Downregulation and abnormal expression of e-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis

Human Pathology

Volumn 30, Issue 4, 1999, Pages 458-466

  Zheng, Zhong ^b   Pan, Jie ^b   Chu, Bin ^b   Wong, Yong Chuan ^b   Cheung, Annie Lai Man ^b   Tsao, Sai Wah ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NONE

Author keywords

E cadherin; Metastasis; Nasopharyngeal carcinoma; Staging; Survival; catenin

Indexed keywords

BETA CATENIN; UVOMORULIN;

ADULT; ADVANCED CANCER; ARTICLE; CANCER RADIOTHERAPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; NASOPHARYNX CARCINOMA; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

EID: 0032940579     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90123-5     Document Type: Article

References (25)

1. Simons MJ, Shanmugaratnam K: International Union Against Cancer: Epidemiology of Nasopharyngeal Carcinoma (vol 71). Geneva, Switzerland, World Health Organization, 1982, pp 10-16
2. Shanmugaratnam K, Sobin LH: Histological typing of upper respiratory tract tumors, in International Histological Classification of Tumors. Geneva, Switzerland, World Health Organization, 1978, pp 32-33
3. Sham JST, Choy D: Prognosis factors of nasopharyngeal carcinoma: A review of 759 patients. Br J Radiol 63:51-58, 1990
4. Hu M: Epidemiology of nasopharyngeal carcinoma, in Etiology and Pathogenesis of Nasopharyngeal Carcinoma. Beijing, People's Republic of China, Chinese Academy of Science Press, 1985, pp 1-17
5. Nicholls JM: Nasopharyngeal carcinoma: Classification and histologic appearance. Adv Anat Pathol 4:71-84, 1997
6. Flores AD, Dickson RI, Riding K, et al: Cancer of nasopharynx in British Columbia. Am J Clin Oncol 4:281-291, 1996
7. Mayer B, Johnson JP, Leitl F, et al: E-cadherin expression in primary and metastatic gastric cancer down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 53:1690-1695, 1993
8. Gagliardi G, Kandemir O, Liu D, et al: Changes in E-cadherin in immunoreactivity in the adenima-carcinoma sequence of large-bowel. Virchows Arch 426:149-154, 1995
9. Richmond PJM, Karayiannakis AJ, Nagafuchi A, et al: Aberrant E-cadherin and α-catenin expression in prostate cancer: Correlation with patient survival. Cancer Res 57:3189-3193, 1997
10. Nakanishi Y, Ochiai A, Akimoto S, et al: Expression of E-cadherin, α-catenin, α-catenin and plakoglobin in esophageal carcinoma and its prognostic significance. Oncology 54:158-165, 1997
11. Siitonen SM, Kononen JT, Helen HJ, et al: Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer. Anat Pathol 105:394-402, 1996
12. Wasielewski RV, Rhein A, Werner M, et al: Immunohistochemical detection of E-cadherin in differentiated thyriod carcinomas correlates with clinical outcome. Cancer Res 57:2501-2507, 1997
13. Andrews NA, Jones AS, Helliwell TR, et al: Expression of the E-cadherin-catenin cell adhesion complex in primary squanous cell carcinomas of the head and neck and their node métastases. Br J Cancer 75:1474-1480, 1997
14. Birchmeier W, Weidner KM, Hulsken J, et al: Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinoma. Semin Cancer Biol 4:231-239, 1993
15. Ponta H, Hoffman M, Herrilich P: Recent advances in genetics of metastasis. Eur J Cancer 13:1995-2001, 1994
16. Miller JR, Moon RT: Signal transduction through β-catenin and specification of cell fate during embryogenesis. Genes Dev 10:2527-2539, 1996
17. Valizadeh A, Karayiannakis AJ, Ei-Hariry I, et al: Expression of E-cadherin-associated molecules (α-, β- and γ-catenins and p120) in colorectal polyps. Am J Pathol 150:1977-1984, 1997
18. Kitaeva MN, Grogan L, Williams JP, et al: Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumor. Cancer Res 57:4478-4481, 1997
19. Ho JHK: Stage classification of nasopharyngeal carcinoma: A review in nasopharyngeal carcinoma, etiology and control. IARC Scientific Publications 20:99-113, 1978
20. Norton AJ: Microwave oven heating for antigen unmasking in routinely processed tissue sections. J Pathol 171:79-80, 1991
21. Frixen UH, Behrens L, Sachs M, et al: Cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113:173-185, 1991
22. Hinck L, Nathke IS, Papkoff J, et al: Dynamics of cadherin/ catenin complex formation: Novel protein interactions and pathways of complex assembly. J Cell Biol 125:1327-1340, 1994
23. Munemitsu S, Albert I, Souza B, et al: Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A 92:3046-3050, 1994
24. Schipper JH, Frixen UH, Behrens J, et al: E-cadherin expression in squamous cell carcinomas of head and neck: Inverse correlation with tumour dedifferentiation and lymph node metastasis. Cancer Res 51:6328-6337, 1991
25. Fahraeus R, Chen W, Trivedi P, et al: Decreased expression of E-cadherin and increased invasive capacity in EBV-LMP-transfected human epithelial and murine adenocarcinoma cells. Int J Cancer 52:834-838, 1992