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Volumn 49, Issue 1, 2014, Pages 262-275

Does restraining nitric oxide biosynthesis rescue from toxins-induced parkinsonism and sporadic parkinson's disease?

Author keywords

Nitric oxide; Nitric oxide synthase; Nitric oxide synthase inhibitors; Parkinson's disease; Rodent models

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMPHETAMINE; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; LIPOPOLYSACCHARIDE; MANEB; METHAMPHETAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PARAQUAT; PEROXYNITRITE; REACTIVE NITROGEN SPECIES; RESERPINE; ROTENONE; TOXIN;

EID: 84894369187     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8517-4     Document Type: Review
Times cited : (22)

References (129)
  • 1
    • 33749184503 scopus 로고    scopus 로고
    • Contribution of genomics and proteomics in understanding the role of modifying factors in Parkinson's disease
    • 1:CAS:528:DC%2BD28XmtFSltb0%3D 16955754
    • Singh MP, Patel S, Dikshit M, Gupta YK (2006) Contribution of genomics and proteomics in understanding the role of modifying factors in Parkinson's disease. Indian J Biochem Biophys 43:69-81
    • (2006) Indian J Biochem Biophys , vol.43 , pp. 69-81
    • Singh, M.P.1    Patel, S.2    Dikshit, M.3    Gupta, Y.K.4
  • 2
    • 84868147021 scopus 로고    scopus 로고
    • Rodent models and contemporary molecular techniques: Notable feats yet incomplete explanations of Parkinson's disease pathogenesis
    • 1:CAS:528:DC%2BC38XhsVeiurbK 22736079 10.1007/s12035-012-8291-8
    • Yadav S, Dixit A, Agrawal S, Singh A, Srivastava G, Singh AK, Srivastava PK, Prakash O, Singh MP (2012) Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis. Mol Neurobiol 46:495-512
    • (2012) Mol Neurobiol , vol.46 , pp. 495-512
    • Yadav, S.1    Dixit, A.2    Agrawal, S.3    Singh, A.4    Srivastava, G.5    Singh, A.K.6    Srivastava, P.K.7    Prakash, O.8    Singh, M.P.9
  • 3
    • 84877328104 scopus 로고    scopus 로고
    • Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease
    • 1:CAS:528:DC%2BC3sXptVyktrs%3D 23562983 10.1016/j.bbadis.2013.03.019
    • Dixit A, Srivastava G, Verma D, Mishra M, Singh PK, Prakash O, Singh MP (2013) Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease. Biochim Biophys Acta 1832:1227-1240
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1227-1240
    • Dixit, A.1    Srivastava, G.2    Verma, D.3    Mishra, M.4    Singh, P.K.5    Prakash, O.6    Singh, M.P.7
  • 4
    • 30444439216 scopus 로고    scopus 로고
    • The discovery of nitric oxide and its role in vascular biology
    • 1:CAS:528:DC%2BD28XisVClsQ%3D%3D 16402104 10.1038/sj.bjp.0706458
    • Moncada S, Higgs EA (2006) The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147:S193-S201
    • (2006) Br J Pharmacol , vol.147
    • Moncada, S.1    Higgs, E.A.2
  • 5
    • 33747596451 scopus 로고    scopus 로고
    • Nitric oxide synthase, typical flavohemoproteins and their complicated enzymology
    • 1:STN:280:DC%2BD28vpslegtA%3D%3D 16921779
    • Jachymova M, Masters BS, Horky K, Zima T, Martasek P (2006) Nitric oxide synthase, typical flavohemoproteins and their complicated enzymology. Cas Lek Cesk 145:526-531
    • (2006) Cas Lek Cesk , vol.145 , pp. 526-531
    • Jachymova, M.1    Masters, B.S.2    Horky, K.3    Zima, T.4    Martasek, P.5
  • 6
    • 67349230279 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications
    • 1:CAS:528:DC%2BD1MXltlejt7k%3D 19298861 10.1016/j.niox.2009.03.001
    • Zhou L, Zhu DY (2009) Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 20:223-230
    • (2009) Nitric Oxide , vol.20 , pp. 223-230
    • Zhou, L.1    Zhu, D.Y.2
  • 7
    • 0027080129 scopus 로고
    • NO news is good news. (nitric oxide; Includes information about other significant advances & discoveries of 1992) (Molecule of the Year)
    • 1:STN:280:DyaK3s7htVegug%3D%3D 1361684 10.1126/science.1361684
    • Culotta E, Koshland DE Jr (1992) NO news is good news. (nitric oxide; includes information about other significant advances & discoveries of 1992) (Molecule of the Year). Science 258(5090):1862-1864
    • (1992) Science , vol.258 , Issue.5090 , pp. 1862-1864
    • Culotta, E.1    Koshland, Jr.D.E.2
  • 8
    • 33750465142 scopus 로고    scopus 로고
    • Nitric oxide synthase regulation and diversity: Implications in Parkinson's disease
    • 1:CAS:528:DC%2BD28XhtFOhs7zM 16934505 10.1016/j.niox.2006.07.003
    • Kavya R, Saluja R, Singh S, Dikshit M (2006) Nitric oxide synthase regulation and diversity: implications in Parkinson's disease. Nitric Oxide 15:280-294
    • (2006) Nitric Oxide , vol.15 , pp. 280-294
    • Kavya, R.1    Saluja, R.2    Singh, S.3    Dikshit, M.4
  • 9
    • 0031306928 scopus 로고    scopus 로고
    • Role of nitric oxide in growth of solid tumours: A balancing act
    • 1:CAS:528:DyaK1cXktVSrug%3D%3D 9493011
    • Chinje EC, Stratford IJ (1997) Role of nitric oxide in growth of solid tumours: a balancing act. Essays Biochem 32:61-72
    • (1997) Essays Biochem , vol.32 , pp. 61-72
    • Chinje, E.C.1    Stratford, I.J.2
  • 10
    • 0029821343 scopus 로고    scopus 로고
    • Binding sites of nitric oxide synthases
    • 1:CAS:528:DyaK28XlvFeis70%3D 8782597 10.1016/S0076-6879(96)68033-1
    • Liu Q, Gross SS (1996) Binding sites of nitric oxide synthases. Methods Enzymol 268:311-324
    • (1996) Methods Enzymol , vol.268 , pp. 311-324
    • Liu, Q.1    Gross, S.S.2
  • 11
    • 0037163086 scopus 로고    scopus 로고
    • Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III
    • 1:CAS:528:DC%2BD38XmsF2jsrs%3D 12048205 10.1074/jbc.M203749200
    • Panda K, Rosenfeld RJ, Ghosh S, Meade AL, Getzoff ED, Stuehr DJ (2002) Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. J Biol Chem 277:31020-31030
    • (2002) J Biol Chem , vol.277 , pp. 31020-31030
    • Panda, K.1    Rosenfeld, R.J.2    Ghosh, S.3    Meade, A.L.4    Getzoff, E.D.5    Stuehr, D.J.6
  • 12
    • 0028902098 scopus 로고
    • DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins
    • 1:CAS:528:DyaK2MXktlCmu7Y%3D 7535955 10.1016/S0968-0004(00)88973-2
    • Ponting CP, Phillips C (1995) DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. Trends Biochem Sci 20:102-103
    • (1995) Trends Biochem Sci , vol.20 , pp. 102-103
    • Ponting, C.P.1    Phillips, C.2
  • 13
    • 56349089470 scopus 로고    scopus 로고
    • Role of nitric oxide synthases in Parkinson's disease: A review on the antioxidant and anti-inflammatory activity of polyphenols
    • 1:CAS:528:DC%2BD1cXhtlOktL3M 18415676 10.1007/s11064-008-9697-6
    • Aquilano K, Baldelli S, Rotilio G, Ciriolo MR (2008) Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res 33:2416-2426
    • (2008) Neurochem Res , vol.33 , pp. 2416-2426
    • Aquilano, K.1    Baldelli, S.2    Rotilio, G.3    Ciriolo, M.R.4
  • 14
    • 0028349156 scopus 로고
    • Nitric oxide synthases in mammals
    • 1:CAS:528:DyaK2cXitlyksbg%3D 7510950
    • Knowles RG, Moncada S (1994) Nitric oxide synthases in mammals. Biochem J 298:249-258
    • (1994) Biochem J , vol.298 , pp. 249-258
    • Knowles, R.G.1    Moncada, S.2
  • 15
    • 84876421931 scopus 로고    scopus 로고
    • Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase
    • 1:CAS:528:DC%2BC3sXlsVGmu7s%3D 23549614 10.1007/s13238-013-2116-z
    • Duan W, Zhou J, Li W, Zhou T, Chen Q, Yang F, Wei T (2013) Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase. Protein Cell 4:286-298
    • (2013) Protein Cell , vol.4 , pp. 286-298
    • Duan, W.1    Zhou, J.2    Li, W.3    Zhou, T.4    Chen, Q.5    Yang, F.6    Wei, T.7
  • 16
    • 77955550457 scopus 로고    scopus 로고
    • Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: Is there any link with lipid peroxidation?
