The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines

Amino Acids

Volumn 46, Issue 3, 2014, Pages 585-594

  Murray Stewart, Tracy ^a   Woster, Patrick M ^b   Casero Jr , Robert A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

CDH 1; Chromatin; Epigenetic; Histone; Methylation; Polyamine

Indexed keywords

1,15 BIS [N5 [3,3 (DIPHENYL)PROPYL] N1 BIGUANIDO] 4,12 DIAZAPENTADECANE; HISTONE; LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG; 1,15-BIS(N5-(3,3-(DIPHENYL)PROPYL)-N1-BIGUANIDO)-4,12-DIAZAPENTADECANE; BENZHYDRYL DERIVATIVE; CADHERIN; ENZYME INHIBITOR; GUANIDINE DERIVATIVE; HISTONE DEMETHYLASE; KDM1A PROTEIN, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA MODIFICATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG TARGETING; E CADHERIN GENE; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; GENE EXPRESSION; GENE SILENCING; GENETIC MARKER; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN MODIFICATION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; TREATMENT RESPONSE; TUMOR SUPPRESSOR GENE; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENETIC EPIGENESIS; GENETICS; HL 60 CELL LINE; LEUKEMIA, MYELOID, ACUTE; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

BENZHYDRYL COMPOUNDS; CADHERINS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; EPIGENESIS, GENETIC; GENE SILENCING; GUANIDINES; HISTONE DEMETHYLASES; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84896313894     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-013-1485-1     Document Type: Article

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