메뉴 건너뛰기




Volumn 7, Issue 4, 1997, Pages 235-246

Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SCAVENGER;

EID: 0031112190     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199704000-00001     Document Type: Article
Times cited : (141)

References (119)
  • 1
    • 0026016470 scopus 로고
    • Treatment of Gram negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin
    • Zeigler EJ, Fisher CJ, Sprung CL, et al: Treatment of Gram negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. New Engl J Med 324:429-436, 1991.
    • (1991) New Engl J Med , vol.324 , pp. 429-436
    • Zeigler, E.J.1    Fisher, C.J.2    Sprung, C.L.3
  • 2
    • 0028557981 scopus 로고
    • The CHESS Trial Study Group: Treatment of septic shock with human monoclonal antibody HA-1A
    • McCloskey R, Straube R, Sanders C, Smith S, Smith C: The CHESS Trial Study Group: Treatment of septic shock with human monoclonal antibody HA-1A. Ann Int Med 121:1-5, 1994.
    • (1994) Ann Int Med , vol.121 , pp. 1-5
    • McCloskey, R.1    Straube, R.2    Sanders, C.3    Smith, S.4    Smith, C.5
  • 3
    • 0027731546 scopus 로고
    • Plasma cytokine and endotoxin levels correlate with survival in patients with sepsis syndrome
    • Casey L, Balk R, Bone R: Plasma cytokine and endotoxin levels correlate with survival in patients with sepsis syndrome. Ann Int Med 119:771-778, 1993.
    • (1993) Ann Int Med , vol.119 , pp. 771-778
    • Casey, L.1    Balk, R.2    Bone, R.3
  • 4
    • 0026558535 scopus 로고
    • Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute phase proteins during the treatment of severe sepsis in humans
    • Dofferhoff A, Bom V, de Vries-Hospers H, et al: Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute phase proteins during the treatment of severe sepsis in humans. Crit Care Med 20:185-192, 1992.
    • (1992) Crit Care Med , vol.20 , pp. 185-192
    • Dofferhoff, A.1    Bom, V.2    De Vries-Hospers, H.3
  • 5
    • 0026741759 scopus 로고
    • Overproduction of nitric oxide in cytokinemediated and septic shock
    • Kilbourn R, Griffith O: Overproduction of nitric oxide in cytokinemediated and septic shock. J Natl Cancer Inst 84:827-831, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 827-831
    • Kilbourn, R.1    Griffith, O.2
  • 6
    • 0028361220 scopus 로고
    • Search for sepsis drugs goes on despite past failures
    • Stone R: Search for sepsis drugs goes on despite past failures. Science 264:365-367, 1994.
    • (1994) Science , vol.264 , pp. 365-367
    • Stone, R.1
  • 7
    • 0028018567 scopus 로고
    • The Sepsis Study Syndrome Study Group. Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebo-controlled multicenter trial
    • Fisher CJ, Slotman GJ, Opal SM, et al: The Sepsis Study Syndrome Study Group. Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebo-controlled multicenter trial. Crit Care Med 22:12-21, 1994.
    • (1994) Crit Care Med , vol.22 , pp. 12-21
    • Fisher, C.J.1    Slotman, G.J.2    Opal, S.M.3
  • 9
    • 0027281370 scopus 로고
    • Mini review: Choice of bacteria in animal models of sepsis
    • Cross A, Opal S, Sadoff J, Gemski P: Mini review: Choice of bacteria in animal models of sepsis. Infect Immun 61:2741-2747, 1993.
    • (1993) Infect Immun , vol.61 , pp. 2741-2747
    • Cross, A.1    Opal, S.2    Sadoff, J.3    Gemski, P.4
  • 10
    • 0026048714 scopus 로고
    • The Pathogenesis of sepsis
    • Bone R: The Pathogenesis of sepsis. Ann Int Med 115:457-469, 1991.
    • (1991) Ann Int Med , vol.115 , pp. 457-469
    • Bone, R.1
  • 11
    • 0027511853 scopus 로고
    • The discovery of nitric oxide in the vessel wall: A unifying concept in the pathogenesis of sepsis
    • Palmer RMJ: The discovery of nitric oxide in the vessel wall: A unifying concept in the pathogenesis of sepsis. Arch Surg 128:396-401, 1993.
    • (1993) Arch Surg , vol.128 , pp. 396-401
    • Palmer, R.M.J.1
  • 12
    • 0028248331 scopus 로고
    • Role of the L-arginine-nitric oxide pathway in circulatory shock
    • Thiemermann C: Role of the L-arginine-nitric oxide pathway in circulatory shock. Adv Pharmacol 28:45-79, 1994.
    • (1994) Adv Pharmacol , vol.28 , pp. 45-79
    • Thiemermann, C.1
  • 13
    • 0028945506 scopus 로고
    • Alterations in nitric oxide production in various forms of circulatory shock
    • Szabó C: Alterations in nitric oxide production in various forms of circulatory shock: New Horizons 3:2-32, 1995.
    • (1995) New Horizons , vol.3 , pp. 2-32
    • Szabó, C.1
  • 14
    • 0006613708 scopus 로고    scopus 로고
    • Animal models of sepsis
    • Feelisch M, Stamler J (eds): Sussex England and Chichester UK: John Wiley and Sons, Ltd.
    • Kilbourn RG: Animal models of sepsis. In Feelisch M, Stamler J (eds): Methods in Nitric Oxide Research. Sussex England and Chichester UK: John Wiley and Sons, Ltd., pp 619-630, 1996.
