메뉴 건너뛰기




Volumn 4, Issue 6, 2010, Pages 723-734

Animal models of cigarette smoke-induced chronic obstructive pulmonary disease

Author keywords

airway remodeling; chronic bronchitis; emphysema; exacerbation; pulmonary hypertension

Indexed keywords

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CCR6 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE B INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MACROPHAGE ELASTASE INHIBITOR; PROTEINASE INHIBITOR; ROFLUMILAST; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR INHIBITOR; UNCLASSIFIED DRUG;

EID: 78650047604     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.10.68     Document Type: Article
Times cited : (54)

References (122)
  • 1
    • 42049101172 scopus 로고    scopus 로고
    • Mechanisms of cigarette smoke-induced COPD: Insights from animal models
    • Churg A, Cosio M, Wright JL. Mechanisms of cigarette smoke-induced COPD: insights from animal models. Am. J. Physiol. 294, L612-L631 (2008).
    • (2008) Am. J. Physiol. , vol.294
    • Churg, A.1    Cosio, M.2    Wright, J.L.3
  • 2
    • 84942256806 scopus 로고    scopus 로고
    • Development of alveoli
    • Harding R, Pinkerton KE, Plopper CG (Eds). Elsevier Academic Press, London, UK
    • McGowan SE, Snyder JM. Development of alveoli. In: The Lung: Development, Aging and the Environment. Harding R, Pinkerton KE, Plopper CG (Eds). Elsevier Academic Press, London, UK, 55-73 (2004).
    • (2004) The Lung: Development, Aging and the Environment , pp. 55-73
    • McGowan, S.E.1    Snyder, J.M.2
  • 3
    • 84942291879 scopus 로고    scopus 로고
    • Compensatory lung growth: Relationship to postnatal lung growth and adaption in destructive lung disease
    • Harding R, Pinkerton KE, Plopper CG (Eds). Elsevier Academic Press, London, UK
    • Hsia CCW, Johnson RL, Weibel ER. Compensatory lung growth: relationship to postnatal lung growth and adaption in destructive lung disease. In: The Lung: Development, Aging and the Environment. Harding R, Pinkerton KE, Plopper CG (Eds). Elsevier Academic Press, London, UK, 187-199 (2004).
    • (2004) The Lung: Development, Aging and the Environment , pp. 187-199
    • Ccw, H.1    Johnson, R.L.2    Weibel, E.R.3
  • 4
    • 33646164645 scopus 로고    scopus 로고
    • Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice defcient in Clara cell secretory protein
    • Plopper CG, Mango GW, Hatch GE et al. Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice defcient in Clara cell secretory protein. Toxicol. Appl. Pharm. 213, 74-85 (2006).
    • (2006) Toxicol. Appl. Pharm. , vol.213 , pp. 74-85
    • Plopper, C.G.1    Mango, G.W.2    Hatch, G.E.3
  • 5
    • 33644781601 scopus 로고    scopus 로고
    • Oxidant and antioxidant balance in the airways and airway diseases
    • Rahman I, Biswas SK, Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur. J. Pharmacol. 533, 222-239 (2006).
    • (2006) Eur. J. Pharmacol. , vol.533 , pp. 222-239
    • Rahman, I.1    Biswas, S.K.2    Kode, A.3
  • 6
    • 7044229899 scopus 로고    scopus 로고
    • The development of emphysema in cigarette smoke-exposed mice is strain dependent
    • Guerassimov A, Hoshino M, Takubo Y et al. The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am. J. Respir. Crit. Care Med. 170, 974-980 (2005).
    • (2005) Am. J. Respir. Crit. Care Med. , vol.170 , pp. 974-980
    • Guerassimov, A.1    Hoshino, M.2    Takubo, Y.3
  • 7
    • 77955643925 scopus 로고    scopus 로고
    • Anti-infammatory effects of celecoxib in rat lungs with smoke-induced emphysema
    • In press
    • Roh GS, Yi CO, Cho YJ et al. Anti-infammatory effects of celecoxib in rat lungs with smoke-induced emphysema. Am. J. Physiol. (2010) (In press).
    • (2010) Am. J. Physiol.
    • Roh, G.S.1    Yi, C.O.2    Cho, Y.J.3
  • 8
    • 0034474704 scopus 로고    scopus 로고
    • Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?
    • MacNee W, Rahman I. Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease? Trends Mol. Med. 7, 55-62 (2001).
    • (2001) Trends Mol. Med. , vol.7 , pp. 55-62
    • MacNee, W.1    Rahman, I.2
  • 9
    • 0029740875 scopus 로고    scopus 로고
    • MacNee W Role of oxidants/antioxidants in smoking-induced lung diseases
    • Rahman I, MacNee W Role of oxidants/antioxidants in smoking-induced lung diseases. Free Radic. Biol. Med. 21, 669-681 (1996).
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 669-681
    • Rahman, I.1
  • 10
    • 33644839261 scopus 로고    scopus 로고
    • Superoxide dismutase expression attenuates cigarette smoke-or elastase-generated emphysema in mice
    • Foronjy RF, Mirochnitchenko O, Propokenko A et al. Superoxide dismutase expression attenuates cigarette smoke-or elastase-generated emphysema in mice. Am. J. Respir. Crit. Care Med. 173, 623-631 (2006).
    • (2006) Am. J. Respir. Crit. Care Med. , vol.173 , pp. 623-631
    • Foronjy, R.F.1    Mirochnitchenko, O.2    Propokenko, A.3
  • 11
    • 58549105575 scopus 로고    scopus 로고
    • Blake DJ et al Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
    • Sussan TE, Rangasamy T, Blake DJ et al Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc. Natl Acad. Sci. USA 106, 250-255 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 250-255
    • Sussan, T.E.1    Rangasamy, T.2
  • 12
    • 77954470662 scopus 로고    scopus 로고
    • Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema
    • Yoshida T, Mett I, Bhunia AK et al Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat. Med. 16, 767-774 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 767-774
    • Yoshida, T.1    Mett, I.2    Bhunia, A.K.3
  • 13
    • 74949088495 scopus 로고    scopus 로고
    • Targeted disruption of NF-kB1 (p50) augments cigarette smoke-induced lung infammation and emphysema in mice: A critical role of p50 in chromatin remodeling
    • Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I. Targeted disruption of NF-kB1 (p50) augments cigarette smoke-induced lung infammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am. J. Physiol. 298, 197-209 (2010).
