The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase κ

Biochemistry

Volumn 48, Issue 20, 2009, Pages 4239-4246

  Niimi, Naoko ^a   Sassa, Akira ^a,b   Katafuchi, Atsushi ^a   Grúz, Petr ^a   Fujimoto, Hirofumi ^c   Bonala, Radha Rani ^d   Johnson, Francis ^d   Ohta, Toshihiro ^b   Nohmi, Takehiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TYROSINE; BENZO[A]PYRENE DIOLEPOXIDE; CATALYTIC CONSTANTS; DNA ADDUCTS; DNA DAMAGES; DNA LESIONS; DNA POLYMERASE; DNA REPLICATIONS; E. COLI; GENOTOXIC; HUMAN DNA POLYMERASE; HYDROXY GROUPS; PRIMER EXTENSION; WILD-TYPE ENZYMES;

AMINATION; AMINES; AMINO ACIDS; DNA; ESCHERICHIA COLI; ETHYLENE GLYCOL; GENES; ORGANIC ACIDS; POLYMERS;

NUCLEIC ACIDS;

DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA POLYMERASE; DNA POLYMERASE KAPPA; NUCLEOTIDE; PRIMER DNA; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BASE MISPAIRING; DNA BINDING; DNA REPAIR; DNA TEMPLATE; PRIORITY JOURNAL;

AMINO ACIDS; BASE PAIR MISMATCH; CATALYSIS; DNA ADDUCTS; DNA PRIMERS; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENETIC VECTORS; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; TYROSINE;

ESCHERICHIA COLI;

EID: 66149161889     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900153t     Document Type: Article

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