-
1
-
-
5344233478
-
Pulmonary arterial hypertension
-
doi:10.1056/NEJMra035488. PubMed: 15483284
-
Farber HW, Loscalzo J (2004) Pulmonary arterial hypertension. N Engl J Med 351: 1655-1665. doi:10.1056/NEJMra035488. PubMed: 15483284.
-
(2004)
N Engl J Med
, vol.351
, pp. 1655-1665
-
-
Farber, H.W.1
Loscalzo, J.2
-
2
-
-
46749142123
-
Molecular pathogenesis of pulmonary arterial hypertension
-
doi:10.1172/JCI33452. PubMed: 18596905
-
Rabinovitch M (2008) Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 118: 2372-2379. doi:10.1172/JCI33452. PubMed: 18596905.
-
(2008)
J Clin Invest
, vol.118
, pp. 2372-2379
-
-
Rabinovitch, M.1
-
3
-
-
79960961583
-
Mechanisms of disease: Pulmonary arterial hypertension
-
doi:10.1038/nrcardio.2011.87. PubMed: 21691314
-
Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger F (2011) Mechanisms of disease: pulmonary arterial hypertension. Nat Rev Cardiol 8: 443-455. doi:10.1038/nrcardio.2011.87. PubMed: 21691314.
-
(2011)
Nat Rev Cardiol
, vol.8
, pp. 443-455
-
-
Schermuly, R.T.1
Ghofrani, H.A.2
Wilkins, M.R.3
Grimminger, F.4
-
4
-
-
30444439216
-
The discovery of nitric oxide and its role in vascular biology
-
PubMed: 16402104
-
Moncada S, Higgs EA (2006) The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147 Suppl 1: S193-S201. PubMed: 16402104.
-
(2006)
Br J Pharmacol
, vol.147
, Issue.SUPPL. 1
-
-
Moncada, S.1
Higgs, E.A.2
-
5
-
-
33645780634
-
Endothelial nitric oxide synthase in vascular disease: From marvel to menace
-
doi:10.1161/CIRCULATIONAHA.105.602532. PubMed: 16585403
-
Förstermann U, Münzel T (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113: 1708-1714. doi:10.1161/CIRCULATIONAHA.105.602532. PubMed: 16585403.
-
(2006)
Circulation
, vol.113
, pp. 1708-1714
-
-
Förstermann, U.1
Münzel, T.2
-
6
-
-
58149138838
-
Vascular protection by tetrahydrobiopterin: Progress and therapeutic prospects
-
doi:10.1016/j.tips.2008.10.003. PubMed: 19042039
-
Katusic ZS, d'Uscio LV, Nath KA (2009) Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects. Trends Pharmacol Sci 30: 48-54. doi:10.1016/j.tips.2008.10.003. PubMed: 19042039.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 48-54
-
-
Katusic, Z.S.1
D'Uscio, L.V.2
Nath, K.A.3
-
7
-
-
80051549032
-
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
-
doi:10.1016/j.niox.2011.04.004. PubMed: 21550412
-
Crabtree MJ, Channon KM (2011) Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide 25: 81-88. doi:10.1016/j.niox.2011.04.004. PubMed: 21550412.
-
(2011)
Nitric Oxide
, vol.25
, pp. 81-88
-
-
Crabtree, M.J.1
Channon, K.M.2
-
8
-
-
41849144894
-
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
-
doi: 10.1152/ajpheart.00823.2007. PubMed: 18192221
-
Crabtree MJ, Smith CL, Lam G, Goligorsky MS, Gross SS (2008) Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS. Am J Physiol Heart Circ Physiol 294: H1530-H1540. doi: 10.1152/ajpheart.00823.2007. PubMed: 18192221.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Crabtree, M.J.1
Smith, C.L.2
Lam, G.3
Goligorsky, M.S.4
Gross, S.S.5
-
9
-
-
80052310958
-
Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo
-
doi:10.1152/ajpheart.01089.2010. PubMed: 21622822
-
Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J et al. (2011) Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo. Am J Physiol Heart Circ Physiol 301: H721-H729. doi:10.1152/ajpheart.01089.2010. PubMed: 21622822.
