메뉴 건너뛰기




Volumn 8, Issue 5, 2013, Pages

Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; LIGAND; MYC PROTEIN;

EID: 84877934286     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063563     Document Type: Article
Times cited : (105)

References (46)
  • 2
    • 34047181147 scopus 로고    scopus 로고
    • Drug insight: role of the androgen receptor in the development and progression of prostate cancer
    • Taplin ME, (2007) Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol 4: 236-244.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 236-244
    • Taplin, M.E.1
  • 3
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour Activity of MDV3100 in a Phase 1-2 Study of Castration-Resistant Prostate Cancer
    • Scher HI, Beer TM, Higano C, Anand A, Taplin M-E, et al. (2010) Antitumour Activity of MDV3100 in a Phase 1-2 Study of Castration-Resistant Prostate Cancer. Lancet 375: 1437-1446.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.3    Anand, A.4    Taplin, M.-E.5
  • 4
  • 5
    • 84863393126 scopus 로고    scopus 로고
    • Effects of abiraterone acetate on androgen signaling in castrate-resistant prostate cancer in bone
    • Efstathiou E, Titus M, Tsavachidou D, Tzelepi V, Wen S, et al. (2012) Effects of abiraterone acetate on androgen signaling in castrate-resistant prostate cancer in bone. J Clin Oncol 30: 637-643.
    • (2012) J Clin Oncol , vol.30 , pp. 637-643
    • Efstathiou, E.1    Titus, M.2    Tsavachidou, D.3    Tzelepi, V.4    Wen, S.5
  • 6
    • 84859405971 scopus 로고    scopus 로고
    • MDV3100 effects on androgen receptor (AR) signaling and bone marrow testosterone concentration modulation: A preliminary report
    • abstr 4501
    • Efstathiou E, Titus MA, Tsavachidou D, Hoang A, Karlou M, Wen S, et al. (2011) MDV3100 effects on androgen receptor (AR) signaling and bone marrow testosterone concentration modulation: A preliminary report. J Clin Oncol 29: abstr 4501.
    • (2011) J Clin Oncol , vol.29
    • Efstathiou, E.1    Titus, M.A.2    Tsavachidou, D.3    Hoang, A.4    Karlou, M.5    Wen, S.6
  • 7
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Guo Z, Yang X, Sun F, Jiang R, Linn DE, et al. (2009) A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 69: 2305-2313.
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5
  • 8
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, et al. (2009) Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 69: 16-22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5
  • 9
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • Sun S, Sprenger CC, Vessella RL, Haugk K, Soriano K, et al. (2010) Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 120: 2715-2730.
    • (2010) J Clin Invest , vol.120 , pp. 2715-2730
    • Sun, S.1    Sprenger, C.C.2    Vessella, R.L.3    Haugk, K.4    Soriano, K.5
  • 10
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, et al. (2011) Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19: 575-586.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5
  • 11
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    • Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, et al. (2011) Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 19: 792-804.
    • (2011) Cancer Cell , vol.19 , pp. 792-804
    • Mulholland, D.J.1    Tran, L.M.2    Li, Y.3    Cai, H.4    Morim, A.5
  • 13
    • 0035328474 scopus 로고    scopus 로고
    • Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
    • Linja MJ, Savinainen KJ, Saramaki OR, Tammela TL, Vessella RL, et al. (2001) Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer. Cancer Res 61: 3550-3555.
    • (2001) Cancer Res , vol.61 , pp. 3550-3555
    • Linja, M.J.1    Savinainen, K.J.2    Saramaki, O.R.3    Tammela, T.L.4    Vessella, R.L.5
  • 14
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinanen R, et al. (1995) In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 9: 401-406.
    • (1995) Nat Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1    Hyytinen, E.2    Koivisto, P.3    Tanner, M.4    Keinanen, R.5
  • 15
    • 0036510548 scopus 로고    scopus 로고
    • Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways
    • Ueda T, Bruchovsky N, Sadar MD, (2002) Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem 277: 7076-7085.