    • (2010) Am. J. Physiol. , vol.298 , pp. 197-209
    • Rajendrasozhan, S.1    Chung, S.2    Sundar, I.K.3    Yao, H.4    Rahman, I.5
  • 14
    • 66649127821 scopus 로고    scopus 로고
    • Immunologic aspects of chronic obstructive pulmonary disease
    • Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N. Engl. J. Med. 360, 2445-2454 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2445-2454
    • Cosio, M.G.1    Saetta, M.2    Agusti, A.3
  • 15
    • 33646671144 scopus 로고    scopus 로고
    • An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse
    • Pemberton PA, Cantwell JS, Kim KM et al An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD 3, 303-310 (2005).
    • (2005) COPD , vol.3 , pp. 303-310
    • Pemberton, P.A.1    Cantwell, J.S.2    Kim, K.M.3
  • 17
    • 33845496958 scopus 로고    scopus 로고
    • Role of tumour necrosis factor-a receptor p75 in cigarette smoke-induced pulmonary infammation and emphysema
    • D'hulst AI, Bracke KR, Maes T et al. Role of tumour necrosis factor-a receptor p75 in cigarette smoke-induced pulmonary infammation and emphysema. Eur. Respir. J. 28, 102-112 (2006).
    • (2006) Eur. Respir. J. , vol.28 , pp. 102-112
    • D'Hulst, A.I.1    Bracke, K.R.2    Maes, T.3
  • 18
    • 34247604963 scopus 로고    scopus 로고
    • Unexpected failure of anit-tumor necrosis factor therapy in chronic obstructive pulmonary disease
    • Barnes PJ. Unexpected failure of anit-tumor necrosis factor therapy in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 175, 866-867 (2007).
    • (2007) Am. J. Respir. Crit. Care Med. , vol.175 , pp. 866-867
    • Barnes, P.J.1
  • 20
    • 69149098943 scopus 로고    scopus 로고
    • Rofumilast in mo derate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: Two randomised clinical trials
    • Fabbri LM, Calverley P, Izquierdo-Alonso JL et al. Rofumilast in mo derate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet 374, 695-703 (2009).
    • (2009) Lancet , vol.374 , pp. 695-703
    • Fabbri, L.M.1    Calverley, P.2    Izquierdo-Alonso, J.L.3
  • 21
    • 0032743423 scopus 로고    scopus 로고
    • Quantum proteolysis by neutrophils: Implications for pulmonary emphysema in a(1)-antitrypsin deficiency
    • Campbell EJ, Campbell MA, Boudkedes SS, Owen CA. Quantum proteolysis by neutrophils: implications for pulmonary emphysema in a(1)-antitrypsin defciency. J. Clin. Invest. 104, 337-344 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 337-344
    • Campbell, E.J.1    Campbell, M.A.2    Boudkedes, S.S.3    Owen, C.A.4
  • 22
    • 33751213597 scopus 로고    scopus 로고
    • Cigarette smoke inhibits alveolar repair: A mechanism for the development of emphysema
    • Rennard SI, Togo S, Holz O. Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema. Proc. Am. Thorac. Soc. 3, 703-708 (2006).
    • (2006) Proc. Am. Thorac. Soc. , vol.3 , pp. 703-708
    • Rennard, S.I.1    Togo, S.2    Holz, O.3
  • 23
    • 49049115995 scopus 로고    scopus 로고
    • Animal models of chronic obstructive pulmonary disease
    • Wright JL, Cosio M, Churg A. Animal models of chronic obstructive pulmonary disease. Am. J. Physiol. 295, L1-L5 (2008).
    • (2008) Am. J. Physiol. , vol.295
    • Wright, J.L.1    Cosio, M.2    Churg, A.3
  • 24
    • 34447556991 scopus 로고    scopus 로고
    • Pathobiology of chronic obstructive pulmonary disease
    • Yoshida T, Tuder RM. Pathobiology of chronic obstructive pulmonary disease. Physiol. Rev. 87, 1047-1082 (2007).
    • (2007) Physiol. Rev. , vol.87 , pp. 1047-1082
    • Yoshida, T.1    Tuder, R.M.2
  • 27
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Hogg JC, Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350, 2645-2653 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3
  • 28
    • 74849104954 scopus 로고    scopus 로고
    • What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease
    • Hogg JC, McDonough JE, Gosselink JV, Hayashi S. What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 6, 668-672 (2009).
    • (2009) Proc. Am. Thorac. Soc. , vol.6 , pp. 668-672
    • Hogg, J.C.1    McDonough, J.E.2    Gosselink, J.V.3    Hayashi, S.4
  • 30
    • 0037764092 scopus 로고    scopus 로고
    • COPD exacerbations: Defnitions and classifcations
    • Berge S, Wedzicha JA. COPD exacerbations: defnitions and classifcations. Eur. Respir. J. 41, 46s-53s (2003).
    • (2003) Eur. Respir. J. , vol.41
    • Berge, S.1    Wedzicha, J.A.2
  • 31
    • 34648823020 scopus 로고    scopus 로고
    • Cigarette smoke-induced pulmonary infammation, but not airway remodelling, is attenuated in chemokine receptor 5-defcient mice
    • Bracke KR, D'hulst AI, Maes T et al. Cigarette smoke-induced pulmonary infammation, but not airway remodelling, is attenuated in chemokine receptor 5-defcient mice. Clin. Exp. Allergy 37, 1467-1479 (2007).
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 1467-1479
    • Bracke, K.R.1    D'Hulst, A.I.2    Maes, T.3
  • 32
    • 26944462695 scopus 로고    scopus 로고
    • Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs
    • Lee J-H, Lee D-S, Kim E-K et al. Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am. J. Respir. Crit. Care Med. 172, 987-993 (2005).
    • (2005) Am. J. Respir. Crit. Care Med. , vol.172 , pp. 987-993
    • Lee, J.-H.1    Lee, D.-S.2    Kim, E.-K.3
  • 33
    • 68149105815 scopus 로고    scopus 로고
    • Simvastatin attenuates experimental small airway remodelling in rats
    • Ou X-M, Wen F-Q, Uhal BD et al. Simvastatin attenuates experimental small airway remodelling in rats. Respirology 14, 734-745 (2009).
