Quinoline-based p300 histone acetyltransferase inhibitors with Pro-apoptotic activity in human leukemia U937 cells

ChemMedChem

Volumn 9, Issue 3, 2014, Pages 542-548

  Lenoci, Alessia ^a   Tomassi, Stefano ^b   Conte, Mariarosaria ^c   Benedetti, Rosaria ^c   Rodriguez, Veronica ^a   Carradori, Simone ^a   Secci, Daniela ^a   Castellano, Sabrina ^d   Sbardella, Gianluca ^d   Filetici, Patrizia ^a   Novellino, Ettore ^b   Altucci, Lucia ^c,e   Rotili, Dante ^a   Mai, Antonello ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF SALERNO   (Italy)

^e INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

apoptosis; epigenetics; leukemia; lysine acetyltransferases (KATs); p300; structure activity relationships

Indexed keywords

2 METHYL 3 CARBETHOXY QUINOLINE; ACYLTRANSFERASE INHIBITOR; E1A ASSOCIATED P300 PROTEIN; ETHYL 2 METHYL 6 PHENETHOXYQUINOLINE 3 CARBOXYLATE; ETHYL 6 [(5 AMINOPENTYL)OXY] 2 METHYLQUINOLINE 3 CARBOXYLATE HYDROCHLORIDE; ETHYL 6 [[5 (ALLYLAMINO)PENTYL]OXY] 2 METHYLQUINOLINE 3 CARBOXYLATE; ETHYL 6 HYDROXY 2 METHYLQUINOLINE 3 CARBOXYLATE; HISTONE ACETYLTRANSFERASE; HISTONE H3; HISTONE H4; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VORINOSTAT;

ALKYLATION; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PRIORITY JOURNAL;

APOPTOSIS; EPIGENETICS; LEUKEMIA; LYSINE ACETYLTRANSFERASES (KATS); P300; STRUCTURE-ACTIVITY RELATIONSHIPS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 84896698147     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300536     Document Type: Article

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