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Volumn 7, Issue 12, 2010, Pages 1399-1414

Development of cytarabine prodrugs and delivery systems for leukemia treatment

Author keywords

amino acid; arabinofuranosylcytosine; araC; chitosan; cytarabine; delivery system; fatty acid cytarabine; liposome; nanoparticle; prodrug

Indexed keywords

ARA C 5' ELAIDIC ACID ESTER; CHITOSAN; CLORETAZINE; CP 4055; CYTARABINE; CYTARABINE 5' STEARYLPHOSPHATE; CYTARABINE DERIVATIVE; ELACYT; FATTY ACID DERIVATIVE; GEMCITABINE; IDARUBICIN; IRINOTECAN; LIPOSOME; NANOPARTICLE; NIOSOME; POLYMER; TOPOTECAN; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 78649937348     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.2010.527330     Document Type: Review
Times cited : (92)

References (97)
  • 1
    • 77953632119 scopus 로고    scopus 로고
    • Pharmacogenomics of pediatric acute lymphoblastic leukemia
    • Meeker ND, Yang JJ, Schiffman JD. Pharmacogenomics of pediatric acute lymphoblastic leukemia. Expert Opin Pharmacother 2010;11(10):1621-32
    • (2010) Expert Opin Pharmacother , vol.11 , Issue.10 , pp. 1621-1632
    • Meeker, N.D.1    Yang, J.J.2    Schiffman, J.D.3
  • 2
    • 0033565561 scopus 로고    scopus 로고
    • The biology of chronic myeloid leukemia
    • Faderl S, Talpaz M, Estrov Z, et al. The biology of chronic myeloid leukemia. N Engl J Med 1999;341:164-72
    • (1999) N. Engl. J. Med. , vol.341 , pp. 164-172
    • Faderl, S.1    Talpaz, M.2    Estrov, Z.3
  • 3
    • 77953673996 scopus 로고    scopus 로고
    • Available from Pdf Last accessed 15 July 2010
    • The Leukemia and Lymphoma Society, Facts 2009-2010. Available from: attachments/National/br-1247234696. pdf [Last accessed 15 July 2010]
    • (2009) Leukemia and Lymphoma Society Facts
  • 7
    • 33646823805 scopus 로고    scopus 로고
    • Recent advances in the management of multiple myeloma
    • Kumar L, Vikram P, Kochupilla V. Recent advances in the management of multiple myeloma. Nat Med J Ind 2006;19(2):80-9
    • (2006) Nat. Med. J. Ind. , vol.19 , Issue.2 , pp. 80-89
    • Kumar, L.1    Vikram, P.2    Kochupilla, V.3
  • 8
    • 66149116471 scopus 로고    scopus 로고
    • Ligand-based targeted therapy for cancer tissue
    • Das M, Mohanty C, Sahoo SK. Ligand-based targeted therapy for cancer tissue. Expert Opin Drug Deliv 2009;6(3):285-304
    • (2009) Expert Opin. Drug. Deliv. , vol.6 , Issue.3 , pp. 285-304
    • Das, M.1    Mohanty, C.2    Sahoo, S.K.3
  • 9
    • 76749154506 scopus 로고    scopus 로고
    • Induction therapy in acute myeloid leukemia: Intensifying and targeting the approach
    • Fernandez HF, Rowe JM. Induction therapy in acute myeloid leukemia: intensifying and targeting the approach. Cur Opin Hematol 2010;17(2):79-84
    • (2010) Cur. Opin. Hematol. , vol.17 , Issue.2 , pp. 79-84
    • Fernandez, H.F.1    Rowe, J.M.2
  • 10
    • 0034053435 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia: Current treatment concepts
    • Arya LS. Acute lymphoblastic leukemia: current treatment concepts. Ind Pediatrics 2000;37(4):397-406
    • (2000) Ind. Pediatrics , vol.37 , Issue.4 , pp. 397-406
    • Arya, L.S.1
  • 11
    • 0018758170 scopus 로고
    • Long term follow-up of combination chemotherapy-radiotherapy of stage III Hodgkins disease: A cancer and acute leukemia group B study
    • Hoogstraten B, Glidewell O, Holland JF, et al. Long term follow-up of combination chemotherapy-radiotherapy of stage III Hodgkins disease: a Cancer and Acute Leukemia Group B study. Cancer 1979;43(4):1234-44
    • (1979) Cancer , vol.43 , Issue.4 , pp. 1234-1244
    • Hoogstraten, B.1    Glidewell, O.2    Holland, J.F.3
  • 12
    • 77952533409 scopus 로고    scopus 로고
    • Clinical applications of PET and PET/CT in pediatric malignancies
    • Kumar R, Shandal V, Shamim SA, et al. Clinical applications of PET and PET/ CT in pediatric malignancies. Expert Rev Anticancer Ther 2010;10(5):755-68
    • (2010) Expert Rev. Anticancer. Ther. , vol.10 , Issue.5 , pp. 755-768
    • Kumar, R.1    Shandal, V.2    Shamim, S.A.3
  • 13
    • 34249096219 scopus 로고    scopus 로고
    • Current and emerging treatment options in chronic myeloid leukemia
    • Jabbour E, Cortes JE, Giles FJ, et al. Current and emerging treatment options in chronic myeloid leukemia. Cancer 2007;109(11):2171-81
    • (2007) Cancer , vol.109 , Issue.11 , pp. 2171-2181
    • Jabbour, E.1    Cortes, J.E.2    Giles, F.J.3
  • 14
    • 51349092514 scopus 로고    scopus 로고
    • Recent advances in management of acute myeloid leukemia AML
    • Shah M, Agarwal B. Recent advances in management of acute myeloid leukemia (AML). Ind J Pediat 2008;75(8):831-37
    • (2008) Ind. J. Pediat. , vol.75 , Issue.8 , pp. 831-837
    • Shah, M.1    Agarwal, B.2
  • 15
    • 55749100536 scopus 로고    scopus 로고
    • Modern approaches to treating chronic myelogenous leukemia
    • Pinilla-Ibarz J, Bello C. Modern approaches to treating chronic myelogenous leukemia. Cur Oncol Rep 2008;10(5):365-71
