메뉴 건너뛰기




Volumn 10, Issue 3, 2014, Pages 425-435

Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction

Author keywords

Cytochrome P450 enzyme system; Drug interactions, information systems; Glucocorticoid receptors

Indexed keywords

CYTOCHROME P450; DEXAMETHASONE; GLUCOCORTICOID; XENOBIOTIC AGENT;

EID: 84894167162     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2014.878703     Document Type: Review
Times cited : (43)

References (72)
  • 1
    • 84879169185 scopus 로고    scopus 로고
    • Basic and clinical pharmacology of glucocorticosteroids
    • quiz 32
    • Becker DE. Basic and clinical pharmacology of glucocorticosteroids. Anesth Prog 2013;60:25-31.quiz 32
    • (2013) Anesth Prog , vol.60 , pp. 25-31
    • Becker, D.E.1
  • 2
    • 0036143130 scopus 로고    scopus 로고
    • Molecular mechanisms of glucocorticoid antiproliferative effects: Antagonism of transcription factor activity by glucocorticoid receptor
    • Almawi WY, Melemedjian OK. Molecular mechanisms of glucocorticoid antiproliferative effects: Antagonism of transcription factor activity by glucocorticoid receptor. J Leukoc Biol 2002;71:9-15
    • (2002) J Leukoc Biol , vol.71 , pp. 9-15
    • Almawi, W.Y.1    Melemedjian, O.K.2
  • 3
    • 80051793838 scopus 로고    scopus 로고
    • Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: A systematic review and meta-analysis
    • Teuffel O, Kuster SP, Hunger SP, et al. Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: A systematic review and meta-analysis. Leukemia 2011;25:1232-8
    • (2011) Leukemia , vol.25 , pp. 1232-8
    • Teuffel, O.1    Kuster, S.P.2    Hunger, S.P.3
  • 5
    • 4944227995 scopus 로고    scopus 로고
    • Adjuvant analgesics in cancer pain management
    • Lussier D, Huskey AG, Portenoy RK. Adjuvant analgesics in cancer pain management. Oncologist 2004;9:571-91
    • (2004) Oncologist , vol.9 , pp. 571-91
    • Lussier, D.1    Huskey, A.G.2    Portenoy, R.K.3
  • 6
    • 77949902983 scopus 로고    scopus 로고
    • Prevention and treatment of systemic glucocorticoid side effects
    • Moghadam-Kia S, Werth VP. Prevention and treatment of systemic glucocorticoid side effects. Int J Dermatol 2010;49:239-48
    • (2010) Int J Dermatol , vol.49 , pp. 239-48
    • Moghadam-Kia, S.1    Werth, V.P.2
  • 7
    • 33947408320 scopus 로고    scopus 로고
    • Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side-effect management
    • Sokol KC, Knudsen JF, Li MM. Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side-effect management. J Clin Pharm Ther 2007;32:169-75
    • (2007) J Clin Pharm Ther , vol.32 , pp. 169-75
    • Sokol, K.C.1    Knudsen, J.F.2    Li, M.M.3
  • 8
    • 0041317355 scopus 로고    scopus 로고
    • Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids
    • Hesselink DA, Ngyuen H, Wabbijn M, et al. Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids. Br J Clin Pharmacol 2003;56:327-30
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 327-30
    • Hesselink, D.A.1    Ngyuen, H.2    Wabbijn, M.3
  • 9
    • 84866458626 scopus 로고    scopus 로고
    • Important drug interactions in patients with rheumatic disorders: Interactions of glucocorticoids, immunosuppressants and antimalarial drugs
    • Hromadkova L, Soukup T, Vlcek J. Important drug interactions in patients with rheumatic disorders: Interactions of glucocorticoids, immunosuppressants and antimalarial drugs. Drugs Today (Barc) 2012;48:545-53
    • (2012) Drugs Today (Barc) , vol.48 , pp. 545-53
    • Hromadkova, L.1    Soukup, T.2    Vlcek, J.3
  • 10
    • 77957557404 scopus 로고    scopus 로고
    • Regulation of drugmetabolizing cytochrome p450 enzymes by glucocorticoids
    • Comprehenive review of molecular mechanisms of CYP induction by glucocorticoids
    • Dvorak Z, Pavek P. Regulation of drugmetabolizing cytochrome p450 enzymes by glucocorticoids. Drug Metab Rev 2010;42:621-35. Comprehenive review of molecular mechanisms of CYP induction by glucocorticoids.
