Modulation of feeding behaviour by blocking purinergic receptors in the rat nucleus accumbens: A combined microdialysis, electroencephalographic and behavioural study

European Journal of Neuroscience

Volumn 19, Issue 2, 2004, Pages 396-404

  Kittner, H ^a   Krugel U ^a   Hoffmann, E ^a   Illes, P ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

4 disulphonic acid; 8 (p sulphophenyl) theophylline; Endogenous ATP; P1 receptors; P2 receptors; Pyridoxalphosphate 6 azophenyl 2 ; Ventral tegmental area

Indexed keywords

8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE RECEPTOR BLOCKING AGENT; DOPAMINE; PURINE P2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID;

ARTICLE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINE RELEASE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ELECTROENCEPHALOGRAPHY; FEEDING BEHAVIOR; FOOD INTAKE; MALE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; TISSUE DISTRIBUTION;

ANIMALS; DOPAMINE; EATING; ELECTROENCEPHALOGRAPHY; FEEDING BEHAVIOR; MALE; MICRODIALYSIS; NUCLEUS ACCUMBENS; PYRIDOXAL PHOSPHATE; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC;

EID: 0842265604     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0953-816X.2003.03090.x     Document Type: Article

References (62)

1. Ballarin, M., Reiriz, J., Ambrosio, S. & Mahy, N. (1995) Effect of locally infused 2-chloroadenosine, an A1 receptor agonist, on spontaneous and evoked dopamine release in rat neostriatum. Neurosci. Lett., 185, 29-32.
2. Bogdanov, Y.D., Wildman, S.S., Clements, M.P., King, B.F. & Burnstock, G. (1998) Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Br. J. Pharmacol., 124, 428-430.
3. Boyer, J.L., Zohn, I.E., Jacobson, K.A. & Harden, T.K. (1994) Differential effects of P2-purinoceptor antagonists on phospholipase C-and adenylyl cyclase-coupled P2Y-purinoceptors. Br. J. Pharmacol., 113, 614-620.
4. Burnstock, G. (1986) Purines and cotransmitters in adrenergic and cholinergic neurones. Prog. Brain Res., 68, 193-203.
5. Burnstock, G. (2001) Purine-mediated signalling in pain and visceral perception. Trends Pharmacol. Sci., 22, 182-188.
6. Chan, C.F. & Lin-Shiau, S.Y. (2001) Suramin prevents cerebellar granule cell-death induced by dequalinium. Neurochem. Int., 38, 135-143.
7. Charlton, S.J., Brown, C.A., Weisman, G.A., Turner, J.T., Erb, L. & Boarder, M.R. (1996) PPADS and suramin as antagonists at cloned P2Y-and P2U-purinoceptors. Br. J. Pharmacol., 118, 704-710.
8. Chin, J.H. (1989) Adenosine receptors in brain: neuromodulation and role in epilepsy. Ann. Neurol., 26, 695-698.
9. Communi, D., Robaye, B. & Boeynaems, J.M. (1999) Pharmacological characterization of the human P2Y11 receptor. Br. J. Pharmacol., 128, 1199-1206.
10. Cunha, R.A., Sebastiao, A.M. & Ribeiro, J.A. (1998) Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors. J. Neurosci., 18, 1987-1995.
11. Dixon, A.K., Gubitz, A.K., Sirinathsinghji, D.J., Richardson, P.J. & Freeman, T.C. (1996) Tissue distribution of adenosine receptor mRNAs in the rat. Br. J. Pharmacol., 118, 1461-1468.
12. Dol-Gleizes, F., Mares, A.M., Savi, P. & Herbert, J.M. (1999) Relaxant effect of 2-methyl-thio-adenosine diphosphate on rat thoracic aorta: effect of clopidogrel. Eur. J. Pharmacol., 367, 247-253.
13. Dunwiddie, T.V., Diao, L. & Proctor, W.R. (1997) Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus. J. Neurosci., 17, 7673-7682.
14. Edwards, F.A. (1996) Features of P2X receptor-mediated synapses in the rat brain: why doesn't ATP kill the postsynaptic cell? CIBA Found. Symp., 198, 278-286.
15. Enoch, M.A., Rohrbaugh, J.W., Davis, E.Z., Harris, C.R., Ellingson, R.J., Andreason, P., Moore, V., Varner, J.L., Brown, G.L., Eckardt, M.J. & Goldman, D. (1995) Relationship of genetically transmitted alpha EEG traits to anxiety disorders and alcoholism. Am. J. Med. Genet., 60, 400-408.
16. Fredholm, B.B. & Dunwiddie, T.V. (1988) How does adenosine inhibit transmitter release? Trends Pharmacol. Sci., 9, 130-134.
17. Fredholm, B.B., Abbracchio, M.P., Burnstock, G., Daly, J.W., Harden, T.K., Jacobson, K.A., Leff, P. & Williams, M. (1994) Nomenclature and classification of purinoceptors. Pharmacol. Rev., 46, 143-156.