    • (2008) Cur. Oncol. Rep. , vol.10 , Issue.5 , pp. 365-371
    • Pinilla-Ibarz, J.1    Bello, C.2
  • 16
    • 77449134856 scopus 로고    scopus 로고
    • Standard therapies for acute myeloid leukemia
    • Matsumura I. Standard therapies for acute myeloid leukemia. Rinsho Ketsueki 2009;50(10):1389-400
    • (2009) Rinsho Ketsueki , vol.50 , Issue.10 , pp. 1389-1400
    • Matsumura, I.1
  • 17
    • 0027941369 scopus 로고
    • Intensive postremission chemotherapy in adults with acute myeloid leukemia
    • Mayer RJ, Davis RB, Schiffer CA. Intensive postremission chemotherapy in adults with acute myeloid leukemia. N Engl J Med 1994;331:896-903
    • (1994) N. Engl. J. Med. , vol.331 , pp. 896-903
    • Mayer, R.J.1    Davis, R.B.2    Schiffer, C.A.3
  • 18
    • 74549195798 scopus 로고    scopus 로고
    • Current and emerging therapies for acute myeloid leukemia
    • Robak T, Wierzbowska A. Current and emerging therapies for acute myeloid leukemia. Clin Ther 2009;31(2):2349-70
    • (2009) Clin. Ther. , vol.31 , Issue.2 , pp. 2349-2370
    • Robak, T.1    Wierzbowska, A.2
  • 19
    • 42649088421 scopus 로고    scopus 로고
    • Comparison of ICE ifosfamidecarboplatin-etoposide versus DHAP cytosine arabinoside-cisplatindexamethasone as salvage chemotherapy in patients with relapsed or refractory lymphoma
    • Abali H, Urun Y, Oksuzoglu B, et al. Comparison of ICE (ifosfamidecarboplatin- etoposide) versus DHAP (cytosine arabinoside- cisplatindexamethasone) as salvage chemotherapy in patients with relapsed or refractory lymphoma. Cancer Invest 2008;26(4):401-6
    • (2008) Cancer Invest. , vol.26 , Issue.4 , pp. 401-406
    • Abali, H.1    Urun, Y.2    Oksuzoglu, B.3
  • 20
    • 0032998454 scopus 로고    scopus 로고
    • Feasibility of ESHAP + G-CSF as peripheral blood hematopoietic progenitor cell mobilisation regimen in resistant and relapsed lymphoma: A single-center study of 22 patients
    • Petit J, Boque C, Cancelas JA, et al. Feasibility of ESHAP + G-CSF as peripheral blood hematopoietic progenitor cell mobilisation regimen in resistant and relapsed lymphoma: a single-center study of 22 patients. Leuk Lymphoma 1999;34(1-2):119-27
    • (1999) Leuk Lymphoma , vol.34 , Issue.1-2 , pp. 119-127
    • Petit, J.1    Boque, C.2    Cancelas, J.A.3
  • 21
    • 68549133393 scopus 로고    scopus 로고
    • A novel regimen combining high dose cytarabine and bortezomib has activity in multiply relapsed and refractory mantle cell lymphoma - Long-term results of a multicenter observation study
    • Weigert O, Weidmann E, Mueck R, et al. A novel regimen combining high dose cytarabine and bortezomib has activity in multiply relapsed and refractory mantle cell lymphoma - long-term results of a multicenter observation study. Leuk Lymphoma 2009;50(5):716-22
    • (2009) Leuk Lymphoma , vol.50 , Issue.5 , pp. 716-722
    • Weigert, O.1    Weidmann, E.2    Mueck, R.3
  • 22
    • 77952301490 scopus 로고    scopus 로고
    • Successful treatment with hyper-CVAD and highly active anti-retroviral therapy HAART for AIDS-related burkitt lymphoma
    • Suzuki K, Nakazato T, Sanada Y, et al. Successful treatment with hyper-CVAD and highly active anti-retroviral therapy (HAART) for AIDS-related Burkitt lymphoma. Rinsho Ketsueki 2010;51(3):207-12
    • (2010) Rinsho Ketsueki , vol.51 , Issue.3 , pp. 207-212
    • Suzuki, K.1    Nakazato, T.2    Sanada, Y.3
  • 23
    • 0033964380 scopus 로고    scopus 로고
    • Results of treatment with hyper-CVAD a dose-intensive regimen in adult acute lymphocytic leukemia
    • Kantarjian HM, OBrien S, Smith TL, et al. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol 2000;18(3):547-61
    • (2000) J. Clin. Oncol. , vol.18 , Issue.3 , pp. 547-561
    • Kantarjian, H.M.1    O'Brien, S.2    Smith, T.L.3
  • 24
    • 0023356575 scopus 로고
    • Saturation of ara-CTP accumulation during high-dose ara-C therapy: Pharmacologic rationale for intermediate-dose ara-C
    • Plunkett W, Liliemark JO, Estey E, Keating MJ. Saturation of ara-CTP accumulation during high-dose ara-C therapy: pharmacologic rationale for intermediate-dose ara-C. Semin Oncol 1987;14:159-66
    • (1987) Semin Oncol. , vol.14 , pp. 159-166
    • Plunkett, W.1    Liliemark, J.O.2    Estey, E.3    Keating, M.J.4
  • 25
    • 0017028517 scopus 로고
    • The lethality of aranucleotides
    • Cohen SS. The lethality of aranucleotides. Med Biol 1976;54(5):299-326
    • (1976) Med. Biol. , vol.54 , Issue.5 , pp. 299-326
    • Cohen, S.S.1
  • 26
    • 0025737279 scopus 로고
    • Effect of dose on the pharmacokinetic and pharmacodynamic effects of cytarabine
    • Capizzi RL, White JC, Powell BL,Perrino F. Effect of dose on the pharmacokinetic and pharmacodynamic effects of cytarabine. Semin Hematol 1991;28(4):54-69
    • (1991) Semin Hematol. , vol.28 , Issue.4 , pp. 54-69
    • Capizzi, R.L.1    White, J.C.2    Powell, B.L.3    Perrino, F.4
  • 27
    • 0020577333 scopus 로고
