Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2

Journal of Biological Chemistry

Volumn 286, Issue 45, 2011, Pages 39489-39496

  Ritchie, Tasha K ^a   Kwon, Hyewon ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ATP-BINDING CASSETTE TRANSPORTERS; CANCER CELLS; CATALYTIC CYCLES; CONFORMATIONAL ANALYSIS; CONFORMATIONAL CHANGE; DRUG RESISTANCE; DRUG-DRUG INTERACTIONS; HIGH RESOLUTION; INTERMEDIATE STATE; ISOFORMS; LIPID SYSTEMS; NANODISCS; NUCLEOTIDE-BINDING DOMAIN; P-GLYCOPROTEIN; PHARMACOKINETIC PROPERTIES; PURIFIED PROTEIN; STRUCTURAL DATA; TRAPPED STATE; TUMOR CELLS; VINBLASTINE;

ANTIBODIES; GLYCOPROTEINS; LIPID BILAYERS; MAMMALS; NUCLEOTIDES; SURFACE PLASMON RESONANCE;

DRUG INTERACTIONS;

ADENOSINE DIPHOSPHATE; ANTIBODY; GLYCOPROTEIN P; MONOCLONAL ANTIBODY MRK 16; MULTIDRUG RESISTANCE PROTEIN 1; NANODISC; UIC2 ANTIBODY; UNCLASSIFIED DRUG; VINBLASTINE;

ANTIGEN BINDING; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG RELEASE; LIGAND BINDING; LIPID BILAYER; NANOANALYSIS; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN HYDROLYSIS; SURFACE PLASMON RESONANCE;

ADENOSINE DIPHOSPHATE; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT, ACTIVE; HUMANS; LIPID BILAYERS; P-GLYCOPROTEIN; PROTEIN CONFORMATION; VINBLASTINE;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 80655125018     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.284554     Document Type: Article

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