    • 1:CAS:528:DC%2BC3cXlslCqurY%3D 20455021 10.1007/s11064-010-0176-5
    • Gupta SP, Patel S, Yadav S, Singh AK, Singh S, Singh MP (2010) Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation? Neurochem Res 35:1206-1213
    • (2010) Neurochem Res , vol.35 , pp. 1206-1213
    • Gupta, S.P.1    Patel, S.2    Yadav, S.3    Singh, A.K.4    Singh, S.5    Singh, M.P.6
  • 17
    • 79951634450 scopus 로고    scopus 로고
    • Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse
    • 1:CAS:528:DC%2BC3MXivF2ksr0%3D 20964710
    • Singhal NK, Srivastava G, Patel DK, Jain SK, Singh MP (2011) Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. J Pineal Res 50:97-109
    • (2011) J Pineal Res , vol.50 , pp. 97-109
    • Singhal, N.K.1    Srivastava, G.2    Patel, D.K.3    Jain, S.K.4    Singh, M.P.5
  • 18
    • 33750482304 scopus 로고    scopus 로고
    • Role of nitric oxide/nitric oxide synthase in Parkinson's disease
    • 1:CAS:528:DC%2BD2MXovVOntbY%3D
    • Kavya R, Dikshit M (2005) Role of nitric oxide/nitric oxide synthase in Parkinson's disease. Ann Neurosci 12:1-5
    • (2005) Ann Neurosci , vol.12 , pp. 1-5
    • Kavya, R.1    Dikshit, M.2
  • 19
    • 0038103656 scopus 로고    scopus 로고
    • Nitric oxide and S-nitrosylation: Excitotoxic and cell signaling mechanism
    • 1:CAS:528:DC%2BD3sXjs1agsLw%3D 12753948 10.1016/S0248-4900(03)00004-2
    • Nelson EJ, Connolly J, McArthur P (2003) Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism. Biol Cell 95:3-8
    • (2003) Biol Cell , vol.95 , pp. 3-8
    • Nelson, E.J.1    Connolly, J.2    McArthur, P.3
  • 20
    • 33947583867 scopus 로고    scopus 로고
    • NO-cGMP signaling and regenerative medicine involving stem cells
    • 1:CAS:528:DC%2BD2sXjtlyms74%3D 17043768 10.1007/s11064-006-9167-y
    • Madhusoodanan KS, Murad F (2007) NO-cGMP signaling and regenerative medicine involving stem cells. Neurochem Res 32:681-694
    • (2007) Neurochem Res , vol.32 , pp. 681-694
    • Madhusoodanan, K.S.1    Murad, F.2
  • 21
    • 84866685568 scopus 로고    scopus 로고
    • Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury
    • 1:CAS:528:DC%2BC38Xhs1Omtr7J 3498522 22960186 10.1016/j.expneurol.2012. 08.024
    • Hall ED, Wang JA, Miller DM (2012) Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury. Exp Neurol 238:176-182
    • (2012) Exp Neurol , vol.238 , pp. 176-182
    • Hall, E.D.1    Wang, J.A.2    Miller, D.M.3
  • 22
    • 4744369832 scopus 로고    scopus 로고
    • Upregulation of guanylyl cyclase expression and activity in striatum of MPTP-induced parkinsonism in mice
    • 1:CAS:528:DC%2BD2cXot1WksLY%3D 15464991 10.1016/j.bbrc.2004.09.028
    • Chalimoniuk M, Langfort J, Lukacova N, Marsala J (2004) Upregulation of guanylyl cyclase expression and activity in striatum of MPTP-induced parkinsonism in mice. Biochem Biophys Res Commun 324:118-126
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 118-126
    • Chalimoniuk, M.1    Langfort, J.2    Lukacova, N.3    Marsala, J.4
  • 23
    • 84857680450 scopus 로고    scopus 로고
    • The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila
    • 1:CAS:528:DC%2BC38Xjs12ktrc%3D 3290610 22393355 10.1371/journal.pone. 0030958
    • Kanao T, Sawada T, Davies SA, Ichinose H, Hasegawa K, Takahashi R, Hattori N, Imai Y (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS One 7(2):e30958
    • (2012) PLoS One , vol.7 , Issue.2 , pp. 30958
    • Kanao, T.1    Sawada, T.2    Davies, S.A.3    Ichinose, H.4    Hasegawa, K.5    Takahashi, R.6    Hattori, N.7    Imai, Y.8
  • 24
    • 84875437378 scopus 로고    scopus 로고
    • Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy
    • 1:CAS:528:DC%2BC3sXhtlyjtbjL 23536077 10.1523/JNEUROSCI.3659-12.2013
    • Cooke RM, Mistry R, Challiss RA, Straub VA (2013) Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy. J Neurosci 33:5626-5637
    • (2013) J Neurosci , vol.33 , pp. 5626-5637
    • Cooke, R.M.1    Mistry, R.2    Challiss, R.A.3    Straub, V.A.4
  • 25
    • 67449116584 scopus 로고    scopus 로고
    • Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism - The possible key role of PKG
    • 1:CAS:528:DC%2BD1MXosVCmtbs%3D 19457107 10.1111/j.1471-4159.2009.06147.x
    • Chalimoniuk M, Stolecka A, Ziemińska E, Stepień A, Langfort J, Strosznajder JB (2009) Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism - the possible key role of PKG. J Neurochem 110:307-317
    • (2009) J Neurochem , vol.110 , pp. 307-317
    • Chalimoniuk, M.1    Stolecka, A.2    Ziemińska, E.3    Stepień, A.4    Langfort, J.5    Strosznajder, J.B.6
  • 26
    • 0036513249 scopus 로고    scopus 로고
    • Does nitric oxide modulate mitochondrial energy generation and apoptosis?
