Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 30, 2013, Pages 12172-12179

  Tanabe, Koji ^a   Nakamura, Michiko ^a   Narita, Megumi ^a   Takahashi, Kazutoshi ^a   Yamanaka, Shinya ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

ES cells; HDF; IPS cell; Stemness; Transcription factor

Indexed keywords

CYCLIN D1; GLYCOPROTEIN; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P53; SHORT HAIRPIN RNA; TRA 1 60 ANTIGEN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CELL PLURIPOTENCY; CHILD; CONTROLLED STUDY; EMBRYONIC STEM CELL; FEMALE; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN FIBROBLAST; SOMATIC CELL; TRANSGENE;

ES CELLS; HDF; IPS CELL; STEMNESS; TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; FIBROBLASTS; HUMANS; PLURIPOTENT STEM CELLS;

EID: 84880651864     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310291110     Document Type: Article

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