    • (2010) Drug Metab Rev , vol.42 , pp. 621-35
    • Dvorak, Z.1    Pavek, P.2
  • 11
    • 84894129721 scopus 로고    scopus 로고
    • David nelson's p450 homepage. Available from: An electoric database of CYP enzymes
    • David nelson's p450 homepage. Available from: Http://drnelson.Utmem.Edu/ human.P450.Table.Html. An electoric database of CYP enzymes.
  • 12
    • 0034973607 scopus 로고    scopus 로고
    • Cytochromes p450 and metabolism of xenobiotics
    • Excellent review of cytochrome P450 enzymes
    • Anzenbacher P, Anzenbacherova E. Cytochromes p450 and metabolism of xenobiotics. Cell Mol Life Sci 2001;58:737-47. Excellent review of cytochrome P450 enzymes.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 737-47
    • Anzenbacher, P.1    Anzenbacherova, E.2
  • 13
    • 53849143575 scopus 로고    scopus 로고
    • Tissue-specific glucocorticoid action: A family affair
    • Excellent review on GC
    • Gross KL, Cidlowski JA. Tissue-specific glucocorticoid action: A family affair. Trends Endocrinol Metab 2008;19:331-9. Excellent review on GC.
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 331-9
    • Gross, K.L.1    Cidlowski, J.A.2
  • 14
    • 70449348176 scopus 로고    scopus 로고
    • Mechanisms generating diversity in glucocorticoid receptor signaling
    • Excellent review on GCs
    • Revollo JR, Cidlowski JA. Mechanisms generating diversity in glucocorticoid receptor signaling. Ann NY Acad Sci 2009;1179:167-78. Excellent review on GCs.
    • (2009) Ann NY Acad Sci , vol.1179 , pp. 167-78
    • Revollo, J.R.1    Cidlowski, J.A.2
  • 17
    • 0034889129 scopus 로고    scopus 로고
    • Cross-talk between pro-inflammatory transcription factors and glucocorticoids
    • Review on anti-inflammatory effects of GC
    • Adcock IM, Caramori G. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol Cell Biol 2001;79:376-84 . Review on anti-inflammatory effects of GC.