    • Subcutaneous infusion of cytosine arabinoside a practical alternative to intravenous infusion
    • Slevin ML, Piall EM, Aherne GW, et al. Subcutaneous infusion of cytosine arabinoside. A practical alternative to intravenous infusion. Cancer Chemother Pharmacol 1983;10(2):112-14
    • (1983) Cancer Chemother Pharmacol , vol.10 , Issue.2 , pp. 112-114
    • Slevin, M.L.1    Piall, E.M.2    Aherne, G.W.3
  • 28
    • 0021800252 scopus 로고
    • Prodrugs do they have advantages in clinical practice
    • Stella VJ, Charman WN, Naringrekar VH. Prodrugs. Do they have advantages in clinical practice? Drugs 1985;29:455-73
    • (1985) Drugs , vol.29 , pp. 455-473
    • Stella, V.J.1    Charman, W.N.2    Naringrekar, V.H.3
  • 29
  • 30
    • 0016430387 scopus 로고
    • Rationale for design of biologically reversible drug derivatives: Prodrugs
    • Sinkula AA, Yalkowsky SH. Rationale for design of biologically reversible drug derivatives: prodrugs. J Pharm Sci 1975;64:181-210
    • (1975) J. Pharm. Sci. , vol.64 , pp. 181-210
    • Sinkula, A.A.1    Yalkowsky, S.H.2
  • 31
    • 67649111006 scopus 로고    scopus 로고
    • Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues
    • Peterson LW, McKenna CE. Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues. Expert Opin Drug Deliv 2009;6(4):405-20
    • (2009) Expert Opin. Drug. Deliv. , vol.6 , Issue.4 , pp. 405-420
    • Peterson, L.W.1    McKenna, C.E.2
  • 33
    • 77956183144 scopus 로고    scopus 로고
    • Synthesis and in vivo evaluation of N4-amino acid derivatives of cytarabine for improving the oral delivery of cytarabine
    • Jin MJ, Hong JH, Han HK. Synthesis and in vivo evaluation of N4-amino acid derivatives of cytarabine for improving the oral delivery of cytarabine. J Korean Pharm Sci 2008;38(4):255-9
    • (2008) J. Korean. Pharm. Sci. , vol.38 , Issue.4 , pp. 255-259
    • Jin, M.J.1    Hong, J.H.2    Han, H.K.3
  • 34
    • 62649140994 scopus 로고    scopus 로고
    • Syn thesis transport and pharmacokinetics of 5-amino acid ester prodrugs of 1-beta-darabinofuranosylcytosine
    • Sun Y, Sun J, Shi L, et al. Synthesis, transport and pharmacokinetics of 5-amino acid ester prodrugs of 1-beta-Darabinofuranosylcytosine. Mol Pharm 2009;6(1):315-25
    • (2009) Mol. Pharm. , vol.6 , Issue.1 , pp. 315-325
    • Sun, Y.1    Sun, J.2    Shi, L.3
  • 35
    • 42949174825 scopus 로고    scopus 로고
    • Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting
    • Li F, Maag J, Alfredson H. Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. J Pharm Sci 2008;97(3):1109-34
    • (2008) J. Pharm. Sci. , vol.97 , Issue.3 , pp. 1109-1134
    • Li, F.1    Maag, J.2    Alfredson, H.3
  • 36
    • 7444249091 scopus 로고    scopus 로고
    • Carboxylic acid and phosphate ester derivatives of fluconazole: Synthesis and antifungal activities
    • Nam NH, Sardari S, Selecky M, Parang K. Carboxylic acid and phosphate ester derivatives of fluconazole: Synthesis and antifungal activities. Bioorg Med Chem 2004;12(23):6255-69
    • (2004) Bioorg. Med. Chem. , vol.12 , Issue.23 , pp. 6255-6269
    • Nam, N.H.1    Sardari, S.2    Selecky, M.3    Parang, K.4
  • 37
    • 67650450487 scopus 로고    scopus 로고
    • Synthesis and evaluation of anti-tumor activities of N4 fatty acyl amino acid derivatives of 1-beta-arabinofuranosylcytosine
    • Liu B, Cui C, Duan W, et al. Synthesis and evaluation of anti-tumor activities of N4 fatty acyl amino acid derivatives of 1-beta- arabinofuranosylcytosine. Eur J Med Chem 2009;44:3596-600
    • (2009) Eur. J. Med. Chem. , vol.44 , pp. 3596-3600
    • Liu, B.1    Cui, C.2    Duan, W.3
  • 38
    • 1242286151 scopus 로고    scopus 로고
    • Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukaemia and solid tumour cell lines
    • Bergman AM, Kuiper CM, Voorn DA, et al. Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukaemia and solid tumour cell lines. Biochem Pharmacol 2004;67:503-11
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 503-511
    • Bergman, A.M.1    Kuiper, C.M.2    Voorn, D.A.3
  • 39
    • 0033564132 scopus 로고    scopus 로고
    • Antitumour activity of P-4055 elaidic acid-cytarabine compared to cytarabine in metastatic and s.c. human tumour xenograft models
    • Breistol K, Balzarini J, Sandvold ML, et al. Antitumour activity of P-4055 (Elaidic Acid-Cytarabine) compared to cytarabine in metastatic and s.c. human tumour xenograft models. Cancer Res 1999;59:2944-9
    • (1999) Cancer Res. , vol.59 , pp. 2944-2949
    • Breistol, K.1    Balzarini, J.2    Sandvold, M.L.3
  • 40
    • 0025270335 scopus 로고
    • Effects of 1-beta-darabinofuranosylcytosine on DNA replication intermediates monitored by PH-step alkaline elution
    • Ross DD, Chen SR, Cuddy DP. Effects of 1-beta-Darabinofuranosylcytosine on DNA replication intermediates monitored by PH-step alkaline elution. Cancer Res 1990;50:2658-66
    • (1990) Cancer Res. , vol.50 , pp. 2658-2666
    • Ross, D.D.1    Chen, S.R.2    Cuddy, D.P.3
  • 41