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.301
-
-
Noguchi, K.1
Hamadate, N.2
Matsuzaki, T.3
Sakanashi, M.4
Nakasone, J.5
-
10
-
-
27644537902
-
Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: Insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression
-
doi: 10.1161/01.RES.0000187447.03525.72. PubMed: 16179591
-
Bendall JK, Alp NJ, Warrick N, Cai S, Adlam D et al. (2005) Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression. Circ Res 97: 864-871. doi: 10.1161/01.RES.0000187447.03525.72. PubMed: 16179591.
-
(2005)
Circ Res
, vol.97
, pp. 864-871
-
-
Bendall, J.K.1
Alp, N.J.2
Warrick, N.3
Cai, S.4
Adlam, D.5
-
11
-
-
17744386526
-
Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension
-
doi:10.1161/01.CIR. 0000162470.26840.89. PubMed: 15824200
-
Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T et al. (2005) Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension. Circulation 111: 2126-2133. doi:10.1161/01.CIR. 0000162470.26840.89. PubMed: 15824200.
-
(2005)
Circulation
, vol.111
, pp. 2126-2133
-
-
Khoo, J.P.1
Zhao, L.2
Alp, N.J.3
Bendall, J.K.4
Nicoli, T.5
-
12
-
-
17744381754
-
Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse
-
doi:10.1161/01.CIR.0000163268.32638.F4. PubMed: 15824199
-
Nandi M, Miller A, Stidwill R, Jacques TS, Lam AA et al. (2005) Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse. Circulation 111: 2086-2090. doi:10.1161/01.CIR.0000163268.32638.F4. PubMed: 15824199.
-
(2005)
Circulation
, vol.111
, pp. 2086-2090
-
-
Nandi, M.1
Miller, A.2
Stidwill, R.3
Jacques, T.S.4
Lam, A.A.5
-
13
-
-
33744793993
-
Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: Role of NADPH oxidase and endothelial NO synthase
-
doi:10.1152/ajplung.00408.2005. PubMed: 16684951
-
Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A et al. (2006) Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol 290: L1069-L1077. doi:10.1152/ajplung.00408.2005. PubMed: 16684951.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.290
-
-
Grobe, A.C.1
Wells, S.M.2
Benavidez, E.3
Oishi, P.4
Azakie, A.5
-
14
-
-
34147118950
-
Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension
-
PubMed: 17142346
-
Konduri GG, Bakhutashvili I, Eis A, Pritchard K Jr. (2007) Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension. Am J Physiol Heart Circ Physiol 292: H1812-H1820. PubMed: 17142346.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
-
-
Konduri, G.G.1
Bakhutashvili, I.2
Eis, A.3
Pritchard Jr., K.4
-
15
-
-
84856643843
-
Pulmonary hypertension in advanced chronic obstructive pulmonary disease
-
doi:10.1097/MCP.0b013e32834f2093. PubMed: 22189454
-
Orr R, Smith LJ, Cuttica MJ (2012) Pulmonary hypertension in advanced chronic obstructive pulmonary disease. Curr Opin Pulm Med 18: 138-143. doi:10.1097/MCP.0b013e32834f2093. PubMed: 22189454.
-
(2012)
Curr Opin Pulm Med
, vol.18
, pp. 138-143
-
-
Orr, R.1
Smith, L.J.2
Cuttica, M.J.3
-
16
-
-
33745713119
-
Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia
-
doi:10.1038/sj.bjp.0706779. PubMed: 16715116
-
Fresquet F, Pourageaud F, Leblais V, Brandes RP, Savineau JP et al. (2006) Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia. Br J Pharmacol 148: 714-723. doi:10.1038/sj.bjp.0706779. PubMed: 16715116.