    • (2001) Immunol Cell Biol , vol.79 , pp. 376-84
    • Adcock, I.M.1    Caramori, G.2
  • 18
    • 0030059885 scopus 로고    scopus 로고
    • Identification of a novel dexamethasone responsive enhancer in the human cyp3a5 gene and its activation in human and rat liver cells
    • Schuetz JD, Schuetz EG, Thottassery JV, et al. Identification of a novel dexamethasone responsive enhancer in the human cyp3a5 gene and its activation in human and rat liver cells. Mol Pharmacol 1996;49:63-72
    • (1996) Mol Pharmacol , vol.49 , pp. 63-72
    • Schuetz, J.D.1    Schuetz, E.G.2    Thottassery, J.V.3
  • 19
    • 0037016761 scopus 로고    scopus 로고
    • Transcriptional regulation of cyp2c9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
    • Gerbal-Chaloin S, Daujat M, Pascussi JM, et al. Transcriptional regulation of cyp2c9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. J Biol Chem 2002;277:209-17
    • (2002) J Biol Chem , vol.277 , pp. 209-17
    • Gerbal-Chaloin, S.1    Daujat, M.2    Pascussi, J.M.3
  • 20
    • 34548433471 scopus 로고    scopus 로고
    • Examination of glucocorticoid receptor alpha-mediated transcriptional regulation of p-glycoprotein, cyp3a4, and cyp2c9 genes in placental trophoblast cell lines
    • Pavek P, Cerveny L, Svecova L, et al. Examination of glucocorticoid receptor alpha-mediated transcriptional regulation of p-glycoprotein, cyp3a4, and cyp2c9 genes in placental trophoblast cell lines. Placenta 2007;28:1004-11
    • (2007) Placenta , vol.28 , pp. 1004-11
    • Pavek, P.1    Cerveny, L.2    Svecova, L.3
  • 21
    • 70450157394 scopus 로고    scopus 로고
    • The transcriptional regulation of the human cyp2c genes
    • Chen Y, Goldstein JA. The transcriptional regulation of the human cyp2c genes. Curr Drug Metab 2009;10:567-78
    • (2009) Curr Drug Metab , vol.10 , pp. 567-78
    • Chen, Y.1    Goldstein, J.A.2
  • 22
    • 0042844649 scopus 로고    scopus 로고
    • Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the cyp2c19 promoter
    • Chen Y, Ferguson SS, Negishi M, Goldstein JA. Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the cyp2c19 promoter. Mol Pharmacol 2003;64:316-24
    • (2003) Mol Pharmacol , vol.64 , pp. 316-24
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 23
    • 23944516070 scopus 로고    scopus 로고
    • Human cyp2c8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane x receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha
    • Ferguson SS, Chen Y, LeCluyse EL, et al. Human cyp2c8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane x receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol 2005;68:747-57
    • (2005) Mol Pharmacol , vol.68 , pp. 747-57
    • Ferguson, S.S.1    Chen, Y.2    LeCluyse, E.L.3
  • 24
    • 33646517938 scopus 로고    scopus 로고
    • Evaluation of 170 xenobiotics as transactivators of human pregnane x receptor (hpxr) and correlation to known cyp3a4 drug interactions
    • A paper that show interaction of commonly used drugs with PXR
    • Sinz M, Kim S, Zhu Z, et al. Evaluation of 170 xenobiotics as transactivators of human pregnane x receptor (hpxr) and correlation to known cyp3a4 drug interactions. Curr Drug Metab 2006;7:375-88 . A paper that show interaction of commonly used drugs with PXR.
    • (2006) Curr Drug Metab , vol.7 , pp. 375-88
    • Sinz, M.1    Kim, S.2    Zhu, Z.3
  • 25
    • 38549087625 scopus 로고    scopus 로고
    • Dexamethasone-mediated up-regulation of human cyp2a6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4{alpha} to the proximal promoter
    • Onica T, Nichols K, Larin M, et al. Dexamethasone-mediated up-regulation of human cyp2a6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4{alpha} to the proximal promoter. Mol Pharmacol 2008;73:451-60
