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Volumn 9, Issue , 2012, Pages

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease

Author keywords

Astrocytes; Diapocynin; Dopamine; Microglia; Neuroinflammation; Neuroprotection; Oxidative stress; Parkinson's disease

Indexed keywords


EID: 84867670576     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-241     Document Type: Article
Times cited : (96)

References (41)
  • 1
    • 3142523288 scopus 로고    scopus 로고
    • Genetic clues to the pathogenesis of Parkinson's disease
    • Vila M, Przedborski S. Genetic clues to the pathogenesis of Parkinson's disease. Nat Med 2004, Suppl 10:58-62.
    • (2004) Nat Med , vol.Suppl 10 , pp. 58-62
    • Vila, M.1    Przedborski, S.2
  • 2
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: mechanisms and models
    • 10.1016/S0896-6273(03)00568-3, 12971891
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003, 39:889-909. 10.1016/S0896-6273(03)00568-3, 12971891.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 3
    • 70350555275 scopus 로고    scopus 로고
    • Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease
    • 10.1523/JNEUROSCI.4144-09.2009, 2862566, 19864567
    • Ghosh A, Roy A, Matras J, Brahmachari S, Gendelman HE, Pahan K. Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J Neurosci 2009, 29:13543-13556. 10.1523/JNEUROSCI.4144-09.2009, 2862566, 19864567.
    • (2009) J Neurosci , vol.29 , pp. 13543-13556
    • Ghosh, A.1    Roy, A.2    Matras, J.3    Brahmachari, S.4    Gendelman, H.E.5    Pahan, K.6
  • 4
    • 0038044029 scopus 로고    scopus 로고
    • Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
    • Gao HM, Liu B, Hong JS. Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 2003, 23:6181-6187.
    • (2003) J Neurosci , vol.23 , pp. 6181-6187
    • Gao, H.M.1    Liu, B.2    Hong, J.S.3
  • 5
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • 10.1212/WNL.38.8.1285, 3399080
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291. 10.1212/WNL.38.8.1285, 3399080.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 6
    • 0343844458 scopus 로고    scopus 로고
    • Nitric oxide synthase and neuronal vulnerability in Parkinson's disease
    • 10.1016/0306-4522(95)00578-1, 8737406
    • Hunot S, Boissiere F, Faucheux B, Brugg B, Mouatt-Prigent A, Agid Y, Hirsch EC. Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 1996, 72:355-363. 10.1016/0306-4522(95)00578-1, 8737406.
    • (1996) Neuroscience , vol.72 , pp. 355-363
    • Hunot, S.1    Boissiere, F.2    Faucheux, B.3    Brugg, B.4    Mouatt-Prigent, A.5    Agid, Y.6    Hirsch, E.C.7
  • 7
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 2000, 74:2213-2216.
    • (2000) J Neurochem , vol.74 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 8
    • 0347711117 scopus 로고    scopus 로고
    • NADPH oxidases: not just for leukocytes anymore!
    • 10.1016/S0968-0004(03)00194-4, 13678962
    • Bokoch GM, Knaus UG. NADPH oxidases: not just for leukocytes anymore!. Trends Biochem Sci 2003, 28:502-508. 10.1016/S0968-0004(03)00194-4, 13678962.
    • (2003) Trends Biochem Sci , vol.28 , pp. 502-508
    • Bokoch, G.M.1    Knaus, U.G.2
  • 9
    • 44649173705 scopus 로고    scopus 로고
    • Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death
    • 10.1016/j.freeradbiomed.2008.04.007, 2664084, 18456001
    • Awasthi YC, Sharma R, Sharma A, Yadav S, Singhal SS, Chaudhary P, Awasthi S. Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med 2008, 45:111-118. 10.1016/j.freeradbiomed.2008.04.007, 2664084, 18456001.
    • (2008) Free Radic Biol Med , vol.45 , pp. 111-118
    • Awasthi, Y.C.1    Sharma, R.2    Sharma, A.3    Yadav, S.4    Singhal, S.S.5    Chaudhary, P.6    Awasthi, S.7
  • 10
    • 34948869744 scopus 로고    scopus 로고
    • Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells
    • 10.1016/j.neuro.2007.08.008, 2140261, 17904225
    • Anantharam V, Kaul S, Song C, Kanthasamy A, Kanthasamy AG. Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology 2007, 28:988-997. 10.1016/j.neuro.2007.08.008, 2140261, 17904225.
    • (2007) Neurotoxicology , vol.28 , pp. 988-997
    • Anantharam, V.1    Kaul, S.2    Song, C.3    Kanthasamy, A.4    Kanthasamy, A.G.5
  • 12
    • 22844432344 scopus 로고    scopus 로고
    • Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat
    • 10.1016/j.amjhyper.2005.02.017, 16053986
    • Zhang Y, Chan MM, Andrews MC, Mori TA, Croft KD, McKenzie KU, Schyvens CG, Whitworth JA. Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat. Am J Hypertens 2005, 18:910-916. 10.1016/j.amjhyper.2005.02.017, 16053986.
