CELLS; CELL ADHESION; CELL MOVEMENT; CHEMOKINES, CXC; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; FLOW CYTOMETRY; HUMANS; LEUKEMIA, B-CELL, ACUTE; LEUKEMIA, LYMPHOCYTIC, ACUTE; MICE; MICE, SCID; PERTUSSIS TOXIN; PROTEIN BINDING; RECEPTORS, CXCR4; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; VASCULAR CELL ADHESION MOLECULE-1; VIRULENCE FACTORS, BORDETELLA;

EID: 0035652927     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00741-X     Document Type: Article

References (44)

1. Cellular interactions
2. Interaction of acute leukemia cells with the bone marrow microenvironment; implications for control of minimal residual disease
3. hi stem cells to bone marrow stroma
4. Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells
5. Analysis of the mechanism of adhesion of precursor-B acute lymphoblastic leukemia cells to bone marrow fibroblasts
6. Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of β 1 and β 2 integrin mechanisms
7. Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia
8. Migration of acute lymphoblastic leukemia cells into bone marrow stroma
9. Subpopulations of bone marrow fibroblasts support VLA-4-mediated migration of B-cell precursors
10. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
11. The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4
12. Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1)
13. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells
14. Effects of the chemokine stromal-derived factor-1 on the migration and localisation of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers
15. Signal sequence trap; a cloning strategy for secreted proteins and type I membrane proteins
16. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene
17. B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement
18. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
19. The α-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion
20. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
21. The molecular biology of leukocyte chemoattractant receptors
22. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
23. VLA-4 is involved in the engraftment of the human pre-B acute lymphoblastic leukaemia cell line NALM-6 in SCID mice
24. Measurement of candida-specific blastogenesis; comparison of carboxyfouorescein succinimidyl ester labelling of T cells, thymidine incorporation, and CD69 expression
25. The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways
26. Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 α-induced lymphocyte polarization and chemotaxis
27. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
28. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
29. In vivo localization of B lymphocyte progenitor cells in mouse bone marrow
30. + cells during postirradiation regeneration
31. + cells; role in transendothelial/stromal migration and engraftment of NOD/SCID mice
32. + cells on vascular endothelium under shear flow
33. Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells; a possible role in homing of haemopoietic progenitor cells to bone marrow
34. Differences between bone marrow and lung endothelial cells
35. Chemokines and the arrest of lymphocytes rolling under flow conditions
36. Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1
37. Vascular cell adhesion molecule (VCAM)-Ig fusion protein defines distinct affinity states of the very late antigen-4 (VLA-4) receptor
38. Granulocyte-macrophage colony-stimulating factor regulates the functional adhesive state of very late antigen-4 expressed by eosinophils
39. Integrin affinity modulation
40. Macrophage inflammatory protein 1α enhances in a different manner adhesion of hematopoietic progenitor cells from bone marrow, cord blood, and mobilized peripheral blood
41. Stromal cell-derived factor-1α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors; a potential mechanism for cooperative induction of chemotaxis
42. Activated R-ras, Rac1, PI 3-kinase, and PKCepsilon can each restore cell spreading inhibited by isolated integrin β1 cytoplasmic domains
43. Role of the PI3K regulatory subunit in the control of actin organization and cell migration
44. GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility