-
1
-
-
70349335633
-
ABC transporters: A riddle wrapped in a mystery inside an enigma
-
Jones, P. M., O'Mara, M. L., and George, A. M. (2009) ABC transporters: a riddle wrapped in a mystery inside an enigma Trends Biochem. Sci. 34, 520-531
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 520-531
-
-
Jones, P.M.1
O'Mara, M.L.2
George, A.M.3
-
2
-
-
27144451192
-
Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: Evidence for simultaneous binding of both drugs
-
Lugo, M. R. and Sharom, F. J. (2005) Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs Biochemistry 44, 14020-14029
-
(2005)
Biochemistry
, vol.44
, pp. 14020-14029
-
-
Lugo, M.R.1
Sharom, F.J.2
-
3
-
-
73949135792
-
Mechanisms of multidrug resistance in cancer
-
Gillet, J. P. and Gottesman, M. M. (2010) Mechanisms of multidrug resistance in cancer Methods Mol. Biol. 596, 47-76
-
(2010)
Methods Mol. Biol.
, vol.596
, pp. 47-76
-
-
Gillet, J.P.1
Gottesman, M.M.2
-
4
-
-
0036176510
-
Mechanisms of cancer drug resistance
-
Gottesman, M. M. (2002) Mechanisms of cancer drug resistance Annu. Rev. Med. 53, 615-627
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 615-627
-
-
Gottesman, M.M.1
-
5
-
-
0017153755
-
Drug-resistant mutants of Chinese hamster ovary cells possess an altered cell surface carbohydrate component
-
Juliano, R. (1976) Drug-resistant mutants of Chinese hamster ovary cells possess an altered cell surface carbohydrate component J. Supramol. Struct. 4, 521-526
-
(1976)
J. Supramol. Struct.
, vol.4
, pp. 521-526
-
-
Juliano, R.1
-
6
-
-
84856271899
-
The P-glycoprotein multidrug transporter
-
Sharom, F. J. (2011) The P-glycoprotein multidrug transporter Essays Biochem. 50, 161-178
-
(2011)
Essays Biochem.
, vol.50
, pp. 161-178
-
-
Sharom, F.J.1
-
7
-
-
78650524176
-
An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
-
Jeynes, B. and Provias, J. (2011) An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis Neurosci. Lett. 487, 389-393
-
(2011)
Neurosci. Lett.
, vol.487
, pp. 389-393
-
-
Jeynes, B.1
Provias, J.2
-
8
-
-
63449139456
-
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
-
Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P. M., Trinh, Y. T., Zhang, Q., Urbatsch, I. L., and Chang, G. (2009) Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science 323, 1718-1722
-
(2009)
Science
, vol.323
, pp. 1718-1722
-
-
Aller, S.G.1
Yu, J.2
Ward, A.3
Weng, Y.4
Chittaboina, S.5
Zhuo, R.6
Harrell, P.M.7
Trinh, Y.T.8
Zhang, Q.9
Urbatsch, I.L.10
Chang, G.11
-
9
-
-
84867883248
-
Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans
-
Jin, M. S., Oldham, M. L., Zhang, Q., and Chen, J. (2012) Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans Nature 490, 566-569
-
(2012)
Nature
, vol.490
, pp. 566-569
-
-
Jin, M.S.1
Oldham, M.L.2
Zhang, Q.3
Chen, J.4
-
10
-
-
0029784872
-
Secondary and tertiary structure changes of reconstituted P-glycoprotein. A Fourier transform attenuated total reflection infrared spectroscopy analysis
-
Sonveaux, N., Shapiro, A. B., Goormaghtigh, E., Ling, V., and Ruysschaert, J. M. (1996) Secondary and tertiary structure changes of reconstituted P-glycoprotein. A Fourier transform attenuated total reflection infrared spectroscopy analysis J. Biol. Chem. 271, 24617-24624
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24617-24624
-
-
Sonveaux, N.1
Shapiro, A.B.2
Goormaghtigh, E.3
Ling, V.4
Ruysschaert, J.M.5
-
11
-
-
0037417765
-
Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle
-
Qu, Q., Russell, P. L., and Sharom, F. J. (2003) Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle Biochemistry 42, 1170-1177
-
(2003)
Biochemistry
, vol.42
, pp. 1170-1177
-
-
Qu, Q.1
Russell, P.L.2
Sharom, F.J.3
-
12
-
-
31844448665
-
The translocation mechanism of P-glycoprotein
-
Callaghan, R., Ford, R. C., and Kerr, I. D. (2006) The translocation mechanism of P-glycoprotein FEBS Lett. 580, 1056-1063
-
(2006)
FEBS Lett.