    • 10344233199 scopus 로고    scopus 로고
    • Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines
    • DOI 10.1081/NCN-200027735
    • Bergman AM, Kuiper CM, Myhren F, et al. Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukaemia and solid tumour cell lines. Nucleosides Nucleotides Nucleic Acids 2004;23:1523-6 (Pubitemid 39625956)
    • (2004) Nucleosides, Nucleotides and Nucleic Acids , vol.23 , Issue.8-9 , pp. 1523-1526
    • Bergman, A.M.1    Kuiper, C.M.2    Myhren, F.3    Sandvold, M.L.4    Hendriks, H.R.5    Peters, G.J.6
  • 42
    • 58149096305 scopus 로고    scopus 로고
    • CP-4055 and CP-4126 are active in ara-C and gemcitabine-resistant lymphoma cell lines
    • Galmarini CM, Myhren F, Sandvold ML. CP-4055 and CP-4126 are active in ara-C and gemcitabine-resistant lymphoma cell lines. Br J Haematol 2009;144(2):273-5
    • (2009) Br. J. Haematol. , vol.144 , Issue.2 , pp. 273-275
    • Galmarini, C.M.1    Myhren, F.2    Sandvold, M.L.3
  • 43
    • 42049090008 scopus 로고    scopus 로고
    • Anti proliferative activity of elacy CP-4055 in combination with cloretazine VNP40101M idarubicin, gemcitabine irinotecan and topotecan in human leukemia and lymphoma cells
    • Adams DJ, Sandvold ML, Myhren F, et al. Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Leuk Lymphoma 2008;49(4):786-97
    • (2008) Leuk Lymphoma , vol.49 , Issue.4 , pp. 786-797
    • Adams, D.J.1    Sandvold, M.L.2    Myhren, F.3
  • 44
    • 58149095946 scopus 로고    scopus 로고
    • Intravenous administration of CP-4055 elacyttm in patients with solid tumours a phase 1 study
    • Dueland S, Aamdal S, Lind MJ, et al. Intravenous administration of CP-4055 (ElacytTM) in patients with solid tumours. A phase 1 study. Acta Oncol 2009;48:137-45
    • (2009) Acta. Oncol. , vol.48 , pp. 137-145
    • Dueland, S.1    Aamdal, S.2    Lind, M.J.3
  • 45
    • 77956188936 scopus 로고    scopus 로고
    • Synthesis and evaluation of fatty acyl ester derivatives of cytarabine as anti-leukemia agents
    • Chhikara BS, Mandal D, Parang K. Synthesis and evaluation of fatty acyl ester derivatives of cytarabine as anti-leukemia agents. Eur J Med Chem 2010;45(10):4601-8
    • (2010) Eur. J. Med. Chem. , vol.45 , Issue.10 , pp. 4601-4608
    • Chhikara, B.S.1    Mandal, D.2    Parang, K.3
  • 46
    • 67649111006 scopus 로고    scopus 로고
    • Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues
    • Peterson LW, McKenna CE. Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues. Expert Opin Drug Deliv 2009;6(4):405-20
    • (2009) Expert Opin. Drug. Deliv. , vol.6 , Issue.4 , pp. 405-420
    • Peterson, L.W.1    McKenna, C.E.2
  • 47
    • 0018575385 scopus 로고
    • Nucleoside conjugates as potential antitumor agents 2 synthesis and biological activity of 1-b-darabinofuranosylcytosine conjugates of prednisolone and prednisone
    • Hong CI, Nechaev A, West CR. Nucleoside conjugates as potential antitumor agents. 2. Synthesis and biological activity of 1-b-Darabinofuranosylcytosine conjugates of prednisolone and prednisone. J Med Chem 1979;22:1428-32
    • (1979) J. Med. Chem. , Issue.22 , pp. 1428-1432
    • Hong, C.I.1    Nechaev, A.2    West, C.R.3
  • 48
    • 0017618331 scopus 로고
    • A phospholipid derivative of cytosine arabinoside and its conversion to phosphatidylinositol by animal tissue
    • Raetz CRH, Chu MY, Srivastava SP, Turcotte JG. A phospholipid derivative of cytosine arabinoside and its conversion to phosphatidylinositol by animal tissue. Science 1977;196:303-5
    • (1977) Science , vol.196 , pp. 303-305
    • Raetz, C.R.H.1    Chu, M.Y.2    Srivastava, S.P.3    Turcotte, J.G.4
  • 49
    • 0020054279 scopus 로고
    • Lipophilic 5¢-alkyl phosphate esters of 1-beta- darabinofuranosylcytosine and its N4-acyl and 2,2¢-anhydro-3¢-O-acyl derivatives as potential prodrugs
    • Rosowsky A, Kim SH, Ross J, Wick MM. Lipophilic 5¢-alkyl phosphate esters of 1-beta-Darabinofuranosylcytosine and its N4-acyl and 2,2¢-anhydro-3¢-O-acyl derivatives as potential prodrugs. J Med Chem 1982;25:171-8
    • (1982) J. Med. Chem. , vol.25 , pp. 171-178
    • Rosowsky, A.1    Kim, S.H.2    Ross, J.3    Wick, M.M.4
  • 50
    • 0018238739 scopus 로고
    • The syn thesis characterization and preliminary biological evaluation of 1-beta-D-arabinofuranosylcytosine-5¢- diphosphate-L-12-dipalmitin
    • MacCoss M, Ryu EK, Matsushita T. The synthesis, characterization, and preliminary biological evaluation of 1-beta-D-arabinofuranosylcytosine-5¢- diphosphate-L-1,2-dipalmitin. Biochem Biophys Res Commun 1978;85:714-23
    • (1978) Biochem. Biophys. Res. Commun , vol.85 , pp. 714-723
    • MacCoss, M.1    Ryu, E.K.2    Matsushita, T.3
  • 51
    • 0025219938 scopus 로고
    • Participation of the peroxisomal beta-oxidation system in the chain shortening of PCA16 a metabolite of the cytosine arabinoside prodrug YNKO1 in rat liver
