Human DNA polymerase κ bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides

Journal of Biological Chemistry

Volumn 277, Issue 40, 2002, Pages 37604-37611

  Fischhaber, Paula L ^a   Gerlach, Valerie L ^b   Feaver, William J ^c   Hatahet, Zafer ^d   Wallace, Susan S ^a   Friedberg, Errol C ^d,e  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c CURAGEN CORPORATION   (United States)

^d Molecular Staging Inc   (United States)

^e UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYMES; GENES; GLYCOLS; MUTAGENESIS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

MISINCORPORATION RATES; NUCLEOTIDES;

BIOCHEMISTRY;

ADENINE; DNA BASE; DNA POLYMERASE; DNA POLYMERASE KAPPA; GLYCOL; GUANINE; NUCLEOTIDE DERIVATIVE; PURINE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; IN VITRO STUDY; KINETICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STEADY STATE; STEREOISOMERISM;

ADENINE; BASE SEQUENCE; DNA; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HUMANS; NUCLEIC ACID CONFORMATION; PROTEINS; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC; THYMINE;

EID: 0037020269     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206027200     Document Type: Article

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