    • (2005) Am J Hypertens , vol.18 , pp. 910-916
    • Zhang, Y.1    Chan, M.M.2    Andrews, M.C.3    Mori, T.A.4    Croft, K.D.5    McKenzie, K.U.6    Schyvens, C.G.7    Whitworth, J.A.8
  • 15
    • 34548101125 scopus 로고    scopus 로고
    • Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease
    • 10.1124/jpet.107.124669, 17565007
    • Zhang D, Anantharam V, Kanthasamy A, Kanthasamy AG. Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J Pharmacol Exp Ther 2007, 322:913-922. 10.1124/jpet.107.124669, 17565007.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 913-922
    • Zhang, D.1    Anantharam, V.2    Kanthasamy, A.3    Kanthasamy, A.G.4
  • 17
    • 79951536222 scopus 로고    scopus 로고
    • Kanthasamy AG: α-Synuclein negatively regulates protein kinase Cdelta expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity
    • 10.1523/JNEUROSCI.5634-10.2011, 3041642, 21307242
    • Jin H, Kanthasamy A, Ghosh A, Yang Y, Anantharam V. Kanthasamy AG: α-Synuclein negatively regulates protein kinase Cdelta expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neurosci 2011, 31:2035-2051. 10.1523/JNEUROSCI.5634-10.2011, 3041642, 21307242.
    • (2011) J Neurosci , vol.31 , pp. 2035-2051
    • Jin, H.1    Kanthasamy, A.2    Ghosh, A.3    Yang, Y.4    Anantharam, V.5
  • 18
    • 84862487151 scopus 로고    scopus 로고
    • Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease
    • Roy A, Ghosh A, Jana A, Liu X, Brahmachari S, Gendelman HE, Pahan K. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PLoS One 2012,
    • (2012) PLoS One
    • Roy, A.1    Ghosh, A.2    Jana, A.3    Liu, X.4    Brahmachari, S.5    Gendelman, H.E.6    Pahan, K.7
  • 19
    • 36749015082 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    • 10.1073/pnas.0704908104, 2141849, 18000063
    • Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 2007, 104:18754-18759. 10.1073/pnas.0704908104, 2141849, 18000063.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18754-18759
    • Ghosh, A.1    Roy, A.2    Liu, X.3    Kordower, J.H.4    Mufson, E.J.5    Hartley, D.M.6    Ghosh, S.7    Mosley, R.L.8    Gendelman, H.E.9    Pahan, K.10
  • 20
    • 0037947448 scopus 로고    scopus 로고
    • NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • 10.1073/pnas.0937239100, 156340, 12721370
    • Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A 2003, 100:6145-6150. 10.1073/pnas.0937239100, 156340, 12721370.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6145-6150
    • Wu, D.C.1    Teismann, P.2    Tieu, K.3    Vila, M.4    Jackson-Lewis, V.5    Ischiropoulos, H.6    Przedborski, S.7
  • 21
    • 0032560486 scopus 로고    scopus 로고
    • Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • 10.1073/pnas.95.13.7659, 22714, 9636206
    • Ara J, Przedborski S, Naini AB, Jackson-Lewis V, Trifiletti RR, Horwitz J, Ischiropoulos H. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proc Natl Acad Sci U S A 1998, 95:7659-7663. 10.1073/pnas.95.13.7659, 22714, 9636206.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7659-7663
    • Ara, J.1    Przedborski, S.2    Naini, A.B.3    Jackson-Lewis, V.4    Trifiletti, R.R.5    Horwitz, J.6    Ischiropoulos, H.7
  • 23
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
    • 10.1152/physrev.00044.2005, 17237347
    • Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007, 87:245-313. 10.1152/physrev.00044.2005, 17237347.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 25
    • 78651267346 scopus 로고    scopus 로고
    • Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury
    • Impellizzeri D, Mazzon E, Esposito E, Paterniti I, Bramanti P, Cuzzocrea S. Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury. Free Radic Res 2010, 45:221-236.
    • (2010) Free Radic Res , vol.45 , pp. 221-236
    • Impellizzeri, D.1    Mazzon, E.2    Esposito, E.3    Paterniti, I.4    Bramanti, P.5    Cuzzocrea, S.6
  • 26
    • 32044434181 scopus 로고    scopus 로고
    • Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice
    • 10.1016/j.ejphar.2005.11.061, 16405885
    • Hougee S, Hartog A, Sanders A, Graus YM, Hoijer MA, Garssen J, van den Berg WB, van Beuningen HM, Smit HF. Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice. Eur J Pharmacol 2006, 531:264-269. 10.1016/j.ejphar.2005.11.061, 16405885.
    • (2006) Eur J Pharmacol , vol.531 , pp. 264-269
    • Hougee, S.1    Hartog, A.2    Sanders, A.3    Graus, Y.M.4    Hoijer, M.A.5    Garssen, J.6    van den Berg, W.B.7    van Beuningen, H.M.8    Smit, H.F.9