    • (1996) Methods in Nitric Oxide Research , pp. 619-630
    • Kilbourn, R.G.1
  • 15
    • 0025195627 scopus 로고
    • G-methyl-L- Arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide
    • G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide. Proc Natl Acad Sci USA 87:3629-3632, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3629-3632
    • Kilbourn, R.G.1    Gross, S.S.2    Jubran, A.3
  • 16
    • 0026762484 scopus 로고
    • Inhibition of interleukin-lainduced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-la-induced hypotension by N-omega-L-aminoarginine
    • Kilbourn RG, Gross SS, Lodato RF, et al: Inhibition of interleukin-lainduced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-la-induced hypotension by N-omega-L-aminoarginine. J Natl Cancer Inst 84:1008-1016, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1008-1016
    • Kilbourn, R.G.1    Gross, S.S.2    Lodato, R.F.3
  • 18
    • 0028180766 scopus 로고
    • G-methyl-Larginine, an inhibitor of nitric oxide formation, reverses IL-2 mediated hypotension in dogs
    • G-methyl-Larginine, an inhibitor of nitric oxide formation, reverses IL-2 mediated hypotension in dogs. J Appl Physiol 76:1130-1137, 1994.
    • (1994) J Appl Physiol , vol.76 , pp. 1130-1137
    • Kilbourn, R.G.1    Owen-Schaub, L.B.2    Cromeens, D.M.3
  • 20
    • 18244419633 scopus 로고
    • Impaired vascular reactivity in the rat following endotoxin treatment can be endothelium independent, yet involves the L-arginine pathway
    • Fleming I, Gray G, Julou-Schaeffer G, Parrat J, Schott C, Stoclet J: Impaired vascular reactivity in the rat following endotoxin treatment can be endothelium independent, yet involves the L-arginine pathway. J Physiol 423:18P, 1990.
    • (1990) J Physiol , vol.423
    • Fleming, I.1    Gray, G.2    Julou-Schaeffer, G.3    Parrat, J.4    Schott, C.5    Stoclet, J.6
  • 21
    • 0026334414 scopus 로고
    • Inhibition of nitric oxide synthesis in septic shock: How much is beneficial?
    • Nava E, Palmer R, Moncada S: Inhibition of nitric oxide synthesis in septic shock: How much is beneficial? Lancet 338:1555-1557, 1991.
    • (1991) Lancet , vol.338 , pp. 1555-1557
    • Nava, E.1    Palmer, R.2    Moncada, S.3
  • 22
    • 0028577721 scopus 로고
    • Beneficial effects and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel potent and selective inhibitor of inducible nitric oxide synthase
    • Szabó C, Southan G, Thiemermann C: Beneficial effects and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci USA 91:12472-12476, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12472-12476
    • Szabó, C.1    Southan, G.2    Thiemermann, C.3
  • 23
    • 0029940933 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition during experimental sepsis improves renal excretory function in the presence of chronically elevated atrial naturetic peptide
    • Hinder F, Booke M, Traber L, et al: Nitric oxide synthase inhibition during experimental sepsis improves renal excretory function in the presence of chronically elevated atrial naturetic peptide: Crit Care Med 24:131-136, 1996.
    • (1996) Crit Care Med , vol.24 , pp. 131-136
    • Hinder, F.1    Booke, M.2    Traber, L.3
  • 24
    • 0030133340 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition versus norepinephrine in ovine sepsis: Effects on regional blood flows
    • Booke M, Hinder F, McGuire R, Traber L, Traber D: Nitric oxide synthase inhibition versus norepinephrine in ovine sepsis: Effects on regional blood flows. Shock 5:362-370, 1996.
    • (1996) Shock , vol.5 , pp. 362-370
    • Booke, M.1    Hinder, F.2    McGuire, R.3    Traber, L.4    Traber, D.5
  • 25
    • 0028855814 scopus 로고
    • Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxic shock
    • Klemm P, Thiemermann C, Winklmaier G, Martorana P, Henning R: Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxic shock. Br J Pharmacol 114:363-368, 1995.
    • (1995) Br J Pharmacol , vol.114 , pp. 363-368
    • Klemm, P.1    Thiemermann, C.2    Winklmaier, G.3    Martorana, P.4    Henning, R.5
  • 26
    • 0027055199 scopus 로고
    • Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone
    • Teale D, Atkinson A: Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone. J Antimicrob Chemother 30:839-842, 1992.
    • (1992) J Antimicrob Chemother , vol.30 , pp. 839-842
    • Teale, D.1    Atkinson, A.2
  • 27
    • 0025925235 scopus 로고
    • G-Monomelhyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock
    • G-Monomelhyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biochem Biophys Res Commun 178:1135-1140, 1991.
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 1135-1140
    • Klabunde, R.E.1    Ritger, R.C.2
  • 28
    • 0028065729 scopus 로고
    • Protective role of NO in the regional hemodynamic changes during acute endotoxemia in rats
    • Mulder M, VanLambalgen A, Huisman L: Protective role of NO in the regional hemodynamic changes during acute endotoxemia in rats. Am J Physiol 266:H1558-H1564, 1994.
    • (1994) Am J Physiol , vol.266
    • Mulder, M.1    VanLambalgen, A.2    Huisman, L.3
  • 29
    • 0028297087 scopus 로고
    • Effects of L-arginine and L-nitro arginine treatment on blood pressure and cardiac output in a rabbit endotoxin shock model
    • Pastor C, Teisseire B, Vicaut E: Effects of L-arginine and L-nitro arginine treatment on blood pressure and cardiac output in a rabbit endotoxin shock model. Crit Care Med 22:465-469, 1994.
