Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice

Toxicology and Applied Pharmacology

Volumn 159, Issue 1, 1999, Pages 25-30

  Fredriksson, A ^a   Schroder N ^b   Eriksson, P ^c   Izquierdo, I ^a,b   Archer, T ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c NONE

Author keywords

Basal ganglia; Days 10 12; Deficits; Errors; Fe+2; Habituation; High low doses; Iron supplementation; Latency; Locomotion; Neonatal; NMRI mice; Parkinsonism; Radial maze; Rearing; Total iron content

Indexed keywords

FERROUS SUCCINATE; IRON;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BEHAVIOR DISORDER; BRAIN DYSFUNCTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; MALE; MAZE TEST; MOTOR ACTIVITY; MOUSE; NEWBORN; NONHUMAN; ORAL DRUG ADMINISTRATION; PERINATAL DRUG EXPOSURE; TASK PERFORMANCE;

EID: 0345281624     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8711     Document Type: Article

References (39)

1. Archer T., Fredriksson A., Jonsson G., Lewander T., Mohammed A. K., Ross S. B., Soderberg U. Central noradrenaline depletion antagonizes aspects of d-amphetamine-induced hyperactivity in the rat. Psychopharmacology. 88:1986;141-146.
2. Bolles R. G., Woods P. J. The ontogeny of behaviour in the albino rat. Anim. Behav. 12:1964;427-441.
3. Bradley C. K., Hillman L., Sherman A. R., Leedy D., Cordano A. Evaluation of two iron-fortified, milk-based formulas during infancy. Pediatrics. 91:1993;908-914.
4. Campbell B. A., Lytle L. D., Fibiger H. C. Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science. 166:1969;635-637.
5. Celada A., Busset R., Gutierrez J., Herreros V. No correlation between iron concentration in breast milk and maternal iron stores. Helv. Paediatr. Acta. 37:1982;11-16.
6. Connor J. R., Pavlick G., Karli D., Menzies S. L., Palmer C. A histochemical study of iron-positive cells in the developing rat brain. J. Comp. Neurol. 355:1995;111-123.
7. Davison A. N., Dobbing J. Applied Neurochemistry. 1968;Blackwell, Oxford.
8. Dewey K. G., Finley D. A., Lonnerdal B. Breast milk volume and composition during late lactation (7-20 months). J. Pediatr. Gastroenterol. Nutr. 3:1984;713-720.
9. Dewey K. G., Lonnerdal B. Milk and nutrient intake of breast-fed infants from 1 to 6 months: relation to growth and fatness. J. Pediatr. Gastroenterol. Nutr. 2:1983;497-506.
10. Dexter D. T., Carayon A., Javoy-Agid F., Agid Y., Wells F. R., Daniel S. E., Lees A. J., Jenner P., Marsden C. D. Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain. 114:1991;1953-1975.
11. Dexter D. T., Wells F. R., Agid F., Agid Y., Lees A. J., Jenner P., Marsden C. D. Increased nigral iron content in postmortem parkinsonian brain [letter]. Lancet. 2:1987;1219-1220.
12. Drayer B. P., Olanow W., Burger P., Johnson G. A., Herfkens R., Riederer S. Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology. 159:1986;493-498.
13. Dwork A. J., Lawler G., Zybert P. A., Durkin M., Osman M., Willson N., Barkai A. I. An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res. 518:1990;31-39.
14. Fellman V., Rapola J., Pihko H., Varilo T., Raivio K. O. Iron-overload disease in infants involving fetal growth retardation, lactic acidosis, liver haemosiderosis, and aminoaciduria [see comments]. Lancet. 351:1998;490-493.
15. Fredriksson A., Dencker L., Archer T., Danielsson B. R. Prenatal coexposure to metallic mercury vapour and methylmercury produce interactive behavioural changes in adult rats. Neurotoxicol. Teratol. 18:1996;129-134.
16. Glowinski J., Iversen L. L. Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J. Neurochem. 13:1966;655-669.