    • Yoshida Y, Yamada J, Watanabe T, et al. Participation of the peroxisomal beta-oxidation system in the chain shortening of PCA16, a metabolite of the cytosine arabinoside prodrug, YNKO1, in rat liver. Biochem Pharmacol 1990;39:1505-12
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 1505-1512
    • Yoshida, Y.1    Yamada, J.2    Watanabe, T.3
  • 52
    • 0019275878 scopus 로고
    • Synthetic nucleosides and nucleotides XVI synthesis and biological evaluations of a series of 1-beta-D-arabinofuranosylcytosine 5¢-alkyl or arylphosphates
    • Saneyoshi M, Morozumi M, Kodama K, et al. Synthetic nucleosides and nucleotides. XVI. Synthesis and biological evaluations of a series of 1-beta-D-arabinofuranosylcytosine 5¢-alkyl or arylphosphates. Chem Pharm Bull 1980;28:2915-23
    • (1980) Chem. Pharm. Bull. , vol.28 , pp. 2915-2923
    • Saneyoshi, M.1    Morozumi, M.2    Kodama, K.3
  • 53
    • 0028978603 scopus 로고
    • Pharmacokinetics of ara-CMP-stearate YNK01: Phase I study of the oral Ara-C derivative
    • Schleyer E, Braess J, Ramsauer B, et al. Pharmacokinetics of Ara-CMP-stearate (YNK01): phase I study of the oral Ara-C derivative. Leukemia 1995;9:1085-90
    • (1995) Leukemia , vol.9 , pp. 1085-1090
    • Schleyer, E.1    Braess, J.2    Ramsauer, B.3
  • 54
    • 0028180444 scopus 로고
    • Clinical pharmacology of 1-beta-Darabinofuranosylcytosine-5¢- stearylphosphate an orally administered long-acting derivative of low-dose 1-beta-D-arabinofuranosylcytosine
    • Ueda T, Kamiya K, Urasaki Y, et al. Clinical pharmacology of 1-beta-Darabinofuranosylcytosine- 5¢- stearylphosphate, an orally administered long-acting derivative of low-dose 1-beta-D- arabinofuranosylcytosine. Cancer Res 1994;54:109-13
    • (1994) Cancer Res. , vol.54 , pp. 109-113
    • Ueda, T.1    Kamiya, K.2    Urasaki, Y.3
  • 55
    • 0031682978 scopus 로고    scopus 로고
    • Oral cytarabine ocfosfate in acute myeloid leukemia and non-Hodgkins lymphoma phase I/II studies and pharmacokinetics
    • Braess J, Freund M, Hanauske A, et al. Oral cytarabine ocfosfate in acute myeloid leukemia and non-Hodgkins lymphoma phase I/II studies and pharmacokinetics. Leukemia 1998;12:1618-26
    • (1998) Leukemia , vol.12 , pp. 1618-1626
    • Braess, J.1    Freund, M.2    Hanauske, A.3
  • 56
    • 43049125243 scopus 로고    scopus 로고
    • YNK01 an oral cytosine arabinoside derivative in acute myeloid leukemia and chronic myeloid leukemia
    • Heussner P, Willemze R, Ganser A, et al. YNK01, an oral cytosine arabinoside derivative in acute myeloid leukemia and chronic myeloid leukemia. Haematol Blood Transfus 1997;38:882-5
    • (1997) Haematol. Blood Transfus. , vol.38 , pp. 882-885
    • Heussner, P.1    Willemze, R.2    Ganser, A.3
  • 58
    • 68649114340 scopus 로고    scopus 로고
    • Special features of mixed phosphotriester derivatives of cytarabine
    • This article reports a study of comparative enzymatic hydrolysis of the phosphate prodrugs of cytarabine
    • Gouy MH, Jordheim LP, Lefebvre I, et al. Special features of mixed phosphotriester derivatives of cytarabine. Bioorg Med Chem 2009;17:6340-47. This article reports a study of comparative enzymatic hydrolysis of the phosphate prodrugs of cytarabine.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 6340-47
    • Gouy, M.H.1    Jordheim, L.P.2    Lefebvre, I.3
  • 59
    • 3142752643 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug
    • Tobias SC, Borch RF. Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharma 2004;1(2):112-6
    • (2004) Mol. Pharma. , vol.1 , Issue.2 , pp. 112-116
    • Tobias, S.C.1    Borch, R.F.2
  • 60
    • 77950026170 scopus 로고    scopus 로고
    • Phophoramidates of 2¢-beta-darabinouridine AraU as phosphate prodrugs design synthesis in vitro activity and metabolism
    • Mehellou Y, Valente R, Mottram H, et al. Phophoramidates of 2¢-beta-Darabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism. Bioorg Med Chem 2010;18:2439-46
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 2439-2446
    • Mehellou, Y.1    Valente, R.2    Mottram, H.3
  • 61
    • 77950822780 scopus 로고    scopus 로고
    • Novel drug delivery systems for sustained and targeted delivery of anti-cancer drugs: Current status and future prospects
    • Utreja P, Jain S, Tiwary AK. Novel drug delivery systems for sustained and targeted delivery of anti-cancer drugs: current status and future prospects. Curr Drug Deliv 2010;7(2):152-61
    • (2010) Curr. Drug. Deliv. , vol.7 , Issue.2 , pp. 152-161
    • Utreja, P.1    Jain, S.2    Tiwary, A.K.3
  • 62
    • 34948876504 scopus 로고    scopus 로고
    • Nucleoside analogue delivery systems in cancer therapy
    • This review discusses the utility of different delivery systems useful for the nucleoside drugs in respective therapy
    • Diab R, Degobert G, Hamoudeh M, et al. Nucleoside analogue delivery systems in cancer therapy. Expert Opin Drug Deliv 2007;4(5):513-31. This review discusses the utility of different delivery systems useful for the nucleoside drugs in respective therapy.
