Titrating lovaza from 4 to 8 to 12 grams/day in patients with primary hypertriglyceridemia who had triglyceride levels >500 mg/dl despite conventional triglyceride lowering therapy

Lipids in Health and Disease

Volumn 11, Issue , 2012, Pages

  Glueck, Charles J ^a   Khan, Naseer ^a   Riaz, Muhammad ^a   Padda, Jagjit ^a   Khan, Zia ^a   Wang, Ping ^a  

^a JEWISH HOSPITAL   (United States)

Author keywords

Lovaza; Severe primary hypertriglyceridemia; Triglyceride; Triglyceride lowering therapy

Indexed keywords

CHOLESTEROL; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; OMEGA 3 ACID ETHYL ESTER; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; DIABETES CONTROL; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS;

AGED; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; HYPERTRIGLYCERIDEMIA; HYPOLIPIDEMIC AGENTS; MALE; MIDDLE AGED; TRIGLYCERIDES;

EID: 84867902225     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-11-143     Document Type: Article

References (32)

1. Omacor in familial combined hyperlipidemia: effects on lipids and low density lipoprotein subclasses. Calabresi L, Donati D, Pazzucconi F, Sirtori CR, Franceschini G, Atherosclerosis 2000 148 2 387 96 10.1016/S0021-9150(99)00267-1 10657575 (Pubitemid 30064470)
2. Novel developments in omega-3 fatty acid-based strategies. Davidson MH, Kling D, Maki KC, Curr Opin Lipidol 2011 22 6 437 44 10.1097/MOL. 0b013e32834bd642 21986642
3. Fish-oil esters of plant sterols differ from vegetable-oil sterol esters in triglycerides lowering, carotenoid bioavailability and impact on plasminogen activator inhibitor-1 (PAI-1) concentrations in hypercholesterolemic subjects. Jones PJ, Demonty I, Chan YM, Herzog Y, Pelled D, Lipids Health Dis 2007 6 28 10.1186/1476-511X-6-28 17961204
4. Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides. Sadovsky R, Kris-Etherton P, Postgrad Med 2009 121 4 145 53 10.3810/pgm.2009.07.2020 19820283
5. Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia. Barter P, Ginsberg HN, Am J Cardiol 2008 102 8 1040 5 10.1016/j.amjcard.2008.05.056 18929706
6. Treatment of severe familial hypertriglyceridemia during pregnancy with very-low-fat diet and n-3 fatty acids. Glueck CJ, Streicher P, Wang P, Sprecher D, Falko JM, Nutrition 1996 12 3 202 5 10.1016/S0899-9007(97)85060-5 8798226 (Pubitemid 26238751)
7. An observational study of severe hypertriglyceridemia, hypertriglyceridemic acute pancreatitis, and failure of triglyceride-lowering therapy when estrogens are given to women with and without familial hypertriglyceridemia. Goldenberg NM, Wang P, Glueck CJ, Clin Chim Acta 2003 332 1-2 11 9 12763274 (Pubitemid 36577483)
8. Severe hypertriglyceridemia and pancreatitis when estrogen replacement therapy is given to hypertriglyceridemic women. Glueck CJ, Lang J, Hamer T, Tracy T, J Lab Clin Med 1994 123 1 59 64 8288962 (Pubitemid 2048470)
9. Fish oils in hypertriglyceridemia: a dose-response study. Harris WS, Rothrock DW, Fanning A, Inkeles SB, Goodnight SH Jr, Illingworth DR, Connor WE, Am J Clin Nutr 1990 51 3 399 406 2309646
10. Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia. Sanders TA, Sullivan DR, Reeve J, Thompson GR, Arteriosclerosis 1985 5 5 459 65 10.1161/01.ATV.5.5.459 4038159 (Pubitemid 15231301)
11. Can the hypotriglyceridemic effect of fish oil concentrate be sustained? Schectman G, Kaul S, Cherayil GD, Lee M, Kissebah A, Ann Intern Med 1989 110 5 346 52 2492785 (Pubitemid 19073650)
12. The acute effects of a single very high dose of n-3 fatty acids on plasma lipids and lipoproteins in healthy subjects. Svaneborg N, Moller JM, Schmidt EB, Varming K, Lervang HH, Dyerberg J, Lipids 1994 29 2 145 7 10.1007/BF02537154 8152348 (Pubitemid 24073051)
13. Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus. Brouwers MC, de Graaf J, van Greevenbroek MM, Schaper N, Stehouwer CD, Stalenhoef AF, Curr Opin Lipidol 2010 21 6 530 8 10.1097/MOL.0b013e32833ea9ec 20739883
14. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ, Arterioscler Thromb Vasc Biol 2004 24 8 149 61 10.1161/01.ATV. 0000133317.49796.0E 15297292
15. The effect of apolipoprotein E polymorphism on the response to lipid-lowering treatment with atorvastatin or fenofibrate. Christidis DS, Liberopoulos EN, Kakafika AI, Miltiadous GA, Cariolou M, Ganotakis ES, Mikhailidis DP, Elisaf MS, J Cardiovasc Pharmacol Ther 2006 11 3 211 21 10.1177/1074248406293732 17056835 (Pubitemid 44536190)
16. All-cause and cardiovascular mortality in treated patients with severe hypertriglyceridaemia: A long-term prospective registry study. Neil HA, Cooper J, Betteridge DJ, Capps N, McDowell IF, Durrington PN, Seed M, Mann JI, Humphries SE, Atherosclerosis 2010 211 2 618 23 10.1016/j.atherosclerosis.2010. 03.006 20356595
17. Chylomicronemia syndrome. Interaction of genetic and acquired hypertriglyceridemia. Brunzell JD, Bierman EL, Med Clin North Am 1982 66 2 455 68 7040847 (Pubitemid 12115376)
18. Primary type V hyperlipoproteinemia. A descriptive study in 32 families. Greenberg BH, Blackwelder WC, Levy RI, Ann Intern Med 1977 87 5 526 34 200162 (Pubitemid 8223597)
19. Major lipids, apolipoproteins, and risk of vascular disease. Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, Packard CJ, Collins R, Thompson SG, Danesh J, JAMA 2009 302 18 1993 2000 19903920
20. Treatment of primary chylomicronemia due to familial hypertriglyceridemia by omega-3 fatty acids. Richter WO, Jacob BG, Ritter MM, Schwandt P, Metabolism 1992 41 10 1100 5 10.1016/0026-0495(92)90293-J 1406295
21. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial). Bays HE, Ballantyne CM, Kastelein JJ, Isaacsohn JL, Braeckman RA, Soni PN, Am J Cardiol 2011 108 5 682 90 10.1016/j.amjcard.2011.04.015 21683321
22. Koh KK, Quon MJ, Shin KC, Lim S, Lee Y, Sakuma I, Lee K, Han SH, Shin EK, Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia Atherosclerosis 2011
23. Drug treatment of combined hyperlipidemia. Wierzbicki AS, Mikhailidis DP, Wray R, Am J Cardiovasc Drugs 2001 1 5 327 36 10.2165/00129784-200101050-00003 14728015
24. Treatment of diabetic dyslipidemia. Garg A, Am J Cardiol 1998 81 4A 47B 51B 9526814 (Pubitemid 28113946)
25. Grundy SM, Atlas of Atherosclerosis and Metabolic Syndrome 2010
26. Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndrome. Kaushik SV, Plaisance EP, Kim T, Huang EY, Mahurin AJ, Grandjean PW, Mathews ST, Diabetes Metab Res Rev 2009 25 5 427 34 10.1002/dmrr.967 19405044
27. Diabetic dyslipidemia. Kreisberg RA, Am J Cardiol 1998 82 12A 67 73 discussion 85U-6U
28. Niacin plus Simvastatin Reduces Coronary Stenosis Progression Among Patients with Metabolic Syndrome Despite a Modest Increase in Insulin Resistance: A Subgroup Analysis of the HDL-Atherosclerosis Treatment Study (HATS). Vittone F, Chait A, Morse JS, Fish B, Brown BG, Zhao XQ, J Clin Lipidol 2007 1 3 203 10 10.1016/j.jacl.2007.05.003 18591993 (Pubitemid 47055291)
29. Comparison of statins in hypertriglyceridemia. Stein EA, Lane M, Laskarzewski P, Am J Cardiol 1998 81 4A 66B 9B 9526817 (Pubitemid 28113949)
30. Dietary management of hyperlipoproteinemia. Levy RI, Bonnell M, Ernst ND, J Am Diet Assoc 1971 58 5 406 16 5574141
31. Combination therapy with metformin and fenofibrate for insulin resistance in obesity. Li XM, Li Y, Zhang NN, Xie YH, Shi YQ, J Int Med Res 2011 39 5 1876 82 22117989
32. Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes. Malin SK, Gerber R, Chipkin SR, Braun B, Diabetes Care 2012 35 1 131 6 10.2337/dc11-0925 22040838