Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis

PLoS Computational Biology

Volumn 7, Issue 3, 2011, Pages

  Xing, Heming ^a   McDonagh, Paul D ^a   Bienkowska, Jadwiga ^b   Cashorali, Tanya ^a   Runge, Karl ^a   Miller, Robert E ^a   DeCaprio, Dave ^a   Church, Bruce ^a   Roubenoff, Ronenn ^b,c   Khalil, Iya G ^a   Carulli, John ^b  

^a Gene Network Sciences Inc   (United States)

^b BIOGEN   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; PATIENT TREATMENT;

ARTHRITIS PATIENTS; CAUSAL MODELING; ENSEMBLE SIMULATION; GENE EXPRESSION DATA; GENES EXPRESSION; GENETIC EXPRESSIONS; KEY REGULATORS; NETWORK ENSEMBLE; RHEUMATOID ARTHRITIS; TUMOR NECROSIS FACTORS;

DISEASES;

GON 4 LIKE PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN RAP2C; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ABATACEPT; ANTIBODY CONJUGATE; ANTIRHEUMATIC AGENT; IL32 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; LASS5 PROTEIN, HUMAN; SPHINGOSINE ACYLTRANSFERASE;

ARTICLE; CAUSAL MODELING; COMPUTER MODEL; DATA ANALYSIS; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ANALYSIS; GENOTYPE; PREDICTION; RHEUMATOID ARTHRITIS; SCORING SYSTEM; COMPUTER SIMULATION; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; COMPUTER SIMULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOCONJUGATES; INTERLEUKINS; SPHINGOSINE N-ACYLTRANSFERASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79953670434     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001105     Document Type: Article

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