    • 1:CAS:528:DC%2BD38XitFShsLg%3D 11994742 10.1038/nrm762
    • Moncada S, Erusalimsky JD (2002) Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol 3:214-220
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 214-220
    • Moncada, S.1    Erusalimsky, J.D.2
  • 27
    • 84877075192 scopus 로고    scopus 로고
    • Overexpressed neuroglobin raises threshold for nitric oxide-induced impairment of mitochondrial respiratory activities and stress signaling in primary cortical neurons
    • 1:CAS:528:DC%2BC3sXptV2itrk%3D 23587847 10.1016/j.niox.2013.03.008
    • Singh S, Zhuo M, Gorgun M, Englander EW (2013) Overexpressed neuroglobin raises threshold for nitric oxide-induced impairment of mitochondrial respiratory activities and stress signaling in primary cortical neurons. Nitric Oxide 32:21-28
    • (2013) Nitric Oxide , vol.32 , pp. 21-28
    • Singh, S.1    Zhuo, M.2    Gorgun, M.3    Englander, E.W.4
  • 28
    • 36348953730 scopus 로고    scopus 로고
    • Nitric oxide and mitochondrial signaling: From physiology to pathophysiology
    • 1:CAS:528:DC%2BD2sXhtlahtL3I 17885213 10.1161/ATVBAHA.107.151167
    • Erusalimsky JD, Moncada S (2007) Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol 27:2524-2531
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2524-2531
    • Erusalimsky, J.D.1    Moncada, S.2
  • 29
    • 84883180845 scopus 로고    scopus 로고
    • Role of oxidative stress in Parkinson's disease
    • 3620453 23585717 10.5607/en.2013.22.1.11
    • Hwang O (2013) Role of oxidative stress in Parkinson's disease. Exp Neurobiol 22:11-17
    • (2013) Exp Neurobiol , vol.22 , pp. 11-17
    • Hwang, O.1
  • 30
    • 84866253155 scopus 로고    scopus 로고
    • Redox regulation of protein function via cysteine S-nitrosylation and its relevance to neurodegenerative diseases
    • 3431077 22956959 10.1155/2012/463756 1:CAS:528:DC%2BC38Xht1OqsbjI
    • Akhtar MW, Sunico CR, Nakamura T, Lipton SA (2012) Redox regulation of protein function via cysteine S-nitrosylation and its relevance to neurodegenerative diseases. Int J Cell Biol 2012:463756
    • (2012) Int J Cell Biol , vol.2012 , pp. 463756
    • Akhtar, M.W.1    Sunico, C.R.2    Nakamura, T.3    Lipton, S.A.4
  • 33
    • 84867670576 scopus 로고    scopus 로고
    • Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease
    • 1:CAS:528:DC%2BC38Xhsl2jsLzM 3488558 23092448 10.1186/1742-2094-9-241
    • Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Srivastava P, Dranka BP, Kalyanaraman B, Kanthasamy AG (2012) Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. J Neuroinflammation 9:241
    • (2012) J Neuroinflammation , vol.9 , pp. 241
    • Ghosh, A.1    Kanthasamy, A.2    Joseph, J.3    Anantharam, V.4    Srivastava, P.5    Dranka, B.P.6    Kalyanaraman, B.7    Kanthasamy, A.G.8
  • 34
    • 84870291915 scopus 로고    scopus 로고
    • Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice
    • 1:CAS:528:DC%2BC38XhsF2msrjN 23069581 10.1016/j.lfs.2012.10.003
    • Sung YH, Kim SC, Hong HP, Park CY, Shin MS, Kim CJ, Seo JH, Kim DY, Kim DJ, Cho HJ (2012) Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice. Life Sci 91:1309-1316
    • (2012) Life Sci , vol.91 , pp. 1309-1316
    • Sung, Y.H.1    Kim, S.C.2    Hong, H.P.3    Park, C.Y.4    Shin, M.S.5    Kim, C.J.6    Seo, J.H.7    Kim, D.Y.8    Kim, D.J.9    Cho, H.J.10
  • 35
    • 84876557548 scopus 로고    scopus 로고
    • Hypothermia reduces toll-like receptor 3-activated microglial interferon-β and nitric oxide production
    • Matsui T, Motoki Y, Yoshida Y (2013) Hypothermia reduces toll-like receptor 3-activated microglial interferon-β and nitric oxide production. Mediat Inflamm 2013:436263
    • (2013) Mediat Inflamm , vol.2013 , pp. 436263
    • Matsui, T.1    Motoki, Y.2    Yoshida, Y.3
  • 36
    • 84860359394 scopus 로고    scopus 로고
    • Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration
    • 1:CAS:528:DC%2BC38XktFOnsLk%3D 3302220 22393127 10.1084/jem.20110698
    • Colombo E, Cordiglieri C, Melli G, Newcombe J, Krumbholz M, Parada LF, Medico E, Hohlfeld R, Meinl E, Farina C (2012) Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med 209:521-535
    • (2012) J Exp Med , vol.209 , pp. 521-535
    • Colombo, E.1    Cordiglieri, C.2    Melli, G.3    Newcombe, J.4    Krumbholz, M.5    Parada, L.F.6    Medico, E.7    Hohlfeld, R.8    Meinl, E.9    Farina, C.10
  • 39
    • 0036244305 scopus 로고    scopus 로고
    • Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis
    • 1:CAS:528:DC%2BD38XksVajtrc%3D 12033432 10.1515/BC.2002.045
    • Boyd CS, Cadenas E (2002) Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol Chem 383:411-423
    • (2002) Biol Chem , vol.383 , pp. 411-423
    • Boyd, C.S.1    Cadenas, E.2
  • 41
    • 36549060678 scopus 로고    scopus 로고
    • Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway
    • 1:CAS:528:DC%2BD2sXhsVSktrbP 17624318 10.1016/j.biopsych.2007.04.020
    • Guo S, Yan J, Yang T, Yang X, Bezard E, Zhao B (2007) Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway. Biol Psychiatry 62:1353-1362
    • (2007) Biol Psychiatry , vol.62 , pp. 1353-1362
    • Guo, S.1    Yan, J.2    Yang, T.3    Yang, X.4    Bezard, E.5    Zhao, B.6
  • 42
    • 52649158749 scopus 로고    scopus 로고
    • Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease
    • 1:CAS:528:DC%2BD1cXhtFKhu73F 2630458 18663495 10.1007/s10048-008-0137-1
    • Hancock DB, Martin ER, Vance JM, Scott WK (2008) Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. Neurogenetics 9:249-262
    • (2008) Neurogenetics , vol.9 , pp. 249-262
    • Hancock, D.B.1    Martin, E.R.2    Vance, J.M.3    Scott, W.K.4
  • 44
    • 33845704887 scopus 로고    scopus 로고
    • Comprehensive association analysis of the NOS2A gene with Parkinson disease
    • 1:CAS:528:DC%2BD28Xht1GmtbrM 17159127 10.1212/01.wnl.0000247672.41736.bd
    • Schulte C, Sharma M, Mueller JC, Lichtner P, Prestel J, Berg D, Gasser T (2006) Comprehensive association analysis of the NOS2A gene with Parkinson disease. Neurology 67:2080-2082
    • (2006) Neurology , vol.67 , pp. 2080-2082
    • Schulte, C.1    Sharma, M.2    Mueller, J.C.3    Lichtner, P.4    Prestel, J.5    Berg, D.6    Gasser, T.7
  • 45
    • 33846839625 scopus 로고    scopus 로고
    • No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes
    • 1:CAS:528:DC%2BD2sXhsFOitL0%3D 17174475 10.1016/j.neulet.2006.11.044
    • Huerta C, Sánchez-Ferrero E, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Alvarez V (2007) No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes. Neurosci Lett 413:202-205
    • (2007) Neurosci Lett , vol.413 , pp. 202-205
    • Huerta, C.1    Sánchez-Ferrero, E.2    Coto, E.3    Blázquez, M.4    Ribacoba, R.5    Guisasola, L.M.6    Salvador, C.7    Alvarez, V.8
  • 46
    • 69249221597 scopus 로고    scopus 로고
    • The effect of a promoter polymorphism on the transcription of nitric oxide synthase 1 and its relevance to Parkinson's disease