    • (2008) Mol Pharmacol , vol.73 , pp. 451-60
    • Onica, T.1    Nichols, K.2    Larin, M.3
  • 26
    • 0029992789 scopus 로고    scopus 로고
    • Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human cyp3a4 and rabbit cyp3a6 in primary cultures of adult rat and rabbit hepatocytes
    • Barwick JL, Quattrochi LC, Mills AS, et al. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human cyp3a4 and rabbit cyp3a6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 1996;50:10-16
    • (1996) Mol Pharmacol , vol.50 , pp. 10-16
    • Barwick, J.L.1    Quattrochi, L.C.2    Mills, A.S.3
  • 27
    • 0033000991 scopus 로고    scopus 로고
    • A reporter gene assay to assess the molecular mechanisms of xenobioticdependent induction of the human cyp3a4 gene in vitro
    • Ogg MS, Williams JM, Tarbit M, et al. A reporter gene assay to assess the molecular mechanisms of xenobioticdependent induction of the human cyp3a4 gene in vitro. Xenobiotica 1999;29:269-79
    • (1999) Xenobiotica , vol.29 , pp. 269-79
    • Ogg, M.S.1    Williams, J.M.2    Tarbit, M.3
  • 28
    • 0010258751 scopus 로고    scopus 로고
    • Regulation of the cyp3a4 gene by hydrocortisone and xenobiotics: Role of the glucocorticoid and pregnane x receptors
    • El-Sankary W, Plant NJ, Gibson GG, Moore DJ. Regulation of the cyp3a4 gene by hydrocortisone and xenobiotics: Role of the glucocorticoid and pregnane x receptors. Drug Metab Dispos 2000;28:493-6
    • (2000) Drug Metab Dispos , vol.28 , pp. 493-6
    • El-Sankary, W.1    Plant, N.J.2    Gibson, G.G.3    Moore, D.J.4
  • 29
    • 0036707623 scopus 로고    scopus 로고
    • Glucocorticoid-mediated induction of cyp3a4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane x receptor response element
    • El-Sankary W, Bombail V, Gibson GG, Plant N. Glucocorticoid-mediated induction of cyp3a4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane x receptor response element. Drug Metab Dispos 2002;30:1029-34
    • (2002) Drug Metab Dispos , vol.30 , pp. 1029-34
    • El-Sankary, W.1    Bombail, V.2    Gibson, G.G.3    Plant, N.4
  • 30
    • 41549114526 scopus 로고    scopus 로고
    • Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome p450 superfamily in human extrahepatic tissues
    • A review on extrahepatic regulation of CYPs
    • Pavek P, Dvorak Z. Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome p450 superfamily in human extrahepatic tissues. Curr Drug Metab 2008;9:129-43 . A review on extrahepatic regulation of CYPs.
    • (2008) Curr Drug Metab , vol.9 , pp. 129-43
    • Pavek, P.1    Dvorak, Z.2
  • 31
    • 0037450436 scopus 로고    scopus 로고
    • The expression of cyp2b6, cyp2c9 and cyp3a4 genes: A tangle of networks of nuclear and steroid receptors
    • Pascussi JM, Gerbal-Chaloin S, Drocourt L, et al. The expression of cyp2b6, cyp2c9 and cyp3a4 genes: A tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 2003;1619:243-53
    • (2003) Biochim Biophys Acta , vol.1619 , pp. 243-53
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Drocourt, L.3
  • 32
    • 33846864449 scopus 로고    scopus 로고
    • Transcriptional regulation and expression of cyp3a4 in hepatocytes
    • Martinez-Jimenez CP, Jover R, Donato MT, et al. Transcriptional regulation and expression of cyp3a4 in hepatocytes. Curr Drug Metab 2007;8:185-94
    • (2007) Curr Drug Metab , vol.8 , pp. 185-94
    • Martinez-Jimenez, C.P.1    Jover, R.2    Donato, M.T.3
  • 33
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane x receptor and retinoid x receptor-alpha expression in human hepatocytes: Synergistic increase of cyp3a4 induction by pregnane x receptor activators