    • (1994) Crit Care Med , vol.22 , pp. 465-469
    • Pastor, C.1    Teisseire, B.2    Vicaut, E.3
  • 30
    • 0028019463 scopus 로고
    • The effects of nitric oxide inhibition on regional hemodynamics during hyperdynamic endotoxemia
    • Henderson J, Statman R, Cunningham J: The effects of nitric oxide inhibition on regional hemodynamics during hyperdynamic endotoxemia. Arch Surg 129:1271-1275, 1994.
    • (1994) Arch Surg , vol.129 , pp. 1271-1275
    • Henderson, J.1    Statman, R.2    Cunningham, J.3
  • 31
    • 0028937191 scopus 로고
    • Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs
    • Cobb P, Natanson C, Huffman W: Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs. Am J Physiol 268:H1634-H1642, 1995.
    • (1995) Am J Physiol , vol.268
    • Cobb, P.1    Natanson, C.2    Huffman, W.3
  • 32
    • 0028059160 scopus 로고
    • Nitric oxide inhibition in the treatment of the sepsis syndrome is detrimental to tissue oxygenation
    • Stratman R, Cheng W, Cunningham JN: Nitric oxide inhibition in the treatment of the sepsis syndrome is detrimental to tissue oxygenation. J Surg Res 57:93-98, 1994.
    • (1994) J Surg Res , vol.57 , pp. 93-98
    • Stratman, R.1    Cheng, W.2    Cunningham, J.N.3
  • 33
    • 0028980301 scopus 로고
    • Systemic and gut oxygen extraction during endotoxemia: Role of nitric oxide synthesis
    • Schumacker P, Kazaglis J, Connolly H: Systemic and gut oxygen extraction during endotoxemia: Role of nitric oxide synthesis. Am J Respir Crit Care Med 151:107-115, 1995.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 107-115
    • Schumacker, P.1    Kazaglis, J.2    Connolly, H.3
  • 34
    • 0029039108 scopus 로고
    • Effects of nitric oxide inhibitor on hemodynamic change and oxygen delivery in septic dogs
    • Mitaka C, Hirara Y, Ichikawa K: Effects of nitric oxide inhibitor on hemodynamic change and oxygen delivery in septic dogs. Am J Physiol 268:H2017-H2023, 1995.
    • (1995) Am J Physiol , vol.268
    • Mitaka, C.1    Hirara, Y.2    Ichikawa, K.3
  • 35
    • 0025200266 scopus 로고
    • G-monomethyl-L-arginine inhibits endotoxin-induced nitrite/ nitrate biosynthesis while promoting hepatic damage
    • G-monomethyl-L-arginine inhibits endotoxin-induced nitrite/ nitrate biosynthesis while promoting hepatic damage. J Leukocyte Biol 48:565-569, 1990.
    • (1990) J Leukocyte Biol , vol.48 , pp. 565-569
    • Billiar, T.1    Curran, R.2    Habrecht, B.3
  • 36
    • 0028144708 scopus 로고
    • Inhibition of nitric oxide synthesis is detrimental during endotoxemia
    • Minnard E, Shou J, Naama H: Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch Surg 129:142-148, 1994.
    • (1994) Arch Surg , vol.129 , pp. 142-148
    • Minnard, E.1    Shou, J.2    Naama, H.3
  • 37
    • 0028148138 scopus 로고
    • Detrimental effects of nitric oxide synthase inhibition may be caused by high levels of tumor necrosis factor and interleukin 6
    • Tiao GRJ, Ogle C: Detrimental effects of nitric oxide synthase inhibition may be caused by high levels of tumor necrosis factor and interleukin 6. Surgery 116:332-338, 1994.
    • (1994) Surgery , vol.116 , pp. 332-338
    • Tiao, G.R.J.1    Ogle, C.2
  • 38
    • 0028956317 scopus 로고
    • Detrimental effects of a nitric oxide synthase inhibitor (Nω-nitro-L-arginine methyl ester) in a murine sepsis model
    • Fukahatsu K, Saito H, Fukushima R: Detrimental effects of a nitric oxide synthase inhibitor (Nω-nitro-L-arginine methyl ester) in a murine sepsis model. Arch Surg 130:410-414, 1994.
    • (1994) Arch Surg , vol.130 , pp. 410-414
    • Fukahatsu, K.1    Saito, H.2    Fukushima, R.3
  • 39
    • 0013645321 scopus 로고
    • G-Amino-L-arginine, an inhibitor of nitric oxide synthase, increases lethality in canine endotoxic shock
    • G-Amino-L-arginine, an inhibitor of nitric oxide synthase, increases lethality in canine endotoxic shock: Clin Res 39:321 A, 1991.
    • (1991) Clin Res , vol.39
    • Cobb, P.1    Natanson, C.2    Solomon, M.3
  • 40
    • 0017265552 scopus 로고
    • The role of glucose in endotoxin shock
    • Hinshaw L: The role of glucose in endotoxin shock. Circ Shock 3:1-9, 1976.
    • (1976) Circ Shock , vol.3 , pp. 1-9
    • Hinshaw, L.1
  • 41
    • 0024527954 scopus 로고
    • Historical perspective of endotoxin effects on hemodynamics in animals
    • Passmore JC, Reichard SM, Reynolds DG, et al. (eds): New York, NY: Alan Liss, Inc.