    • 1:CAS:528:DC%2BD1MXnt1SisLg%3D 19326438 10.1002/jnr.22045
    • Rife T, Rasoul B, Pullen N, Mitchell D, Grathwol K, Kurth J (2009) The effect of a promoter polymorphism on the transcription of nitric oxide synthase 1 and its relevance to Parkinson's disease. J Neurosci Res 87:2319-2325
    • (2009) J Neurosci Res , vol.87 , pp. 2319-2325
    • Rife, T.1    Rasoul, B.2    Pullen, N.3    Mitchell, D.4    Grathwol, K.5    Kurth, J.6
  • 47
    • 0037082303 scopus 로고    scopus 로고
    • 5′-Flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan
    • 1:CAS:528:DC%2BD38XmsFKjsQ%3D%3D 11809160 10.1016/S0022-510X(01)00666-9
    • Lo HS, Hogan EL, Soong BW (2002) 5′-Flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan. J Neurol Sci 194:11-13
    • (2002) J Neurol Sci , vol.194 , pp. 11-13
    • Lo, H.S.1    Hogan, E.L.2    Soong, B.W.3
  • 49
    • 12244299912 scopus 로고    scopus 로고
    • Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study
    • 1:CAS:528:DC%2BD3sXjt1ahtw%3D%3D 12490535 10.1093/hmg/ddg009
    • Levecque C, Elbaz A, Clavel J, Richard F, Vidal JS, Amouyel P, Tzourio C, Alpérovitch A, Chartier-Harlin MC (2003) Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study. Hum Mol Genet 12:79-86
    • (2003) Hum Mol Genet , vol.12 , pp. 79-86
    • Levecque, C.1    Elbaz, A.2    Clavel, J.3    Richard, F.4    Vidal, J.S.5    Amouyel, P.6    Tzourio, C.7    Alpérovitch, A.8    Chartier-Harlin, M.C.9
  • 50
    • 57949085678 scopus 로고    scopus 로고
    • Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: A proteomic approach
    • 1:CAS:528:DC%2BD1MXht1GntQ%3D%3D 18977210 10.1016/j.cca.2008.09.026
    • Sinha A, Srivastava N, Singh S, Singh AK, Bhushan S, Shukla R, Singh MP (2009) Identification of differentially displayed proteins in cerebrospinal fluid of Parkinson's disease patients: a proteomic approach. Clin Chim Acta 400:14-20
    • (2009) Clin Chim Acta , vol.400 , pp. 14-20
    • Sinha, A.1    Srivastava, N.2    Singh, S.3    Singh, A.K.4    Bhushan, S.5    Shukla, R.6    Singh, M.P.7
  • 51
    • 34548313729 scopus 로고    scopus 로고
    • Mechanistic aspects of Parkinson's disease: Alpha-synuclein and the biomembrane
    • 1:CAS:528:DC%2BD2sXnsVOqtLo%3D 17652776 10.1007/s12013-007-0014-9
    • Beyer K (2007) Mechanistic aspects of Parkinson's disease: alpha-synuclein and the biomembrane. Cell Biochem Biophys 47:285-299
    • (2007) Cell Biochem Biophys , vol.47 , pp. 285-299
    • Beyer, K.1
  • 52
    • 0025695636 scopus 로고
    • Nitric oxide mediates iron release from ferritin
    • 1:CAS:528:DyaK3MXjvVWjsQ%3D%3D 2177332 10.1016/0003-9861(90)90680-W
    • Reif DW, Simmons RD (1990) Nitric oxide mediates iron release from ferritin. Arch Biochem Biophys 283:537-541
    • (1990) Arch Biochem Biophys , vol.283 , pp. 537-541
    • Reif, D.W.1    Simmons, R.D.2
  • 53
    • 84859443870 scopus 로고    scopus 로고
    • Thiamine and Parkinson's disease
    • 1:CAS:528:DC%2BC38Xjs1GrsrY%3D 10.1016/j.jns.2012.02.008
    • Luong KV, Nguyen LT (2012) Thiamine and Parkinson's disease. J Neurol Sci 316:1-8
    • (2012) J Neurol Sci , vol.316 , pp. 1-8
    • Luong, K.V.1    Nguyen, L.T.2
  • 54
    • 77955085868 scopus 로고    scopus 로고
    • Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases
    • 1:CAS:528:DC%2BC3cXmsFSqsbo%3D 20333559 10.1007/s12035-010-8113-9
    • Gu Z, Nakamura T, Lipton SA (2010) Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol 41:55-72
    • (2010) Mol Neurobiol , vol.41 , pp. 55-72
    • Gu, Z.1    Nakamura, T.2    Lipton, S.A.3
  • 55
    • 2542534741 scopus 로고    scopus 로고
    • S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
    • 1:CAS:528:DC%2BD2cXkt1Ggu7c%3D 15105460 10.1126/science.1093891
    • Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304:1328-1331
    • (2004) Science , vol.304 , pp. 1328-1331
    • Chung, K.K.1    Thomas, B.2    Li, X.3    Pletnikova, O.4    Troncoso, J.C.5    Marsh, L.6    Dawson, V.L.7    Dawson, T.M.8
  • 57
    • 36749094065 scopus 로고    scopus 로고
    • S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease
    • 1:CAS:528:DC%2BD2sXhtl2lsbnE 2141847 18003920 10.1073/pnas.0705904104
    • Fang J, Nakamura T, Cho DH, Gu Z, Lipton SA (2007) S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A 104:18742-1847
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18742-21847
    • Fang, J.1    Nakamura, T.2    Cho, D.H.3    Gu, Z.4    Lipton, S.A.5
  • 58
    • 0036010592 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease
    • 1:CAS:528:DC%2BD38XjsFWjtrc%3D 11948617 10.1002/bies.10067
    • Betarbet R, Sherer TB, Greenamyre JT (2002) Animal models of Parkinson's disease. Bioessays 24:308-318
    • (2002) Bioessays , vol.24 , pp. 308-318
    • Betarbet, R.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 59
    • 1442274907 scopus 로고    scopus 로고
    • JNK activation by tetrahydrobiopterin: Implication for Parkinson's disease
    • 1:CAS:528:DC%2BD2cXitFamu70%3D 14991847 10.1002/jnr.20012
    • Choi HJ, Lee SY, Cho Y, Hwang O (2004) JNK activation by tetrahydrobiopterin: implication for Parkinson's disease. J Neurosci Res 75:715-721
    • (2004) J Neurosci Res , vol.75 , pp. 715-721
    • Choi, H.J.1    Lee, S.Y.2    Cho, Y.3    Hwang, O.4
  • 60
    • 61549143699 scopus 로고    scopus 로고
    • Age and sex-differences in the nitric oxide synthase expression and dopamine concentration in the murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • 1:CAS:528:DC%2BD1MXivVehsrs%3D 19401171 10.1016/j.brainres.2008.12.081
    • Joniec I, Ciesielska A, Kurkowska-Jastrzebska I, Przybylkowski A, Czlonkowska A, Czlonkowski A (2009) Age and sex-differences in the nitric oxide synthase expression and dopamine concentration in the murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Res 1261:7-19
    • (2009) Brain Res , vol.1261 , pp. 7-19
    • Joniec, I.1    Ciesielska, A.2    Kurkowska-Jastrzebska, I.3    Przybylkowski, A.4    Czlonkowska, A.5    Czlonkowski, A.6
  • 61
    • 79952860820 scopus 로고    scopus 로고
    • S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases
    • 1:CAS:528:DC%2BC3MXjsVGhurY%3D 20812868 10.1089/ars.2010.3570
    • Nakamura T, Lipton SA (2011) S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxid Redox Signal 14:1479-1492
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1479-1492
    • Nakamura, T.1    Lipton, S.A.2
  • 63
    • 84864927303 scopus 로고    scopus 로고
    • Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neuroinflammation in vitro and in vivo
    • 1:CAS:528:DC%2BC38XhsFaksL3P 22863927 10.1248/bpb.b12-00127
    • Kim HG, Ju MS, Ha SK, Lee H, Lee H, Kim SY, Oh MS (2012) Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neuroinflammation in vitro and in vivo. Biol Pharm Bull 35:1287-1294
    • (2012) Biol Pharm Bull , vol.35 , pp. 1287-1294