    • Pascussi JM, Drocourt L, Fabre JM, et al. Dexamethasone induces pregnane x receptor and retinoid x receptor-alpha expression in human hepatocytes: Synergistic increase of cyp3a4 induction by pregnane x receptor activators. Mol Pharmacol 2000;58:361-72
    • (2000) Mol Pharmacol , vol.58 , pp. 361-72
    • Pascussi, J.M.1    Drocourt, L.2    Fabre, J.M.3
  • 34
    • 0035659943 scopus 로고    scopus 로고
    • Dual effect of dexamethasone on cyp3a4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane x receptor
    • Pascussi JM, Drocourt L, Gerbal-Chaloin S, et al. Dual effect of dexamethasone on cyp3a4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane x receptor. Eur J Biochem 2001;268:6346-58
    • (2001) Eur J Biochem , vol.268 , pp. 6346-58
    • Pascussi, J.M.1    Drocourt, L.2    Gerbal-Chaloin, S.3
  • 35
    • 0033664347 scopus 로고    scopus 로고
    • Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: Consequences on cytochrome p450 gene regulation
    • Pascussi JM, Gerbal-Chaloin S, Fabre JM, et al. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: Consequences on cytochrome p450 gene regulation. Mol Pharmacol 2000;58:1441-50
    • (2000) Mol Pharmacol , vol.58 , pp. 1441-50
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Fabre, J.M.3
  • 36
    • 33745656989 scopus 로고    scopus 로고
    • Regulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor
    • Harper PA, Riddick DS, Okey AB. Regulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor. Biochem Pharmacol 2006;72:267-79
    • (2006) Biochem Pharmacol , vol.72 , pp. 267-79
    • Harper, P.A.1    Riddick, D.S.2    Okey, A.B.3
  • 37
    • 0032970253 scopus 로고    scopus 로고
    • Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor
    • Linder MW, Falkner KC, Srinivasan G, et al. Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor. Drug Metab Rev 1999;31:247-71
    • (1999) Drug Metab Rev , vol.31 , pp. 247-71
    • Linder, M.W.1    Falkner, K.C.2    Srinivasan, G.3
  • 39
    • 62549089278 scopus 로고    scopus 로고
    • Dexamethasone controls aryl hydrocarbon receptor (ahr)-mediated cyp1a1 and cyp1a2 expression and activity in primary cultures of human hepatocytes
    • Vrzal R, Stejskalova L, Monostory K, et al. Dexamethasone controls aryl hydrocarbon receptor (ahr)-mediated cyp1a1 and cyp1a2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact 2009;179:288-96
    • (2009) Chem Biol Interact , vol.179 , pp. 288-96
    • Vrzal, R.1    Stejskalova, L.2    Monostory, K.3
  • 40
    • 84881529383 scopus 로고    scopus 로고
    • Circadian events in human diseases and in cytochrome p450-related drug metabolism and therapy
    • Kosir R, Spaninger K, Rozman D. Circadian events in human diseases and in cytochrome p450-related drug metabolism and therapy. IUBMB Life 2013;65:487-96
    • (2013) IUBMB Life , vol.65 , pp. 487-96
    • Kosir, R.1    Spaninger, K.2    Rozman, D.3
  • 41
    • 84884731992 scopus 로고    scopus 로고
    • Sex differences in the circadian variation of cytochrome p450 genes and corresponding nuclear receptors in mouse liver
    • Lu YF, Jin T, Xu Y, et al. Sex differences in the circadian variation of cytochrome p450 genes and corresponding nuclear receptors in mouse liver. Chronobiol Int 2013;30:1135-43
    • (2013) Chronobiol Int , vol.30 , pp. 1135-43
    • Lu, Y.F.1    Jin, T.2    Xu, Y.3
  • 42
    • 0030726508 scopus 로고    scopus 로고
    • Preclinical evaluation of drug-drug interaction potential: Present status of the application of primary human hepatocytes in the evaluation of cytochrome p450 induction