    • Reicher JR: Historical perspective of endotoxin effects on hemodynamics in animals. In Passmore JC, Reichard SM, Reynolds DG, et al. (eds): Perspectives in Shock Research: Metabolism, Immunology, Mediators, and Models. New York, NY: Alan Liss, Inc., 1989, pp 77-94.
    • (1989) Perspectives in Shock Research: Metabolism, Immunology, Mediators, and Models , pp. 77-94
    • Reicher, J.R.1
  • 42
    • 0024993323 scopus 로고
    • Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo
    • Thiemermann C, Vane J: Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol 182:591-595, 1990.
    • (1990) Eur J Pharmacol , vol.182 , pp. 591-595
    • Thiemermann, C.1    Vane, J.2
  • 44
    • 0027476883 scopus 로고
    • Nitric oxide mediated hyporeactivity to noradrenaline precedes nitric oxide synthase induction in endotoxin shock
    • Szabó C, Mithchell J, Thiemermann C, Vane JR: Nitric oxide mediated hyporeactivity to noradrenaline precedes nitric oxide synthase induction in endotoxin shock. Br J Pharmacol 108:786-792, 1993.
    • (1993) Br J Pharmacol , vol.108 , pp. 786-792
    • Szabó, C.1    Mithchell, J.2    Thiemermann, C.3    Vane, J.R.4
  • 46
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages
    • Ding A, Nathan C, Stuehr D: Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J Immunol 141:2407-2412, 1988.
    • (1988) J Immunol , vol.141 , pp. 2407-2412
    • Ding, A.1    Nathan, C.2    Stuehr, D.3
  • 48
    • 0029162814 scopus 로고
    • The killing of Leishmania major by human macrophages is mediated by nitric oxide induction after ligation of the Fc epsilon RII/CD23 surface antigen
    • Vouldoukis I, Riveros-Moreno V, Dugas B, et al: The killing of Leishmania major by human macrophages is mediated by nitric oxide induction after ligation of the Fc epsilon RII/CD23 surface antigen. Proc Natl Acad Sci USA 92:7804-7808, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7804-7808
    • Vouldoukis, I.1    Riveros-Moreno, V.2    Dugas, B.3
  • 49
    • 0030076587 scopus 로고    scopus 로고
    • A selective inhibitor of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis: Comparison with two nonselective strategies
    • Aranow J, Zhuang J, Wang H, Larkin V, Smith M, Fink M: A selective inhibitor of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis: Comparison with two nonselective strategies. Shock 5:116-121, 1996.
    • (1996) Shock , vol.5 , pp. 116-121
    • Aranow, J.1    Zhuang, J.2    Wang, H.3    Larkin, V.4    Smith, M.5    Fink, M.6
  • 50
    • 0028140215 scopus 로고
    • Inhibition of nitric oxide synthase in experimental Gram-negative sepsis
    • Evans T, Carpenter A, Silva A: Inhibition of nitric oxide synthase in experimental Gram-negative sepsis. J Infect Dis 169:343-349, 1994.
    • (1994) J Infect Dis , vol.169 , pp. 343-349
    • Evans, T.1    Carpenter, A.2    Silva, A.3
  • 51
    • 0027120411 scopus 로고
    • Systemic and pulmonary reactions in swine with endotoxemia and Gram-negative bacteremia
    • Olson N, Kruse-Elliott K, Dodam J: Systemic and pulmonary reactions in swine with endotoxemia and Gram-negative bacteremia. J Am Vet Med Assoc 200:1171-1884, 1992.
    • (1992) J Am Vet Med Assoc , vol.200 , pp. 1171-1884
    • Olson, N.1    Kruse-Elliott, K.2    Dodam, J.3
  • 52
    • 0026613744 scopus 로고
    • G-monomethyl-L-arginine are abolished in a canine shock model using high dose endotoxin
    • G-monomethyl-L-arginine are abolished in a canine shock model using high dose endotoxin. Res Commun Chem Pathol Pharmacol 78:57-68, 1992.
    • (1992) Res Commun Chem Pathol Pharmacol , vol.78 , pp. 57-68
    • Klabunde, R.E.1
  • 53
    • 85033283857 scopus 로고
    • G-methyl-L-arginine, an inhibitor of nitric oxide formation acts synergistically to improve cardiovascular performance in endotoxic dogs
    • G-methyl-L-arginine, an inhibitor of nitric oxide formation acts synergistically to improve cardiovascular performance in endotoxic dogs. Crit Care Med 22:1825-1840, 1995.
    • (1995) Crit Care Med , vol.22 , pp. 1825-1840
    • Kilbourn, R.G.1    Cromeens, D.M.2    Chelly, F.D.3    Griffith, O.4
  • 54
    • 0028157456 scopus 로고
    • Detrimental hemodynamic effects of nitric oxide synthase inhibition in septic shock
    • Robertson F, Offner P, Ciceri D: Detrimental hemodynamic effects of nitric oxide synthase inhibition in septic shock. Arch Surg 129:149-156, 1994.
    • (1994) Arch Surg , vol.129 , pp. 149-156
    • Robertson, F.1    Offner, P.2    Ciceri, D.3
  • 55
    • 0028989755 scopus 로고
    • G-Monomethyl-L-arginine, an inhibitor of nitric oxide production, reverses interleukin-2 mediated hypotension in humans
    • G-Monomethyl-L-arginine, an inhibitor of nitric oxide production, reverses interleukin-2 mediated hypotension in humans. Crit Care Med 23:1018-1024, 1995.
