Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: An insight into oestrogen receptor activation and PI3K/Akt signalling

British Journal of Pharmacology

Volumn 168, Issue 7, 2013, Pages 1758-1770

  Sun, Bing ^a   Xiao, Jing ^a   Sun, Xiao Bo ^a   Wu, Ying ^b  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

cardiac dysfunction; endotoxin; notoginsenoside R1; oestrogen receptor; PI3K PKB (Akt) signalling pathway

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTROGEN RECEPTOR ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NOTOGINSENOSIDE R1; PHOSPHATIDYLINOSITOL 3 KINASE; PHYTOESTROGEN; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENDOTOXEMIA; ENZYME PHOSPHORYLATION; HEART DISEASE; HEART FUNCTION; HEART PROTECTION; HEART STIMULATION; INFLAMMATION; MALE; MOUSE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CYTOKINES; ENDOTOXEMIA; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; GINSENOSIDES; HEART; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MYOCARDIUM; NF-KAPPA B; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84875123671     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12063     Document Type: Article

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