    • (2007) Expert Opin. Drug. Deliv. , vol.4 , Issue.5 , pp. 513-531
    • Diab, R.1    Degobert, G.2    Hamoudeh, M.3
  • 63
    • 34247868742 scopus 로고    scopus 로고
    • Site directed drug delivery by non-viral mode
    • Dubey SK, Pandey A, Mishra R, et al. Site directed drug delivery by non-viral mode. Ind J Biotech 2007;6(2):159-74
    • (2007) Ind. J. Biotech. , vol.6 , Issue.2 , pp. 159-174
    • Dubey, S.K.1    Pandey, A.2    Mishra, R.3
  • 64
    • 69749110108 scopus 로고    scopus 로고
    • Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine
    • Kripp M, Hofheinz RD. Treatment of lymphomatous and leukemic meningitis with liposomal encapsulated cytarabine. Int J Nanomedicine 2008;3(4):397-401
    • (2008) Int. J. Nanomedicine , vol.3 , Issue.4 , pp. 397-401
    • Kripp, M.1    Hofheinz, R.D.2
  • 65
    • 77953445866 scopus 로고    scopus 로고
    • Natural polysaccharide hydrogels as novel excipients for modified drug delivery systems: A review
    • Manjanna KM, Kumar TMP, Shivakumar B. Natural polysaccharide hydrogels as novel excipients for modified drug delivery systems: a review. Int J ChemTech Res 2010;2(1):509-25
    • (2010) Int. J. Chem. Tech. Res. , vol.2 , Issue.1 , pp. 509-525
    • Manjanna, K.M.1    Kumar, T.M.P.2    Shivakumar, B.3
  • 66
    • 0028533656 scopus 로고
    • Anti-cancer drug Ara-C release from phema hydrogels
    • Trigo RM, Blanco MD, Teijon JM, Sastre R. Anti-cancer drug, Ara-C, release from pHEMA hydrogels. Biomater 1994;15(14):1181-6
    • (1994) Biomater. , vol.15 , Issue.14 , pp. 1181-1186
    • Trigo, R.M.1    Blanco, M.D.2    Teijon, J.M.3    Sastre, R.4
  • 67
    • 0033191642 scopus 로고    scopus 로고
    • Cytarabine trapping in poly 2-hydroxyethyl methacrylate-coacrylamide hydrogels: Drug delivery studies
    • Sastre RL, Blanco MD, Gomez C, et al. Cytarabine trapping in poly(2-hydroxyethyl methacrylate-coacrylamide) hydrogels: drug delivery studies. Polym Int 1999;48:843-50
    • (1999) Polym. Int. , vol.48 , pp. 843-850
    • Sastre, R.L.1    Blanco, M.D.2    Gomez, C.3
  • 68
    • 76149115554 scopus 로고    scopus 로고
    • Liposomal cancer therapy: Exploiting tumor characteristics
    • Kaasgaard T, Andresen TL. Liposomal cancer therapy: exploiting tumor characteristics. Expert Opin Drug Deliv 2010;7(2):225-43
    • (2010) Expert Opin. Drug. Deliv. , vol.7 , Issue.2 , pp. 225-243
    • Kaasgaard, T.1    Andresen, T.L.2
  • 69
    • 77953912416 scopus 로고    scopus 로고
    • Strategy for effective brain drug delivery
    • Alam MI, Beg S, Samad A, et al. Strategy for effective brain drug delivery. Eur J Pharm Sci 2010;40(5):385-403
    • (2010) Eur. J. Pharm. Sci. , vol.40 , Issue.5 , pp. 385-403
    • Alam, M.I.1    Beg, S.2    Samad, A.3
  • 70
    • 68149089776 scopus 로고    scopus 로고
    • Advances in gene delivery through molecular design of cationic lipids
    • Bhattacharya S, Bajaj A. Advances in gene delivery through molecular design of cationic lipids. Chem Commun 2009;31:4632-56
    • (2009) Chem. Commun. , vol.31 , pp. 4632-4656
    • Bhattacharya, S.1    Bajaj, A.2
  • 71
    • 77049116222 scopus 로고    scopus 로고
    • Cationic lipid-mediated nucleic acid delivery: Beyond being cationic
    • Rao NM. Cationic lipid-mediated nucleic acid delivery: beyond being cationic. Chem Phys Lipids 2010;163(3):245-52
    • (2010) Chem. Phys. Lipids , vol.163 , Issue.3 , pp. 245-252
    • Rao, N.M.1
  • 72
    • 0034000453 scopus 로고    scopus 로고
    • Tumour vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • Maeda H, Wu J, Sawa T, et al. Tumour vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000;65:271-84
    • (2000) J. Control. Release. , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3
  • 73
    • 77953609568 scopus 로고    scopus 로고
    • Targeting anticancer drugs to tumor vasculature using cationic liposomes
    • Abu Lila AS, Ishida T, Kiwada H. Targeting anticancer drugs to tumor vasculature using cationic liposomes. Pharma Res 2010;27(7):1171-83
    • (2010) Pharma Res. , vol.27 , Issue.7 , pp. 1171-1183
    • Abu Lila, A.S.1    Ishida, T.2    Kiwada, H.3
  • 75
    • 39049158179 scopus 로고    scopus 로고
    • Liposomal cytarabine for leukemic and lymphomatous meningitis: Recent developments
    • This review has a detailed analysis of reports related to liposomal formulation of cytarabine
    • Benesch M, Urban C. Liposomal cytarabine for leukemic and lymphomatous meningitis: recent developments. Expert Opin Pharm 2008;9(2):301-9 . This review has a detailed analysis of reports related to liposomal formulation of cytarabine.