18. Fröhlich, R., Boehm, S. & Illes, P (1996) Pharmacological characterization of P2 purinoceptor types in rat locus coeruleus neurons. Eur. J. Pharmacol., 315, 255-261.
19. Ganote, C.E. & Armstrong, S.C. (2000) Adenosine and preconditioning in the rat heart. Cardiovasc. Res., 45, 134-140.
20. Goodman, R.R. & Synder, S.H. (1982) Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine. J. Neurosci., 2, 1230-1241.
21. Gu, J.G., Bardoni, R., Magherini, P.C. & MacDermott, A.B. (1998) Effects of the P2-purinoceptor antagonists suramin and pyridoxal-phosphate-6- azophenyl-2′,4′-disulfonic acid on glutamatergic synaptic transmission in rat dorsal horn neurons of the spinal cord. Neurosci. Lett.; 253, 167-170.
22. Gustafsson, L.E. (1984) Adenosine antagonism and related effects of theophylline derivatives in guinea pig ileum longitudinal muscle. Acta Physiol. Scand., 122, 191-198.
23. Hernandez, L. & Hoebel, B.G. (1988a) Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens. Physiol. Behav., 44, 599-606.
24. Hernandez, L. & Hoebel, B.G. (1988b) Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life Sci., 42, 1705-1712.
25. Jarvis, M.F. & Williams, M. (1989) Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS 21680. Eur. J. Pharmacol., 168, 243-246.
26. Jones, F.W. & Holmes, D.S. (1976) Alcoholism, alpha production, and biofeedback. J. Consult. Clin. Psychol., 44, 224-228.
27. Kalivas, P.W., Churchill, L. & Klitenick, M.A. (1993) GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area. Neuroscience, 57, 1047-1060.
28. Kittner, H., Krügel, U., Poelchen, W., Sieler, D., Reinhardt, R., von Kügelgen, I. & Illes, P. (1999) P2 receptor-mediated activation of noradrenergic and dopaminergic neurons in the rat brain. Prog. Brain Res., 120, 223-235.
29. Kittner, H., Krügel, U., El Ashmawy, I.M. & Illes, P. (2000a) Suppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P(2) purinoceptors. Eur. J. Pharmacol., 406, R13-R14.
30. Kittner, H., Krügel, U., Hoffmann, E. & Illes, P. (2000b) Effects of intra-accumbens injection of 2-methylthio ATP: a combined open field and electroencephalographic study in rats. Psychopharmacology (Berl.), 150, 123-131.
31. Kittner, H., Krügel, U. & Illes, P. (2001) The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2′4′-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural sensitization caused by repeated amphetamine injections in rats. Neuroscience, 102, 241-243.
32. Kropf, W., Kuschinsky, K. & Krieglstein, J. (1991) Conditioning of apomorphine effects: simultaneous analysis of the alterations in cortical electroencephalogram and behaviour. Naunyn Schmiedebergs Arch. Pharmacol., 343, 559-567.
33. Krügel, U., Kittner, H. & Illes, P. (1999) Adenosine 5′-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo. Neurosci. Lett., 265, 49-52.
34. Krügel, U., Kittner, H., Franke, H. & Illes, P (2001a) Stimulation of P2 receptors in the ventral tegmental area enhances dopaminergic mechanisms in vivo. Neuropharmacology, 40, 1084-1093.
35. Krügel, U., Kittner, H. & Illes, P. (2001b) Mechanisms of adenosine 5′-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo. Synapse, 39, 222-232.
36. Krügel, U., Kittner, H., Franke, H. & Illes, P. (2003) Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo. Synapse, 47, 134-142.
37. Lichtensteiger, W., Felix, D., Lienhart, R. & Hefti, F. (1976) A quantitative correlation between single unit activity and fluorescence intensity of dopamine neurones in zona compacta of substantia nigra, as demonstrated under the influence of nicotine and physostigmine. Brain Res., 117, 85-103.
38. Lukas, S.E., Mendelson, J.H., Benedikt, R.A. & Jones, B. (1986) EEG alpha activity increases during transient episodes of ethanol-induced euphoria. Pharmacol. Biochem. Behav., 25, 889-895.
39. Machleidt, W., Gutjahr, L. & Hinrichs, H. (1994) Die Spektralmuster der Grundgefühle: Hunger, Angst, Aggression, Trauer und Freude. EEG-EMG, 25, 81-97.
