In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ

DNA Repair

Volumn 15, Issue 1, 2014, Pages 21-28

  Sassa, Akira ^a,b,f   Suzuki, Tetsuya ^a,g   Kanemaru, Yuki ^a,h   Niimi, Naoko ^a,i   Fujimoto, Hirofumi ^c   Katafuchi, Atsushi ^a,j   Grúz, Petr ^a   Yasui, Manabu ^a   Gupta, Ramesh C ^d   Johnson, Francis ^d   Ohta, Toshihiro ^b   Honma, Masamitsu ^a   Adachi, Noritaka ^e   Nohmi, Takehiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d STONY BROOK UNIVERSITY   (United States)

^e YOKOHAMA CITY UNIVERSITY   (Japan)

^f NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^g NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Japan)

^h SHOWA UNIVERSITY   (Japan)

ⁱ TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^j FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

more..

Author keywords

Benzo a pyrene diolepoxide N2 guanine; DNA polymerase ; Translesion DNA synthesis

Indexed keywords

BENZO[A]PYRENE DIOLEPOXIDE-N(2)-GUANINE; DNA POLYMERASE Κ; TRANSLESION DNA SYNTHESIS;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CATALYTIC DOMAIN; CELL LINE; DEOXYGUANOSINE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION RATE; PHENYLALANINE;

EID: 84894247498     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.12.008     Document Type: Article

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