    • (2002) J Biol Chem , vol.277 , pp. 7076-7085
    • Ueda, T.1    Bruchovsky, N.2    Sadar, M.D.3
  • 16
    • 80051963331 scopus 로고    scopus 로고
    • Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
    • Chang KH, Li R, Papari-Zareei M, Watumull L, Zhao YD, et al. (2011) Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer. Proc Natl Acad Sci U S A 108: 13728-13733.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13728-13733
    • Chang, K.H.1    Li, R.2    Papari-Zareei, M.3    Watumull, L.4    Zhao, Y.D.5
  • 17
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q, Li W, Zhang Y, Yuan X, Xu K, et al. (2009) Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 138: 245-256.
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5
  • 18
    • 0141569009 scopus 로고    scopus 로고
    • Myc-driven murine prostate cancer shares molecular features with human prostate tumors
    • Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, et al. (2003) Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 4: 223-238.
    • (2003) Cancer Cell , vol.4 , pp. 223-238
    • Ellwood-Yen, K.1    Graeber, T.G.2    Wongvipat, J.3    Iruela-Arispe, M.L.4    Zhang, J.5
  • 20
    • 0031059179 scopus 로고    scopus 로고
    • Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization
    • Jenkins RB, Qian J, Lieber MM, Bostwick DG, (1997) Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. Cancer Res 57: 524-531.
    • (1997) Cancer Res , vol.57 , pp. 524-531
    • Jenkins, R.B.1    Qian, J.2    Lieber, M.M.3    Bostwick, D.G.4
  • 21
  • 22
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, et al. (2011) BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146: 904-917.
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3    Rahl, P.B.4    Shi, J.5
  • 24
    • 1842612441 scopus 로고    scopus 로고
    • Molecular determinants of resistance to antiandrogen therapy
    • Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, et al. (2004) Molecular determinants of resistance to antiandrogen therapy. Nat Med 10: 33-39.
    • (2004) Nat Med , vol.10 , pp. 33-39
    • Chen, C.D.1    Welsbie, D.S.2    Tran, C.3    Baek, S.H.4    Chen, R.5
  • 25
    • 33845884027 scopus 로고    scopus 로고
    • Integrative molecular concept modeling of prostate cancer progression
    • Tomlins SA, Mehra R, Rhodes DR, Cao X, Wang L, et al. (2007) Integrative molecular concept modeling of prostate cancer progression. Nat Genet 39: 41-51.
    • (2007) Nat Genet , vol.39 , pp. 41-51
    • Tomlins, S.A.1    Mehra, R.2    Rhodes, D.R.3    Cao, X.4    Wang, L.5
  • 26
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, et al. (2009) Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324: 787-790.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3    Chen, Y.4    Watson, P.A.5
  • 27
    • 0034662959 scopus 로고    scopus 로고
    • A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest
    • Claassen GF, Hann SR, (2000) A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta-induced cell-cycle arrest. Proc Natl Acad Sci U S A 97: 9498-9503.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9498-9503
    • Claassen, G.F.1    Hann, S.R.2
  • 29
    • 84856069665 scopus 로고    scopus 로고
    • A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
    • Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, et al. (2012) A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science 335: 348-353.
    • (2012) Science , vol.335 , pp. 348-353
    • Kessler, J.D.1    Kahle, K.T.2    Sun, T.3    Meerbrey, K.L.4    Schlabach, M.R.5
  • 30
    • 77956588949 scopus 로고    scopus 로고
    • Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state
    • den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, et al. (2010) Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood 116: 1498-1505.
    • (2010) Blood , vol.116 , pp. 1498-1505
    • den Hollander, J.1    Rimpi, S.2    Doherty, J.R.3    Rudelius, M.4    Buck, A.5
  • 31
    • 69949098536 scopus 로고    scopus 로고
    • miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    • Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, et al. (2009) miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell 35: 610-625.
    • (2009) Mol Cell , vol.35 , pp. 610-625
    • Lal, A.1    Navarro, F.2    Maher, C.A.3    Maliszewski, L.E.4    Yan, N.5
  • 32
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, et al. (2008) Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 68: 4447-4454.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5
  • 35
    • 33751018274 scopus 로고    scopus 로고
    • Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc
    • Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, et al. (2006) Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol 26: 8418-8426.