-
(2006)
Br J Pharmacol
, vol.148
, pp. 714-723
-
-
Fresquet, F.1
Pourageaud, F.2
Leblais, V.3
Brandes, R.P.4
Savineau, J.P.5
-
17
-
-
33644798841
-
Hypoxic pulmonary hypertension: Role of superoxide and NADPH oxidase (gp91phox)
-
PubMed: 16085672
-
Liu JQ, Zelko IN, Erbynn EM, Sham JS, Folz RJ (2006) Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox). Am J Physiol Lung Cell Mol Physiol 290: L2-10. PubMed: 16085672.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.290
-
-
Liu, J.Q.1
Zelko, I.N.2
Erbynn, E.M.3
Sham, J.S.4
Folz, R.J.5
-
18
-
-
40449104933
-
The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester
-
doi:10.2353/ajpath.2008.070439. PubMed: 18276789. Available online at: doi:10.2353/ajpath.2008.070439 Available online at: PubMed: 18276789
-
Billon A, Lehoux S, Leen Lam Shang L, Laurell H, Filipe C et al. (2008) The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester. Am J Pathol 172: 830-838. doi:10.2353/ajpath.2008.070439. PubMed: 18276789. Available online at: doi:10.2353/ajpath.2008.070439 Available online at: PubMed: 18276789
-
(2008)
Am J Pathol
, vol.172
, pp. 830-838
-
-
Billon, A.1
Lehoux, S.2
Leen Lam Shang, L.3
Laurell, H.4
Filipe, C.5
-
19
-
-
0345310069
-
Coronary hemodynamics in endothelial NO synthase knockout mice
-
doi:10.1161/01.RES.82.2.186. PubMed: 9468189
-
Gödecke A, Decking UK, Ding Z, Hirchenhain J, Bidmon HJ et al. (1998) Coronary hemodynamics in endothelial NO synthase knockout mice. Circ Res 82: 186-194. doi:10.1161/01.RES.82.2.186. PubMed: 9468189.
-
(1998)
Circ Res
, vol.82
, pp. 186-194
-
-
Gödecke, A.1
Decking, U.K.2
Ding, Z.3
Hirchenhain, J.4
Bidmon, H.J.5
-
20
-
-
84869220435
-
Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice
-
PubMed: 22785174
-
Cheng H, Wang H, Fan X, Paueksakon P, Harris RC (2012) Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Kidney Int, 82: 1176-83. PubMed: 22785174.
-
(2012)
Kidney Int
, vol.82
, pp. 1176-1183
-
-
Cheng, H.1
Wang, H.2
Fan, X.3
Paueksakon, P.4
Harris, R.C.5
-
21
-
-
79960711345
-
Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice
-
doi:10.1111/j.1440-1681.2011.05535.x. PubMed: 21554376
-
Jo H, Otani H, Jo F, Shimazu T, Okazaki T et al. (2011) Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. Clin Exp Pharmacol Physiol 38: 485-493. doi:10.1111/j.1440-1681.2011.05535.x. PubMed: 21554376.
-
(2011)
Clin Exp Pharmacol Physiol
, vol.38
, pp. 485-493
-
-
Jo, H.1
Otani, H.2
Jo, F.3
Shimazu, T.4
Okazaki, T.5
-
22
-
-
33745009958
-
Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats
-
doi: 10.1016/j.jacc.2006.01.071. PubMed: 16781385
-
Li H, Witte K, August M, Brausch I, Gödtel-Armbrust U et al. (2006) Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol 47: 2536-2544. doi: 10.1016/j.jacc.2006.01. 071. PubMed: 16781385.
-
(2006)
J Am Coll Cardiol
, vol.47
, pp. 2536-2544
-
-
Li, H.1
Witte, K.2
August, M.3
Brausch, I.4
Gödtel-Armbrust, U.5
-
23
-
-
50449108911
-
Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: The possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase
-
doi:10.1253/circj.CJ-08-0072. PubMed: 18724032
-
Masano T, Kawashima S, Toh R, Satomi-Kobayashi S, Shinohara M et al. (2008) Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase. Circ J 72: 1512-1519. doi:10.1253/circj.CJ-08-0072. PubMed: 18724032.
-
(2008)
Circ J
, vol.72
, pp. 1512-1519
-
-
Masano, T.1
Kawashima, S.2
Toh, R.3
Satomi-Kobayashi, S.4
Shinohara, M.5
-
24
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
doi:10.1006/meth.2001.1262. PubMed: 11846609
-
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. doi:10.1006/meth.2001.1262. PubMed: 11846609.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
25
-
-
77957220423
-
Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice
-
doi:10.1124/jpet.110.168724. PubMed: 20610621
-
Xia N, Daiber A, Habermeier A, Closs EI, Thum T et al. (2010) Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 335: 149-154. doi:10.1124/jpet.110.168724. PubMed: 20610621.
