Design and synthesis of vidarabine prodrugs as antiviral agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 792-796

  Shen, Wei ^a   Kim, Jae Seung ^a   Kish, Phillip E ^a   Zhang, Jie ^a   Mitchell, Stefanie ^a   Gentry, Brian G ^b   Breitenbach, Julie M ^b   Drach, John C ^b   Hilfinger, John ^a  

^a TSRL INC   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Adenosine deaminase; Amino acid ester prodrug; Antiviral activity; ara A; ara H; Arahypoxanthine; Caco 2 permeability; Levulinate ester; Oral bioavailability; Phosphoramidate prodrug; Selective protection of nucleoside; Vidarabine

Indexed keywords

5' O DEXTRO VALYLVIDARABINE; AMINO ACID DERIVATIVE; ANTIVIRUS AGENT; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG; VIDARABINE; VIDARABINE DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; COWPOX VIRUS; DRUG ABSORPTION; DRUG DESIGN; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; NONHUMAN; POXVIRUS; VACCINIA VIRUS;

ADMINISTRATION, ORAL; ANTIVIRAL AGENTS; ARABINONUCLEOSIDES; CACO-2 CELLS; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESTERS; HELA CELLS; HUMANS; LEVULINIC ACIDS; NUCLEOSIDES; POXVIRIDAE; PRODRUGS; VIDARABINE;

ARA; POXVIRIDAE;

EID: 58549108392     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.031     Document Type: Article

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