    • (2009) Respirology , vol.14 , pp. 734-745
    • Ou, X.-M.1    Wen, F.-Q.2    Uhal, B.D.3
  • 34
    • 78650037593 scopus 로고    scopus 로고
    • Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling
    • In press
    • Wright JL, Zhou S, Preobrazhenska O et al. Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling. Am. J. Respir. Crit. Care Med. (2010) (In press).
    • (2010) Am. J. Respir. Crit. Care Med.
    • Wright, J.L.1    Zhou, S.2    Preobrazhenska, O.3
  • 35
    • 0018776388 scopus 로고
    • Predictors of mortality in chronic obstructive pulmonary disease
    • Traver GA, Cline MG, Burrows B. Predictors of mortality in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 119, 895-902 (1979).
    • (1979) Am. Rev. Respir. Dis. , vol.119 , pp. 895-902
    • Traver, G.A.1    Cline, M.G.2    Burrows, B.3
  • 36
    • 42149117821 scopus 로고    scopus 로고
    • Pulmonary hypertension associated with COPD
    • Elwing J, Panos RJ. Pulmonary hypertension associated with COPD. Int. J. COPD 3, 55-70 (2008).
    • (2008) Int. J. COPD , vol.3 , pp. 55-70
    • Elwing, J.1    Panos, R.J.2
  • 37
    • 0035708801 scopus 로고    scopus 로고
    • Pulmonary hypertension associated with COPD
    • Naeije R, Barbera JA. Pulmonary hypertension associated with COPD. Crit. Care 5, 286-289 (2001).
    • (2001) Crit. Care , vol.5 , pp. 286-289
    • Naeije, R.1    Barbera, J.A.2
  • 38
    • 0036331883 scopus 로고    scopus 로고
    • Pulmonary hypertension in patients with chronic obstructive pulmonary disease: Recent advances in pathophysiology and management
    • Hida W, Tun Y, Kikuchi Y, Okabe S, Shirato K. Pulmonary hypertension in patients with chronic obstructive pulmonary disease: recent advances in pathophysiology and management. Respirology 7, 3-13 (2002).
    • (2002) Respirology , vol.7 , pp. 3-13
    • Hida, W.1    Tun, Y.2    Kikuchi, Y.3    Okabe, S.4    Shirato, K.5
  • 39
    • 58149376383 scopus 로고    scopus 로고
    • Treating pulmonary hypertension in COPD: Where do we start
    • Hoeper MM. Treating pulmonary hypertension in COPD: where do we start. Eur. Respir. J. 32, 541-542 (2008).
    • (2008) Eur. Respir. J. , vol.32 , pp. 541-542
    • Hoeper, M.M.1
  • 40
    • 67649349601 scopus 로고    scopus 로고
    • Pulmonary hypertension in patients with chronic obstructive pulmonary disease
    • Barbera JA, Blanco I. Pulmonary hypertension in patients with chronic obstructive pulmonary disease. Drugs 69, 1153-1171 (2009).
    • (2009) Drugs , vol.69 , pp. 1153-1171
    • Barbera, J.A.1    Blanco, I.2
  • 41
    • 0020512180 scopus 로고
    • The structure and function of the pulmonary vasculature in mild chronic obstructive pulmonary disease
    • Wright JL, Lawson L, Pare PD et al. The structure and function of the pulmonary vasculature in mild chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 128, 702-707 (1983).
    • (1983) Am. Rev. Respir. Dis. , vol.128 , pp. 702-707
    • Wright, J.L.1    Lawson, L.2    Pare, P.D.3
  • 42
    • 0021744276 scopus 로고
    • Lung disease in long-term cigarette smokers with and without chronic air-fow obstruction
    • Hale KA, Ewing SL, Gosnell BA, Niewoehner DE. Lung disease in long-term cigarette smokers with and without chronic air-fow obstruction. Am. Rev. Respir. Dis. 130, 716-721 (1984).
    • (1984) Am. Rev. Respir. Dis. , vol.130 , pp. 716-721
    • Hale, K.A.1    Ewing, S.L.2    Gosnell, B.A.3    Niewoehner, D.E.4
  • 43
    • 0026573643 scopus 로고
    • Analysis of the structure of the muscular pulmonary arteries in patients with pulmonary hypertension and COPD: National Institutes of Health Nocturnal Oxygen Therapy Trial
    • Wright JL, Petty TL, Thurlbeck WM. Analysis of the structure of the muscular pulmonary arteries in patients with pulmonary hypertension and COPD: National Institutes of Health Nocturnal Oxygen Therapy Trial. Lung 170, 109-124 (1992).
    • (1992) Lung , vol.170 , pp. 109-124
    • Wright, J.L.1    Petty, T.L.2    Thurlbeck, W.M.3
  • 44
    • 0038056173 scopus 로고    scopus 로고
    • Pulmonary hypertension in chronic obstructive pulmonary disease
    • Barbera JA, Peinado VI, Santos S. Pulmonary hypertension in chronic obstructive pulmonary disease. Eur. Respir. J. 21, 892-905 (2003).
    • (2003) Eur. Respir. J. , vol.21 , pp. 892-905
    • Barbera, J.A.1    Peinado, V.I.2    Santos, S.3
  • 45
    • 0034162943 scopus 로고    scopus 로고
    • Pulmonary artery remodeling modifes pulmonary hypertension during exercise in severe emphysema
    • Kubo K, Ge R-L, Koizumi T et al. Pulmonary artery remodeling modifes pulmonary hypertension during exercise in severe emphysema. Respir. Physiol. 120, 71-79 (2000).
    • (2000) Respir. Physiol. , vol.120 , pp. 71-79
    • Kubo, K.1    Ge, R.-L.2    Koizumi, T.3
  • 46
    • 0037925255 scopus 로고    scopus 로고
    • Effects of pulmonary artery remodeling on pulmonary circulation after lung volume reduction surgery
    • Haniuda M, Kubo K, Fijimoto K et al. Effects of pulmonary artery remodeling on pulmonary circulation after lung volume reduction surgery. Thorac. Cardiovasc. Surg. 51, 154-158 (2003).