, vol.580
, pp. 1056-1063
-
-
Callaghan, R.1
Ford, R.C.2
Kerr, I.D.3
-
13
-
-
84864564117
-
Perspectives on the structure-function of ABC transporters: The Switch and Constant Contact models
-
George, A. M. and Jones, P. M. (2012) Perspectives on the structure-function of ABC transporters: the Switch and Constant Contact models Prog. Biophys. Mol. Biol. 109, 95-107
-
(2012)
Prog. Biophys. Mol. Biol.
, vol.109
, pp. 95-107
-
-
George, A.M.1
Jones, P.M.2
-
14
-
-
0035682157
-
The mechanism of action of multidrug-resistance-linked P-glycoprotein
-
Sauna, Z. E., Smith, M. M., Muller, M., Kerr, K. M., and Ambudkar, S. V. (2001) The mechanism of action of multidrug-resistance-linked P-glycoprotein J. Bioenerg. Biomembr. 33, 481-491
-
(2001)
J. Bioenerg. Biomembr.
, vol.33
, pp. 481-491
-
-
Sauna, Z.E.1
Smith, M.M.2
Muller, M.3
Kerr, K.M.4
Ambudkar, S.V.5
-
15
-
-
0037663389
-
P-glycoprotein catalytic mechanism: Studies of the ADP-vanadate inhibited state
-
Urbatsch, I. L., Tyndall, G. A., Tombline, G., and Senior, A. E. (2003) P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state J. Biol. Chem. 278, 23171-23179
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23171-23179
-
-
Urbatsch, I.L.1
Tyndall, G.A.2
Tombline, G.3
Senior, A.E.4
-
16
-
-
0034763005
-
Rational use of in vitro P-glycoprotein assays in drug discovery
-
Polli, J. W., Wring, S. A., Humphreys, J. E., Huang, L., Morgan, J. B., Webster, L. O., and Serabjit-Singh, C. S. (2001) Rational use of in vitro P-glycoprotein assays in drug discovery J. Pharmacol. Exp. Ther. 299, 620-628
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 620-628
-
-
Polli, J.W.1
Wring, S.A.2
Humphreys, J.E.3
Huang, L.4
Morgan, J.B.5
Webster, L.O.6
Serabjit-Singh, C.S.7
-
17
-
-
84858767204
-
Role of the D-loops in allosteric control of ATP hydrolysis in an ABC transporter
-
Jones, P. M. and George, A. M. (2012) Role of the D-loops in allosteric control of ATP hydrolysis in an ABC transporter J. Phys. Chem. A 116, 3004-3013
-
(2012)
J. Phys. Chem. A
, vol.116
, pp. 3004-3013
-
-
Jones, P.M.1
George, A.M.2
-
18
-
-
79951973326
-
Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein
-
Parveen, Z., Stockner, T., Bentele, C., Pferschy, S., Kraupp, M., Freissmuth, M., Ecker, G. F., and Chiba, P. (2011) Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein Mol. Pharmacol. 79, 443-452
-
(2011)
Mol. Pharmacol.
, vol.79
, pp. 443-452
-
-
Parveen, Z.1
Stockner, T.2
Bentele, C.3
Pferschy, S.4
Kraupp, M.5
Freissmuth, M.6
Ecker, G.F.7
Chiba, P.8
-
19
-
-
33645805657
-
In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: A recommendation for probe substrates
-
Rautio, J., Humphreys, J. E., Webster, L. O., Balakrishnan, A., Keogh, J. P., Kunta, J. R., Serabjit-Singh, C. J., and Polli, J. W. (2006) In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates Drug Metab. Dispos. 34, 786-792
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 786-792
-
-
Rautio, J.1
Humphreys, J.E.2
Webster, L.O.3
Balakrishnan, A.4
Keogh, J.P.5
Kunta, J.R.6
Serabjit-Singh, C.J.7
Polli, J.W.8
-
20
-
-
77956635483
-
Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1
-
Crowley, E., O'Mara, M. L., Kerr, I. D., and Callaghan, R. (2010) Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 FEBS J. 277, 3974-3985
-
(2010)
FEBS J.
, vol.277
, pp. 3974-3985
-
-
Crowley, E.1
O'Mara, M.L.2
Kerr, I.D.3
Callaghan, R.4
-
21
-
-
0035937707
-
Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates
-
Kerr, K. M., Sauna, Z. E., and Ambudkar, S. V. (2001) Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates J. Biol. Chem. 276, 8657-8664
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8657-8664
-
-
Kerr, K.M.1
Sauna, Z.E.2
Ambudkar, S.V.3
-
22
-
-
34548507482
-
Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein
-
Storm, J., O'Mara, M. L., Crowley, E. H., Peall, J., Tieleman, D. P., Kerr, I. D., and Callaghan, R. (2007) Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein Biochemistry 46, 9899-9910
-
(2007)
Biochemistry
, vol.46
, pp. 9899-9910
-
-
Storm, J.1
O'Mara, M.L.2
Crowley, E.H.3
Peall, J.4
Tieleman, D.P.5
Kerr, I.D.6
Callaghan, R.7
-
23
-
-
84863614150
-
Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle
-
Syberg, F., Suveyzdis, Y., Kotting, C., Gerwert, K., and Hofmann, E. (2012) Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle J. Biol. Chem. 287, 23923-23931
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 23923-23931
-
-
Syberg, F.1
Suveyzdis, Y.2
Kotting, C.3
Gerwert, K.4
Hofmann, E.5
-
24
-
-
84855476209
-
Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy
-
Verhalen, B., Ernst, S., Borsch, M., and Wilkens, S. (2012) Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy J. Biol. Chem. 287, 1112-1127
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 1112-1127
-
-
Verhalen, B.1
Ernst, S.2
Borsch, M.3
Wilkens, S.4
-
26
-
-
0032492724
-
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state
-
Ramachandra, M., Ambudkar, S. V., Chen, D., Hrycyna, C. A., Dey, S., Gottesman, M. M., and Pastan, I. (1998) Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state Biochemistry 37, 5010-5019
-
(1998)
Biochemistry
, vol.37
, pp. 5010-5019
-
-
Ramachandra, M.1
Ambudkar, S.V.2
Chen, D.3
Hrycyna, C.A.4
Dey, S.5
Gottesman, M.M.6
Pastan, I.7
-
27
-
-
84862893463
-
On the catalytic mechanism of human ATP citrate lyase
-
Fan, F., Williams, H. J., Boyer, J. G., Graham, T. L., Zhao, H., Lehr, R., Qi, H., Schwartz, B., Raushel, F. M., and Meek, T. D. (2012) On the catalytic mechanism of human ATP citrate lyase Biochemistry 51, 5198-5211
-
(2012)
Biochemistry
, vol.51
, pp. 5198-5211
-
-
Fan, F.1
Williams, H.J.2
Boyer, J.G.3
Graham, T.L.4
Zhao, H.5
Lehr, R.6
Qi, H.7
Schwartz, B.8
Raushel, F.M.9
Meek, T.D.10
-
28
-
-
0022399326
-
Positional isotope exchange and kinetic experiments with Escherichia coli guanosine-5′-monophosphate synthetase
-
von der Saal, W., Crysler, C. S., and Villafranca, J. J. (1985) Positional isotope exchange and kinetic experiments with Escherichia coli guanosine-5′-monophosphate synthetase Biochemistry 24, 5343-5350
-
(1985)
Biochemistry
, vol.24
, pp. 5343-5350
-
-
Von Der Saal, W.1
Crysler, C.S.2
Villafranca, J.J.3
-
29
-
-
0017922020
-
18O) shift in 31P nuclear magnetic resonance applied to a study of enzyme-catalyzed phosphate - Phosphate exchange and phosphate (oxygen) - Water exchange reactions
-
18O) shift in 31P nuclear magnetic resonance applied to a study of enzyme-catalyzed phosphate - phosphate exchange and phosphate (oxygen) - water exchange reactions Proc. Natl. Acad. Sci. U. S. A. 75, 200-203
-
(1978)
Proc. Natl. Acad. Sci. U. S. A.