    • (1995) Crit Care Med , vol.23 , pp. 1018-1024
    • Kilbourn, R.1    Fonseca, G.A.2    Griffith, O.3
  • 56
    • 0026729192 scopus 로고
    • Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis
    • Meyer J, Traber L, Nelson S, et al: Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis. J Appl Physiol 73:324-328, 1992.
    • (1992) J Appl Physiol , vol.73 , pp. 324-328
    • Meyer, J.1    Traber, L.2    Nelson, S.3
  • 58
    • 0028200290 scopus 로고
    • Increased organ blood flow in chronic endotoxemia is reversed by nitric oxide synthase inhibition
    • Meyer J, Hinder F, Stothert J, et al: Increased organ blood flow in chronic endotoxemia is reversed by nitric oxide synthase inhibition. J Appl Physiol 76:2785-2793, 1994.
    • (1994) J Appl Physiol , vol.76 , pp. 2785-2793
    • Meyer, J.1    Hinder, F.2    Stothert, J.3
  • 59
    • 0030051646 scopus 로고    scopus 로고
    • Changes in regional hemodynamics after nitric oxide synthase inhibition during ovine bacteremia
    • Lingnau W, McGuire R, Dehring D, et al: Changes in regional hemodynamics after nitric oxide synthase inhibition during ovine bacteremia. Am J Physiol 270:R207-R216, 1996.
    • (1996) Am J Physiol , vol.270
    • Lingnau, W.1    McGuire, R.2    Dehring, D.3
  • 60
    • 2542580243 scopus 로고
    • Hemodynamic effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) in conscious sheep during septic shock
    • Bone H, Traber L, Schenarts P, Spaulding T, Traber D: Hemodynamic effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) in conscious sheep during septic shock. Anesthesiology 83:A232, 1995.
    • (1995) Anesthesiology , vol.83
    • Bone, H.1    Traber, L.2    Schenarts, P.3    Spaulding, T.4    Traber, D.5
  • 61
    • 0024801264 scopus 로고
    • The cardiovascular response of normal humans to the administration of endotoxin
    • Suffredini A, Fromm R, Parker M, et al: The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321: 280-287, 1989.
    • (1989) N Engl J Med , vol.321 , pp. 280-287
    • Suffredini, A.1    Fromm, R.2    Parker, M.3
  • 62
    • 0028937191 scopus 로고
    • Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs
    • Cobb P, Natanson C, Hoffman W: Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs. Am J Physiol 268:H1634-H1642, 1995.
    • (1995) Am J Physiol , vol.268
    • Cobb, P.1    Natanson, C.2    Hoffman, W.3
  • 63
    • 0022965168 scopus 로고
    • Ultimate survival from septic shock
    • Azimi G, Vincent, J-L: Ultimate survival from septic shock. Resuscitation 14:245-253, 1986.
    • (1986) Resuscitation , vol.14 , pp. 245-253
    • Azimi, G.1    Vincent, J.-L.2
  • 65
    • 0024520830 scopus 로고
    • Endotoxin and tumor necrosis factor challenges in the dog simulate the cardiovascular profile of human septic shock
    • Natanson C, Eichenholz P, Danner R, et al: Endotoxin and tumor necrosis factor challenges in the dog simulate the cardiovascular profile of human septic shock. J Exp Med 169:823-832, 1989.
    • (1989) J Exp Med , vol.169 , pp. 823-832
    • Natanson, C.1    Eichenholz, P.2    Danner, R.3
  • 66
    • 0028917423 scopus 로고
    • Effects of inhibition of endothelium-derived relaxing factor on hemodynamics and oxygen utilization during group B streptococcal sepsis in piglets
    • Meadow W, Rudinsky B, Bell A, Hipps R: Effects of inhibition of endothelium-derived relaxing factor on hemodynamics and oxygen utilization during group B streptococcal sepsis in piglets. Crit Care Med 23:705-714, 1995.
    • (1995) Crit Care Med , vol.23 , pp. 705-714
    • Meadow, W.1    Rudinsky, B.2    Bell, A.3    Hipps, R.4
  • 68
    • 0025268896 scopus 로고
    • Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin
    • Kilbourn RG, Belloni P: Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl Cancer lust 82:772-776, 1990.
    • (1990) J Natl Cancer Lust , vol.82 , pp. 772-776
    • Kilbourn, R.G.1    Belloni, P.2
  • 69
    • 0025973551 scopus 로고
    • Interleukin-1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells
    • Beasley D, Schwartz JH, Brenner BM: Interleukin-1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells. J Clin Invest 87:602-608, 1991.
    • (1991) J Clin Invest , vol.87 , pp. 602-608
    • Beasley, D.1    Schwartz, J.H.2    Brenner, B.M.3
  • 70
    • 6444233402 scopus 로고
    • Septic shock: A central role for nitric oxide
    • Schlage G, Redl H (eds): Vienna, Austria: Springer-Verlag
    • Kilbourn, RG: Septic shock: A central role for nitric oxide. In: Schlage G, Redl H (eds): 4th Wiggers Bernard Conference on Shock, Sepsis, and Organ Failure. Vienna, Austria: Springer-Verlag, 1995, pp 153-179.
    • (1995) 4th Wiggers Bernard Conference on Shock, Sepsis, and Organ Failure , pp. 153-179
    • Kilbourn, R.G.1
  • 71
    • 0028999596 scopus 로고
    • Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    • MacMicking J, Nathan C, Horn G, et al: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650, 1995.
