Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly

Journal of Neuroscience Research

Volumn 87, Issue 9, 2009, Pages 2145-2156

  Gu, Bin ^a   Nakamichi, Noritaka ^a   Zhang, Wen Sheng ^b   Nakamura, Yukary ^a   Kambe, Yuki ^a   Fukumori, Ryo ^a   Takuma, Kazuhiro ^a   Yamada, Kiyofumi ^a   Takarada, Takeshi ^a   Taniura, Hideo ^a   Yoneda, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Glutamate; Mitochondrial membrane; NMDAR; Notoginsenoside R1; NR1 NR2B

Indexed keywords

CALCIUM ION; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NOTOGINSENOSIDE R1; PANAX NOTOGINSENG EXTRACT; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; EXCITOTOXICITY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; STRUCTURE ANALYSIS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM SIGNALING; CELL LINE; CELL SURVIVAL; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GINSENOSIDES; GLUTAMIC ACID; HUMANS; INDICATORS AND REAGENTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; OXIDATIVE STRESS; PROPIDIUM; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 65849509914     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22021     Document Type: Article

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