, vol.75
, pp. 200-203
-
-
Cohn, M.1
Hu, A.2
-
30
-
-
0017871985
-
Evaluation of the partitioning of bound inorganic phosphate during medium and intermediate phosphate in equilibrium water oxygen exchange reactions of yeast inorganic pyrophosphatase
-
Hackney, D. D. and Boyer, P. D. (1978) Evaluation of the partitioning of bound inorganic phosphate during medium and intermediate phosphate in equilibrium water oxygen exchange reactions of yeast inorganic pyrophosphatase Proc. Natl. Acad. Sci. U. S. A. 75, 3133-3137
-
(1978)
Proc. Natl. Acad. Sci. U. S. A.
, vol.75
, pp. 3133-3137
-
-
Hackney, D.D.1
Boyer, P.D.2
-
31
-
-
75349083085
-
Utilization of positional isotope exchange experiments to evaluate reversibility of ATP hydrolysis catalyzed by Escherichia coli Lon protease
-
Thomas, J., Fishovitz, J., and Lee, I. (2010) Utilization of positional isotope exchange experiments to evaluate reversibility of ATP hydrolysis catalyzed by Escherichia coli Lon protease Biochem. Cell Biol. 88, 119-128
-
(2010)
Biochem. Cell Biol.
, vol.88
, pp. 119-128
-
-
Thomas, J.1
Fishovitz, J.2
Lee, I.3
-
32
-
-
42349098379
-
Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC)
-
Williams, L., Fan, F., Blanchard, J. S., and Raushel, F. M. (2008) Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC) Biochemistry 47, 4843-4850
-
(2008)
Biochemistry
, vol.47
, pp. 4843-4850
-
-
Williams, L.1
Fan, F.2
Blanchard, J.S.3
Raushel, F.M.4
-
33
-
-
71549142855
-
Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs
-
Ritchie, T. K., Grinkova, Y. V., Bayburt, T. H., Denisov, I. G., Zolnerciks, J. K., Atkins, W. M., and Sligar, S. G. (2009) Chapter 11-Reconstitution of membrane proteins in phospholipid bilayer nanodiscs Methods Enzymol. 464, 211-231
-
(2009)
Methods Enzymol.
, vol.464
, pp. 211-231
-
-
Ritchie, T.K.1
Grinkova, Y.V.2
Bayburt, T.H.3
Denisov, I.G.4
Zolnerciks, J.K.5
Atkins, W.M.6
Sligar, S.G.7
-
34
-
-
0023874147
-
A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: Application to lens ATPases
-
Chifflet, S., Torriglia, A., Chiesa, R., and Tolosa, S. (1988) A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases Anal. Biochem. 168, 1-4
-
(1988)
Anal. Biochem.