40. Maldonado-Irizarry, C.S., Swanson, C.J. & Kelley, A.E. (1995) Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus. J. Neurosci., 15, 6779-6788.
41. Masi, F., Scheggi, S., Mangiavacchi, S., Tolu, P., Tagliamonte, A., De Montis, M.G. & Gambarana, C. (2001) Dopamine output in the nucleus accumbens shell is related to the acquisition and the retention of a motivated appetitive behavior in rats. Brain Res., 903, 102-109.
42. Motin, L. & Bennett, M.R. (1995) Effect of P2-purinoceptor antagonists on glutamatergic transmission in the rat hippocampus. Br. J. Pharmacol., 115, 1276-1280.
43. 12 receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides. Mol. Pharmacol., 60, 416-420.
44. Okada, M., Mizuno, K. & Kaneko, S. (1996) Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum. Neurosci. Lett., 212, 53-56.
45. Paxinos, G. & Watson, C. (1986) The Rat Brain Stereotaxic Coordinates. Academic Press, San Diego.
46. Pintor, J., Porras, A., Mora, F. & Miras-Portugal, M.T. (1995) Dopamine receptor blockade inhibits the amphetamine-induced release of diadenosine polyphosphates, diadenosine tetraphosphate and diadenosine pentaphosphate, from neostriatum of the conscious rat. J. Neurochem., 64, 670-676.
47. Radhakishun, F.S., Westerink, B.H. & van Ree, J.M. (1988) Dopamine release in the nucleus accumbens of freely moving rats determined by on-line dialysis: effects of apomorphine and the neuroleptic-like peptide desenkephalin-gamma-endorphin. Neurosci. Lett., 89, 328-334.
48. Ralevic, V. & Burnstock, G. (1998) Receptors for purines and pyrimidines. Pharmacol. Rev., 50, 413-492.
49. Rau, J.H., Struve, F.A. & Green, R.S. (1979) Electroencephalographic correlates of compulsive eating. Clin. Electroencephalogr., 10, 180-189.
50. Romo, R. & Schultz, W. (1985) Prolonged changes in dopaminergic terminal excitability and short changes in dopaminergic neuron discharge rate after short peripheral stimulation in monkey. Neurosci. Lett., 62, 335-340.
51. Scarnati, E. & Pacitti, C. (1982) Neuronal responses to iontophoretically applied dopamine, glutamate, and GABA of identified dopaminergic cells in the rat substantia nigra after kainic acid-induced destruction of the striatum. Exp. Brain Res., 46, 377-382.
52. Schultz, W. (1986) Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey. J. Neurophysiol., 56, 1439-1461.
53. Stratford, T.R. & Kelley, A.E. (1999) Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J. Neurosci., 19, 11 040-11 048.
54. Stratford, T.R., Swanson, C.J. & Kelley, A. (1998) Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell. Behav. Brain Res., 93, 43-50.
55. Vigne, P., Pacaud, P., Urbach, V., Feolde, E., Breittmayer, J.P. & Frelin, C. (1996) The effect of PPADS as an antagonist of inositol (1,4,5) trisphosphate induced intracellular calcium mobilization. Br. J. Pharmacol., 119, 360-364.
56. Wager-Srdar, S., Levine, A.S. & Morley, J.E. (1984) Food intake: opioid/purine interactions. Pharmacol. Biochem. Behav., 21, 33-38.
57. Westerink, B.H., Kwint, H.F. & deVries, J.B. (1996) The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain. J. Neurosci., 16, 2605-2611.
58. Windscheif, U., Radziwon, P., Breddin, H.K., Baumert, H.G., Lambrecht, G. & Mutschler, E. (1995) Two different inhibitory effects of pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid on adenosine diphosphate-induced human platelet aggregation. Arzneimittelforschung, 45, 994-997.
59. Wu, Q., Reith, M.E., Walker, Q.D., Kuhn, C.M., Carroll, F.I. & Garris, P.A. (2002) Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. J. Neurosci., 22, 6272-6681.
60. Yim, C.Y. & Mogenson, G.J. (1980) Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens. Brain Res., 199, 466-473.
61. Yoshida, M., Yokoo, H., Mizoguchi, K., Kawahara, H., Tsuda, A., Nishikawa, T. & Tanaka, M. (1992) Eating and drinking cause increased dopamine release in the nucleus accumbens and ventral tegmental area in the rat: measurement by in vivo microdialysis. Neurosci. Lett., 139, 73-76.
62. Zhang, Y.X., Yamashita, H., Ohshita, T., Sawamoto, N. & Nakamura, S. (1995) ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum. Brain Res., 691, 205-212.