  • 27
    • 33744509306 scopus 로고    scopus 로고
    • Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    • 10.1016/j.brainres.2006.03.060, 16650838
    • Wang Q, Tompkins KD, Simonyi A, Korthuis RJ, Sun AY, Sun GY. Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 2006, 1090:182-189. 10.1016/j.brainres.2006.03.060, 16650838.
    • (2006) Brain Res , vol.1090 , pp. 182-189
    • Wang, Q.1    Tompkins, K.D.2    Simonyi, A.3    Korthuis, R.J.4    Sun, A.Y.5    Sun, G.Y.6
  • 28
    • 79952454137 scopus 로고    scopus 로고
    • Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease
    • 10.1016/j.neulet.2011.01.077, 3086715, 21300136
    • Dumont M, Stack C, Elipenhali C, Calingasan NY, Wille E, Beal MF. Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease. Neurosci Lett 2011, 492:150-154. 10.1016/j.neulet.2011.01.077, 3086715, 21300136.
    • (2011) Neurosci Lett , vol.492 , pp. 150-154
    • Dumont, M.1    Stack, C.2    Elipenhali, C.3    Calingasan, N.Y.4    Wille, E.5    Beal, M.F.6
  • 30
    • 84863116750 scopus 로고    scopus 로고
    • Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease
    • Gao HM, Liu B, Zhang W, Hong JS. Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J 2003, 17:1954-1956.
    • (2003) FASEB J , vol.17 , pp. 1954-1956
    • Gao, H.M.1    Liu, B.2    Zhang, W.3    Hong, J.S.4
  • 31
    • 14544290505 scopus 로고    scopus 로고
    • Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells
    • 10.1016/j.bbagen.2004.12.008, 15716123
    • Vejrazka M, Micek R, Stipek S. Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells. Biochim Biophys Acta 2005, 1722:143-147. 10.1016/j.bbagen.2004.12.008, 15716123.
    • (2005) Biochim Biophys Acta , vol.1722 , pp. 143-147
    • Vejrazka, M.1    Micek, R.2    Stipek, S.3
  • 32
    • 0026486613 scopus 로고
    • Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures
    • 10.1073/pnas.89.22.10945, 50459, 1279698
    • Galea E, Feinstein DL, Reis DJ. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc Natl Acad Sci U S A 1992, 89:10945-10949. 10.1073/pnas.89.22.10945, 50459, 1279698.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10945-10949
    • Galea, E.1    Feinstein, D.L.2    Reis, D.J.3
  • 34
    • 0346463000 scopus 로고    scopus 로고
    • NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    • Qin L, Liu Y, Wang T, Wei SJ, Block ML, Wilson B, Liu B, Hong JS. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 2004, 279:1415-1421.
    • (2004) J Biol Chem , vol.279 , pp. 1415-1421
    • Qin, L.1    Liu, Y.2    Wang, T.3    Wei, S.J.4    Block, M.L.5    Wilson, B.6    Liu, B.7    Hong, J.S.8
  • 36
    • 0029917194 scopus 로고    scopus 로고
    • Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease
    • 10.1073/pnas.93.7.2696, 39693, 8610103
    • Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER, Mizuno Y. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci U S A 1996, 93:2696-2701. 10.1073/pnas.93.7.2696, 39693, 8610103.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2696-2701
    • Yoritaka, A.1    Hattori, N.2    Uchida, K.3    Tanaka, M.4    Stadtman, E.R.5    Mizuno, Y.6
  • 37
    • 0033034787 scopus 로고    scopus 로고
    • 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites
    • Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. J Neurochem 1999, 72:1617-1624.
    • (1999) J Neurochem , vol.72 , pp. 1617-1624
    • Picklo, M.J.1    Amarnath, V.2    McIntyre, J.O.3    Graham, D.G.4    Montine, T.J.5
  • 39
    • 0027295944 scopus 로고
    • Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging
    • 10.1016/0006-8993(93)90312-B, 8106113
    • Date I, Yoshimoto Y, Imaoka T, Miyoshi Y, Gohda Y, Furuta T, Asari S, Ohmoto T. Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging. Brain Res 1993, 621:150-154. 10.1016/0006-8993(93)90312-B, 8106113.
    • (1993) Brain Res , vol.621 , pp. 150-154
    • Date, I.1    Yoshimoto, Y.2    Imaoka, T.3    Miyoshi, Y.4    Gohda, Y.5    Furuta, T.6    Asari, S.7    Ohmoto, T.8
  • 41
    • 44849113246 scopus 로고    scopus 로고
    • Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin
    • Wang Q, Smith RE, Luchtefeld R, Sun AY, Simonyi A, Luo R, Sun GY. Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin. Phytomedicine 2008, 15:493-503.
    • (2008) Phytomedicine , vol.15 , pp. 493-503
    • Wang, Q.1    Smith, R.E.2    Luchtefeld, R.3    Sun, A.Y.4    Simonyi, A.5    Luo, R.6    Sun, G.Y.7


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