    • Li AP, Maurel P, Gomez-Lechon MJ, et al. Preclinical evaluation of drug-drug interaction potential: Present status of the application of primary human hepatocytes in the evaluation of cytochrome p450 induction. Chem Biol Interact 1997;107:5-16
    • (1997) Chem Biol Interact , vol.107 , pp. 5-16
    • Li, A.P.1    Maurel, P.2    Gomez-Lechon, M.J.3
  • 45
    • 0036971089 scopus 로고    scopus 로고
    • Sirolimus steady-state trough concentrations are not affected by bolus methylprednisolone therapy in renal allograft recipients
    • Backman L, Kreis H, Morales JM, et al. Sirolimus steady-state trough concentrations are not affected by bolus methylprednisolone therapy in renal allograft recipients. Br J Clin Pharmacol 2002;54:65-8
    • (2002) Br J Clin Pharmacol , vol.54 , pp. 65-8
    • Backman, L.1    Kreis, H.2    Morales, J.M.3
  • 46
    • 27644467774 scopus 로고    scopus 로고
    • Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to cyp3a5 and mdr1 polymorphisms and steroids
    • Mourad M, Mourad G, Wallemacq P, et al. Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to cyp3a5 and mdr1 polymorphisms and steroids. Transplantation 2005;80:977-84
    • (2005) Transplantation , vol.80 , pp. 977-84
    • Mourad, M.1    Mourad, G.2    Wallemacq, P.3
  • 47
    • 0242558148 scopus 로고    scopus 로고
    • Increase in tacrolimus trough levels after steroid withdrawal
    • van Duijnhoven EM, Boots JM, Christiaans MH, et al. Increase in tacrolimus trough levels after steroid withdrawal. Transpl Int 2003;16:721-5
    • (2003) Transpl Int , vol.16 , pp. 721-5
    • Van Duijnhoven, E.M.1    Boots, J.M.2    Christiaans, M.H.3
  • 48
    • 0242351679 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation
    • Anglicheau D, Flamant M, Schlageter MH, et al. Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation. Nephrol Dial Transplant 2003;18:2409-14
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 2409-14
    • Anglicheau, D.1    Flamant, M.2    Schlageter, M.H.3
  • 49
    • 4344561078 scopus 로고    scopus 로고
    • Time-related clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and corticosteroids: A prospective study in one hundred de novo renal transplant recipients
    • Kuypers DR, Claes K, Evenepoel P, et al. Time-related clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and corticosteroids: A prospective study in one hundred de novo renal transplant recipients. Clin Pharmacokinet 2004;43:741-62
    • (2004) Clin Pharmacokinet , vol.43 , pp. 741-62
    • Kuypers, D.R.1    Claes, K.2    Evenepoel, P.3
  • 50
    • 48249120712 scopus 로고    scopus 로고
    • Corticosteroid interactions with cyclosporine tacrolimus mycophenolate and sirolimus: Fact or fiction?
    • Lam S, Partovi N, Ting LS, Ensom MH. Corticosteroid interactions with cyclosporine, tacrolimus, mycophenolate, and sirolimus: Fact or fiction? Ann Pharmacother 2008;42:1037-47
    • (2008) Ann Pharmacother , vol.42 , pp. 1037-47
    • Lam, S.1    Partovi, N.2    Ting, L.S.3    Ensom, M.H.4
  • 51
    • 84983727007 scopus 로고    scopus 로고
    • Effect of cyp3a4 inducer dexamethasone on hepatotoxicity of lapatinib: Clinical and in vitro evidence
    • A clinical and in vitro evidence on DDI between lapatinib and dexamethasone
    • Teo YL, Saetaew M, Chanthawong S, et al. Effect of cyp3a4 inducer dexamethasone on hepatotoxicity of lapatinib: Clinical and in vitro evidence. Breast Cancer Res Treat 2012;133:703-11 . A clinical and in vitro evidence on DDI between lapatinib and dexamethasone.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 703-11
    • Teo, Y.L.1    Saetaew, M.2    Chanthawong, S.3
  • 52
    • 77958455487 scopus 로고    scopus 로고