    • (1995) Cell , vol.81 , pp. 641-650
    • MacMicking, J.1    Nathan, C.2    Horn, G.3
  • 72
    • 0029035476 scopus 로고
    • Altered immune responses in mice lacking inducible nitric oxide synthase
    • Wei XQ, Charles I, Smith A, et al: Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408-411, 1995.
    • (1995) Nature , vol.375 , pp. 408-411
    • Wei, X.Q.1    Charles, I.2    Smith, A.3
  • 73
    • 0028889439 scopus 로고    scopus 로고
    • Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death
    • Laubach V, Shesely E, Smithies O, Sherman P: Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci USA 92:10688-10692, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.92 , pp. 10688-10692
    • Laubach, V.1    Shesely, E.2    Smithies, O.3    Sherman, P.4
  • 75
    • 0025958430 scopus 로고
    • Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues
    • Lambert LE, Whitten JP, Baron BM, Cheng HC, Doherty NS, McDonald IA: Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues. Life Sci 48:69-75, 1991.
    • (1991) Life Sci , vol.48 , pp. 69-75
    • Lambert, L.E.1    Whitten, J.P.2    Baron, B.M.3    Cheng, H.C.4    Doherty, N.S.5    McDonald, I.A.6
  • 77
    • 0027402115 scopus 로고
    • Selective inhibition of the inducible NO synthase by aminoguanidine
    • Misko TP, Moore WM, Kasten TP, et al: Selective inhibition of the inducible NO synthase by aminoguanidine. Eur J Pharmacol 233:119-125, 1993.
    • (1993) Eur J Pharmacol , vol.233 , pp. 119-125
    • Misko, T.P.1    Moore, W.M.2    Kasten, T.P.3
  • 78
    • 0028089793 scopus 로고
    • Potent and selective inhibition of human nitric oxide synthases
    • Garvey EP, Oplinger JA, Tanoury GJ, et al: Potent and selective inhibition of human nitric oxide synthases. J Biol Chem 269:26669-26676, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 26669-26676
    • Garvey, E.P.1    Oplinger, J.A.2    Tanoury, G.J.3
  • 79
    • 0028848015 scopus 로고
    • Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity
    • Southan GJ, Szabó C, Thiemermann C: Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114:510-516, 1995.
    • (1995) Br J Pharmacol , vol.114 , pp. 510-516
    • Southan, G.J.1    Szabó, C.2    Thiemermann, C.3
  • 80
    • 0030032721 scopus 로고    scopus 로고
    • Spontaneous rearrangement of aminoalkylguanidines into mercaptoalkylguanidines: A novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform
    • Southan GJ, Zingarelli B, O'Connor M, Salzman A, Szabó C: Spontaneous rearrangement of aminoalkylguanidines into mercaptoalkylguanidines: A novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117:619-632, 1996.
    • (1996) Br J Pharmacol , vol.117 , pp. 619-632
    • Southan, G.J.1    Zingarelli, B.2    O'Connor, M.3    Salzman, A.4    Szabó, C.5
  • 81
    • 0029899544 scopus 로고    scopus 로고
    • Pharmacological characterization of guanidinoethyldisulphide (CED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform
    • Szabó C, Bryk R, Zingarelli B, et al: Pharmacological characterization of guanidinoethyldisulphide (CED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform. Br J Pharmacol 118:1659-1668, 1996.
    • (1996) Br J Pharmacol , vol.118 , pp. 1659-1668
    • Szabó, C.1    Bryk, R.2    Zingarelli, B.3
  • 82
    • 0028799424 scopus 로고
    • The multiple organ dysfunction by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase
    • Thiemerman C, Rutten H, Wu CC, Vane JR: The multiple organ dysfunction by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 116:2845-2851, 1995.
    • (1995) Br J Pharmacol , vol.116 , pp. 2845-2851
    • Thiemerman, C.1    Rutten, H.2    Wu, C.C.3    Vane, J.R.4
  • 83
    • 0029797733 scopus 로고    scopus 로고
    • Selective inhibition of the inducible isoform of nitric oxide synthase inhibits endotoxin-induced pulmonary leak
    • Arkovitz M, Garcia VF, Wispe JR, Szabó C: Selective inhibition of the inducible isoform of nitric oxide synthase inhibits endotoxin-induced pulmonary leak. J Pediatr Surg 31:1009-1015, 1996.
    • (1996) J Pediatr Surg , vol.31 , pp. 1009-1015
    • Arkovitz, M.1    Garcia, V.F.2    Wispe, J.R.3    Szabó, C.4
  • 84
    • 0028911559 scopus 로고
    • Aminoguanidine inhibits the delayed circulatory failure in endotoxic shock in the anaesthetized rat
    • Wu CC, Chen SJ, Szabó CS, Thiemermann C, Vane JR: Aminoguanidine inhibits the delayed circulatory failure in endotoxic shock in the anaesthetized rat. BrJ Pharmacol 114:1666-1672, 1995.
    • (1995) BrJ Pharmacol , vol.114 , pp. 1666-1672
    • Wu, C.C.1    Chen, S.J.2    Szabó, C.S.3    Thiemermann, C.4    Vane, J.R.5
  • 85
    • 0030040255 scopus 로고    scopus 로고
    • Commentary: Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
    • Southan GJ, Szabó C: Commentary: Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol 51:383-394, 1996.
