Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases κ and ζ in human cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 32, 2010, Pages 14116-14121

  Yoon, Jung Hoon ^a   Bhatia, Gita ^a   Prakash, Satya ^a   Prakash, Louise ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

DNA polymerases kappa and zeta; Error free bypass of thymine glycol; Replicative lesion bypass; Thymine glycol bypass in humans

Indexed keywords

DNA POLYMERASE; GLYCOL; PLASMID VECTOR; REACTIVE OXYGEN METABOLITE; THYMINE; 5,6 DIHYDRO 5,6 DIHYDROXYTHYMINE; DNA DIRECTED DNA POLYMERASE; DNA POLYMERASE ZETA; DRUG DERIVATIVE; POLK PROTEIN, HUMAN;

ARTICLE; CATALYSIS; DNA REPLICATION; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PLASMID; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; DNA DAMAGE; DNA REPAIR; METABOLISM;

DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HUMANS; THYMINE;

EID: 77956289981     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007795107     Document Type: Article

References (30)

1. Adelamn R, Saul RL, Ames BN (1988) Oxidative damage to DNA: Relation to species metabolic rate andlife span. Proc Natl Acad Sci USA 85:2706-2708.
2. Frenkel K, Goldstein MS, Teebor GW (1981) Identification of the cis-thymine glycol moeity in chemically oxidized and gamma-irradiated deoxyribonucleotic acid by high-pressure liquid chromatography analysis. Biochemistry 20:7566-7571.
3. Teoule R, Bert C, Bonicel A (1977) Thymine fragment damage retained in the DNA polynucleotide chain after gamma irradiation in aerated solutions. II. Radiat Res 72:190-200. (Pubitemid 8220374)
4. Ikeda S, et al. (1998) Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-232 as the active nucleophilic residue. J Biol Chem 273:21585-21593.
5. Reardon JT, Bessho T, Kung HC, Bolton PH, Sancar A (1997) In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in xeroderma pigmentosum patients. Proc Natl Acad Sci USA 94:9463-9468.
6. Johnson RE, Yu S-L, Prakash S, Prakash L (2003) Yeast DNA polymerase zeta (ζ) is essential for error-free replication past thymine glycol. Gene Dev 17:77-87.
7. Kusumoto R, Masutani C, Iwai S, Hanaoka F (2002) Translesion synthesis by human DNA polymerase η across thymine glycol lesions. Biochemistry 41:6090-6099. (Pubitemid 34498915)
8. Kao JY, Goljer I, Phan TA, Bolton PH (1993) Characterization of the effects of a thymine glycol residue on the structure, dynamics, and stability of duplex DNA by NMR. J Biol Chem 268:17787-17793.
9. Kung HC, Bolton PH (1997) Structure of a duplex DNA containing a thymine glycol residue in solution. J Biol Chem 272:9227-9236. (Pubitemid 27154932)
10. McNulty JM, Jerkovic B, Bolton PH, Basu AK (1998) Replication inhibition and miscoding properties of DNA templates containing a site-specific cis-thymine glycol or urea rsidue. Chem Res Toxicol 11:666-673.
11. Fischhaber PL, et al. (2002) Human DNA polymerase κ bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. J Biol Chem 277:37604-37611.
12. Prakash S, Johnson RE, Prakash L (2005) Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem 74:317-353.
13. Nelson JR, Lawrence CW, Hinkle DC (1996) Thymine-thymine dimer bypass by yeast DNA polymerase ζ. Science 272:1646-1649.
14. Johnson RE, Washington MT, Haracska L, Prakash S, Prakash L (2000) Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions. Nature 406:1015-1019.
15. Johnson RE, Haracska L, Prakash S, Prakash L (2001) Role of DNA polymerase h in the bypass of a (6-4) TT photoproduct. Mol Cell Biol 21:3558-3563. (Pubitemid 32381791)
16. Haracska L, et al. (2001) Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sites. Gene Dev 15:945-954.
17. 6- ethenodeoxyadenosine lesion by human DNA polymerase ι. Nat Struct Mol Biol 13:619-625.
18. Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK (2008) Protein-template directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase. Structure 16:239-245. (Pubitemid 351215208)
19. Yoon J-H, Prakash L, Prakash S (2009) Highly error-free role of DNA polymerase h in the replicative bypass of UV induced pyrimidine dimers in mouse and human cells. Proc Natl Acad Sci USA 106:18219-18224.
20. Yoon J-H, Prakash L, Prakash S (2010) Error-free replicative bypass of (6-4) photoproducts by DNA polymerase ζ in mouse and human cells. Gene Dev 24:123-128.
21. Lustig MJ, Cadet J, Boorstein RJ, Teebor GW (1992) Synthesis of the diasteromers of thymidine glycol, determination of concentrations and rates of interconversion of theis cis-transepimers at equilibrium and demonstration of differential alkali lability within DNA. Nucleic Acids Res 20:4839-4845.
22. Acharya N, Yoon J-H, Hurwitz J, Prakash L, Prakash S (2010) DNA polymerase η lacking the ubiquitin-binding domain promotes replicative lesion bypass in human cells. Proc Natl Acad Sci USA 107:10401-10405.
23. Mezzina M, Mench CFM, Courtin P, Sarasin A (1988) Replication of simian virus 40 DNA after UV irradiation: Evidence of growing fork blockage and single-stranded gaps in daughter strands. J Virol 62:4249-4258.
24. Sarasin AR, Hanawalt PC (1980) Replication of ultraviolet-irradiated simian virus 40 in monkey kidney cells. J Mol Biol 138:299-319.
25. Bresson A, Fuchs RPP (2002) Lesion bypass in yeast cells: Pol η participates in a multi-DNA polymerase process. EMBO J 21:3881-3887. (Pubitemid 34787060)
26. Lone S, et al. (2007) Human DNA polymerase κ encircles DNA: Implications for mismatch extension and lesion bypass. Mol Cell 25:601-614.
27. Silverstein TD, et al. (2010) Structural basis for the suppression of skin cancers by DNA polymerase η. Nature 465:1039-1044.
28. Trincao J, et al. (2001) Structure of the catalytic core of S. cerevisiae DNA polymerase h: implications for translesion DNA synthesis. Mol Cell 8:417-426.
29. Nair DT, Johnson RE, Prakash S, Prakash L, Aggarwal AK (2004) Replication by human DNA polymerase ι occurs via Hoogsteen base-pairing. Nature 430:377-380. (Pubitemid 38937748)
30. Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK (2005) Human DNA polymerase ι incorporates dCTP opposite template G via a G. C+ Hoogsteen base pair. Structure 13:1569-1577.