-
(2010)
J Pharmacol Exp Ther
, vol.335
, pp. 149-154
-
-
Xia, N.1
Daiber, A.2
Habermeier, A.3
Closs, E.I.4
Thum, T.5
-
26
-
-
38849137975
-
beta-adrenergic relaxation in pulmonary arteries: Preservation of the endothelial nitric oxide-dependent beta2 component in pulmonary hypertension
-
PubMed: 18006484
-
Leblais V, Delannoy E, Fresquet F, Bégueret H, Bellance N et al. (2008) beta-adrenergic relaxation in pulmonary arteries: preservation of the endothelial nitric oxide-dependent beta2 component in pulmonary hypertension. Cardiovasc Res 77: 202-210. PubMed: 18006484.
-
(2008)
Cardiovasc Res
, vol.77
, pp. 202-210
-
-
Leblais, V.1
Delannoy, E.2
Fresquet, F.3
Bégueret, H.4
Bellance, N.5
-
27
-
-
79959259447
-
Hypoxia does neither stimulate pulmonary artery endothelial cell proliferation in mice and rats with pulmonary hypertension and vascular remodeling nor in human pulmonary artery endothelial cells
-
doi:10.1159/000327005. PubMed: 21691120
-
Yu L, Hales CA (2011) Hypoxia does neither stimulate pulmonary artery endothelial cell proliferation in mice and rats with pulmonary hypertension and vascular remodeling nor in human pulmonary artery endothelial cells. J Vasc Res 48: 465-475. doi:10.1159/000327005. PubMed: 21691120.
-
(2011)
J Vasc Res
, vol.48
, pp. 465-475
-
-
Yu, L.1
Hales, C.A.2
-
28
-
-
27644564685
-
Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice
-
doi:10.1161/01.RES.0000188211.83193.1a. PubMed: 16195480
-
Yu L, Quinn DA, Garg HG, Hales CA (2005) Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice. Circ Res 97: 937-945. doi:10.1161/01.RES.0000188211.83193.1a. PubMed: 16195480.
-
(2005)
Circ Res
, vol.97
, pp. 937-945
-
-
Yu, L.1
Quinn, D.A.2
Garg, H.G.3
Hales, C.A.4
-
29
-
-
0030023029
-
Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung
-
PubMed: 8772540
-
Le Cras TD, Xue C, Rengasamy A, Johns RA (1996) Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol 270: L164-L170. PubMed: 8772540.
-
(1996)
Am J Physiol
, vol.270
-
-
Le Cras, T.D.1
Xue, C.2
Rengasamy, A.3
Johns, R.A.4
-
30
-
-
0029957529
-
Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodeling in the hypoxic rat
-
doi:10.1161/01.HYP.28.5.743. PubMed: 8901818
-
Xue C, Johns RA (1996) Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodeling in the hypoxic rat. Hypertension 28: 743-753. doi:10.1161/01.HYP.28.5.743. PubMed: 8901818.
-
(1996)
Hypertension
, vol.28
, pp. 743-753
-
-
Xue, C.1
Johns, R.A.2
-
31
-
-
0036199685
-
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
-
doi:10.1172/JCI0214442. PubMed: 11901190
-
Zou MH, Shi C, Cohen RA (2002) Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 109: 817-826. doi:10.1172/JCI0214442. PubMed: 11901190.
-
(2002)
J Clin Invest
, vol.109
, pp. 817-826
-
-
Zou, M.H.1
Shi, C.2
Cohen, R.A.3
-
32
-
-
0032921860
-
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: Protective effect of sepiapterin
-
doi:10.1097/00005344-199902000-00018. PubMed: 10028940
-
Ishii M, Shimizu S, Momose K, Yamamoto T (1999) SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin. J Cardiovasc Pharmacol 33: 295-300. doi:10.1097/00005344-199902000-00018. PubMed: 10028940.
