Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 301, Issue 4, 2011, Pages

  Farkas, Laszlo ^a,b,c   Farkas, Daniela ^a,b,c   Warburton, David ^d   Gauldie, Jack ^a   Shi, Wei ^d   Stampfli, Martin R ^a,b   Voelkel, Norbert F ^c   Kolb, Martin ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Animal model; Emphysema; Genetic predisposition

Indexed keywords

CIGARETTE SMOKE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HOMEOSTASIS; IMMUNOFLUORESCENCE TEST; KNOCKOUT MOUSE; LASER CAPTURE MICRODISSECTION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG EMPHYSEMA; LUNG ENDOTHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LASERS; MICE; MICE, KNOCKOUT; MICRODISSECTION; PNEUMOCYTES; POLYMERASE CHAIN REACTION; PULMONARY ALVEOLI; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; RISK FACTORS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMOKING; TOBACCO; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80053367572     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00369.2010     Document Type: Article

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