Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site

Journal of Medicinal Chemistry

Volumn 57, Issue 5, 2014, Pages 1694-1707

  Dibrov, Sergey M ^a   Parsons, Jerod ^a,b   Carnevali, Maia ^a,c   Zhou, Shu ^a,d   Rynearson, Kevin D ^a   Ding, Kejia ^a   Garcia Sega, Emily ^a,e   Brunn, Nicholas D ^a   Boerneke, Mark A ^a   Castaldi, Maria P ^a,f   Hermann, Thomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

^c Aridis Pharmaceuticals LLC   (United States)

^d San Diego   (United States)

^e BRIDGEWATER STATE UNIVERSITY   (United States)

^f ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYSTREPTAMINE; ANTIBIOTIC AGENT; ANTIVIRUS AGENT; BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; CYANINE DYE; ERYTHROMYCIN; HEPATITIS C VIRUS TRANSLATION INHIBITOR; KETOLIDE; LIGAND; LINEZOLID; LYSINE DERIVATIVE; MACROLIDE; OLIGONUCLEOTIDE; PAROMOMYCIN; PHENAZINE DERIVATIVE; PROTEIN INHIBITOR; RNA; TOBRAMYCIN; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG SYNTHESIS; DRUG TARGETING; HEPATITIS C VIRUS; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; IN VITRO STUDY; INTERNAL RIBOSOME ENTRY SITE; LIGAND BINDING; MOLECULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; PHARMACOPHORE; PLASMA; PROTEIN CONFORMATION; PROTEIN DOMAIN; REVIEW; RNA CONFORMATION; STRUCTURE ACTIVITY RELATION; TITRIMETRY; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSCRIPTION; X RAY CRYSTALLOGRAPHY;

5' UNTRANSLATED REGIONS; HEPACIVIRUS; MODELS, MOLECULAR; PROTEIN BIOSYNTHESIS; RIBOSOMES;

EID: 84896299923     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401312n     Document Type: Review

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