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Volumn 48, Issue 1, 2012, Pages 225-233

Neuroprotection by silencing iNOS expression in a 6-OHDA model of Parkinson's disease

Author keywords

Bax; Caspase 3; Microglia; P53; Striatum; TH

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; APOMORPHINE; BRAIN PROTEIN; CASPASE 3; DOPAMINE; HOMOVANILLIC ACID; OX 42 PROTEIN; OXIDOPAMINE; PROTEIN BAX; PROTEIN P53; SMALL INTERFERING RNA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 84865122074     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9814-5     Document Type: Article
Times cited : (45)

References (29)
  • 1
    • 67349128956 scopus 로고    scopus 로고
    • Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
    • 19514131 10.1016/j.abb.2009.01.018 1:CAS:528:DC%2BD1MXmvF2hurY%3D
    • Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (2009) Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Arch Biochem Biophys 486:95-102
    • (2009) Arch Biochem Biophys , vol.486 , pp. 95-102
    • Athar, M.1    Back, J.H.2    Kopelovich, L.3    Bickers, D.R.4    Kim, A.L.5
  • 2
    • 0035178264 scopus 로고    scopus 로고
    • Role of nitric oxide in a progressive neurodegeneration model of parkinson's disease in the rat
    • DOI 10.1179/135100001101536436
    • Barthwal MK, Srivastava N, Dikshit M (2001) Role of nitric oxide in a progressive neurodegeneration model of Parkinson's disease in the rat. Redox Rep 6:297-302 (Pubitemid 33094661)
    • (2001) Redox Report , vol.6 , Issue.5 , pp. 297-302
    • Barthwal, M.K.1    Srivastava, N.2    Dikshit, M.3
  • 3
    • 0025824668 scopus 로고
    • Intranigral iron injection induces behavioral and biochemical "parkinsonism" in rats
    • Ben-Shachar D, Youdim MB (1991) Intranigral iron injection induces behavioral and biochemical "parkinsonism" in rats. J Neurochem 57:2133-2135 (Pubitemid 21922868)
    • (1991) Journal of Neurochemistry , vol.57 , Issue.6 , pp. 2133-2135
    • Ben-Shachar, D.1    Youdim, M.B.H.2
  • 4
    • 33847042324 scopus 로고    scopus 로고
    • Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: New clues from an old model
    • 17284180 10.1111/j.1460-9568.2006.05285.x
    • Blandini F, Levandis G, Bazzini E, Nappi G, Armentero MT (2007) Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old model. Eur J Neurosci 25:397-405
    • (2007) Eur J Neurosci , vol.25 , pp. 397-405
    • Blandini, F.1    Levandis, G.2    Bazzini, E.3    Nappi, G.4    Armentero, M.T.5
  • 5
    • 47049116273 scopus 로고    scopus 로고
    • The 6-hydroxydopamine model: News from the past
    • 18595767 10.1016/j.parkreldis.2008.04.015
    • Blandini F, Armentero MT, Martignoni E (2008) The 6-hydroxydopamine model: news from the past. Parkinsonism Relat Disord 14:S124-129
    • (2008) Parkinsonism Relat Disord , vol.14 , pp. 124-129
    • Blandini, F.1    Armentero, M.T.2    Martignoni, E.3
  • 6
    • 79551488606 scopus 로고    scopus 로고
    • Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease
    • 21185368 10.1016/j.freeradbiomed.2010.12.026 1:CAS:528: DC%2BC3MXhtlejtbk%3D
    • Broom L, Marinova-Mutafchieva L, Sadeghian M, Davis JB, Medhurst AD, Dexter DT (2011) Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. Free Radic Biol Med 50:633-640
    • (2011) Free Radic Biol Med , vol.50 , pp. 633-640
    • Broom, L.1    Marinova-Mutafchieva, L.2    Sadeghian, M.3    Davis, J.B.4    Medhurst, A.D.5    Dexter, D.T.6
  • 7
    • 80054015303 scopus 로고    scopus 로고
    • Chronic progesterone treatment of male rats with unilateral 6-hydroxydopamine lesion of the dorsal striatum exasperates parkinsonian symptoms
    • 21888950 10.1016/j.neuroscience.2011.08.043 1:CAS:528:DC%2BC3MXhtlejtb3M
    • Chao OY, Huston JP, von Bothmer A, Pum ME (2011) Chronic progesterone treatment of male rats with unilateral 6-hydroxydopamine lesion of the dorsal striatum exasperates parkinsonian symptoms. Neuroscience 196:228-236
    • (2011) Neuroscience , vol.196 , pp. 228-236
    • Chao, O.Y.1    Huston, J.P.2    Von Bothmer, A.3    Pum, M.E.4
