Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 4, 2009, Pages 1132-1135

  Mai, Antonello ^a   Rotili, Dante ^a   Tarantino, Domenico ^a   Nebbioso, Angela ^b   Castellano, Sabrina ^c   Sbardella, Gianluca ^c   Tini, Marc ^d   Altucci, Lucia ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d Siebens Drake Research Institute   (Canada)

Author keywords

4 Hydroxyquinoline; Apoptosis; Chromatin remodeling; Cytodifferentiation; Epigenetics; Histone acetylation; Histone acetyltransferase; p300 CBP

Indexed keywords

ALKYL GROUP; ALPHA TUBULIN; ANACARDIC ACID; BUTYROLACTONE; CARBOXYL GROUP; HISTONE ACETYLTRANSFERASE GCN5; HISTONE ACETYLTRANSFERASE PCAF; HISTONE H3; MB 3; QUINOLINOL DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL LYSATE; CELL STRAIN U937; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

COMBINATORIAL CHEMISTRY TECHNIQUES; HISTONE ACETYLTRANSFERASES; HUMANS; HYDROXYQUINOLINES; MOLECULAR STRUCTURE; P300-CBP TRANSCRIPTION FACTORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 59749103028     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.097     Document Type: Article

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