    • Kim, H.G.1    Ju, M.S.2    Ha, S.K.3    Lee, H.4    Lee, H.5    Kim, S.Y.6    Oh, M.S.7
  • 64
    • 84862487151 scopus 로고    scopus 로고
    • Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease
    • 1:CAS:528:DC%2BC38Xpt1WlurY%3D 3377667 22723850 10.1371/journal.pone. 0038113
    • Roy A, Ghosh A, Jana A, Liu X, Brahmachari S, Gendelman HE, Pahan K (2012) Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PLoS One 7:e38113
    • (2012) PLoS One , vol.7 , pp. 38113
    • Roy, A.1    Ghosh, A.2    Jana, A.3    Liu, X.4    Brahmachari, S.5    Gendelman, H.E.6    Pahan, K.7
  • 65
    • 61649122828 scopus 로고    scopus 로고
    • Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: A neurochemical study
    • 19250222 10.1111/j.1749-6632.2008.03678.x 1:CAS:528:DC%2BD1MXktFKltL8%3D
    • Di Matteo V, Pierucci M, Benigno A, Crescimanno G, Esposito E, Di Giovanni G (2009) Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: a neurochemical study. Ann N Y Acad Sci 1155:309-315
    • (2009) Ann N y Acad Sci , vol.1155 , pp. 309-315
    • Di Matteo, V.1    Pierucci, M.2    Benigno, A.3    Crescimanno, G.4    Esposito, E.5    Di Giovanni, G.6
  • 66
    • 84866052969 scopus 로고    scopus 로고
    • 7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease
    • 1:CAS:528:DC%2BC38XhtlamurrN 22877786 10.1016/j.neuropharm.2012.07.031
    • Yuste JE, Echeverry MB, Ros-Bernal F, Gomez A, Ros CM, Campuzano CM, Fernandez-Villalba E, Herrero MT (2012) 7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease. Neuropharmacology 63:1258-1267
    • (2012) Neuropharmacology , vol.63 , pp. 1258-1267
    • Yuste, J.E.1    Echeverry, M.B.2    Ros-Bernal, F.3    Gomez, A.4    Ros, C.M.5    Campuzano, C.M.6    Fernandez-Villalba, E.7    Herrero, M.T.8
  • 67
    • 77954154834 scopus 로고    scopus 로고
    • Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide
    • 1:CAS:528:DC%2BC3cXhtlyqu7nE 20594414 10.1179/174329210X12650506623447
    • Singh S, Kumar S, Dikshit M (2010) Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide. Redox Rep 15:115-122
    • (2010) Redox Rep , vol.15 , pp. 115-122
    • Singh, S.1    Kumar, S.2    Dikshit, M.3
  • 68
    • 33746342757 scopus 로고    scopus 로고
    • Involvement of nitric oxide in neurodegeneration: A study on the experimental models of Parkinson's disease
    • 1:CAS:528:DC%2BD2MXmtlert7c%3D 15949131 10.1179/135100005X38842
    • Singh S, Das T, Ravindran A, Chaturvedi RK, Shukla Y, Agarwal AK, Dikshit M (2005) Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson's disease. Redox Rep 10:103-109
    • (2005) Redox Rep , vol.10 , pp. 103-109
    • Singh, S.1    Das, T.2    Ravindran, A.3    Chaturvedi, R.K.4    Shukla, Y.5    Agarwal, A.K.6    Dikshit, M.7
  • 69
    • 84865122074 scopus 로고    scopus 로고
    • Neuroprotection by silencing iNOS expression in a 6-OHDA model of Parkinson's disease
    • 22638860 10.1007/s12031-012-9814-5 1:CAS:528:DC%2BC38XhtFGhsLvN
    • Li M, Dai FR, Du XP, Yang QD, Chen Y (2012) Neuroprotection by silencing iNOS expression in a 6-OHDA model of Parkinson's disease. J Mol Neurosci 48:225-233
    • (2012) J Mol Neurosci , vol.48 , pp. 225-233
    • Li, M.1    Dai, F.R.2    Du, X.P.3    Yang, Q.D.4    Chen, Y.5
  • 70
    • 79551488606 scopus 로고    scopus 로고
    • Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease
    • 1:CAS:528:DC%2BC3MXhtlejtbk%3D 21185368 10.1016/j.freeradbiomed.2010.12. 026
    • Broom L, Marinova-Mutafchieva L, Sadeghian M, Davis JB, Medhurst AD, Dexter DT (2011) Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. Free Radic Biol Med 50:633-640
    • (2011) Free Radic Biol Med , vol.50 , pp. 633-640
    • Broom, L.1    Marinova-Mutafchieva, L.2    Sadeghian, M.3    Davis, J.B.4    Medhurst, A.D.5    Dexter, D.T.6
  • 71
    • 58149466868 scopus 로고    scopus 로고
    • Oxidative and inflammatory pathways in Parkinson's disease
    • 1:CAS:528:DC%2BD1MXktVejtw%3D%3D 18363100 10.1007/s11064-008-9656-2
    • Miller RL, James-Kracke M, Sun GY, Sun AY (2009) Oxidative and inflammatory pathways in Parkinson's disease. Neurochem Res 34:55-65
    • (2009) Neurochem Res , vol.34 , pp. 55-65
    • Miller, R.L.1    James-Kracke, M.2    Sun, G.Y.3    Sun, A.Y.4
  • 72
    • 34249788747 scopus 로고    scopus 로고
    • Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome
    • 1:CAS:528:DC%2BD28Xht1WgsLfP 17127363 10.2741/2128
    • Gomez C, Bandez MJ, Navarro A (2007) Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci 12:1079-1093
    • (2007) Front Biosci , vol.12 , pp. 1079-1093
    • Gomez, C.1    Bandez, M.J.2    Navarro, A.3
  • 73
    • 84863666597 scopus 로고    scopus 로고
    • Mitochondrial complex i inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models
    • 1:CAS:528:DC%2BC38XhtVelu7%2FE 22574684 10.3109/10408444.2012.680431
    • Xiong N, Long X, Xiong J, Jia M, Chen C, Huang J, Ghoorah D, Kong X, Lin Z, Wang T (2012) Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models. Crit Rev Toxicol 42:613-632
    • (2012) Crit Rev Toxicol , vol.42 , pp. 613-632
    • Xiong, N.1    Long, X.2    Xiong, J.3    Jia, M.4    Chen, C.5    Huang, J.6    Ghoorah, D.7    Kong, X.8    Lin, Z.9    Wang, T.10
  • 74
    • 81055140360 scopus 로고    scopus 로고
    • Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and l-dopa toxicity
    • 1:CAS:528:DC%2BC3MXhsVahtLnP 21889550 10.1016/j.neures.2011.08.008
    • Abdin AA, Sarhan NI (2011) Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and l-dopa toxicity. Neurosci Res 71:387-395
    • (2011) Neurosci Res , vol.71 , pp. 387-395
    • Abdin, A.A.1    Sarhan, N.I.2
  • 75
    • 0141996495 scopus 로고    scopus 로고
    • Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis
    • 1:CAS:528:DC%2BD3sXotVyjsbs%3D 14561532 10.1016/j.lfs.2003.06.013
    • Tada-Oikawa S, Hiraku Y, Kawanishi M, Kawanishi S (2003) Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis. Life Sci 73:3277-3288
    • (2003) Life Sci , vol.73 , pp. 3277-3288
    • Tada-Oikawa, S.1    Hiraku, Y.2    Kawanishi, M.3    Kawanishi, S.4
  • 76
    • 0141767129 scopus 로고    scopus 로고
    • Role of nitric oxide in rotenone-induced nigro-striatal injury
    • 1:CAS:528:DC%2BD3sXnsV2itLg%3D 12950443 10.1046/j.1471-4159.2003.01938.x
    • He Y, Imam SZ, Dong Z, Jankovic J, Ali SF, Appel SH, Le W (2003) Role of nitric oxide in rotenone-induced nigro-striatal injury. J Neurochem 86:1338-1345
    • (2003) J Neurochem , vol.86 , pp. 1338-1345
    • He, Y.1    Imam, S.Z.2    Dong, Z.3    Jankovic, J.4    Ali, S.F.5    Appel, S.H.6    Le, W.7
  • 77
    • 1542513224 scopus 로고    scopus 로고
    • Chronic administration of rotenone increases levels of nitric oxide and lipid peroxidation products in rat brain
    • 1:CAS:528:DC%2BD2cXitFKntrs%3D 15026259 10.1016/j.expneurol.2003.12.005
    • Bashkatova V, Alam M, Vanin A, Schmidt WJ (2004) Chronic administration of rotenone increases levels of nitric oxide and lipid peroxidation products in rat brain. Exp Neurol 186:235-241