, vol.168
, pp. 1-4
-
-
Chifflet, S.1
Torriglia, A.2
Chiesa, R.3
Tolosa, S.4
-
36
-
-
0017089363
-
A stereochemical method for detection of ATP terminal phosphate transfer in enzymatic reactions. Glutamine synthetase
-
Midelfort, C. F. and Rose, I. A. (1976) A stereochemical method for detection of ATP terminal phosphate transfer in enzymatic reactions. Glutamine synthetase J. Biol. Chem. 251, 5881-5887
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 5881-5887
-
-
Midelfort, C.F.1
Rose, I.A.2
-
37
-
-
0019130595
-
P-31 Nuclear Magnetic-Resonance Application to Positional Isotope Exchange-Reactions Catalyzed by Escherichia coli Carbamoyl-Phosphate Synthetase - Analysis of Forward and Reverse Enzymatic-Reactions
-
Raushel, F. M. and Villafranca, J. J. (1980) P-31 Nuclear Magnetic-Resonance Application to Positional Isotope Exchange-Reactions Catalyzed by Escherichia coli Carbamoyl-Phosphate Synthetase-Analysis of Forward and Reverse Enzymatic-Reactions Biochemistry 19, 3170-3174
-
(1980)
Biochemistry
, vol.19
, pp. 3170-3174
-
-
Raushel, F.M.1
Villafranca, J.J.2
-
38
-
-
0029124166
-
P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site
-
Urbatsch, I. L., Sankaran, B., Weber, J., and Senior, A. E. (1995) P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site J. Biol. Chem. 270, 19383-19390
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19383-19390
-
-
Urbatsch, I.L.1
Sankaran, B.2
Weber, J.3
Senior, A.E.4
-
39
-
-
4544284056
-
The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein
-
Rothnie, A., Storm, J., Campbell, J., Linton, K. J., Kerr, I. D., and Callaghan, R. (2004) The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein J. Biol. Chem. 279, 34913-34921
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34913-34921
-
-
Rothnie, A.1
Storm, J.2
Campbell, J.3
Linton, K.J.4
Kerr, I.D.5
Callaghan, R.6
-
40
-
-
80655125018
-
Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2
-
Ritchie, T. K., Kwon, H., and Atkins, W. M. (2011) Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2 J. Biol. Chem. 286, 39489-39496
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 39489-39496
-
-
Ritchie, T.K.1
Kwon, H.2
Atkins, W.M.3
-
41
-
-
4744358624
-
The ATP switch model for ABC transporters
-
Higgins, C. F. and Linton, K. J. (2004) The ATP switch model for ABC transporters Nat. Struct. Mol. Biol. 11, 918-926
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 918-926
-
-
Higgins, C.F.1
Linton, K.J.2
-
42
-
-
33846688359
-
Structure and function of ABC transporters: The ATP switch provides flexible control
-
Linton, K. J. and Higgins, C. F. (2007) Structure and function of ABC transporters: the ATP switch provides flexible control Pflugers Arch. 453, 555-567
-
(2007)
Pflugers Arch.
, vol.453
, pp. 555-567
-
-
Linton, K.J.1
Higgins, C.F.2
-
43
-
-
33644840984
-
The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)
-
Ambudkar, S. V., Kim, I. W., and Sauna, Z. E. (2006) The power of the pump: mechanisms of action of P-glycoprotein (ABCB1) Eur. J. Pharm. Sc. 27, 392-400
-
(2006)
Eur. J. Pharm. Sc.
, vol.27
, pp. 392-400
-
-
Ambudkar, S.V.1
Kim, I.W.2
Sauna, Z.E.3
-
44
-
-
79953173207
-
P-glycoprotein retains drug-stimulated ATPase activity upon covalent linkage of the two nucleotide binding domains at their C-terminal ends
-
Verhalen, B. and Wilkens, S. (2011) P-glycoprotein retains drug-stimulated ATPase activity upon covalent linkage of the two nucleotide binding domains at their C-terminal ends J. Biol. Chem. 286, 10476-10482
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 10476-10482
-
-
Verhalen, B.1
Wilkens, S.2
|