    • (2003) Thorac. Cardiovasc. Surg. , vol.51 , pp. 154-158
    • Haniuda, M.1    Kubo, K.2    Fijimoto, K.3
  • 47
    • 0018857114 scopus 로고
    • Morphologic changes in the muscular pulmonary arteries: Relationship to cigarette smoking, airway disease, and emphysema
    • Hale KA, Niewoehner DE, Cosio MG. Morphologic changes in the muscular pulmonary arteries: relationship to cigarette smoking, airway disease, and emphysema. Am. Rev. Respir. Dis. 122, 273-278 (1980).
    • (1980) Am. Rev. Respir. Dis. , vol.122 , pp. 273-278
    • Hale, K.A.1    Niewoehner, D.E.2    Cosio, M.G.3
  • 48
    • 0028352642 scopus 로고
    • Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers
    • Kiowski W, Linder L, Stoschitzky K et al. Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers. Circulation 90, 27-34 (1994).
    • (1994) Circulation , vol.90 , pp. 27-34
    • Kiowski, W.1    Linder, L.2    Stoschitzky, K.3
  • 49
    • 0025829458 scopus 로고
    • Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease
    • Dinh-Xuan AT, Higenbottam TW, Clelland CA et al. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N. Engl. J. Med. 324, 1539-1547 (1991).
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1539-1547
    • Dinh-Xuan, A.T.1    Higenbottam, T.W.2    Clelland, C.A.3
  • 50
    • 0027311051 scopus 로고
    • Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine defciency
    • Dinh-Xuan AT, Pepke-Zaba J, Butt AY, Cremona G, Higenbottam TW. Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine defciency. Br. J. Pharmacol. 109, 587-591 (1993).
    • (1993) Br. J. Pharmacol. , vol.109 , pp. 587-591
    • Dinh-Xuan, A.T.1    Pepke-Zaba, J.2    Butt, A.Y.3    Cremona, G.4    Higenbottam, T.W.5
  • 51
    • 34247849179 scopus 로고    scopus 로고
    • Susceptibility to pulmonary hypertension in inbred strains of mice exposed to cigarette smoke
    • Nadziejko C, Fang K, Bravo A, Gordon T. Susceptibility to pulmonary hypertension in inbred strains of mice exposed to cigarette smoke. J. Appl. Physiol. 102, 1780-1785 (2007).
    • (2007) J. Appl. Physiol. , vol.102 , pp. 1780-1785
    • Nadziejko, C.1    Fang, K.2    Bravo, A.3    Gordon, T.4
  • 52
    • 0026051652 scopus 로고
    • Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig
    • Wright JL, Churg A. Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig. Exp. Lung Res. 17, 997-1009 (1991).
    • (1991) Exp. Lung Res. , vol.17 , pp. 997-1009
    • Wright, J.L.1    Churg, A.2
  • 53
    • 0030947533 scopus 로고    scopus 로고
    • Guinea pig pulmonary hypertension caused by cigarette smoke cannot be explained by capillary bed destruction
    • Yamato H, Sun J-P, Churg A, Wright JL. Guinea pig pulmonary hypertension caused by cigarette smoke cannot be explained by capillary bed destruction. J. Appl. Physiol. 82, 1644-1653 (1997).
    • (1997) J. Appl. Physiol. , vol.82 , pp. 1644-1653
    • Yamato, H.1    Sun, J.-P.2    Churg, A.3    Wright, J.L.4
  • 54
    • 0027415595 scopus 로고
    • The relationship of increased pulmonary artery pressure and airfow obstruction to emphysema
    • Wright JL. The relationship of increased pulmonary artery pressure and airfow obstruction to emphysema. J. Appl. Physiol. 74, 1320-1324 (1993).
    • (1993) J. Appl. Physiol. , vol.74 , pp. 1320-1324
    • Wright, J.L.1
  • 55
    • 33646378188 scopus 로고    scopus 로고
    • Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig
    • Wright JL, Tai H, Churg A. Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig. J. Appl. Physiol. 100, 672-678 (2006).
    • (2006) J. Appl. Physiol. , vol.100 , pp. 672-678
    • Wright, J.L.1    Tai, H.2    Churg, A.3
  • 56
    • 73949109501 scopus 로고    scopus 로고
    • Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig
    • Ferrer E, Peinado VI, Diez M et al. Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig. Respir. Res. 10, 76-87 (2009).
    • (2009) Respir. Res. , vol.10 , pp. 76-87
    • Ferrer, E.1    Peinado, V.I.2    Diez, M.3
  • 57
    • 7744236642 scopus 로고    scopus 로고
    • Cigarette smoke induces persisting increases of vasoactive mediators in pulmonary arteries
    • Wright JL, Tai H, Churg A. Cigarette smoke induces persisting increases of vasoactive mediators in pulmonary arteries. Am. J. Respir. Cell Mol. Biol. 31, 501-509 (2004).
    • (2004) Am. J. Respir. Cell Mol. Biol. , vol.31 , pp. 501-509
    • Wright, J.L.1    Tai, H.2    Churg, A.3
  • 58
    • 0031794213 scopus 로고    scopus 로고
    • Glutathione levels play a role in cigarette smoke induced cell proliferation in the rat lung
    • Wright JL, Sun J-P, Churg A. Glutathione levels play a role in cigarette smoke induced cell proliferation in the rat lung. Inhal. Toxicol. 10, 969-994 (1998).
    • (1998) Inhal. Toxicol. , vol.10 , pp. 969-994
    • Wright, J.L.1    Sun, J.-P.2    Churg, A.3
  • 59
    • 0034956355 scopus 로고    scopus 로고
    • Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung
    • Wright JL, Jeng AY, Battistini B. Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung. Inhal. Toxicol. 13, 497-511 (2001).
    • (2001) Inhal. Toxicol. , vol.13 , pp. 497-511
    • Wright, J.L.1    Jeng, A.Y.2    Battistini, B.3
  • 60
    • 0031004944 scopus 로고    scopus 로고
    • Endothelin-A receptor antagonist BQ-610 blocks ciagrette smoke-induced mitogenesis in rat airways and vessels
    • Dadmanesh F, Wright JL. Endothelin-A receptor antagonist BQ-610 blocks ciagrette smoke-induced mitogenesis in rat airways and vessels. Am. J. Physiol. 272, L614-L618 (1997).