    • (2008) Expert Opin. Pharm. , vol.9 , Issue.2 , pp. 301-309
    • Benesch, M.1    Urban, C.2
  • 76
    • 56749183581 scopus 로고    scopus 로고
    • Chitosan-based thermosensitive hydrogel containing liposomes for sustained delivery of cytarabine
    • Mulik R, Kulkarni V, Murthy RSR. Chitosan-based thermosensitive hydrogel containing liposomes for sustained delivery of cytarabine. Drug Devel Ind Pharm 2009;35(1):49-56
    • (2009) Drug. Devel. Ind. Pharm. , vol.35 , Issue.1 , pp. 49-56
    • Mulik, R.1    Kulkarni, V.2    Murthy, R.S.R.3
  • 77
    • 39049158179 scopus 로고    scopus 로고
    • Liposomal cytarabine for leukemic and lymphomatous meningitis: Recent developments
    • Benesch M, Urban C. Liposomal cytarabine for leukemic and lymphomatous meningitis: recent developments. Expert Opin Pharmacother 2008;9(2):301-9
    • (2008) Expert Opin. Pharmacother. , vol.9 , Issue.2 , pp. 301-309
    • Benesch, M.1    Urban, C.2
  • 78
    • 33845694515 scopus 로고    scopus 로고
    • A pharmacokinetic study of intra-CSF administered encapsulated cytarabine depocyt for the treatment of neoplastic meningitis in patients with leukemia lymphoma or solid tumors as part of a phase III study
    • Phuphanich S, Maria B, Braeckman R, Chamberlain M. A pharmacokinetic study of intra-CSF administered encapsulated cytarabine (DepoCyt) for the treatment of neoplastic meningitis in patients with leukemia, lymphoma, or solid tumors as part of a phase III study. J NeuroOncol 2007;81(2):201-8
    • (2007) J. NeuroOncol. , vol.81 , Issue.2 , pp. 201-208
    • Phuphanich, S.1    Maria, B.2    Braeckman, R.3    Chamberlain, M.4
  • 79
    • 0035990086 scopus 로고    scopus 로고
    • An open label trial of sustained-release cytarabine depocyt for the intrathecal treatment of solid tumor neoplastic meningitis
    • Jaeckle KA, Batchelor T, ODay SJ. An open label trial of sustained-release cytarabine (DepoCyt) for the intrathecal treatment of solid tumor neoplastic meningitis. J Neuro Oncol 2002;57(3):231-39
    • (2002) J. Neuro. Oncol. , vol.57 , Issue.3 , pp. 231-239
    • Jaeckle, K.A.1    Batchelor, T.2    O'Day, S.J.3
  • 80
    • 67650178791 scopus 로고    scopus 로고
    • Pharmacokinetics of CPX-351 cytarabine/daunorubicin HCl liposome injection in the mouse
    • Bayne WF, Mayer LD, Swenson CE. Pharmacokinetics of CPX-351 (cytarabine/daunorubicin HCl) liposome injection in the mouse. J Pharm Sci 2009;98(7):2540-48
    • (2009) J. Pharm. Sci. , vol.98 , Issue.7 , pp. 2540-2548
    • Bayne, W.F.1    Mayer, L.D.2    Swenson, C.E.3
  • 81
    • 55049108527 scopus 로고    scopus 로고
    • In vivo maintenance of synergistic cytarabine: Daunorubicin ratios greatly enhances therapeutic efficacy
    • Tardi P, Johnstone S, Harasym N, et al. In vivo maintenance of synergistic cytarabine: daunorubicin ratios greatly enhances therapeutic efficacy. Leuk Res 2009;33:129-39
    • (2009) Leuk Res. , vol.33 , pp. 129-139
    • Tardi, P.1    Johnstone, S.2    Harasym, N.3
  • 82
    • 67650123823 scopus 로고    scopus 로고
    • Phase I study of a liposomal carrier CPX-351 containing an optimized synergistic fixed molar ratio of cytarabine and daunorubicin in advanced leukemias and myelodysplastic syndromes
    • Feldman E, Lancet J, Kolitz JE, et al. Phase I study of a liposomal carrier (CPX-351) containing an optimized, synergistic, fixed molar ratio of cytarabine and daunorubicin in advanced leukemias and myelodysplastic syndromes. Am Soc Hematol Ann Meet Blood 2007;110:900
    • (2007) Am. Soc. Hematol. Ann. Meet Blood , vol.110 , pp. 900
    • Feldman, E.1    Lancet, J.2    Kolitz, J.E.3
  • 83
    • 77955280642 scopus 로고    scopus 로고
    • Leukemia-selective uptake and cytotoxicity of CPX-351 a synergistic fixed-ratio cytarabine: Daunorubicin formulation in bone marrow xenografts
    • Lima WS, Tardia PG, Santos ND. Leukemia-selective uptake and cytotoxicity of CPX-351, a synergistic fixed-ratio cytarabine:daunorubicin formulation, in bone marrow xenografts. Leuk Res 2010;34(9):1214-23
    • (2010) Leuk Res. , vol.34 , Issue.9 , pp. 1214-1223
    • Lima, W.S.1    Tardia, P.G.2    Santos, N.D.3
  • 84
    • 13844256146 scopus 로고    scopus 로고
    • Lipophilic arabinofuranosyl cytosine derivatives in liposomes
    • Schwendener R, Schott H. Lipophilic arabinofuranosyl cytosine derivatives in liposomes. Methods Enzymol 2005;391:58-70
    • (2005) Methods Enzymol. , vol.391 , pp. 58-70
    • Schwendener, R.1    Schott, H.2
  • 85
    • 0028783269 scopus 로고
    • Cell cycle-dependent cytotoxicity and induction of apoptosis by liposomal N4-hexadecyl-1-beta-darabinofuranosylcytosine
    • Horber DH, Von Ballmoos P, Schott H, Schwendener RA. Cell cycle-dependent cytotoxicity and induction of apoptosis by liposomal N4-hexadecyl-1-beta- Darabinofuranosylcytosine. Br J Cancer 1995;72(5):1067-73
