TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: An epigenetic aberration of normal development?

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 304, Issue 2, 2013, Pages

  Warburton, David ^a   Shi, Wei ^a   Xu, Bing ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Emphysema; Epigenetics; Fibrosis; Smad3; TGF

Indexed keywords

BLEOMYCIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSINE; PROTEIN C JUN; SIRTUIN 1; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR PEA3; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BINDING SITE; EPIGENETICS; HISTONE ACETYLATION; HUMAN; LUNG ALVEOLUS WALL; LUNG DEVELOPMENT; LUNG EMPHYSEMA; LUNG FIBROSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; EPIGENOMICS; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; PULMONARY ALVEOLI; PULMONARY EMPHYSEMA; PULMONARY FIBROSIS; RATS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84872407198     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00258.2012     Document Type: Article

References (22)

1. Ask K, Bonniaud P, Maass K, Eickelberg O, Margetts PJ, Warburton D, Groffen J, Gauldie J, Kolb M. Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Int J Biochem Cell Biol 40: 484-495, 2008.
2. Bonniaud P, Margetts PJ, Ask K, Flanders K, Gauldie J, Kolb M. TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis. J Immunol 175: 5390-5395, 2005.
3. Chen H, Sun J, Buckley S, Chen C, Warburton D, Wang XF, Shi W. Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol 288: L683-L691, 2005.
4. Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 32: 285-295, 2008.
5. Colarossi C, Chen Y, Obata H, Jurukovski V, Fontana L, Dabovic B, Rifkin DB. Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol 167: 419-428, 2005.
6. Farkas L, Farkas D, Warburton D, Gauldie J, Shi W, Stampfli MR, Voelkel NF, Kolb M. Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice. Am J Physiol Lung Cell Mol Physiol 301: L391-L401, 2011.
7. Gauldie J, Galt T, Bonniaud P, Robbins C, Kelly M, Warburton D. Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. Am J Pathol 163: 2575-2584, 2003.
8. Kaartinen V, Warburton D. Fibrillin controls TGF-beta activation. Nat Genet 33: 331-332, 2003.
9. Lecart C, Cayabyab R, Buckley S, Morrison J, Kwong KY, Warburton D, Ramanathan R, Jones CA, Minoo P. Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation. Biol Neonate 77: 217-223, 2000.
10. Lindsay ME, Dietz HC. Lessons on the pathogenesis of aneurysm from heritable conditions. Nature 473: 308-316, 2011.
11. Petrides PE, Brenner D. From biochemical analysis to targeted therapies. Fibrogen Tissue Repair 5, Suppl 1: S1, 2012.
12. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 100: 768-776, 1997.
13. Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy and colorectal cancer. Genes Dev 16: 2264-2273, 2002.
14. Tarantal AF, Chen H, Shi TT, Lu CH, Fang AB, Buckley S, Kolb M, Gauldie J, Warburton D, Shi W. Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis. Eur Respir J 36: 907-914, 2010.
15. Toti P, Buonocore G, Tanganelli P, Catella AM, Palmeri ML, Vatti R, Seemayer TA. Bronchopulmonary dysplasia of the premature baby: an immunohistochemical study. Pediatr Pulmonol 24: 22-28, 1997.
16. Warburton D. Developmental responses to lung injury: repair or fibrosis. Fibrogen Tissue Repair 5, Suppl 1: S2, 2012.
17. Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, De Langhe S, Kemp PJ, Riccardi D, Torday J, Bellusci S, Shi W, Lubkin SR, Jesudason E. Lung organogenesis. Curr Top Dev Biol 90: 73-158, 2010.
18. Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng SG, Warburton D, Kolb M, Gauldie J, Shi W. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol 303: L89-L96, 2012.
19. Zhao J, Shi W, Wang YL, Chen H, Bringas P Jr, Datto MB, Frederick JP, Wang XF, Warburton D. Smad3 deficiency attenuates bleomycininduced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 282: L585-L593, 2002.
20. Zhao J, Sime PJ, Bringas P Jr, Tefft JD, Buckley S, Bu D, Gauldie J, Warburton D. Spatial-specific TGF-beta1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung. Eur J Cell Biol 78: 715-725, 1999.
21. Zhao J, Sime PJ, Bringas P Jr, Gauldie J, Warburton D. Adenovirusmediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis. Am J Physiol Lung Cell Mol Physiol 277: L412-L422, 1999.
22. Zhao J, Sime PJ, Bringas P Jr, Gauldie J, Warburton D. Epitheliumspecific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA. Mech Dev 72: 89-100, 1998.