Ginsenoside Rb1 prevents MPP +-induced apoptosis in PC12 cells by stimulating estrogen receptors with consequent activation of ERK1/2, Akt and inhibition of SAPK/JNK, p38 MAPK

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Hashimoto, Ryo ^a   Yu, Jing ^a   Koizumi, Hideki ^a   Ouchi, Yasuyoshi ^a   Okabe, Tetsuro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; ESTROGEN RECEPTOR; GINSENOSIDE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL XL; PROTEIN KINASE B; SMALL INTERFERING RNA; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CYTOTOXICITY; DNA FRAGMENTATION; DRUG STRUCTURE; ENZYME INHIBITION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 84867820015     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/693717     Document Type: Article

References (30)

1. Vogler B. K., Pittler M. H., Ernst E., The efficacy of ginseng. A systematic review of randomised clinical trials. European Journal of Clinical Pharmacology 1999 55 8 567 575 2-s2.0-0032830802 10.1007/s002280050674 (Pubitemid 29489202)
2. Lee S. T., Chu K., Sim J. Y., Heo J. H., Kim M., Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Disease and Associated Disorders 2008 22 3 222 226 2-s2.0-52649150959 10.1097/WAD.0b013e31816c92e6
3. Kennedy D. O., Scholey A. B., Wesnes K. A., Dose dependent changes in cognitive performance and mood following acute administration of Ginseng to healthy young volunteers. Nutritional Neuroscience 2001 4 4 295 310 2-s2.0-0035202967 (Pubitemid 33130418)
4. Ziemba A. W., Chmura J., Kaciuba-Uscilko H., Nazar K., Wisnik P., Gawronski W., Ginseng treatment improves psychomotor performance at rest and during graded exercise in young athletes. International Journal of Sport Nutrition 1999 9 4 371 377 2-s2.0-0033376978
5. D'Angelo L., Grimaldi R., Caravaggi M., A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. Journal of Ethnopharmacology 1986 16 1 15 22 2-s2.0-0022574424 (Pubitemid 16091747)
6. Tamura T., Cui X., Sakaguchi N., Akashi M., Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis. Food and Chemical Toxicology 2008 46 9 3080 3089 2-s2.0-50249163107 10.1016/j.fct.2008.06.011
7. Chen L. W., Wang Y. Q., Wei L. C., Shi M., Chan Y. S., Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS and Neurological DisordersDrug Targets 2007 6 4 273 281 2-s2.0-34547762666 10.2174/187152707781387288 (Pubitemid 47232939)
8. Yoshikawa T., Akiyoshi Y., Susumu T., Tokado H., Fukuzaki K., Nagata R., Samukawa K., Iwao H., Kito G., Ginsenoside Rb1 reduces neurodegeneration in the peri-infarct area of a thromboembolic stroke model in non-human primates. Journal of Pharmacological Sciences 2008 107 1 32 40 2-s2.0-44349164016 10.1254/jphs.FP0071297 (Pubitemid 351744082)
9. Wu J., Jeong H. K., Bulin S. E., Kwon S. W., Park J. H., Bezprozvanny I., Ginsenosides protect striatal neurons in a cellular model of Huntington's disease. Journal of Neuroscience Research 2009 87 8 1904 1912 2-s2.0-66049095622 10.1002/jnr.22017
10. Chen Z., Lu T., Yue X., Wei N., Jiang Y., Chen M., Ni G., Liu X., Xu G., Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: with emphasis on autophagy. Neuroscience Letters 2010 482 3 264 268 2-s2.0-77955924177 10.1016/j.neulet.2010.07.052
11. Ghosh A., Chandran K., Kalivendi S. V., Joseph J., Antholine W. E., Hillard C. J., Kanthasamy A., Kanthasamy A., Kalyanaraman B., Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Free Radical Biology and Medicine 2010 49 11 1674 1684 2-s2.0-78049357951 10.1016/j.freeradbiomed.2010.08.028
12. + Cell Calcium 2009 46 3 209 218 2-s2.0-69249213384 10.1016/j.ceca.2009.07.008
13. Wu Y., Shang Y., Sun S., Liang H., Liu R., Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt/GSK-3 β /caspase-3 mediated signaling pathway. Apoptosis 2007 12 8 1365 1375 2-s2.0-34250866187 10.1007/s10495-007-0065-9 (Pubitemid 46988273)