-
(1999)
J Cardiovasc Pharmacol
, vol.33
, pp. 295-300
-
-
Ishii, M.1
Shimizu, S.2
Momose, K.3
Yamamoto, T.4
-
33
-
-
34249282381
-
(6R) -. 5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm
-
(2007) doi:10.1161/ATVBAHA.107.142257. PubMed: 17413035
-
Mayahi L, Heales S, Owen D, Casas JP, Harris J et al. (2007) (6R) -. (2007) 5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm. Arterioscler Thromb Vasc Biol 27: 1334-1339. doi:10.1161/ATVBAHA.107.142257. PubMed: 17413035.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 1334-1339
-
-
Mayahi, L.1
Heales, S.2
Owen, D.3
Casas, J.P.4
Harris, J.5
-
34
-
-
84865243945
-
Tetrahydrobiopterin Protects Soluble Guanylate Cyclase Against Oxidative Inactivation
-
doi:10.1124/mol.112.079855. PubMed: 22648973
-
Schmidt K, Neubauer A, Kolesnik B, Stasch JP, Werner ER et al. (2012) Tetrahydrobiopterin Protects Soluble Guanylate Cyclase Against Oxidative Inactivation. Mol Pharmacol 82: 420-427. doi:10.1124/mol.112.079855. PubMed: 22648973.
-
(2012)
Mol Pharmacol
, vol.82
, pp. 420-427
-
-
Schmidt, K.1
Neubauer, A.2
Kolesnik, B.3
Stasch, J.P.4
Werner, E.R.5
-
35
-
-
79960810239
-
Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression
-
PubMed: 21637925
-
Cho YR, Kim SH, Ko HY, Kim MD, Choi SW et al. (2011) Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol Rep 26: 861-867. PubMed: 21637925.
-
(2011)
Oncol Rep
, vol.26
, pp. 861-867
-
-
Cho, Y.R.1
Kim, S.H.2
Ko, H.Y.3
Kim, M.D.4
Choi, S.W.5
-
36
-
-
0033696120
-
eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia
-
PubMed: 11000123
-
Quinlan TR, Li D, Laubach VE, Shesely EG, Zhou N et al. (2000) eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 279: L641-L650. PubMed: 11000123.
-
(2000)
Am J Physiol Lung Cell Mol Physiol
, vol.279
-
-
Quinlan, T.R.1
Li, D.2
Laubach, V.E.3
Shesely, E.G.4
Zhou, N.5
-
37
-
-
0034880704
-
Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS
-
PubMed: 11435211
-
Li D, Laubach VE, Johns RA (2001) Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS. Am J Physiol Lung Cell Mol Physiol 281: L369-L376. PubMed: 11435211.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.281
-
-
Li, D.1
Laubach, V.E.2
Johns, R.A.3
-
38
-
-
0032102283
-
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
-
doi:10.1172/JCI2356. PubMed: 9616218
-
Steudel W, Scherrer-Crosbie M, Bloch KD, Weimann J, Huang PL et al. (1998) Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest 101: 2468-2477. doi:10.1172/JCI2356. PubMed: 9616218.
-
(1998)
J Clin Invest
, vol.101
, pp. 2468-2477
-
-
Steudel, W.1
Scherrer-Crosbie, M.2
Bloch, K.D.3
Weimann, J.4
Huang, P.L.5
-
39
-
-
0032896721
-
The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
-
doi:10.1172/JCI3862. PubMed: 9916141
-
Fagan KA, Fouty BW, Tyler RC, Morris KG Jr., Hepler LK et al. (1999) The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 103: 291-299. doi:10.1172/JCI3862. PubMed: 9916141.
-
(1999)
J Clin Invest
, vol.103
, pp. 291-299
-
-
Fagan, K.A.1
Fouty, B.W.2
Tyler, R.C.3
Morris Jr., K.G.4
Hepler, L.K.5
-
40
-
-
46849095596
-
Regulation of eNOS-derived superoxide by endogenous methylarginines
-
doi:10.1021/bi702377a. PubMed: 18553936
-
Druhan LJ, Forbes SP, Pope AJ, Chen CA, Zweier JL et al. (2008) Regulation of eNOS-derived superoxide by endogenous methylarginines. Biochemistry 47: 7256-7263. doi:10.1021/bi702377a. PubMed: 18553936.