    • (1996) Biochem Pharmacol , vol.51 , pp. 383-394
    • Southan, G.J.1    Szabó, C.2
  • 86
    • 23444446083 scopus 로고
    • Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis
    • Natanson C, Hoffman W, Suffredini A, Eichacker P, Danner R: Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann Int Med 120:771-783, 1994.
    • (1994) Ann Int Med , vol.120 , pp. 771-783
    • Natanson, C.1    Hoffman, W.2    Suffredini, A.3    Eichacker, P.4    Danner, R.5
  • 88
    • 0028088543 scopus 로고
    • Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion
    • Spain D, Wilson M, Garrison R: Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion. Surgery 116:322-331, 1994.
    • (1994) Surgery , vol.116 , pp. 322-331
    • Spain, D.1    Wilson, M.2    Garrison, R.3
  • 89
    • 0001015597 scopus 로고
    • G-monomethyl-L-arginine HCl (L-NMMA: 546C88) improves survival in a conscious instrumented mouse model of endotoxic shock
    • G-monomethyl-L-arginine HCl (L-NMMA: 546C88) improves survival in a conscious instrumented mouse model of endotoxic shock. Endothelium 3(Suppl):S116, 1995.
    • (1995) Endothelium , vol.3 , Issue.SUPPL.
    • Rees, D.1    Monkhouse, J.2    Moncada, S.3
  • 90
    • 0028271453 scopus 로고
    • Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors
    • Laszlo F, Boughton-Smith N, Whittle BJR: Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br J Pharmacol 111:1309-1315, 1994.
    • (1994) Br J Pharmacol , vol.111 , pp. 1309-1315
    • Laszlo, F.1    Boughton-Smith, N.2    Whittle, B.J.R.3
  • 91
    • 0026684595 scopus 로고
    • Increased circulating nitrogen oxides after human tumor immunotherapy correlate with toxic hemodynamic changes
    • Ochoa J, Curti B, Peitzman A, et al: Increased circulating nitrogen oxides after human tumor immunotherapy correlate with toxic hemodynamic changes. J Natl Cancer Inst 84:864-867, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 864-867
    • Ochoa, J.1    Curti, B.2    Peitzman, A.3
  • 92
    • 0029063992 scopus 로고
    • Increased serum nitrate and nitrite concentrations in children with sepsis syndrome
    • Wong H, Carcillo J, Burkart G, Shah N, Janosky J: Increased serum nitrate and nitrite concentrations in children with sepsis syndrome. Crit Care Med 23:835-842, 1995.
    • (1995) Crit Care Med , vol.23 , pp. 835-842
    • Wong, H.1    Carcillo, J.2    Burkart, G.3    Shah, N.4    Janosky, J.5
  • 93
    • 0028870359 scopus 로고
    • L-arginine: Nitric oxide pathway in endotoxemia and human septic shock
    • Gomez-Jimenez J, Salgado A, Mourelle M, Martin M: L-arginine: Nitric oxide pathway in endotoxemia and human septic shock. Crit Care Med 23:253-258, 1995.
    • (1995) Crit Care Med , vol.23 , pp. 253-258
    • Gomez-Jimenez, J.1    Salgado, A.2    Mourelle, M.3    Martin, M.4
  • 94
    • 0026605238 scopus 로고
    • Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy
    • Hibbs J, Westenfelder C, Taintor R, et al: Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. J Clin Invest 89:867-877, 1992.
    • (1992) J Clin Invest , vol.89 , pp. 867-877
    • Hibbs, J.1    Westenfelder, C.2    Taintor, R.3
  • 95
    • 0027383634 scopus 로고
    • L-NMMA increases blood pressure in man
    • Haynes W, Noon J, Walker B, Webb D: L-NMMA increases blood pressure in man. Lancet 342:931-932, 1993.
    • (1993) Lancet , vol.342 , pp. 931-932
    • Haynes, W.1    Noon, J.2    Walker, B.3    Webb, D.4
  • 96
    • 0026346162 scopus 로고
    • Effects of nitric oxide synthase inhibitors on hypotension in patients with septic shock
    • Petros A, Bennett D, Vallance P: Effects of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338:1557-1558, 1991.
    • (1991) Lancet , vol.338 , pp. 1557-1558
    • Petros, A.1    Bennett, D.2    Vallance, P.3
  • 98
    • 0027963336 scopus 로고
    • Reversal of refractory hypotension in septic shock by inhibitor of nitric oxide synthase
    • Lin PJ, Chang C-H, Chang J-P: Reversal of refractory hypotension in septic shock by inhibitor of nitric oxide synthase. Chest 106:626-629, 1994.
    • (1994) Chest , vol.106 , pp. 626-629
    • Lin, P.J.1    Chang, C.-H.2    Chang, J.-P.3
  • 103
    • 6444225777 scopus 로고
    • Hemodynamic effects of 546C88 (L-A-methylarginine HCL) in an open label, dose escalation study of patients with septic shock
    • Athens, Greece: October 18-22
    • Zaccardelli D, Graver R, Colice G: Hemodynamic effects of 546C88 (L-A-methylarginine HCL) in an open label, dose escalation study of patients with septic shock. 8th European congress of intensive care medicine. Athens, Greece: October 18-22, 1995.
    • (1995) 8th European Congress of Intensive Care Medicine
    • Zaccardelli, D.1    Graver, R.2    Colice, G.3
  • 104
    • 6444232787 scopus 로고
    • ω-mono-methyl-L-arginine in ovine sepsis: Should a continuous infusion be initiated by bolus?