    • (1997) Am. J. Physiol. , vol.272
    • Dadmanesh, F.1    Wright, J.L.2
  • 61
    • 0041810508 scopus 로고    scopus 로고
    • A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels
    • Wright JL, Farmer SG, Churg A. A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels. Eur. Respir. J. 22, 77-81 (2003).
    • (2003) Eur. Respir. J. , vol.22 , pp. 77-81
    • Wright, J.L.1    Farmer, S.G.2    Churg, A.3
  • 62
    • 34547815598 scopus 로고    scopus 로고
    • An MMP-9/-12 inhibitor prevents smoke-induced emphysema and small airway remodeling in guinea pigs
    • Churg A, Wang R, Wang X, Onnervik P-O, Thim K, Wright JL. An MMP-9/-12 inhibitor prevents smoke-induced emphysema and small airway remodeling in guinea pigs. Thorax 62, 706-713 (2007).
    • (2007) Thorax , vol.62 , pp. 706-713
    • Churg, A.1    Wang, R.2    Wang, X.3    Onnervik, P.-O.4    Thim, K.5    Wright, J.L.6
  • 63
    • 78650045656 scopus 로고    scopus 로고
    • Pulmonary hypertension in smoking mice over-expressing protease-activated receptor-2
    • DOI: 10.1183/09031936.00060210 Epub ahead of print
    • De Cunto G, Cardini S, Cirino G, Geppetti P, Lungarella G, Lucattelli M. Pulmonary hypertension in smoking mice over-expressing protease-activated receptor-2. Eur. Respir. J. DOI: 10.1183/09031936.00060210 (2010) (Epub ahead of print).
    • (2010) Eur. Respir. J.
    • De Cunto, G.1    Cardini, S.2    Cirino, G.3    Geppetti, P.4    Lungarella, G.5    Lucattelli, M.6
  • 64
    • 45149117722 scopus 로고    scopus 로고
    • Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: Analysis using guinea pig precision cut lung slices
    • Wright JL, Churg A. Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices. J. Appl. Physiol. 104, 1462-1469 (2008).
    • (2008) J. Appl. Physiol. , vol.104 , pp. 1462-1469
    • Wright, J.L.1    Churg, A.2
  • 65
    • 34748902878 scopus 로고    scopus 로고
    • The effect of smoking cessation and steroid treatment on emphyseam in guinea pigs
    • Milot J, Mechi B, Rad MTS et al. The effect of smoking cessation and steroid treatment on emphyseam in guinea pigs. Resp. Med. 101, 2327-2335 (2007).
    • (2007) Resp. Med. , vol.101 , pp. 2327-2335
    • Milot, J.1    Mechi, B.2    Mts, R.3
  • 66
    • 0036845628 scopus 로고    scopus 로고
    • Smoking cessation decreases the number of metaplastic secretory cells in the small airways of the guinea pig
    • Wright JL, Churg A. Smoking cessation decreases the number of metaplastic secretory cells in the small airways of the guinea pig. Inhal. Toxicol. 14, 101-107 (2002).
    • (2002) Inhal. Toxicol. , vol.14 , pp. 101-107
    • Wright, J.L.1    Churg, A.2
  • 67
    • 0028322034 scopus 로고
    • The effect of smoking cessation on pulmonary and cardiovascular function and structure
    • Wright JL, Sun J-P. The effect of smoking cessation on pulmonary and cardiovascular function and structure. J. Appl. Physiol. 76, 2163-2168 (1994).
    • (1994) J. Appl. Physiol. , vol.76 , pp. 2163-2168
    • Wright, J.L.1    Sun, J.-P.2
  • 68
    • 33745770618 scopus 로고    scopus 로고
    • Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice
    • March TH, Wilder JA, Esparza DC et al. Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice. Toxicol. Sci. 92, 545-559 (2006).
    • (2006) Toxicol. Sci. , vol.92 , pp. 545-559
    • March, T.H.1    Wilder, J.A.2    Esparza, D.C.3
  • 69
    • 1642462975 scopus 로고    scopus 로고
    • Effects of cigarette smoke exposure and cessation on infammatory cells and matrix metalloproteinase activity in mice
    • Seagrave JC, Barr EB, March TH. Effects of cigarette smoke exposure and cessation on infammatory cells and matrix metalloproteinase activity in mice. Exp. Lung Res. 30, 1-15 (2004).
    • (2004) Exp. Lung Res. , vol.30 , pp. 1-15
    • Seagrave, J.C.1    Barr, E.B.2    March, T.H.3
  • 70
    • 71849094775 scopus 로고    scopus 로고
    • Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema
    • Motz GT, Eppert BL, Sun G et al Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema. J. Immunol. 181, 8036-8043 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8036-8043
    • Motz, G.T.1    Eppert, B.L.2    Sun, G.3
  • 71
    • 77956698524 scopus 로고    scopus 로고
    • Infammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation
    • Braber S, Henricks PAJ, Nijkamp FP, Kraneveld AD, Folkerts G. Infammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation. Respir. Res. 11, 99-111 (2010).
    • (2010) Respir. Res. , vol.11 , pp. 99-111
    • Braber, S.1    Paj, H.2    Nijkamp, F.P.3    Kraneveld, A.D.4    Folkerts, G.5
  • 72
    • 0035421665 scopus 로고    scopus 로고
    • Amplifcation of infammation in emphysema and its association with latent adenoviral infection
    • Retamales I, Elliott WM, Meshi B et al. Amplifcation of infammation in emphysema and its association with latent adenoviral infection. Am. Rev. Respir. Dis. 164, 469-473 (2001
    • (2001) Am. Rev. Respir. Dis. , vol.164 , pp. 469-473
    • Retamales, I.1    Elliott, W.M.2    Meshi, B.3
  • 73
    • 0023636536 scopus 로고
    • Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: Relationship to lung function
    • Mullen JBM, Wright JL, Wiggs BR, Pare PD, Hogg JC. Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: relationship to lung function. Thorax 42, 843-848 (1987).
