Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth Factor-β Signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 Axis in Lung Fibroblasts

Journal of Biological Chemistry

Volumn 289, Issue 6, 2014, Pages 3262-3275

  Schwartze, Julian T ^a,b,d   Becker, Simone ^a,b   Sakkas, Elpidoforos ^a,b   Wujak, Lukasz A ^a,b   Niess, Gero ^a,b   Usemann, Jakob ^a,b,e   Reichenberger, Frank ^b,c   Herold, Susanne ^b   Vadász, István ^b   Mayer, Konstantin ^b   Seeger, Werner ^a,b   Morty, Rory E ^a,b  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c Asklepios Lung Hospital   (Germany)

^d UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE RESPIRATORY DISTRESS SYNDROME; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; DEPENDENT PROCESS; LUNG DEVELOPMENT; LUNG FIBROBLASTS; SMOOTH MUSCLE ACTINS; SMOOTH MUSCLE CELLS; TRANSFORMING GROWTH FACTORS;

BIOLOGICAL ORGANS; CELL CULTURE; DIGITAL STORAGE; DRUG PRODUCTS; ENDOTHELIAL CELLS; FIBROBLASTS; HORMONES; MUSCLE; PATIENT TREATMENT; PROTEINS; PULMONARY DISEASES; SIGNALING;

CELL SIGNALING;

ACTIVIN RECEPTOR LIKE KINASE 1; BUDESONIDE; DEXAMETHASONE; FLUTICASONE; GLUCOCORTICOID; MESSENGER RNA; METHYLPREDNISOLONE; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER;

FIBROBLAST; GLUCOCORTICOIDS; LUNG; SMAD TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA (TGFBETA);

ACTIVIN RECEPTORS, TYPE I; ANIMALS; ENDOTHELIAL CELLS; FEMALE; FIBROBLASTS; GLUCOCORTICOIDS; HUMANS; LUNG; MICE; MYOCYTES, SMOOTH MUSCLE; NIH 3T3 CELLS; PROTEIN-SERINE-THREONINE KINASES; PROTEOGLYCANS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84896708550     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.541052     Document Type: Article

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