Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1

FEBS Journal

Volumn 277, Issue 19, 2010, Pages 3974-3985

  Crowley, Emily ^a   O'Mara, Megan L ^b   Kerr, Ian D ^c   Callaghan, Richard ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

ABC transporter; bioenergetic coupling; drug resistance; efflux pumps; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN; PROTEIN TM12; UNCLASSIFIED DRUG; ABCB1 PROTEIN, HUMAN; CYSTEINE; ISOPROTEIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1;

ARTICLE; COVALENT BOND; DRUG BINDING; ENERGY; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENERGY METABOLISM; ENZYME ACTIVE SITE; GENETICS; KINETICS; METABOLISM; MUTATION;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CYSTEINE; ENERGY METABOLISM; HUMANS; KINETICS; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PROTEIN CONFORMATION; PROTEIN ISOFORMS;

EID: 77956635483     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07789.x     Document Type: Article

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