    • Erlotinib in combination with pemetrexed for patients with advanced non-small-cell lung cancer (nsclc): A phase I dose-finding study
    • Ranson M, Reck M, Anthoney A, et al. Erlotinib in combination with pemetrexed for patients with advanced non-small-cell lung cancer (nsclc): A phase I dose-finding study. Ann Oncol 2010;21:2233-9
    • (2010) Ann Oncol , vol.21 , pp. 2233-9
    • Ranson, M.1    Reck, M.2    Anthoney, A.3
  • 53
    • 9144247069 scopus 로고    scopus 로고
    • Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia
    • Kishi S, Yang W, Boureau B, et al. Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia. Blood 2004;103:67-72
    • (2004) Blood , vol.103 , pp. 67-72
    • Kishi, S.1    Yang, W.2    Boureau, B.3
  • 54
    • 79953767582 scopus 로고    scopus 로고
    • Developmental pharmacokinetics of etoposide in 67 children: Lack of dexamethasone effect
    • Urien S, Doz F, Giraud C, et al. Developmental pharmacokinetics of etoposide in 67 children: Lack of dexamethasone effect. Cancer Chemother Pharmacol 2011;67:597-603
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 597-603
    • Urien, S.1    Doz, F.2    Giraud, C.3
  • 55
    • 81255195686 scopus 로고    scopus 로고
    • Effect of cytochrome p450 3a4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or non-hodgkin's lymphoma
    • Hellmann A, Rule S, Walewski J, et al. Effect of cytochrome p450 3a4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or non-hodgkin's lymphoma. Clin Pharmacokinet 2011;50:781-91
    • (2011) Clin Pharmacokinet , vol.50 , pp. 781-91
    • Hellmann, A.1    Rule, S.2    Walewski, J.3
  • 56
    • 34748851541 scopus 로고    scopus 로고
    • Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients
    • Bruggemann SK, Pfaffle S, Peters SO, Wagner T. Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in patients. Drug Metab Dispos 2007;35:1721-4
    • (2007) Drug Metab Dispos , vol.35 , pp. 1721-4
    • Bruggemann, S.K.1    Pfaffle, S.2    Peters, S.O.3    Wagner, T.4
  • 57
    • 0024230301 scopus 로고
    • Rapid development of enhanced clearance after high-dose cyclophosphamide
    • Moore MJ, Hardy RW, Thiessen JJ, et al. Rapid development of enhanced clearance after high-dose cyclophosphamide. Clin Pharmacol Ther 1988;44:622-8
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 622-8
    • Moore, M.J.1    Hardy, R.W.2    Thiessen, J.J.3
  • 58
    • 33845900962 scopus 로고    scopus 로고
    • Aprepitant when added to a standard antiemetic regimen consisting of ondansetron and dexamethasone does not affect vinorelbine pharmacokinetics in cancer patients
    • Loos WJ, de Wit R, Freedman SJ, et al. Aprepitant when added to a standard antiemetic regimen consisting of ondansetron and dexamethasone does not affect vinorelbine pharmacokinetics in cancer patients. Cancer Chemother Pharmacol 2007;59:407-12
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 407-12
    • Loos, W.J.1    De Wit, R.2    Freedman, S.J.3
  • 59
    • 0023212634 scopus 로고
    • Plasma levels of praziquantel decrease when dexamethasone is given simultaneously
    • Vazquez ML, Jung H, Sotelo J. Plasma levels of praziquantel decrease when dexamethasone is given simultaneously. Neurology 1987;37:1561-2
    • (1987) Neurology , vol.37 , pp. 1561-2
    • Vazquez, M.L.1    Jung, H.2    Sotelo, J.3
  • 60
    • 84882338741 scopus 로고    scopus 로고
    • Effect of prednisone on the pharmacokinetics of the integrase inhibitor dolutegravir
    • Song IH, Borland J, Chen S, et al. Effect of prednisone on the pharmacokinetics of the integrase inhibitor dolutegravir. Antimicrob Agents Chemother 2013;57:4394-7
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 4394-7