    • ω-mono-methyl-L-arginine in ovine sepsis: Should a continuous infusion be initiated by bolus? Crit Care Med 23:A164, 1995.
    • (1995) Crit Care Med , vol.23
    • Booke, M.1    Lingnau, W.2    Traber, L.3    Traber, D.4
  • 105
    • 0026741759 scopus 로고
    • Overproduction of nitric oxide in cytokine-mediated and septic shock
    • Kilbourn RG, Griffith OW: Overproduction of nitric oxide in cytokine-mediated and septic shock. J Natl Cancer Inst 84:827-831, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 827-831
    • Kilbourn, R.G.1    Griffith, O.W.2
  • 106
    • 0008375626 scopus 로고    scopus 로고
    • Vasopressor effects of diaspirin cross-linked hemoglobin (DCLHb) in critically ill patients
    • abstract
    • Rhea G, Bodenham A, Mallick A, Prebelski R, Daily E: Vasopressor effects of diaspirin cross-linked hemoglobin (DCLHb) in critically ill patients. Crit Care Med 24:A39, 1996 (abstract).
    • (1996) Crit Care Med , vol.24
    • Rhea, G.1    Bodenham, A.2    Mallick, A.3    Prebelski, R.4    Daily, E.5
  • 107
    • 2342586431 scopus 로고    scopus 로고
    • Comparison of different doses of pyridoxylated hemoglobin polyethylene conjugate in the treatment of hyperdynamic sepsis
    • Bone H, Booke M, Schenarts P, O'Connor M, Traber L, Traber D: Comparison of different doses of pyridoxylated hemoglobin polyethylene conjugate in the treatment of hyperdynamic sepsis. Crit Care Med 24:A27, 1996.
    • (1996) Crit Care Med , vol.24
    • Bone, H.1    Booke, M.2    Schenarts, P.3    O'Connor, M.4    Traber, L.5    Traber, D.6
  • 108
    • 6444241425 scopus 로고
    • Nitric oxide synthase inhibition versus nitric oxide scavenging in sepsis
    • Bone H, Booke M, Traber L, Spaulding T, Traber D: Nitric oxide synthase inhibition versus nitric oxide scavenging in sepsis. Circulation 92:1-46, 1995.
    • (1995) Circulation , vol.92 , pp. 1-46
    • Bone, H.1    Booke, M.2    Traber, L.3    Spaulding, T.4    Traber, D.5
  • 109
    • 0028872983 scopus 로고
    • Methylene blue administration in septic shock: A clinical trial
    • Preiser J-C, Lejeune P, Roman A, et al: Methylene blue administration in septic shock: A clinical trial. Crit Care Med 23:259-264, 1995.
    • (1995) Crit Care Med , vol.23 , pp. 259-264
    • Preiser, J.-C.1    Lejeune, P.2    Roman, A.3
  • 110
  • 112
    • 0027207966 scopus 로고
    • Effects of methylene blue on blood pressure and reactivity to norepinephrine in endotoxemic rats
    • Paya D, Gray G, Stoclet J: Effects of methylene blue on blood pressure and reactivity to norepinephrine in endotoxemic rats. J Cardiovasc Pharmacol 21:926-930, 1993.
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 926-930
    • Paya, D.1    Gray, G.2    Stoclet, J.3
  • 114
    • 0028236580 scopus 로고
    • Inhibition of nitric oxide synthase improves the vasoconstrictive effect of noradrenaline in sepsis
    • Landin L, Lorente J, Renes E, Canas P, Jorge P, Liste D: Inhibition of nitric oxide synthase improves the vasoconstrictive effect of noradrenaline in sepsis. Chest 106:250-256, 1994.
    • (1994) Chest , vol.106 , pp. 250-256
    • Landin, L.1    Lorente, J.2    Renes, E.3    Canas, P.4    Jorge, P.5    Liste, D.6
  • 115
    • 0027939328 scopus 로고
    • The pulmonary effect of nitric oxide synthase inhibition following endotoxemia in a swine model
    • Ogura H, Offner P, Saitoh D, Jordan A, Pruitt B, Cioffi W: The pulmonary effect of nitric oxide synthase inhibition following endotoxemia in a swine model. Arch Surg 129:1233-1239, 1994.
    • (1994) Arch Surg , vol.129 , pp. 1233-1239
    • Ogura, H.1    Offner, P.2    Saitoh, D.3    Jordan, A.4    Pruitt, B.5    Cioffi, W.6
  • 117
    • 0015609611 scopus 로고
    • A clinical review of bleomycin: A new neoplastic agent
    • Blum R, Carter S, Agre A: A clinical review of bleomycin: A new neoplastic agent. Cancer 31:903-914, 1973.
    • (1973) Cancer , vol.31 , pp. 903-914
    • Blum, R.1    Carter, S.2    Agre, A.3
  • 118
    • 0014786201 scopus 로고
    • Vinblastine in the management of testicular cancer
    • Samuels M, Howe C: Vinblastine in the management of testicular cancer. Cancer 25:1009-1017, 1970.
    • (1970) Cancer , vol.25 , pp. 1009-1017
    • Samuels, M.1    Howe, C.2
  • 119
    • 0022544692 scopus 로고
    • Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors: Results with 100 patients
    • Logothetis C, Samuels M, Selig D, et al: Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors: Results with 100 patients. Am J Med 81:219-228, 1986.
    • (1986) Am J Med , vol.81 , pp. 219-228
    • Logothetis, C.1    Samuels, M.2    Selig, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.