Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in vitro: REV1 inserts dC opposite the lesion, and DNA polymerase κ potentially catalyzes extension reaction from the 3′-dC terminus

Journal of Biological Chemistry

Volumn 284, Issue 38, 2009, Pages 25585-25597

  Fukuda, Hirokazu ^a   Takamura Enya, Takeji ^b   Masuda, Yuji ^c   Nohmi, Takehiko ^d   Seki, Chiho ^a   Kamiya, Kenji ^c   Sugimura, Takashi ^a   Masutani, Chikahide ^e   Hanaoka, Fumio ^e,f   Nakagama, Hitoshi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KANAGAWA INSTITUTE OF TECHNOLOGY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COOKED FOOD; DNA ADDUCTS; DNA POLYMERASE; DNA SYNTHESISS; HETEROCYCLIC AMINES; HOT SPOT; IN-VITRO; MODIFIED OLIGONUCLEOTIDES; MOLECULAR MECHANISM;

AMINATION; AMINES; ESCHERICHIA COLI; GENES; NUCLEIC ACIDS; OLIGONUCLEOTIDES; ONCOLOGY; POLYMERS; POSITIVE IONS; PYRIDINE; SYNTHESIS (CHEMICAL); TUMORS;

DNA;

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; APC PROTEIN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE REV1; GUANINE; HETEROCYCLIC COMPOUND; 2 AMINO 1 METHYL 6 PHENYLIMIDAZO(4,5 B)PYRIDINE; 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE; DNA; DNA DIRECTED DNA POLYMERASE; IMIDAZOLE DERIVATIVE; NUCLEAR PROTEIN; NUCLEOTIDYLTRANSFERASE; OLIGONUCLEOTIDE; POLK PROTEIN, HUMAN; REV1 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; DNA SYNTHESIS; DNA TEMPLATE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE DELETION; GENE MUTATION; HUMAN; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; ANIMAL; BIOSYNTHESIS; CELL FREE SYSTEM; CHEMISTRY; COLON TUMOR; DNA ADDUCT; GENETICS; METABOLISM; TUMOR SUPPRESSOR GENE;

ESCHERICHIA COLI; RATTUS;

ANIMALS; CELL-FREE SYSTEM; COLONIC NEOPLASMS; DNA ADDUCTS; DNA, NEOPLASM; DNA-DIRECTED DNA POLYMERASE; GENES, APC; HUMANS; IMIDAZOLES; NUCLEAR PROTEINS; NUCLEOTIDYLTRANSFERASES; OLIGONUCLEOTIDES; RATS; SEQUENCE DELETION;

EID: 70350012245     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.037259     Document Type: Article

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