The Homeodomain Protein HOXB13 Regulates the Cellular Response to Androgens

Molecular Cell

Volumn 36, Issue 3, 2009, Pages 405-416

  Norris, John D ^a   Chang, Ching Yi ^a   Wittmann, Bryan M ^a   Kunder, Rebecca S ^a   Cui, Huaxia ^a   Fan, Daju ^a   Joseph, James D ^a   McDonnell, Donald P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

CELLCYCLE; DNA; HUMDISEASE

Indexed keywords

ANDROGEN; DNA; HOMEODOMAIN PROTEIN; HOMEODOMAIN PROTEIN HOXB13; HOX PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DNA RESPONSIVE ELEMENT; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIPOGENESIS; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CLUSTER ANALYSIS; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; LIPID METABOLISM; MALE; METRIBOLONE; PROSTATIC NEOPLASMS; PROTEIN BINDING; RECEPTORS, ANDROGEN; RECOMBINANT FUSION PROTEINS; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 70449123571     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2009.10.020     Document Type: Article

References (31)

1. Aarnisalo P., Santti H., Poukka H., Palvimo J.J., and Jänne O.A. Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain. Endocrinology 140 (1999) 3097-3105
2. Berger M.F., Badis G., Gehrke A.R., Talukder S., Philippakis A.A., Peña-Castillo L., Alleyne T.M., Mnaimneh S., Botvinnik O.B., Chan E.T., et al. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133 (2008) 1266-1276
3. Bevan C.L., Hoare S., Claessens F., Heery D.M., and Parker M.G. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol. Cell. Biol. 19 (1999) 8383-8392
4. Chang C.Y., Abdo J., Hartney T., and McDonnell D.P. Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. Mol. Endocrinol. 19 (2005) 2478-2490
5. Cleutjens K.B., van der Korput H.A., van Eekelen C.C., van Rooij H.C., Faber P.W., and Trapman J. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol. Endocrinol. 11 (1997) 148-161
6. Huang L., Pu Y., Hepps D., Danielpour D., and Prins G.S. Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes. Endocrinology 148 (2007) 1235-1245
7. Hueber S.D., and Lohmann I. Shaping segments: Hox gene function in the genomic age. Bioessays 30 (2008) 965-979
8. Ikonen T., Palvimo J.J., Kallio P.J., Reinikainen P., and Jänne O.A. Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation. Endocrinology 135 (1994) 1359-1366
9. Jemal A., Siegel R., Ward E., Murray T., Xu J., Smigal C., and Thun M.J. Cancer statistics, 2006. CA Cancer J. Clin. 56 (2006) 106-130
10. Jung C., Kim R.S., Zhang H.J., Lee S.J., and Jeng M.H. HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. Cancer Res. 64 (2004) 9185-9192
11. Koh S.S., Li H., Lee Y.H., Widelitz R.B., Chuong C.M., and Stallcup M.R. Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J. Biol. Chem. 277 (2002) 26031-26035
12. Li X., Kimbrel E.A., Kenan D.J., and McDonnell D.P. Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. Mol. Endocrinol. 16 (2002) 1482-1491
13. Lobaccaro J.M., Poujol N., Térouanne B., Georget V., Fabre S., Lumbroso S., and Sultan C. Transcriptional interferences between normal or mutant androgen receptors and the activator protein 1--dissection of the androgen receptor functional domains. Endocrinology 140 (1999) 350-357
14. López R., Garrido E., Piña P., Hidalgo A., Lazos M., Ochoa R., and Salcedo M. HOXB homeobox gene expression in cervical carcinoma. Int. J. Gynecol. Cancer 16 (2006) 329-335
15. Ma H., Hong H., Huang S.M., Irvine R.A., Webb P., Kushner P.J., Coetzee G.A., and Stallcup M.R. Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins. Mol. Cell. Biol. 19 (1999) 6164-6173
16. Metzger E., Wissmann M., Yin N., Müller J.M., Schneider R., Peters A.H., Günther T., Buettner R., and Schüle R. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437 (2005) 436-439
17. Miao J., Wang Z., Provencher H., Muir B., Dahiya S., Carney E., Leong C.O., Sgroi D.C., and Orsulic S. HOXB13 promotes ovarian cancer progression. Proc. Natl. Acad. Sci. USA 104 (2007) 17093-17098
18. Norris J.D., Joseph J.D., Sherk A.B., Juzumiene D., Turnbull P.S., Rafferty S.W., Cui H., Anderson E., Fan D., Dye D.A., et al. Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. Chem. Biol. 16 (2009) 452-460
19. Noyes M.B., Christensen R.G., Wakabayashi A., Stormo G.D., Brodsky M.H., and Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133 (2008) 1277-1289
20. O'Malley B.W. Coregulators: from whence came these "master genes.". Mol. Endocrinol. 21 (2007) 1009-1013
21. Peterson T.J., Karmakar S., Pace M.C., Gao T., and Smith C.L. The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity. Mol. Cell. Biol. 27 (2007) 5933-5948
22. Sherk A.B., Frigo D.E., Schnackenberg C.G., Bray J.D., Laping N.J., Trizna W., Hammond M., Patterson J.R., Thompson S.K., Kazmin D., et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 68 (2008) 7475-7483
23. Suzuki M., Ueno N., and Kuroiwa A. Hox proteins functionally cooperate with the GC box-binding protein system through distinct domains. J. Biol. Chem. 278 (2003) 30148-30156
24. Swinnen J.V., Van Veldhoven P.P., Esquenet M., Heyns W., and Verhoeven G. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology 137 (1996) 4468-4474
25. Swinnen J.V., Esquenet M., Goossens K., Heyns W., and Verhoeven G. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res. 57 (1997) 1086-1090
26. Wang Q., Sharma D., Ren Y., and Fondell J.D. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J. Biol. Chem. 277 (2002) 42852-42858
27. Wang Q., Carroll J.S., and Brown M. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol. Cell 19 (2005) 631-642
28. Wang Q., Li W., Liu X.S., Carroll J.S., Jänne O.A., Keeton E.K., Chinnaiyan A.M., Pienta K.J., and Brown M. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol. Cell 27 (2007) 380-392
29. Yamashita T., Tazawa S., Yawei Z., Katayama H., Kato Y., Nishiwaki K., Yokohama Y., and Ishikawa M. Suppression of invasive characteristics by antisense introduction of overexpressed HOX genes in ovarian cancer cells. Int. J. Oncol. 28 (2006) 931-938
30. Yeh S., and Chang C. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA 93 (1996) 5517-5521
31. Zeltser L., Desplan C., and Heintz N. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development 122 (1996) 2475-2484