  • 8
    • 0035085211 scopus 로고    scopus 로고
    • Rescue from death but not from functional impairment: Caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals
    • DOI 10.1046/j.1471-4159.2001.00236.x
    • Coelln RV, Kugler S, Bahr M, Weller M, Dichgans J, Schulz JB (2001) Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals. J Neurochem 77:263-273 (Pubitemid 32245100)
    • (2001) Journal of Neurochemistry , vol.77 , Issue.1 , pp. 263-273
    • Von Coelln, R.1    Kugler, S.2    Bahr, M.3    Weller, M.4    Dichgans, J.5    Schulz, J.B.6
  • 9
    • 33947695576 scopus 로고    scopus 로고
    • Nitric oxide in the injured spinal cord: Synthases cross-talk, oxidative stress and inflammation
    • DOI 10.1016/j.brainresrev.2007.01.013, PII S0165017307000197
    • Conti A, Miscusi M, Cardali S, Germanò A, Suzuki H, Cuzzocrea S, Tomasello F (2007) Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation. Brain Res Rev 54:205-218 (Pubitemid 46498169)
    • (2007) Brain Research Reviews , vol.54 , Issue.1 , pp. 205-218
    • Conti, A.1    Miscusi, M.2    Cardali, S.3    Germano, A.4    Suzuki, H.5    Cuzzocrea, S.6    Tomasello, F.7
  • 10
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • DOI 10.1016/S0896-6273(03)00568-3
    • Dauer W, Przedborski S (2003) Parkinson's disease: mechanisms and models. Neuron 39:889-909 (Pubitemid 37130207)
    • (2003) Neuron , vol.39 , Issue.6 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 11
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB (2000) Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 74:2213-2216 (Pubitemid 30217680)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.5 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 12
    • 0036283426 scopus 로고    scopus 로고
    • Modeling Parkinson's disease in rats: An evaluation of 6-OHDA lesions of the nigrostriatal pathway
    • DOI 10.1006/exnr.2002.7891
    • Deumens R, Blokland A, Prickaerts J (2002) Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 175:303-317 (Pubitemid 34634286)
    • (2002) Experimental Neurology , vol.175 , Issue.2 , pp. 303-317
    • Deumens, R.1    Blokland, A.2    Prickaerts, J.3
  • 13
    • 1342309493 scopus 로고    scopus 로고
    • Confirmation of the protective effect of iNOS in an independent cohort of Parkinson disease
    • Hague S, Peuralinna T, Eerola J, Hellström O, Tienari PJ, Singleton AB (2004) Confirmation of the protective effect of iNOS in an independent cohort of Parkinson disease. Neurology 62:635-6 (Pubitemid 38252810)
    • (2004) Neurology , vol.62 , Issue.4 , pp. 635-636
    • Hague, S.1    Peuralinna, T.2    Eerola, J.3    Hellstrom, O.4    Tienari, P.J.5    Singleton, A.B.6
  • 14
    • 18144406539 scopus 로고    scopus 로고
    • Oxidative stress and inflammation in Parkinson's disease: Is there a causal link?
    • DOI 10.1016/j.expneurol.2005.01.013
    • Hald A, Lotharius J (2005) Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Exp Neurol 193:279-290 (Pubitemid 40616179)
    • (2005) Experimental Neurology , vol.193 , Issue.2 , pp. 279-290
    • Hald, A.1    Lotharius, J.2
  • 15
    • 0038790330 scopus 로고    scopus 로고
    • Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment
    • Han BS, Hong HS, Choi WS, Markelonis GJ, Oh TH, Oh YJ (2003) Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment. J Neurosci 23:5069-5078 (Pubitemid 36793234)
    • (2003) Journal of Neuroscience , vol.23 , Issue.12 , pp. 5069-5078
    • Han, B.S.1    Hong, H.-S.2    Choi, W.-S.3    Markelonis, G.J.4    Oh, T.H.5    Oh, Y.J.6
  • 17
    • 33748707584 scopus 로고    scopus 로고
    • Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics
    • DOI 10.1111/j.1471-4159.2006.04025.x
    • Holtz WA, Turetzky JM, Jong YJ, O'Malley KL (2006) Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics. J Neurochem 99:54-69 (Pubitemid 44395130)
    • (2006) Journal of Neurochemistry , vol.99 , Issue.1 , pp. 54-69
    • Holtz, W.A.1    Turetzky, J.M.2    Jong, Y.-J.I.3    O'Malley, K.L.4
  • 18