14. Medema J. P., Scaffidi C., Krammer P. H., Peter M. E., Bcl-x(L) acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex. The Journal of Biological Chemistry 1998 273 6 3388 3393 2-s2.0-0032488664 10.1074/jbc.273.6.3388 (Pubitemid 28109756)
15. Adams J. M., Cory S., The Bcl-2 protein family: arbiters of cell survival. Science 1998 281 5381 1322 1326 2-s2.0-0032575688 (Pubitemid 28406819)
16. Minn A. J., Kettlun C. S., Liang H., Kelekar A., Vander Heiden M. G., Chang B. S., Fesik S. W., Fill M., Thompson C. B., Bcl-x(L) regulates apoptosis by heterodimerization-dependent and -independent mechanisms. EMBO Journal 1999 18 3 632 643 2-s2.0-0033081618 10.1093/emboj/18.3.632 (Pubitemid 29057248)
17. Vander Heiden M. G., Li X. X., Gottleib E., Hill R. B., Thompson C. B., Colombini M., Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. The Journal of Biological Chemistry 2001 276 22 19414 19419 2-s2.0-0035380462 10.1074/jbc.M101590200
18. Christensen L. P., Chapter 1 ginsenosides. Chemistry, biosynthesis, analysis, and potential health effects. Advances in Food and Nutrition Research 2008 55 1 99 2-s2.0-50349101675 10.1016/S1043-4526(08)00401-4
19. Min J. K., Kim J. H., Cho Y. L., Maeng Y. S., Lee S. J., Pyun B. J., Kim Y. M., Park J. H., Kwon Y. G., 20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway. Biochemical and Biophysical Research Communications 2006 349 3 987 994 2-s2.0-33748633513 10.1016/j.bbrc.2006.08.129 (Pubitemid 44380196)
20. Attele A. S., Wu J. A., Yuan C. S., Ginseng pharmacology: multiple constituents and multiple actions. Biochemical Pharmacology 1999 58 11 1685 1693 2-s2.0-0344549853 10.1016/S0006-2952(99)00212-9 (Pubitemid 29505408)
21. Hwang Y. P., Jeong H. G., Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells. Toxicology and Applied Pharmacology 2010 242 1 18 28 2-s2.0-70449535513 10.1016/j.taap.2009.09.009
22. Leung K. W., Cheung L. W. T., Pon Y. L., Wong R. N. S., Mak N. K., Fan T. P. P., Au S. C. L., Tombran-Tink J., Wong A. S. T., Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen β receptor. British Journal of Pharmacology 2007 152 2 207 215 2-s2.0-34948887630 10.1038/sj.bjp.0707359 (Pubitemid 47517604)
23. Lee Y. J., Jin Y. R., Lim W. C., Park W. K., Cho J. Y., Jang S., Lee S. K., Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Archives of pharmacal research 2003 26 1 58 63 2-s2.0-0041308144
24. Yu J., Eto M., Akishita M., Kaneko A., Ouchi Y., Okabe T., Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor. Biochemical and Biophysical Research Communications 2007 353 3 764 769 10.1016/j.bbrc.2006.12. 119 (Pubitemid 46048736)
25. Pike C. J., Carroll J. C., Rosario E. R., Barron A. M., Protective actions of sex steroid hormones in Alzheimer's disease. Frontiers in Neuroendocrinology 2009 30 2 239 258 2-s2.0-67449141652 10.1016/j.yfrne.2009.04. 015
26. Hwang S. L., Yen G. C., Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide. Journal of Agricultural and Food Chemistry 2009 57 6 2576 2582 2-s2.0-64549139702 10.1021/jf8033607
27. Franke T. F., Hornik C. P., Segev L., Shostak G. A., Sugimoto C., PI3K/Akt and apoptosis: size matters. Oncogene 2003 22 56 8983 8998 2-s2.0-1642471831 10.1038/sj.onc.1207115 (Pubitemid 38121699)
28. Amaravadi R., Thompson C. B., The survival kinases Akt and Pim as potential pharmacological targets. Journal of Clinical Investigation 2005 115 10 2618 2624 2-s2.0-26444448463 10.1172/JCI26273 (Pubitemid 41434384)
29. Williams R. J., Spencer J. P. E., Rice-Evans C., Flavonoids: antioxidants or signalling molecules? Free Radical Biology and Medicine 2004 36 7 838 849 2-s2.0-1542605222 10.1016/j.freeradbiomed.2004.01.001 (Pubitemid 38352901)
30. Liu H., Yang J., Du F., Gao X., Ma X., Huang Y., Xu F., Niu W., Wang F., Mao Y., Sun Y., Lu T., Liu C., Zhang B., Li C., Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats. Drug Metabolism and Disposition 2009 37 12 2290 2298 2-s2.0-71049183577 10.1124/dmd.109.029819