Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3678-3689

  Furdas, Silviya D ^a   Shekfeh, Suhaib ^b   Bissinger, Elisabeth Maria ^a   Wagner, Julia M ^a   Schlimme, Sonja ^b   Valkov, Vassil ^a   Hendzel, Michael ^c   Jung, Manfred ^a   Sippl, Wolfgang ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Database screening; Epigenetics; Histone acetyltransferase; PCAF; Pyridoisothiazolones

Indexed keywords

A 4033 0171899; AMINO SUBSTITUTED ISOTHIAZOLONE; AMINOCARBONYLMETHYL DERIVATIVE; ANTINEOPLASTIC AGENT; HISTONE ACETYLTRANSFERASE PCAF; ISOTHIAZOLONE THIONE; K 783 6791; K 783 6798; N BENZYL DERIVATIVE; N BENZYLPYRIDOISOTHIAZOLONE DERIVATIVE; NSC 145097; NSC 279225; NSC 694614; NSC 694615; NSC 694616; NSC 694617; NSC 694618; NSC 694619; NSC 694620; NSC 694621; NSC 694622; NSC 694623; NSC 698599; NSC 698600; NSC 700864; PYRIDOISOTHIAZOLONE DERIVATIVE; PYRIDOISOTHIAZOLONE THIONE; SULFONE; SULFOXIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DATA BASE; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; VIRTUAL REALITY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; ENZYME INHIBITORS; HISTONE ACETYLTRANSFERASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; THIAZOLES;

EID: 79958271461     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.063     Document Type: Article

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