    • (2004) Exp Neurol , vol.186 , pp. 235-241
    • Bashkatova, V.1    Alam, M.2    Vanin, A.3    Schmidt, W.J.4
  • 78
    • 78650881856 scopus 로고    scopus 로고
    • Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention
    • 1:CAS:528:DC%2BC3MXksFygsQ%3D%3D 3169436 21130735 10.1016/j.bbrc.2010.11. 117
    • Pal R, Miranda M, Narayan M (2011) Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention. Biochem Biophys Res Commun 404:324-329
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 324-329
    • Pal, R.1    Miranda, M.2    Narayan, M.3
  • 79
    • 64449085359 scopus 로고    scopus 로고
    • A highly reproducible rotenone model of Parkinson's disease
    • 1:CAS:528:DC%2BD1MXkslKrsro%3D 2757935 19385059 10.1016/j.nbd.2009.01.016
    • Cannon JR, Tapias V, Na HM, Honick AS, Drolet RE, Greenamyre JT (2009) A highly reproducible rotenone model of Parkinson's disease. Neurobiol Dis 34:279-290
    • (2009) Neurobiol Dis , vol.34 , pp. 279-290
    • Cannon, J.R.1    Tapias, V.2    Na, H.M.3    Honick, A.S.4    Drolet, R.E.5    Greenamyre, J.T.6
  • 80
    • 77953262917 scopus 로고    scopus 로고
    • Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models
    • 1:CAS:528:DC%2BC3cXktFOns78%3D 20041858 10.1111/j.1474-9726.2009.00543.x
    • Hu LF, Lu M, Tiong CX, Dawe GS, Hu G, Bian JS (2010) Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models. Aging Cell 9:135-146
    • (2010) Aging Cell , vol.9 , pp. 135-146
    • Hu, L.F.1    Lu, M.2    Tiong, C.X.3    Dawe, G.S.4    Hu, G.5    Bian, J.S.6
  • 81
    • 67650094606 scopus 로고    scopus 로고
    • Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease
    • 1:CAS:528:DC%2BD1MXoslSju7w%3D 19375462 10.1016/j.neuint.2009.04.001
    • Verma R, Nehru B (2009) Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease. Neurochem Int 55:369-375
    • (2009) Neurochem Int , vol.55 , pp. 369-375
    • Verma, R.1    Nehru, B.2
  • 82
    • 60949093034 scopus 로고    scopus 로고
    • Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons
    • 1:CAS:528:DC%2BD1MXivVGqsbo%3D 19111870 10.1016/j.neuint.2008.12.003
    • Bi J, Jiang B, Hao S, Zhang A, Dong Y, Jiang T, An L (2009) Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons. Neurochem Int 54:264-270
    • (2009) Neurochem Int , vol.54 , pp. 264-270
    • Bi, J.1    Jiang, B.2    Hao, S.3    Zhang, A.4    Dong, Y.5    Jiang, T.6    An, L.7
  • 83
    • 84862876684 scopus 로고    scopus 로고
    • Role of secondary mediators in caffeine-mediated neuroprotection in maneb- and paraquat-induced Parkinson's disease phenotype in the mouse
    • 1:CAS:528:DC%2BC3MXhs1OjsL3I 22201039 10.1007/s11064-011-0682-0
    • Yadav S, Gupta SP, Srivastava G, Srivastava PK, Singh MP (2012) Role of secondary mediators in caffeine-mediated neuroprotection in maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. Neurochem Res 37:875-884
    • (2012) Neurochem Res , vol.37 , pp. 875-884
    • Yadav, S.1    Gupta, S.P.2    Srivastava, G.3    Srivastava, P.K.4    Singh, M.P.5
  • 84
    • 63649095770 scopus 로고    scopus 로고
    • Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California
    • 19270050 10.1093/aje/kwp006
    • Costello S, Cockburn M, Bronstein J, Zhang X, Ritz B (2009) Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. Am J Epidemiol 169:919-926
    • (2009) Am J Epidemiol , vol.169 , pp. 919-926
    • Costello, S.1    Cockburn, M.2    Bronstein, J.3    Zhang, X.4    Ritz, B.5
  • 85
    • 84861188146 scopus 로고    scopus 로고
    • Interferon-γ plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways
    • 1:CAS:528:DC%2BC38Xnt1Knuro%3D 21482445 10.1016/j.neurobiolaging.2011.02. 016
    • Mangano EN, Litteljohn D, So R, Nelson E, Peters S, Bethune C, Bobyn J, Hayley S (2012) Interferon-γ plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways. Neurobiol Aging 33:1411-1426
    • (2012) Neurobiol Aging , vol.33 , pp. 1411-1426
    • Mangano, E.N.1    Litteljohn, D.2    So, R.3    Nelson, E.4    Peters, S.5    Bethune, C.6    Bobyn, J.7    Hayley, S.8
  • 87
    • 0037490957 scopus 로고    scopus 로고
    • Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture
    • 1:CAS:528:DC%2BD3sXlsVaitLc%3D 12871774 10.1016/S0168-0102(03)00163-9
    • Shimizu K, Matsubara K, Ohtaki K, Shiono H (2003) Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neurosci Res 46:523-532
    • (2003) Neurosci Res , vol.46 , pp. 523-532
    • Shimizu, K.1    Matsubara, K.2    Ohtaki, K.3    Shiono, H.4
  • 88
    • 0037847451 scopus 로고    scopus 로고
    • Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats
    • 1:CAS:528:DC%2BD3sXjvV2murs%3D 12763259 10.1016/S0006-8993(03)02750-1
    • Shimizu K, Matsubara K, Ohtaki K, Fujimaru S, Saito O, Shiono H (2003) Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain Res 976:243-252
    • (2003) Brain Res , vol.976 , pp. 243-252
    • Shimizu, K.1    Matsubara, K.2    Ohtaki, K.3    Fujimaru, S.4    Saito, O.5    Shiono, H.6
  • 89
    • 55849138355 scopus 로고    scopus 로고
    • The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes
    • 1:CAS:528:DC%2BD1cXhtlensL%2FO 18985485 10.1080/10715760802513733
    • Ahmad I, Kumar A, Shukla S, Prasad Pandey H, Singh C (2008) The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res 42:849-862
    • (2008) Free Radic Res , vol.42 , pp. 849-862
    • Ahmad, I.1    Kumar, A.2    Shukla, S.3    Prasad Pandey, H.4    Singh, C.5
  • 90
    • 0034663061 scopus 로고    scopus 로고
    • Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
    • 1:CAS:528:DC%2BD3cXlvVGjtbs%3D 10934283
    • Kim WG, Mohney RP, Wilson B, Jeohn GH, Liu B, Hong JS (2000) Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci 20:6309-6316
    • (2000) J Neurosci , vol.20 , pp. 6309-6316
    • Kim, W.G.1    Mohney, R.P.2    Wilson, B.3    Jeohn, G.H.4    Liu, B.5    Hong, J.S.6
  • 91
    • 84877699705 scopus 로고    scopus 로고
    • Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide- stimulated BV2 microglial cells
    • 3676815 23698769 10.3390/ijms14059820 1:CAS:528:DC%2BC3sXhtVSktLjM
    • Lee YY, Park JS, Jung JS, Kim DH, Kim HS (2013) Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells. Int J Mol Sci 14:9820-9833
    • (2013) Int J Mol Sci , vol.14 , pp. 9820-9833
    • Lee, Y.Y.1    Park, J.S.2    Jung, J.S.3    Kim, D.H.4    Kim, H.S.5
  • 92
    • 0037330339 scopus 로고    scopus 로고
    • Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration
    • 1:CAS:528:DC%2BD3sXhsVajtr8%3D 12609487 10.1016/S0969-9961(02)00017-7
    • Arimoto T, Bing G (2003) Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiol Dis 12:35-45
    • (2003) Neurobiol Dis , vol.12 , pp. 35-45
    • Arimoto, T.1    Bing, G.2
  • 93
    • 0043170944 scopus 로고    scopus 로고
    • Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum
    • 12871835 10.1038/sj.bjp.0705315 1:CAS:528:DC%2BD3sXmtFemtLw%3D
    • Di Girolamo G, Farina M, Riberio ML, Ogando D, Aisemberg J, De los Santos AR, Martí ML, Franchi AM (2003) Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum. Br J Pharmacol 139:1164-1170
    • (2003) Br J Pharmacol , vol.139 , pp. 1164-1170
    • Di Girolamo, G.1    Farina, M.2    Riberio, M.L.3    Ogando, D.4    Aisemberg, J.5    De Los Santos, A.R.6    Martí, M.L.7    Franchi, A.M.8
  • 95
    • 84884907135 scopus 로고    scopus 로고
    • A guide to neurotoxic animal models of Parkinson's disease
    • 22229125 10.1101/cshperspect.a009316 1:CAS:528:DC%2BC3sXntFWgtLc%3D
    • Tieu K (2011) A guide to neurotoxic animal models of Parkinson's disease. Cold Spring Harb Perspect Med 1:a009316
    • (2011) Cold Spring Harb Perspect Med , vol.1 , pp. 009316
    • Tieu, K.1
  • 96
    • 15244357686 scopus 로고    scopus 로고
    • Free radical production induced by methamphetamine in rat striatal synaptosomes
    • 1:CAS:528:DC%2BD2MXisVClt7s%3D 15781294 10.1016/j.taap.2004.08.008
    • Pubill D, Chipana C, Camins A, Pallàs M, Camarasa J, Escubedo E (2005) Free radical production induced by methamphetamine in rat striatal synaptosomes. Toxicol Appl Pharmacol 204:57-68
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 57-68
    • Pubill, D.1    Chipana, C.2    Camins, A.3    Pallàs, M.4    Camarasa, J.5    Escubedo, E.6
  • 97
    • 34548384274 scopus 로고    scopus 로고
    • Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease
    • 1:STN:280:DC%2BD2svovFOhsA%3D%3D 17708335
    • Rajakumar B, Flumerfelt BA, Hrycyshyn AW, Rajakumar N (2007) Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease. Cell Transplant 16:449-459
    • (2007) Cell Transplant , vol.16 , pp. 449-459
    • Rajakumar, B.1    Flumerfelt, B.A.2    Hrycyshyn, A.W.3    Rajakumar, N.4
  • 98
    • 0031847891 scopus 로고    scopus 로고
    • Effects of 7-nitroindazole, an NOS inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice
    • 1:CAS:528:DyaK1cXks12lsrY%3D 9668670 10.1111/j.1749-6632.1998.tb08227.x
    • Ali SF, Itzhak Y (1998) Effects of 7-nitroindazole, an NOS inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice. Ann N Y Acad Sci 844:122-130
    • (1998) Ann N y Acad Sci , vol.844 , pp. 122-130
    • Ali, S.F.1    Itzhak, Y.2
  • 99
    • 84856400673 scopus 로고    scopus 로고
    • Nitric oxide modulates dopaminergic regulation of prepulse inhibition in the basolateral amygdala
    • 1:CAS:528:DC%2BC38Xht1yhtLc%3D 20837567 10.1177/0269881110379282
    • Salum C, Issy AC, Brandão ML, Guimarães FS, Bel EA (2011) Nitric oxide modulates dopaminergic regulation of prepulse inhibition in the basolateral amygdala. J Psychopharmacol 25:1639-1648
    • (2011) J Psychopharmacol , vol.25 , pp. 1639-1648
    • Salum, C.1    Issy, A.C.2    Brandão, M.L.3    Guimarães, F.S.4    Bel, E.A.5
  • 100
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations
    • 1:CAS:528:DyaE28XlvFSgt7k%3D 4272516 10.1016/0022-510X(73)90175-5
    • Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 20:415-455
    • (1973) J Neurol Sci , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seitelberger, F.5
  • 101
    • 34249039316 scopus 로고    scopus 로고
    • Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain
    • 1:CAS:528:DC%2BD2sXlvFaltro%3D 17478054 10.1016/j.neuroscience.2007.04. 002
    • Bilska A, Dubiel M, Sokołowska-Jezewicz M, Lorenc-Koci E, Włodek L (2007) Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience 146:1758-1771
    • (2007) Neuroscience , vol.146 , pp. 1758-1771
    • Bilska, A.1    Dubiel, M.2    Sokołowska-Jezewicz, M.3    Lorenc-Koci, E.4    Włodek, L.5
  • 102
    • 33645412107 scopus 로고    scopus 로고
    • Different effects of 7-nitroindazole in reserpine-induced hypolocomotion in two strains of mice
    • 1:CAS:528:DC%2BD28XjtFGlsr4%3D 16546164 10.1016/j.ejphar.2006.02.004
    • Tadaiesky MT, Andreatini R, Vital MA (2006) Different effects of 7-nitroindazole in reserpine-induced hypolocomotion in two strains of mice. Eur J Pharmacol 535:199-207
    • (2006) Eur J Pharmacol , vol.535 , pp. 199-207
    • Tadaiesky, M.T.1    Andreatini, R.2    Vital, M.A.3
  • 103
    • 33745991786 scopus 로고    scopus 로고
    • Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced parkinsonism in mice
    • 1:CAS:528:DC%2BD28XntFShsrY%3D 16716528 10.1016/j.neuroscience.2006.04. 022
    • Chalimoniuk M, Lukacova N, Marsala J, Langfort J (2006) Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience 141:1033-1046
    • (2006) Neuroscience , vol.141 , pp. 1033-1046
    • Chalimoniuk, M.1    Lukacova, N.2    Marsala, J.3    Langfort, J.4
  • 104
    • 0029844003 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons
    • 1:CAS:528:DyaK28XlsFenu7w%3D 8782460 10.1038/nm0996-1017
    • Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2:1017-1021
    • (1996) Nat Med , vol.2 , pp. 1017-1021
    • Hantraye, P.1    Brouillet, E.2    Ferrante, R.3    Palfi, S.4    Dolan, R.5    Matthews, R.T.6    Beal, M.F.7
  • 106
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • 1:CAS:528:DC%2BD3cXis12qsrs%3D 10800968 10.1046/j.1471-4159.2000.0742213. x
    • Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB (2000) Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 74(5):2213-2216
    • (2000) J Neurochem , vol.74 , Issue.5 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 108
    • 84864318812 scopus 로고    scopus 로고
    • A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease
    • 1:CAS:528:DC%2BC38XhtVymt73M 3408780 22776646 10.1016/j.neulet.2012.06. 070
    • Stone DK, Kiyota T, Mosley RL, Gendelman HE (2012) A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease. Neurosci Lett 523:167-173
    • (2012) Neurosci Lett , vol.523 , pp. 167-173
    • Stone, D.K.1    Kiyota, T.2    Mosley, R.L.3    Gendelman, H.E.4
  • 109
    • 79955699135 scopus 로고    scopus 로고
    • Expression of mutant alpha-synuclein modulates microglial phenotype in vitro
    • 1:CAS:528:DC%2BC3MXmtlKktrg%3D 3104357 21554732 10.1186/1742-2094-8-44
    • Rojanathammanee L, Murphy EJ, Combs CK (2011) Expression of mutant alpha-synuclein modulates microglial phenotype in vitro. J Neuroinflammation 8:44
    • (2011) J Neuroinflammation , vol.8 , pp. 44
    • Rojanathammanee, L.1    Murphy, E.J.2    Combs, C.K.3
  • 110
    • 79955921784 scopus 로고    scopus 로고
    • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease
    • 1:CAS:528:DC%2BC3MXos1Grsb0%3D 3114815 21245015 10.1289/ehp.1003013
    • Gao HM, Zhang F, Zhou H, Kam W, Wilson B, Hong JS (2011) Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect 119:807-814
    • (2011) Environ Health Perspect , vol.119 , pp. 807-814
    • Gao, H.M.1    Zhang, F.2    Zhou, H.3    Kam, W.4    Wilson, B.5    Hong, J.S.6
  • 111
    • 41149110768 scopus 로고    scopus 로고
    • Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?
