No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes

Neuroscience Letters

Volumn 413, Issue 3, 2007, Pages 202-205

  Huerta, Cecilia ^a   Sánchez Ferrero, Elena ^a   Coto, Eliecer ^a   Blázquez, Marta ^b   Ribacoba, René ^b   Guisasola, Luis M ^b   Salvador, Carlos ^b   Alvarez, Victoria ^b  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b Hospitales Central de Asturias y Mieres   (Spain)

Author keywords

DNA polymorphisms; Mitochondria; Nitric oxide synthases; Parkinson's

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOCHONDRIAL DNA; NEURONAL NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; VARIABLE NUMBER OF TANDEM REPEAT;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; PARKINSON DISEASE; POLYMORPHISM, GENETIC;

EID: 33846839625     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.11.044     Document Type: Article

References (29)

1. Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357 (2001) 593-615
2. Autere J., Moilanen J.S., Finnila S., Soininen H., Mannermaa A., Hartikainen P., Hallikainen M., and Majamaa K. Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia. Hum. Genet. 115 (2004) 29-35
3. Beal M.F. Mitochondria, NO and neurodegeneration. Biochem. Soc. Symp. 66 (1999) 43-54
4. Beal M.F. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann. N. Y. Acad. Sci. 991 (2003) 120-131
5. Beckmann J.S. Peroxynitrite versus hydroxyl radical: the role of nitric oxide in superoxide dependent cerebral injury. Ann. N. Y. Acad. Sci. 738 (1994) 69-75
6. Beckmann J.S., Ye Y.Z., Anderson P.G., Chen J., Accavitti M.A., Tarpey M.M., and White C.R. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol. Chem. Hoppe Seyler 375 (1994) 81-88
7. Cramer K.S., Leamey C.A., and Sur M. Nitric oxide as a signaling molecule in visual system development. Prog. Brain Res. 118 (1998) 101-114
8. Hague S., Peuralinna T., Eerola J., Hellstrom O., Tienari P.J., and Singleton A.B. Confirmation of the protective effect of iNOS in an independent cohort of Parkinson disease. Neurology 62 (2004) 635-636
9. Hantraye P., Brouillet E., Ferrante R., Palfi S., Dolan R., Matthews R.T., and Beal M.F. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat. Med. 2 (1996) 1017-1021
10. Heales S.J., Bolanos J.P., Stewart V.C., Brookes P.S., Land J.M., and Clark J.B. Nitric oxide, mitochondria and neurological disease. Biochim. Biophys. Acta 1410 (1999) 215-228
11. Hirsch E.C., Hunot S., Damier P., and Faucheux B. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?. Ann. Neurol. 44 (1998) S115-S120
12. Huerta C., Castro M.G., Coto E., Blázquez M., Ribacoba R., Guisasola L.M., Salvador C., Martínez C., Lahoz C.H., and Álvarez V. Mitochondrial DNA polymorphisms and risk in Parkinson disease in Spanish. J. Neurol. Sci. 236 (2005) 49-54
13. Hunot S., Boissiere F., Faucheux B., Brugg B., Mouatt-Prigent A., Agid Y., and Hirsch E.C. Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 72 (1996) 355-363
14. Iadecola C., Zhang F., Casey R., Clark H.B., and Ross M.E. Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 27 (1996) 1373-1380
15. Jenner P., and Olanow C.W. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 47 (1996) S161-S170
16. Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y., and Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392 (1998) 605-608
17. Kosel S., Hofhaus G., Maassen A., Vieregge P., and Graeber M.B. Role of mitochondria in Parkinson disease. Biol. Chem. 380 (1999) 865-870
18. Langston J.W., Forno L.S., Tetrud J., Reeves A.G., Kaplan J.A., and Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after MPTP exposure. Ann. Neurol. 46 (1999) 598-605
19. Law A., Gauthier S., and Quirion R. Say no to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res. Rev. 35 (2001) 73-96
20. Levecque C., Elbaz A., Clavel J., Richard F., Vidal J.S., Amouyel P., Tzourio C., Alperovitch A., and Chartier-Harlin M.C. Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study. Hum. Mol. Genet. 12 (2003) 79-86
21. Liberatore G.T., Jackson-Lewis V., Vukosavic S., Mandir A.S., Vila M., McAuliffe W.G., Dawson V.L., Dawson T.M., and Przedborski S. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 5 (1999) 1403-1409
22. Matthews R.T., Beal M.F., Fallon J., Fedorchak K., Huang P.L., Fishman M.C., and Hyman B.T. MPP+ induced substantia nigra degeneration is attenuated in nNOS knock-out mice. Neurobiol. Dis. 4 (1997) 114-121
23. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16 (1988) 1215
24. Olanow C.W., and Tatton W.G. Etiology and pathogenesis of Parkinson's disease. Annu. Rev. Neurosci. 22 (1999) 123-144
25. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., and Nussbaum R.L. Mutation in the alpha-symuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
26. Schapira A.H. Mitochondrial dysfunction in neurodegenerative disorders. Biochim. Biophys. Acta 1366 (1998) 225-233
27. Singer T.P., Castagnoli Jr. N., Ramsay R.R., and Trevor A.J. Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurochem. 49 (1987) 1-8
28. Van der Walt J.M., Nicodemus K.K., Martin E.R., Scott W.K., Nance M.A., Watts R.L., Hubble J.P., Haines J.L., Koller W.C., Lyons K., Pahwa R., Stern M.B., Colcher A., Hiner B.C., Jankovic J., Ondo W.G., Allen Jr. F.H., Goetz C.G., Small G.W., Mastaglia F., Stajich J.M., McLaurin A.C., Middleton L.T., Scott B.L., Schmechel D.E., Pericak-Vance M.A., and Vance J.M. Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am. J. Hum. Genet. 72 (2003) 804-811
29. Zhang Y., Dawson V.L., and Dawson T.M. Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol. Dis. 7 (2000) 240-250