Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 718, Issue 1-2, 2011, Pages 10-17

  Sassa, Akira ^a,b   Niimi, Naoko ^a   Fujimoto, Hirofumi ^c   Katafuchi, Atsushi ^a   Grúz, Petr ^a   Yasui, Manabu ^a   Gupta, Ramesh C ^d   Johnson, Francis ^d   Ohta, Toshihiro ^b   Nohmi, Takehiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

Benzo a pyrene diolepoxide N2 deoxyguanine; DNA polymerase ; Translesion DNA synthesis

Indexed keywords

ALANINE; BENZO[A]PYRENE; DNA POLYMERASE; DNA POLYMERASE KAPPA; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CODON; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ESCHERICHIA COLI; GENE MUTATION; HUMAN; PRIORITY JOURNAL;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BENZO(A)PYRENE; CATALYTIC DOMAIN; DEOXYGUANOSINE; DNA ADDUCTS; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI PROTEINS; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 78650170692     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.11.002     Document Type: Article

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