    • 1:CAS:528:DC%2BD1cXlvVWnsLs%3D 2605676 18407422 10.1016/j.neuroscience. 2008.02.074
    • Phillips RJ, Walter GC, Wilder SL, Baronowsky EA, Powley TL (2008) Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease? Neuroscience 153:733-750
    • (2008) Neuroscience , vol.153 , pp. 733-750
    • Phillips, R.J.1    Walter, G.C.2    Wilder, S.L.3    Baronowsky, E.A.4    Powley, T.L.5
  • 112
    • 84866703142 scopus 로고    scopus 로고
    • LRRK2 and autophagy: A common pathway for disease
    • 1:CAS:528:DC%2BC38XhtlOjurzE 22988880 10.1042/BST20120126
    • Manzoni C (2012) LRRK2 and autophagy: a common pathway for disease. Biochem Soc Trans 40:1147-1151
    • (2012) Biochem Soc Trans , vol.40 , pp. 1147-1151
    • Manzoni, C.1
  • 113
    • 84858620880 scopus 로고    scopus 로고
    • Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
    • 1:CAS:528:DC%2BC38XksFant78%3D 22342962 10.1016/j.neuroscience.2012.02. 001
    • Gillardon F, Schmid R, Draheim H (2012) Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity. Neuroscience 208:41-48
    • (2012) Neuroscience , vol.208 , pp. 41-48
    • Gillardon, F.1    Schmid, R.2    Draheim, H.3
  • 114
    • 84872691988 scopus 로고    scopus 로고
    • Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons
    • 1:CAS:528:DC%2BC3sXhtFGqtLw%3D 23231918 10.1016/j.ajpath.2012.10.027
    • Cherra SJ 3rd, Steer E, Gusdon AM, Kiselyov K, Chu CT (2013) Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am J Pathol 182:474-484
    • (2013) Am J Pathol , vol.182 , pp. 474-484
    • Cherra III, S.J.1    Steer, E.2    Gusdon, A.M.3    Kiselyov, K.4    Chu, C.T.5
  • 116
    • 79960433284 scopus 로고    scopus 로고
    • The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expression
    • 1:CAS:528:DC%2BC3MXovFyrt7w%3D 21737065 10.1016/j.brainres.2011.05.063
    • Brzozowski MJ, Alcantara SL, Iravani MM, Rose S, Jenner P (2011) The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expression. Brain Res 1404:21-30
    • (2011) Brain Res , vol.1404 , pp. 21-30
    • Brzozowski, M.J.1    Alcantara, S.L.2    Iravani, M.M.3    Rose, S.4    Jenner, P.5
  • 117
    • 0036328426 scopus 로고    scopus 로고
    • Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency
    • 1:CAS:528:DC%2BD38XptV2itg%3D%3D 11902126 10.1046/j.0022-3042.2001.00710. x
    • Zorzi G, Thony B, Blau N (2002) Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency. J Neurochem 80:362-644
    • (2002) J Neurochem , vol.80 , pp. 362-644
    • Zorzi, G.1    Thony, B.2    Blau, N.3
  • 118
    • 40949097682 scopus 로고    scopus 로고
    • A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway
    • 1:CAS:528:DC%2BD1cXktVCjsLo%3D 18313645 10.1016/j.brainres.2008.01.088
    • Gomes MZ, Raisman-Vozari R, Del Bel EA (2008) A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain Res 1203:160-169
    • (2008) Brain Res , vol.1203 , pp. 160-169
    • Gomes, M.Z.1    Raisman-Vozari, R.2    Del Bel, E.A.3
  • 119
    • 77951641169 scopus 로고    scopus 로고
    • Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease
    • 19218114
    • Shi C, Zhang YX, Zhang ZF (2009) Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease. Nan Fang Yi Ke Da Xue Xue Bao 29:60-63
    • (2009) Nan Fang Yi Ke da Xue Xue Bao , vol.29 , pp. 60-63
    • Shi, C.1    Zhang, Y.X.2    Zhang, Z.F.3
  • 120
    • 79953306252 scopus 로고    scopus 로고
    • Role of nitric oxide in motor control: Implications for Parkinson's disease pathophysiology and treatment
    • 1:CAS:528:DC%2BC3MXlsVKltr0%3D 21375483 10.2174/138161211795164176
    • Del-Bel E, Padovan-Neto FE, Raisman-Vozari R, Lazzarini M (2011) Role of nitric oxide in motor control: implications for Parkinson's disease pathophysiology and treatment. Curr Pharm Des 17:471-488
    • (2011) Curr Pharm des , vol.17 , pp. 471-488
    • Del-Bel, E.1    Padovan-Neto, F.E.2    Raisman-Vozari, R.3    Lazzarini, M.4
  • 121
    • 84876409647 scopus 로고    scopus 로고
    • Anti-dyskinetic effect of the neuronal nitric oxide synthase inhibitor is linked to decrease of FosB/DeltaFosB expression
    • 1:CAS:528:DC%2BC3sXktFahsrY%3D 23428503 10.1016/j.neulet.2013.02.015
    • Padovan-Neto FE, Ferreira NR, Tavares D, de Aguiar D, Silva CA, Raisman-Vozari R, Del Bel E (2013) Anti-dyskinetic effect of the neuronal nitric oxide synthase inhibitor is linked to decrease of FosB/DeltaFosB expression. Neurosci Lett 541:126-131
    • (2013) Neurosci Lett , vol.541 , pp. 126-131
    • Padovan-Neto, F.E.1    Ferreira, N.R.2    Tavares, D.3    De Aguiar, D.4    Silva, C.A.5    Raisman-Vozari, R.6    Del Bel, E.7
  • 122
    • 84860452656 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase inhibition attenuates the development of l-DOPA-induced dyskinesia in hemi-parkinsonian rats
    • 1:CAS:528:DC%2BC38XltVarur8%3D 22449381 10.1016/j.ejphar.2012.03.008
    • Takuma K, Tanaka T, Takahashi T, Hiramatsu N, Ota Y, Ago Y, Matsuda T (2012) Neuronal nitric oxide synthase inhibition attenuates the development of l-DOPA-induced dyskinesia in hemi-parkinsonian rats. Eur J Pharmacol 683:166-173
    • (2012) Eur J Pharmacol , vol.683 , pp. 166-173
    • Takuma, K.1    Tanaka, T.2    Takahashi, T.3    Hiramatsu, N.4    Ota, Y.5    Ago, Y.6    Matsuda, T.7
  • 125
    • 80051549269 scopus 로고    scopus 로고
    • Parkinson's disease mouse models in translational research
    • 3151483 21559878 10.1007/s00335-011-9330-x
    • Antony PM, Diederich NJ, Balling R (2011) Parkinson's disease mouse models in translational research. Mamm Genome 22:401-419
    • (2011) Mamm Genome , vol.22 , pp. 401-419
    • Antony, P.M.1    Diederich, N.J.2    Balling, R.3
  • 126
    • 79251561841 scopus 로고    scopus 로고
    • Limitations of animal models of Parkinson's disease
    • 1:STN:280:DC%2BC3M%2FptlajsA%3D%3D
    • Potashkin JA, Blume SR, Runkle NK (2010) Limitations of animal models of Parkinson's disease. Park Dis 2011:658083
    • (2010) Park Dis , vol.2011 , pp. 658083
    • Potashkin, J.A.1    Blume, S.R.2    Runkle, N.K.3
  • 127
    • 84863231493 scopus 로고    scopus 로고
    • Protective effect of theaflavins on neuron against 6-hydroxydopamine- induced apoptosis in SH-SY5Y cells
    • 1:CAS:528:DC%2BC38Xmt1Shur4%3D 3303475 22448094 10.3164/jcbn.11-28
    • Luo Z, Zhao Y, Wang Y, Yang X, Zhao B (2012) Protective effect of theaflavins on neuron against 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells. J Clin Biochem Nutr 50:133-138
    • (2012) J Clin Biochem Nutr , vol.50 , pp. 133-138
    • Luo, Z.1    Zhao, Y.2    Wang, Y.3    Yang, X.4    Zhao, B.5
  • 128
    • 84866057219 scopus 로고    scopus 로고
    • Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • 22527634 10.1007/s11481-012-9363-2
    • Ojha RP, Rastogi M, Devi BP, Agrawal A, Dubey GP (2012) Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Neuroimmune Pharmacol 7:609-618
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 609-618
    • Ojha, R.P.1    Rastogi, M.2    Devi, B.P.3    Agrawal, A.4    Dubey, G.P.5
  • 129
    • 0031112190 scopus 로고    scopus 로고
    • Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies
    • 1:STN:280:DyaK2s3msVKjsQ%3D%3D 9110408 10.1097/00024382-199704000-00001
    • Kilbourn RG, Szabó C, Traber DL (1997) Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: lessons learned from experimental and clinical studies. Shock 7:235-246
    • (1997) Shock , vol.7 , pp. 235-246
    • Kilbourn, R.G.1    Szabó, C.2    Traber, D.L.3


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