Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 3, 2011, Pages

  Noguchi, Katsuhiko ^a   Hamadate, Naobumi ^a   Matsuzaki, Toshihiro ^a   Sakanashi, Mayuko ^a   Nakasone, Junko ^a   Uchida, Taro ^a   Arakaki, Kumiko ^a   Kubota, Haruaki ^a   Ishiuchi, Shogo ^a   Masuzaki, Hiroaki ^a   Sugahara, Kazuhiro ^a   Ohya, Yusuke ^a   Sakanashi, Matao ^a   Tsutsui, Masato ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Endothelial function; Methotrexate; Sepiapterin; Superoxide; Tetrahydrobiopterin

Indexed keywords

DIHYDROBIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; METHOTREXATE; SEPIAPTERIN; SUPEROXIDE; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DEPRESSOR RESPONSE; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; HYPERTENSION; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; BIOPTERIN; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FOLIC ACID ANTAGONISTS; MALE; METHOTREXATE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PTERINS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; SUPEROXIDES; TETRAHYDROFOLATE DEHYDROGENASE; UP-REGULATION; VASODILATION; VASODILATOR AGENTS;

EID: 80052310958     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01089.2010     Document Type: Article

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