    • (1995) Br. J. Cancer , vol.72 , Issue.5 , pp. 1067-1073
    • Horber, D.H.1    Von Ballmoos, P.2    Schott, H.3    Schwendener, R.A.4
  • 86
    • 0029016470 scopus 로고
    • Cellular pharmacology of a liposomal preparation of N4-hexadecyl-1-beta- darabinofuranosylcytosine a lipophilic derivative of 1-beta- Darabinofuranosylcytosine
    • Horber DH, Schott H, Schwendener RA. Cellular pharmacology of a liposomal preparation of N4- hexadecyl-1-beta-Darabinofuranosylcytosine, a lipophilic derivative of 1-beta-Darabinofuranosylcytosine. Br J Cancer 1995;71(5):957-62
    • (1995) Br. J. Cancer , vol.71 , Issue.5 , pp. 957-962
    • Horber, D.H.1    Schott, H.2    Schwendener, R.A.3
  • 87
    • 0030608798 scopus 로고    scopus 로고
    • Pharmacokinetics of N4-octadecyl-1-beta-darabinofuranosylcytosine in plasma and whole blood after intravenous and oral administration to mice
    • Rentsch KM, Schwendener RA, Schott H, Hanseler E. Pharmacokinetics of N4-octadecyl-1-beta-Darabinofuranosylcytosine in plasma and whole blood after intravenous and oral administration to mice. J Pharm Pharmacol 1997;49(11):1076-81
    • (1997) J. Pharm. Pharmacol. , vol.49 , Issue.11 , pp. 1076-1081
    • Rentsch, K.M.1    Schwendener, R.A.2    Schott, H.3    Hanseler, E.4
  • 88
    • 0030924555 scopus 로고    scopus 로고
    • Interactions with human blood in vitro and pharmacokinetic properties in mice of liposomal N4-octadecyl-1-beta-darabinofuranosylcytosine a new anticancer drug
    • Koller-Lucae SKM, Schott H, Schwendener RA. Interactions with human blood in vitro and pharmacokinetic properties in mice of liposomal N4-octadecyl-1-beta-Darabinofuranosylcytosine, a new anticancer drug. J Pharmacol Exp Ther 1997;282(3):1572-80
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , Issue.3 , pp. 1572-1580
    • Koller-Lucae, S.K.M.1    Schott, H.2    Schwendener, R.A.3
  • 89
    • 77954213425 scopus 로고    scopus 로고
    • Current issues in research on structure-property relationships in polymer nanocomposites
    • Jancar J, Douglas JF, Starr FW, et al. Current issues in research on structure-property relationships in polymer nanocomposites. Polymer 2010;51(15):3321-43
    • (2010) Polymer , vol.51 , Issue.15 , pp. 3321-3343
    • Jancar, J.1    Douglas, J.F.2    Starr, F.W.3
  • 91
    • 70450221930 scopus 로고    scopus 로고
    • Biodegradable polymeric nanoparticles based drug delivery systems
    • Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 2010;75(1):1-18
    • (2010) Colloids Surf. B Biointerfaces , vol.75 , Issue.1 , pp. 1-18
    • Kumari, A.1    Yadav, S.K.2    Yadav, S.C.3
  • 93
    • 45849084283 scopus 로고    scopus 로고
    • Nanoparticular drug delivery system of cytarabine hydrochloride CTH for improved treatment of lymphoma
    • Rukmani K, Sivakumar M, Kumar SS. Nanoparticular drug delivery system of cytarabine hydrochloride (CTH) for improved treatment of Lymphoma. J Biomed Nanotech 2007;3(1):90-6
    • (2007) J. Biomed. Nanotech. , vol.3 , Issue.1 , pp. 90-96
    • Rukmani, K.1    Sivakumar, M.2    Kumar, S.S.3
  • 94
    • 0343603531 scopus 로고    scopus 로고
    • Chitosan microspheres in PLG films as devices for cytarabine release
    • Blanco MD, Gomez C, Olmo R, et al. Chitosan microspheres in PLG films as devices for cytarabine release. Intern J Pharma 2000;202:29-39
    • (2000) Intern. J. Pharma. , vol.202 , pp. 29-39
    • Blanco, M.D.1    Gomez, C.2    Olmo, R.3
  • 95
    • 73449102914 scopus 로고    scopus 로고
    • Niosomes in sustained and targeted drug delivery: Some recent advances
    • Azeem A, Anwer MK, Talegaonkar S. Niosomes in sustained and targeted drug delivery: some recent advances. J Drug Target 2009;17(9):671-89
    • (2009) J. Drug. Target , vol.17 , Issue.9 , pp. 671-689
    • Azeem, A.1    Anwer, M.K.2    Talegaonkar, S.3
  • 96
    • 34047247870 scopus 로고    scopus 로고
    • Self assembled surfactant nano-structures important in drug delivery: A review
    • Sagar GH, Arunagirinathan MA, Bellare JR. Self assembled surfactant nano-structures important in drug delivery: a review. Ind J Exp Biol 2007;45:133-59
    • (2007) Ind. J. Exp. Biol. , vol.45 , pp. 133-159
    • Sagar, G.H.1    Arunagirinathan, M.A.2    Bellare, J.R.3
  • 97
    • 0034829755 scopus 로고    scopus 로고
    • The efficacy of 1-beta-D-arabinofuranosylcytosine entrapped in niosomes against leukaemia in mice
    • Ruckmani K, Ghosal SK. The efficacy of 1-beta-D-arabinofuranosylcytosine entrapped in niosomes against leukaemia in mice. STP Pharma Sci 2001;11(4):301-3
    • (2001) STP Pharma. Sci. , vol.11 , Issue.4 , pp. 301-303
    • Ruckmani, K.1    Ghosal, S.K.2


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