Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling

Journal of Biological Chemistry

Volumn 286, Issue 33, 2011, Pages 29098-29107

  Chen, Chun An ^a   Lin, Cho Hao ^a   Druhan, Lawrence J ^a   Wang, Tse Yao ^a   Chen, Yeong Renn ^a   Zweier, Jay L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIO-VASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CELLULAR REDOX; DISULFIDE BOND FORMATION; IMMUNOBLOTTING; IMMUNOPRECIPITATIONS; IMMUNOSTAINING; NITRIC-OXIDE SYNTHASE; OXIDATIVE MODIFICATION; PROTEIN THIOLS; RADICAL FORMATION; REACTIVE OXYGEN SPECIES; REDOX REGULATION; SPIN TRAPPING; SUPER OXIDE DISMUTASE; SUPEROXIDE GENERATION; SUPEROXIDES; THIOL OXIDATION; THIYL RADICALS;

AMINO ACIDS; ANTIBODIES; BIOCHEMISTRY; COENZYMES; CONFOCAL MICROSCOPY; COVALENT BONDS; ENDOTHELIAL CELLS; MASS SPECTROMETRY; MUTAGENESIS; NITRIC OXIDE; OXIDATION; PORPHYRINS;

OXYGEN;

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ALANINE; ANTIBODY; CYSTEINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MENADIONE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROTEIN THIYL RADICAL; RADICAL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN; THIOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CHEMICAL MODIFICATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISULFIDE BOND; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME REGULATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MACROMOLECULE; MASS SPECTROMETRY; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SPIN TRAPPING;

ANIMALS; CATTLE; HEME; HUMANS; MUTAGENESIS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; SPIN TRAPPING; SULFHYDRYL COMPOUNDS; SUPEROXIDES;

EID: 80051698652     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.240127     Document Type: Article

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