-
(2008)
Biochemistry
, vol.47
, pp. 7256-7263
-
-
Druhan, L.J.1
Forbes, S.P.2
Pope, A.J.3
Chen, C.A.4
Zweier, J.L.5
-
41
-
-
37149044207
-
Nitric oxide and superoxide generation from endothelial NOS: Modulation by HSP90
-
doi:10.1152/ajplung.00175.2007. PubMed: 17827253
-
Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S et al. (2007) Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol 293: L1444-L1453. doi:10.1152/ajplung.00175.2007. PubMed: 17827253.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.293
-
-
Sud, N.1
Sharma, S.2
Wiseman, D.A.3
Harmon, C.4
Kumar, S.5
-
42
-
-
78650810596
-
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
-
doi:10.1038/nature09599. PubMed: 21179168
-
Chen CA, Wang TY, Varadharaj S, Reyes LA, Hemann C et al. (2010) S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature 468: 1115-1118. doi:10.1038/nature09599. PubMed: 21179168.
-
(2010)
Nature
, vol.468
, pp. 1115-1118
-
-
Chen, C.A.1
Wang, T.Y.2
Varadharaj, S.3
Reyes, L.A.4
Hemann, C.5
-
43
-
-
80051698652
-
Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling
-
doi:10.1074/jbc.M111.240127. PubMed: 21666221
-
Chen CA, Lin CH, Druhan LJ, Wang TY, Chen YR et al. (2011) Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling. J Biol Chem 286: 29098-29107. doi:10.1074/jbc.M111.240127. PubMed: 21666221.
-
(2011)
J Biol Chem
, vol.286
, pp. 29098-29107
-
-
Chen, C.A.1
Lin, C.H.2
Druhan, L.J.3
Wang, T.Y.4
Chen, Y.R.5
-
44
-
-
34447579911
-
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats
-
doi:10.1152/ajplung.00360.2006. PubMed: 17322279
-
Sasaki A, Doi S, Mizutani S, Azuma H (2007) Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats. Am J Physiol Lung Cell Mol Physiol 292: L1480-L1487. doi:10.1152/ajplung.00360.2006. PubMed: 17322279.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
-
-
Sasaki, A.1
Doi, S.2
Mizutani, S.3
Azuma, H.4
-
45
-
-
21744452294
-
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension
-
PubMed: 15827267
-
Pullamsetti S, Kiss L, Ghofrani HA, Voswinckel R, Haredza P et al. (2005) Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension. FASEB J 19: 1175-1177. PubMed: 15827267.
-
(2005)
FASEB J
, vol.19
, pp. 1175-1177
-
-
Pullamsetti, S.1
Kiss, L.2
Ghofrani, H.A.3
Voswinckel, R.4
Haredza, P.5
-
46
-
-
9444220218
-
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension
-
PubMed: 15364894
-
Xu W, Kaneko FT, Zheng S, Comhair SA, Janocha AJ et al. (2004) Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J 18: 1746-1748. PubMed: 15364894.
-
(2004)
FASEB J
, vol.18
, pp. 1746-1748
-
-
Xu, W.1
Kaneko, F.T.2
Zheng, S.3
Comhair, S.A.4
Janocha, A.J.5
-
47
-
-
0035085477
-
Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension
-
doi:10.1097/00005344-200104000-00016. PubMed: 11300662
-
Gorenflo M, Zheng C, Werle E, Fiehn W, Ulmer HE (2001) Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension. J Cardiovasc Pharmacol 37: 489-492. doi:10.1097/ 00005344-200104000-00016. PubMed: 11300662.
-
(2001)
J Cardiovasc Pharmacol
, vol.37
, pp. 489-492
-
-
Gorenflo, M.1
Zheng, C.2
Werle, E.3
Fiehn, W.4
Ulmer, H.E.5
-
48
-
-
20444397009
-
Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice
-
doi:10.1074/jbc.M501103200. PubMed: 15793309
-
Bubikat A, De Windt LJ, Zetsche B, Fabritz L, Sickler H et al. (2005) Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice. J Biol Chem 280: 21594-21599. doi:10.1074/jbc.M501103200. PubMed: 15793309.
-
(2005)
J Biol Chem
, vol.280
, pp. 21594-21599
-
-
Bubikat, A.1
De Windt, L.J.2
Zetsche, B.3
Fabritz, L.4
Sickler, H.5
|