17. Janetzky B., Reichmann H., Youdim M. B. H., Riederer P. Iron and Oxidative Damage in Neurodegenerative Diseases. 1997;Wiley-Liss, New York.
18. Kienzl E., Puchinger L., Jellinger K., Linert W., Stachelberger H., Jameson R. F. The role of transition metals in the pathogenesis of Parkinson's disease. J. Neurol. Sci. 134:1995;69-78.
19. Kirk R. Experimental Design: Procedures for the Behavioural Sciences. 1995;Brooks/Cole, Belmont.
20. Kolb B., Whishaw I. Q. Plasticity in the neocortex: mechanisms underlying recovery from early brain damage. Prog. Neurobiol. 32:1989;235-276.
21. Lonnerdal B. Effects of maternal dietary intake on human milk composition. J. Nutr. 116:1986;499-513.
22. Lonnerdal B. Effects of milk and milk components on calcium, magnesium, and trace element absorption during infancy. Physiol. Rev. 77:1997;643-669.
23. Oestreicher E., Sengstock G. J., Riederer P., Olanow C. W., Dunn A. J., Arendash G. W. Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. Brain Res. 660:1994;8-18.
24. Olton D. S., Walker J. A., Gage F. H. Hippocampal connections and spatial discrimination. Brain Res. 139:1978;295-308.
25. Olton D. S., Werz M. A. Hippocampal function and behavior: spatial discrimination and response inhibition. Physiol. Behav. 20:1978;597-605.
26. Riederer P., Sofic E., Rausch W. D., Schmidt B., Reynolds G. P., Jellinger K., Youdim M. B. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J. Neurochem. 52:1989;515-520.
27. Rustin P., von Kleist-Retzow J. C., Rotig A., Munnich A. Iron overload and mitochondrial diseases [letter; comment]. Lancet. 351:1998;1286-1287.
28. Schmidt W. J., Kretschmer B. D. Behavioural pharmacology of glutamate receptors in the basal ganglia. Neurosci. Biobehav. Rev. 21:1997;381-392.
29. Schulz-Lell G., Buss R., Oldigs H. D., Dorner K., Schaub J. Iron balances in infant nutrition. Acta Paediatr. Scand. 76:1987;585-591.
30. Sengstock G. J., Olanow C. W., Dunn A. J., Barone S. Jr., Arendash G. W. Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. Exp. Neurol. 130:1994;82-94.
31. Sengstock G. J., Olanow C. W., Menzies R. A., Dunn A. J., Arendash G. W. Infusion of iron into the rat substantia nigra: Nigral pathology and dose-dependent loss of striatal dopaminergic markers. J. Neurosci. Res. 35:1993;67-82.
32. Sobotka T. J., Whittaker P., Sobotka J. M., Brodie R. E., Quander D. Y., Robl M., Bryant M., Barton C. N. Neurobehavioral dysfunctions associated with dietary iron overload. Physiol. Behav. 59:1996;213-219.
33. Swaiman K. F. Hallervorden-Spatz syndrome and brain iron metabolism. Arch. Neurol. 48:1991;1285-1293.
34. Taylor E. M., Crowe A., Morgan E. H. Transferrin and iron uptake by the brain: effects of altered iron status. J. Neurochem. 57:1991;1584-1592.
35. Taylor E. M., Morgan E. H. Developmental changes in transferrin and iron uptake by the brain in the rat. Brain Res. Dev. Brain Res. 55:1990;35-42.
36. Temlett J. A., Landsberg J. P., Watt F., Grime G. W. Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: Evidence from proton microprobe elemental microanalysis. J. Neurochem. 62:1994;134-146.
37. Walshe J. M., Cox D. W. Effect of treatment of Wilson's disease on natural history of haemochromatosis. Lancet. 352:1998;112-113.
38. Youdim M. B., Ben-Shachar D., Riederer P. Iron in brain function and dysfunction with emphasis on Parkinson's disease. Eur. Neurol. 31:1991;34-40.
39. Zavaleta N., Nombera J., Rojas R., Hambraeus L., Gislason J., Lönnerdal B. Iron and lactoferrin in milk of anemic mothers given iron supplements. Nutr. Res. 15:1995;681-690.