    • (1987) Thorax , vol.42 , pp. 843-848
    • Jbm, M.1    Wright, J.L.2    Wiggs, B.R.3    Pare, P.D.4    Hogg, J.C.5
  • 76
    • 0000913557 scopus 로고
    • Comparison of mucus glands in the tracheobronchial tree of man and animals
    • Goco RV, Kress MB, Brantigan OC. Comparison of mucus glands in the tracheobronchial tree of man and animals. Ann. NY Acad. Sci. 106, 555-571 (1963).
    • (1963) Ann. NY Acad. Sci. , vol.106 , pp. 555-571
    • Goco, R.V.1    Kress, M.B.2    Brantigan, O.C.3
  • 77
    • 0018159718 scopus 로고
    • Inhalation toxicity studies on cigarette smoke (VII) 6-week comparative experiments using modifed fue-cured cigarettes: Histopathology of the conducting airways
    • Walker D, Wilton LV, Binns R. Inhalation toxicity studies on cigarette smoke (VII) 6-week comparative experiments using modifed fue-cured cigarettes: histopathology of the conducting airways. Toxicology 10, 241-259 (1978).
    • (1978) Toxicology , vol.10 , pp. 241-259
    • Walker, D.1    Wilton, L.V.2    Binns, R.3
  • 78
    • 0015607971 scopus 로고
    • Goblet cell glycoprotein and tracheal gland hypertrophy in rat airways: The effect of tobacco smoke with and without the antiinfammatory agent phenylmethyloxadiozole
    • Jones R, Bolduc P, Reid LM. Goblet cell glycoprotein and tracheal gland hypertrophy in rat airways: the effect of tobacco smoke with and without the antiinfammatory agent phenylmethyloxadiozole. Br. J. Exp. Pathol. 54, 229-239 (1973).
    • (1973) Br. J. Exp. Pathol. , vol.54 , pp. 229-239
    • Jones, R.1    Bolduc, P.2    Reid, L.M.3
  • 79
    • 0018348279 scopus 로고
    • Morphometric analysis of tracheal gland secretion and hypertrophy in male and female rats after experimental exposure to tobacco smoke
    • Hayashi M, Sornberger GC, Huber GL. Morphometric analysis of tracheal gland secretion and hypertrophy in male and female rats after experimental exposure to tobacco smoke. Am. Rev. Respir. Dis. 119, 67-73 (1979).
    • (1979) Am. Rev. Respir. Dis. , vol.119 , pp. 67-73
    • Hayashi, M.1    Sornberger, G.C.2    Huber, G.L.3
  • 80
    • 33644620356 scopus 로고    scopus 로고
    • Respiratory tract mucin genes and mucin glycoproteins in health and disease
    • Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev. 86, 245-278 (2006).
    • (2006) Physiol. Rev. , vol.86 , pp. 245-278
    • Rose, M.C.1    Voynow, J.A.2
  • 81
    • 0035190667 scopus 로고    scopus 로고
    • Airway mucus obstruction: Mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia
    • Rose MC, Nickola TJ, Voynow JA. Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. Am. J. Respir. Cell Mol. Biol 25, 533-537 (2001).
    • (2001) Am. J. Respir. Cell Mol. Biol , vol.25 , pp. 533-537
    • Rose, M.C.1    Nickola, T.J.2    Voynow, J.A.3
  • 82
    • 33745646074 scopus 로고    scopus 로고
    • Differential MUC2 and MUC5AC secretion by stimulated guinea pig tracheal epithelial cells in vivo
    • Chorley BN, Crews AL, Li Y, Adler KB, Minnnicozzi M, Martin LD. Differential MUC2 and MUC5AC secretion by stimulated guinea pig tracheal epithelial cells in vivo. Respir. Res. 7, 35-48 (2006).
    • (2006) Respir. Res. , vol.7 , pp. 35-48
    • Chorley, B.N.1    Crews, A.L.2    Li, Y.3    Adler, K.B.4    Minnnicozzi, M.5    Martin, L.D.6
  • 83
    • 0017648315 scopus 로고
    • An animal model of cigarette smoking in beagle dogs
    • Park SS, Kikkawa Y, Goldring IP et al. An animal model of cigarette smoking in beagle dogs. Am. Rev. Respir. Dis. 115, 971-979 (1977).
    • (1977) Am. Rev. Respir. Dis. , vol.115 , pp. 971-979
    • Park, S.S.1    Kikkawa, Y.2    Goldring, I.P.3
  • 84
    • 0018193560 scopus 로고
    • Differential response in the male and female tracheal epithelium following chronic tobacco smoke inhalation
    • Hayashi M, Sornberger GC, Huber GL. Differential response in the male and female tracheal epithelium following chronic tobacco smoke inhalation. Chest 4, 515-518 (1978).
    • (1978) Chest , vol.4 , pp. 515-518
    • Hayashi, M.1    Sornberger, G.C.2    Huber, G.L.3
  • 85
    • 0015508348 scopus 로고
    • Protection of rat bronchial epithelium against tobacco smoke
    • Jones R, Dolduc P, Reid L. Protection of rat bronchial epithelium against tobacco smoke. Br. Med. J. 2, 142-144 (1972).
    • (1972) Br. Med. J. , vol.2 , pp. 142-144
    • Jones, R.1    Dolduc, P.2    Reid, L.3
  • 86
    • 0014663107 scopus 로고    scopus 로고
    • Goblet cell increase in rat bronchial epithelium after expsoure to cigarette and cigar tobacco smoke
    • Lamb D, Reid L. Goblet cell increase in rat bronchial epithelium after expsoure to cigarette and cigar tobacco smoke. Br. Med. J. 1, 33-35 (2001).
    • (2001) Br. Med. J. , vol.1 , pp. 33-35
    • Lamb, D.1    Reid, L.2
  • 87
    • 0022623634 scopus 로고
    • Inhibition by oral N-acteylcysteine of cigarette smoke-induced 'bronchitis' in the rat
    • Rogers DF, Jeffery PK. Inhibition by oral N-acteylcysteine of cigarette smoke-induced 'bronchitis' in the rat. Exp. Lung Res. 10, 267-283 (1986).
