Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: A novel mechanism of Nrf2/ARE signaling activation

Free Radical Research

Volumn 48, Issue 4, 2014, Pages 445-460

  Meng, X ^a   Sun, G ^a   Ye, J ^b   Xu, H ^c   Wang, H ^d   Sun, X ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

^c Research Academy of Environmental Sciences of Jilin Province   (China)

^d MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Apoptosis; Oxidative stress; PC12 cells; Phase II antioxidant enzymes; Phytoestrogen

Indexed keywords

CASPASE 3; ESTROGEN RECEPTOR; FULVESTRANT; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENT; NOTOGINSENOSIDE R1; PANAX NOTOGINSENG EXTRACT; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; GINSENOSIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; GENE SILENCING; GENETIC TRANSFECTION; LIPID PEROXIDATION; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PC12 CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; PC12 CELL LINE; PHOSPHORYLATION;

ANIMALS; DNA FRAGMENTATION; GINSENOSIDES; HUMANS; MAP KINASE SIGNALING SYSTEM; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PC12 CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84895762922     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2014.885117     Document Type: Article

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