    • 0038143287 scopus 로고    scopus 로고
    • Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
    • DOI 10.1074/jbc.M211821200
    • Holtz WA, O'Malley KL (2003) Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem 278:19367-19377 (Pubitemid 36799332)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.21 , pp. 19367-19377
    • Holtz, W.A.1    O'Malley, K.L.2
  • 20
    • 0036499736 scopus 로고    scopus 로고
    • Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration
    • DOI 10.1016/S0306-4522(01)00562-0, PII S0306452201005620
    • Iravani MM, Kashefi K, Mander P, Rose S, Jenner P (2002) Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience 110:49-58 (Pubitemid 34214759)
    • (2002) Neuroscience , vol.110 , Issue.1 , pp. 49-58
    • Iravani, M.M.1    Kashefi, K.2    Mander, P.3    Rose, S.4    Jenner, P.5
  • 21
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2
    • DOI 10.1006/mcne.2000.0914
    • Knott C, Stern G, Wilkin GP (2000) Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol Cell Neurosci 16:724-739 (Pubitemid 32062060)
    • (2000) Molecular and Cellular Neuroscience , vol.16 , Issue.6 , pp. 724-739
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 23
    • 0037677549 scopus 로고    scopus 로고
    • Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: Role of neuroinflammation
    • Liu B, Gao HM, Hong JS (2003) Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect 111:1065-1073 (Pubitemid 36826886)
    • (2003) Environmental Health Perspectives , vol.111 , Issue.8 , pp. 1065-1073
    • Liu, B.1    Gao, H.-M.2    Hong, J.-S.3
  • 24
    • 0033771987 scopus 로고    scopus 로고
    • Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies
    • 10975910 10.1002/1098-1136(200010)32:1<51::AID-GLIA50>3.0.CO;2-4 1:STN:280:DC%2BD3M%2FivVGlsw%3D%3D
    • Possel H, Noack H, Putzke J, Wolf G, Sies H (2000) Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies. Glia 32:51-59
    • (2000) Glia , vol.32 , pp. 51-59
    • Possel, H.1    Noack, H.2    Putzke, J.3    Wolf, G.4    Sies, H.5
  • 25
    • 27444443115 scopus 로고    scopus 로고
    • Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD40: Relevance to Parkinson's disease
    • DOI 10.1002/jnr.20599
    • Okuno T, Nakatsuji Y, Kumanogoh A, Moriya M, Ichinose H, Sumi H, Fujimura H, Kikutani H, Sakoda S (2005) Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease. J Neurosci Res 81:874-882 (Pubitemid 41532153)
    • (2005) Journal of Neuroscience Research , vol.81 , Issue.6 , pp. 874-882
    • Okuno, T.1    Nakatsuji, Y.2    Kumanogoh, A.3    Moriya, M.4    Ichinose, H.5    Sumi, H.6    Fujimura, H.7    Kikutani, H.8    Sakoda, S.9
  • 26
    • 0042334593 scopus 로고    scopus 로고
    • + but not 6-OHDA induced cell death in dopaminergic neurons
    • DOI 10.1016/S0969-9961(03)00013-5
    • O'Malley KL, Liu J, Lotharius J, Holtz W (2003) Targeted expression of BCL-2 attenuates MPP + but not 6-OHDA induced cell death in dopaminergic neurons. Neurobiol Dis 14:43-51 (Pubitemid 37103178)
    • (2003) Neurobiology of Disease , vol.14 , Issue.1 , pp. 43-51
    • O'Malley, K.L.1    Liu, J.2    Lotharius, J.3    Holtz, W.4
  • 27
    • 0034846276 scopus 로고    scopus 로고
    • Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamine
    • Rodrigues RW, Gomide VC, Chadi G (2001) Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamine. Int J Neurosci 109:91-126 (Pubitemid 32832158)
    • (2001) International Journal of Neuroscience , vol.109 , Issue.1-2 , pp. 91-126
    • Rodrigues, R.W.P.1    Gomide, V.C.2    Chadi, G.3
  • 29
    • 0042528615 scopus 로고    scopus 로고
    • Nitric oxide and reactive oxygen species in Parkinson's disease
    • DOI 10.1080/1521654032000114320
    • Tieu K, Ischiropoulos H, Przedborski S (2003) Nitric oxide and reactive oxygen species in Parkinson's disease. IUBMB Life 55:329-335 (Pubitemid 36975543)
    • (2003) IUBMB Life , vol.55 , Issue.6 , pp. 329-335
    • Tieu, K.1    Ischiropoulos, H.2    Przedborski, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.