Increased dietary cholesterol promotes enhanced mutagenesis in DNA polymerase kappa-deficient mice

DNA Repair

Volumn 12, Issue 10, 2013, Pages 817-823

  Singer, William D ^a   Osimiri, Lindsey C ^a,b   Friedberg, Errol C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

DNA polymerase kappa; Mutagenesis; Polk mice; Translesion DNA synthesis

Indexed keywords

CHOLESTEROL; DNA POLYMERASE; DNA POLYMERASE KAPPA; GUANINE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOE GENE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; GENE; GENOTYPE; HYPERCHOLESTEROLEMIA; LIFE EXPECTANCY; MOUSE; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SURVIVAL RATE; TRANSGENE;

DNA POLYMERASE KAPPA; MUTAGENESIS; POLK(-/-) MICE; TRANSLESION DNA SYNTHESIS;

ANIMALS; CHOLESTEROL, DIETARY; DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; HYPERCHOLESTEROLEMIA; MICE; MICE, KNOCKOUT; MUTAGENESIS; MUTATION RATE; POINT MUTATION;

MUS;

EID: 84885381264     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.07.010     Document Type: Article

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