    • (1986) Exp. Lung Res. , vol.10 , pp. 267-283
    • Rogers, D.F.1    Jeffery, P.K.2
  • 88
    • 0018663782 scopus 로고
    • Cigarette smoke inhalation studies in inbred Syrian Golden hamsters
    • Bernfeld P, Homburger F, Soto E, Pai KJ. Cigarette smoke inhalation studies in inbred Syrian Golden hamsters. J. Natl Cancer Inst. 63, 675-689 (1979).
    • (1979) J. Natl Cancer Inst. , vol.63 , pp. 675-689
    • Bernfeld, P.1    Homburger, F.2    Soto, E.3    Pai, K.J.4
  • 89
    • 0026503964 scopus 로고
    • Effect of long-term exposure to cigarette smoke on the small airways of the guinea pig
    • Wright JL, Ngai T, Churg A. Effect of long-term exposure to cigarette smoke on the small airways of the guinea pig. Exp. Lung Res. 18, 105-114 (1992).
    • (1992) Exp. Lung Res. , vol.18 , pp. 105-114
    • Wright, J.L.1    Ngai, T.2    Churg, A.3
  • 90
    • 13444256632 scopus 로고    scopus 로고
    • Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants
    • Bartalesi B, Cavarra E, Fineschi S et al. Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur. Respir. J. 25, 15-22 (2005).
    • (2005) Eur. Respir. J. , vol.25 , pp. 15-22
    • Bartalesi, B.1    Cavarra, E.2    Fineschi, S.3
  • 91
    • 77649185234 scopus 로고    scopus 로고
    • Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: A potential model of goblet cell hyperplasia
    • Haswell LE, Hewitt K, Thorne D, Richter A, Gaca MD. Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia. Toxicol In Vitro 24, 981-987 (2010).
    • (2010) Toxicol in Vitro , vol.24 , pp. 981-987
    • Haswell, L.E.1    Hewitt, K.2    Thorne, D.3    Richter, A.4    Gaca, M.D.5
  • 92
    • 13544262442 scopus 로고    scopus 로고
    • Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
    • Deshmukh HS, Case LM, Wesselkamper SC et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am. J. Respir. Crit. Care Med. 171, 305-314 (2005).
    • (2005) Am. J. Respir. Crit. Care Med. , vol.171 , pp. 305-314
    • Deshmukh, H.S.1    Case, L.M.2    Wesselkamper, S.C.3
  • 93
    • 0036009464 scopus 로고    scopus 로고
    • Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species
    • Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am. J. Respir. Cell Mol. Biol. 26, 447-452 (2002).
    • (2002) Am. J. Respir. Cell Mol. Biol. , vol.26 , pp. 447-452
    • Fischer, B.M.1    Voynow, J.A.2
  • 94
    • 8644255162 scopus 로고    scopus 로고
    • Neutrophil elastase induces mucus cell metaplasia in mouse lung
    • Voynow JA, Fischer BM, Malarkey DE et al. Neutrophil elastase induces mucus cell metaplasia in mouse lung. Am. J. Physiol. 287, L1293-L1302 (2004).
    • (2004) Am. J. Physiol. , vol.287
    • Voynow, J.A.1    Fischer, B.M.2    Malarkey, D.E.3
  • 97
    • 0035009331 scopus 로고    scopus 로고
    • Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke
    • Takeyama K, Jung B, Shim JJ et al. Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. Am. J. Physiol. 280, L165-L172 (2002).
    • (2002) Am. J. Physiol. , vol.280
    • Takeyama, K.1    Jung, B.2    Shim, J.J.3
  • 98
    • 3242706027 scopus 로고    scopus 로고
    • Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-a-converting enzyme in human airway epithelial (NCI-H292) cells
    • Shao MXG, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-a-converting enzyme in human airway epithelial (NCI-H292) cells. Am. J. Physiol. 287, L420-L427 (2004).
    • (2004) Am. J. Physiol. , vol.287
    • Mxg, S.1    Nakanaga, T.2    Nadel, J.A.3
  • 100
    • 32644434585 scopus 로고    scopus 로고
    • The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production
    • Lee SY, Kang EJ, Hur GY et al. The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production. Respir. Med. 100, 503-511 (2005).
    • (2005) Respir. Med. , vol.100 , pp. 503-511
    • Lee, S.Y.1    Kang, E.J.2    Hur, G.Y.3
  • 101
    • 0034998154 scopus 로고    scopus 로고
    • PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways
    • Komori M, Inoue H, Matsumoto K et al. PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. Am. J. Physiol. 280, L436-L441 (2001).
    • (2001) Am. J. Physiol. , vol.280
    • Komori, M.1    Inoue, H.2    Matsumoto, K.3
  • 102
    • 34250173470 scopus 로고    scopus 로고
    • Exacerbations of chronic obstructive pulmonary disease
    • Celli BR, Barnes PJ. Exacerbations of chronic obstructive pulmonary disease. Eur. Respir. J. 29, 1224-1238 (2007).
    • (2007) Eur. Respir. J. , vol.29 , pp. 1224-1238
    • Celli, B.R.1    Barnes, P.J.2
  • 103
    • 28244497299 scopus 로고    scopus 로고
    • Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations
    • Mallia P, Johnston SL. Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations. Proc. Am. Thorac. Soc. 2, 361-366 (2005).
    • (2005) Proc. Am. Thorac. Soc. , vol.2 , pp. 361-366
    • Mallia, P.1    Johnston, S.L.2
  • 104
    • 70049115394 scopus 로고    scopus 로고
    • Defnitions of exacerbations
    • Effng TW, Kerstjens HAM, Monninkhof EM et al. Defnitions of exacerbations. Chest 136, 918-923 (2009).
    • (2009) Chest , vol.136 , pp. 918-923
    • Effng, T.W.1    Ham, K.2    Monninkhof, E.M.3
  • 105
    • 33645053487 scopus 로고    scopus 로고
    • COPD exacerbations 2: Aetiology
    • Sapey E, Stockley RA. COPD exacerbations 2: aetiology. Thorax 61, 250-258 (2006).
    • (2006) Thorax , vol.61 , pp. 250-258
    • Sapey, E.1    Stockley, R.A.2
  • 106
    • 9644294626 scopus 로고    scopus 로고
    • Role of viruses in exacerbations of chronic obstructive pulmonary disease
    • Wedzicha JA. Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 17, 115-120 (2004).