    • (2006) Mol Cell Biol , vol.26 , pp. 8418-8426
    • Muncan, V.1    Sansom, O.J.2    Tertoolen, L.3    Phesse, T.J.4    Begthel, H.5
  • 37
    • 58949101975 scopus 로고    scopus 로고
    • In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors
    • Snoek R, Cheng H, Margiotti K, Wafa LA, Wong CA, et al. (2009) In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors. Clin Cancer Res 15: 39-47.
    • (2009) Clin Cancer Res , vol.15 , pp. 39-47
    • Snoek, R.1    Cheng, H.2    Margiotti, K.3    Wafa, L.A.4    Wong, C.A.5
  • 38
    • 83355163334 scopus 로고    scopus 로고
    • Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer
    • Zhang Y, Castaneda S, Dumble M, Wang M, Mileski M, et al. (2011) Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer. Mol Cancer Ther 10: 2309-2319.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2309-2319
    • Zhang, Y.1    Castaneda, S.2    Dumble, M.3    Wang, M.4    Mileski, M.5
  • 39
    • 80051940007 scopus 로고    scopus 로고
    • Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer
    • Bradbury RH, Hales NJ, Rabow AA, Walker GE, Acton DG, et al. (2011) Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer. Bioorg Med Chem Lett 21: 5442-5445.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 5442-5445
    • Bradbury, R.H.1    Hales, N.J.2    Rabow, A.A.3    Walker, G.E.4    Acton, D.G.5
  • 40
    • 84873877215 scopus 로고    scopus 로고
    • Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
    • abstr 3848
    • Loddick S, Bradbury R, Broadbent N, Campbell H, Gaughan L, et al. (2012) Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer. Cancer Res 72: abstr 3848.
    • (2012) Cancer Res , vol.72
    • Loddick, S.1    Bradbury, R.2    Broadbent, N.3    Campbell, H.4    Gaughan, L.5
  • 41
    • 23144434218 scopus 로고    scopus 로고
    • Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells
    • Haag P, Bektic J, Bartsch G, Klocker H, Eder IE, (2005) Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. J Steroid Biochem Mol Biol 96: 251-258.
    • (2005) J Steroid Biochem Mol Biol , vol.96 , pp. 251-258
    • Haag, P.1    Bektic, J.2    Bartsch, G.3    Klocker, H.4    Eder, I.E.5
  • 42
    • 70349741087 scopus 로고    scopus 로고
    • Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6
    • Gibbs A, Schwartzman J, Deng V, Alumkal J, (2009) Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. Proc Natl Acad Sci U S A 106: 16663-16668.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16663-16668
    • Gibbs, A.1    Schwartzman, J.2    Deng, V.3    Alumkal, J.4
  • 43
    • 44449108773 scopus 로고    scopus 로고
    • Differential expression of angiogenesis associated genes in prostate cancer bone, liver and lymph node metastases
    • Morrissey C, True LD, Roudier MP, Coleman IM, Hawley S, et al. (2008) Differential expression of angiogenesis associated genes in prostate cancer bone, liver and lymph node metastases. Clin Exp Metastasis 25: 377-388.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 377-388
    • Morrissey, C.1    True, L.D.2    Roudier, M.P.3    Coleman, I.M.4    Hawley, S.5
  • 44
    • 33746602208 scopus 로고    scopus 로고
    • A molecular correlate to the Gleason grading system for prostate adenocarcinoma
    • True L, Coleman I, Hawley S, Huang CY, Gifford D, et al. (2006) A molecular correlate to the Gleason grading system for prostate adenocarcinoma. Proc Natl Acad Sci U S A 103: 10991-10996.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10991-10996
    • True, L.1    Coleman, I.2    Hawley, S.3    Huang, C.Y.4    Gifford, D.5
  • 46
    • 79951714359 scopus 로고    scopus 로고
    • Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial
    • Page ST, Lin DW, Mostaghel EA, Marck BT, Wright JL, et al. (2011) Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial. J Clin Endocrinol Metab 96: 430-437.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 430-437
    • Page, S.T.1    Lin, D.W.2    Mostaghel, E.A.3    Marck, B.T.4    Wright, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.