ERK1/2 activation is involved in the neuroprotective action of P2Y 13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons

Neuropharmacology

Volumn 61, Issue 8, 2011, Pages 1210-1221

  Ortega, Felipe ^a,b   Pérez Sen, Raquel ^a   Delicado, Esmerilda G ^a   Teresa Miras Portugal, M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

ERK; Granule neurons; Neuroprotection; P2X7 receptor; P2Y 13 receptor; PI3kinase

Indexed keywords

2 METHYLTHIOADENOSINE 5' DIPHOSPHATE; 2'(3') O (4 BENZOYLBENZOYL)ADENOSINE 5' TRIPHOSPHATE; A 438079; ADENOSINE DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MRS 2211; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; GRANULE CELL; INTRACELLULAR SIGNALING; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLUTAMIC ACID; MAP KINASE SIGNALING SYSTEM; NEURONS; PHOSPHORYLATION; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X7; THIONUCLEOTIDES; TIME FACTORS;

EID: 80053618330     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.07.010     Document Type: Article

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