    • (2004) Proc. Am. Thorac. Soc. , vol.17 , pp. 115-120
    • Wedzicha, J.A.1
  • 108
    • 30344469896 scopus 로고    scopus 로고
    • Systemic and upper and lower airway infammation at exacerbation of chronic obstructive pulmonary disease
    • Hurst JR, Perera WR, Wilkinson TMA, Donaldson GC, Wedzicha JA. Systemic and upper and lower airway infammation at exacerbation of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 173, 71-78 (2006).
    • (2006) Am. J. Respir. Crit. Care Med. , vol.173 , pp. 71-78
    • Hurst, J.R.1    Perera, W.R.2    Tma, W.3    Donaldson, G.C.4    Wedzicha, J.A.5
  • 111
    • 33745522429 scopus 로고    scopus 로고
    • Gene expression profling in lung tissues from mice exposed to cigarette smoke, lipopolysaccharide, or smoke plus lipopolysaccharide by inhalation
    • Meng QR, Gideon KM, Harbo SJ et al. Gene expression profling in lung tissues from mice exposed to cigarette smoke, lipopolysaccharide, or smoke plus lipopolysaccharide by inhalation. Inhal. Toxicol. 18, 555-568 (2006).
    • (2006) Inhal. Toxicol. , vol.18 , pp. 555-568
    • Meng, Q.R.1    Gideon, K.M.2    Harbo, S.J.3
  • 113
    • 33846061186 scopus 로고    scopus 로고
    • Strain-specifc pulmonary defense achieved after repeated airway immunization with non-typeable Haemophilus infuenzae in a mouse model
    • Koyama J, Ahmed K, Zhao J et al. Strain-specifc pulmonary defense achieved after repeated airway immunization with non-typeable Haemophilus infuenzae in a mouse model. Tohoku J. Exp. Med. 211, 63-74 (2007).
    • (2007) Tohoku J. Exp. Med. , vol.211 , pp. 63-74
    • Koyama, J.1    Ahmed, K.2    Zhao, J.3
  • 114
    • 35848948855 scopus 로고    scopus 로고
    • Animal models of chronic obstructive pulmonary disease exacerbations
    • Gaschler GF, Bauer CMT, Zavitz CCJ, Stampfi MR. Animal models of chronic obstructive pulmonary disease exacerbations. Contrib. Microbiol. 14, 126-141 (2007).
    • (2007) Contrib. Microbiol. , vol.14 , pp. 126-141
    • Gaschler, G.F.1    Cmt, B.2    Ccj, Z.3    Stampfi, M.R.4
  • 115
    • 67349186983 scopus 로고    scopus 로고
    • How cigarette smoke skews immune responses to promote infection, lung disease and cancer
    • Stampfi MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat. Rev. Immunol. 9, 377-384 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 377-384
    • Stampfi, M.R.1    Anderson, G.P.2
  • 116
    • 45549093936 scopus 로고    scopus 로고
    • Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice
    • Robbins CS, Franco F, Mouded M, Cernadas M, Shapiro SD. Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. J. Immunol. 180, 6623-6628 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 6623-6628
    • Robbins, C.S.1    Franco, F.2    Mouded, M.3    Cernadas, M.4    Shapiro, S.D.5
  • 117
    • 77952784713 scopus 로고    scopus 로고
    • Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease
    • Motz GT, Eppert BL, Wortham BW et al. Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease. J. Immunol. 184, 4460-4469 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 4460-4469
    • Motz, G.T.1    Eppert, B.L.2    Wortham, B.W.3
  • 118
    • 0742290128 scopus 로고    scopus 로고
    • Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness
    • Robbins CS, Dawe DE, Goncharova SI et al. Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness. Am. J. Respir. Cell Mol. Biol. 30, 202-211 (2004).
    • (2004) Am. J. Respir. Cell Mol. Biol. , vol.30 , pp. 202-211
    • Robbins, C.S.1    Dawe, D.E.2    Goncharova, S.I.3
  • 119
    • 48749097634 scopus 로고    scopus 로고
    • Cigarette smoke selectively enhances viral PAMP and virus-induced pulmonary innate immune and remodeling responses in mice
    • Kang M-J, Lee CG, Lee J-Y et al. Cigarette smoke selectively enhances viral PAMP and virus-induced pulmonary innate immune and remodeling responses in mice. J. Clin. Invest. 118, 2771-2784 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 2771-2784
    • Kang, M.-J.1    Lee, C.G.2    Lee, J.-Y.3
  • 120
    • 78349300621 scopus 로고    scopus 로고
    • Mechanisms of clearance of nontypeable Haemophilus infuenzae from cigarette smoke-exposed mouse lungs
    • DOI:10.1183/09031936. 00113909 Epub ahead of print
    • Gaschler GJ, Zavitz CCJ, Bauer CMT, Stampfi MR. Mechanisms of clearance of nontypeable Haemophilus infuenzae from cigarette smoke-exposed mouse lungs. Eur. Respir. J. DOI:10.1183/09031936. 00113909 (2010) (Epub ahead of print).
    • (2010) Eur. Respir. J.
    • Gaschler, G.J.1    Ccj, Z.2    Cmt, B.3    Stampfi, M.R.4
  • 121
    • 77349113356 scopus 로고    scopus 로고
    • Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae
    • Phipps JC, Aronoff DM, Curtis JL, Goel D, O'Brien E, Mancuso P. Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae. Infect. Immun. 78, 1214-1230 (2010).
    • (2010) Infect. Immun. , vol.78 , pp. 1214-1230
    • Phipps, J.C.1    Aronoff, D.M.2    Curtis, J.L.3    Goel, D.4    O'Brien, E.5    Mancuso, P.6
  • 122
    • 63349099346 scopus 로고    scopus 로고
    • The role of interleukin-1b in murine cigarette smoke-induced emphysema and small airway remodeling
    • Churg A, Zhou S, Wang X, Wang R, Wright JL. The role of interleukin-1b in murine cigarette smoke-induced emphysema and small airway remodeling. Am. J. Respir. Cell Mol. Biol. 40, 482-490 (2009).
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.40 , pp. 482-490
    • Churg, A.1    Zhou, S.2    Wang, X.3    Wang, R.4    Wright, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.