Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice

Annals of the New York Academy of Sciences

Volumn 1082, Issue , 2006, Pages 52-55

  Ilves, Heini ^a   Kaspar, Roger L ^a   Wang, Qian ^b   Seyhan, Attila A ^a   Vlassov, Alexander V ^a   Contag, Christopher H ^b   Leake, Devin ^c   Johnston, Brian H ^a,b  

^a SomaGenics Inc   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Dharmacon Inc   (United States)

Author keywords

Hepatitis C virus; RNA interference; shRNA; siRNA

Indexed keywords

SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL MODEL; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; LIVER CELL; NONHUMAN; VIRUS INHIBITION;

HEPATITIS C VIRUS;

EID: 33845667426     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1348.060     Document Type: Conference Paper

References (4)

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2. RADHAKRISHNAN, S.K., T.J. LAYDEN & A.L. GARTEL. 2004. RNA interference as a new strategy against viral hepatitis. Virology 323: 173-181.
3. WANG, Q. et al. 2005. Small hairpin RNA efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model. Mol. Ther. 12: 562-568.
4. MCCAFFREY, A.P. et al. 2002. RNA interference in adult mice. Nature 418: 38-39.