Ionizing Radiation Shifts the PAI-1/ID-1 Balance and Activates Notch Signaling in Endothelial Cells

International Journal of Radiation Oncology Biology Physics

Volumn 73, Issue 2, 2009, Pages 506-513

  Scharpfenecker, Marion ^a   Kruse, Jacqueline J C M ^a   Sprong, Debbie ^a   Russell, Nicola S ^a   ten Dijke, Peter ^b   Stewart, Fiona A ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Endothelial cells; HHT; Ionizing radiation; Notch; TGF

Indexed keywords

ANIMAL CELL CULTURE; BLOOD VESSEL PROSTHESES; CHEMICAL ACTIVATION; CYTOLOGY; DNA; ENZYME INHIBITION; GENES; INTERACTIVE DEVICES; IONIZING RADIATION; IRRADIATION; MICROCIRCULATION; MOS CAPACITORS; NUCLEIC ACIDS; ORGANIC ACIDS; RADIATION; RADIATION SHIELDING; RADIOACTIVITY; SELF ASSEMBLY; TARGETS;

BIOCHEMICAL METHODS; CANCER PATIENTS; CELL MIGRATIONS; DNA BINDINGS; DOWNSTREAM TARGETS; HHT; HUMAN MICROVASCULAR ENDOTHELIAL CELLS; MICROVASCULAR ENDOTHELIAL CELLS; NORMAL TISSUES; NOTCH; NOTCH SIGNALING; NOTCH SIGNALING PATHWAYS; NUCLEAR TRANSLOCATIONS; PLASMINOGEN ACTIVATOR INHIBITORS; PROTEIN EXPRESSIONS; TARGET GENES; TRANSFORMING GROWTHS; UP REGULATIONS; VASCULAR HOMEOSTASISES;

ENDOTHELIAL CELLS;

ACTIVIN RECEPTOR LIKE KINASE 1; CESIUM 137; INHIBITOR OF DIFFERENTIATION 1; JAGGED1; MESSENGER RNA; NOTCH RECEPTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ARTICLE; CELL MIGRATION; CHEMICAL ANALYSIS; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; TELANGIECTASIA; UPREGULATION;

ACTIVIN RECEPTORS, TYPE II; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GROWTH DIFFERENTIATION FACTOR 2; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN-SERINE-THREONINE KINASES; RADIATION INJURIES; RECEPTORS, NOTCH; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD PROTEINS; TELANGIECTASIS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 58149357077     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.09.052     Document Type: Article

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