HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2

Stem Cells

Volumn 32, Issue 2, 2014, Pages 364-376

  Prigione, Alessandro ^a,b   Rohwer, Nadine ^c   Hoffmann, Sheila ^b   Mlody, Barbara ^a   Drews, Katharina ^a   Bukowiecki, Raul ^a,b   Blümlein, Katharina ^d   Wanker, Erich E ^b   Ralser, Markus ^d   Cramer, Thorsten ^c   Adjaye, James ^a,e  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e Department of Orthopedic Surgery   (Germany)

Author keywords

Hypoxia inducible factor 1 ; Induced pluripotent stem cells; Metabolism; Pyruvate dehydrogenase kinase 1; Pyruvate kinase isoform M2; Reprogramming

Indexed keywords

HYPOXIA-INDUCIBLE FACTOR 1Α; INDUCED PLURIPOTENT STEM CELLS; METABOLISM; PYRUVATE DEHYDROGENASE KINASE 1; PYRUVATE KINASE ISOFORM M2; REPROGRAMMING;

CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINEAGE; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDUCED PLURIPOTENT STEM CELLS; MEMBRANE PROTEINS; MITOCHONDRIA; NEOPLASMS; NUCLEAR REPROGRAMMING; PROTEIN-SERINE-THREONINE KINASES; THYROID HORMONES;

EID: 84894554252     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1552     Document Type: Article

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