    • Song, I.H.1    Borland, J.2    Chen, S.3
  • 61
    • 0032836340 scopus 로고    scopus 로고
    • Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans
    • Nakajima M, Suzuki T, Sasaki T, et al. Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans. Ther Drug Monit 1999;21:507-13
    • (1999) Ther Drug Monit , vol.21 , pp. 507-13
    • Nakajima, M.1    Suzuki, T.2    Sasaki, T.3
  • 62
    • 85017277289 scopus 로고    scopus 로고
    • Effect of methylprednisolone on cyp3a4-mediated drug metabolism in vivo
    • Villikka K, Varis T, Backman JT, et al. Effect of methylprednisolone on cyp3a4-mediated drug metabolism in vivo. Eur J Clin Pharmacol 2001;57:457-60
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 457-60
    • Villikka, K.1    Varis, T.2    Backman, J.T.3
  • 63
    • 0034682048 scopus 로고    scopus 로고
    • Potentiation of vitamin k antagonists by high-dose intravenous methylprednisolone
    • Evidence on INR rise after concomitantly administered pulse high-dose intravenous methylprednisolone and oral anticoagulants. Possible mechanism - inhibition of CYP450 dependent catabolism of oral anticoagulants
    • Costedoat-Chalumeau N, Amoura Z, Aymard G, et al. Potentiation of vitamin k antagonists by high-dose intravenous methylprednisolone. Ann Intern Med 2000;132:631-5 . Evidence on INR rise after concomitantly administered pulse high-dose intravenous methylprednisolone and oral anticoagulants. Possible mechanism - inhibition of CYP450 dependent catabolism of oral anticoagulants.
    • (2000) Ann Intern Med , vol.132 , pp. 631-5
    • Costedoat-Chalumeau, N.1    Amoura, Z.2    Aymard, G.3
  • 64
    • 35348864364 scopus 로고    scopus 로고
    • Potentiation of fluindione or warfarin by dexamethasone in multiple myeloma and al amyloidosis
    • Sellam J, Costedoat-Chalumeau N, Amoura Z, et al. Potentiation of fluindione or warfarin by dexamethasone in multiple myeloma and al amyloidosis. Joint Bone Spine 2007;74:446-52
    • (2007) Joint Bone Spine , vol.74 , pp. 446-52
    • Sellam, J.1    Costedoat-Chalumeau, N.2    Amoura, Z.3
  • 65
    • 0025217803 scopus 로고
    • Cyclosporin metabolism in human liver microsomes and its inhibition by other drugs
    • Henricsson S, Lindholm A, Aravoglou M. Cyclosporin metabolism in human liver microsomes and its inhibition by other drugs. Pharmacol Toxicol 1990;66:49-52
    • (1990) Pharmacol Toxicol , vol.66 , pp. 49-52
    • Henricsson, S.1    Lindholm, A.2    Aravoglou, M.3
  • 66
    • 33745395225 scopus 로고    scopus 로고
    • Cyp induction-mediated drug interactions: In vitro assessment and clinical implications
    • Good review on DDIs based on CYP induction
    • Lin JH. Cyp induction-mediated drug interactions: In vitro assessment and clinical implications. Pharm Res 2006;23:1089-116 . Good review on DDIs based on CYP induction.
    • (2006) Pharm Res , vol.23 , pp. 1089-116
    • Lin, J.H.1
  • 67
    • 0032532134 scopus 로고    scopus 로고
    • Sxr, a novel steroid and xenobioticsensing nuclear receptor
    • Blumberg B, Sabbagh W Jr, Juguilon H, et al. Sxr, a novel steroid and xenobioticsensing nuclear receptor. Genes Dev 1998;12:3195-205
    • (1998) Genes Dev , vol.12 , pp. 3195-205
    • Blumberg, B.1    Sabbagh Jr., W.2    Juguilon, H.3
  • 68
    • 11844269814 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids
    • Czock D, Keller F, Rasche FM, Haussler U. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet 2005;44:61-98
    • (2005) Clin Pharmacokinet , vol.44 , pp. 61-98
    • Czock, D.1    Keller, F.2    Rasche, F.M.3    Haussler, U.4
  • 69
    • 0023841084 scopus 로고
    • Comparison of methylprednisolone (1 g i.V.) with prednisolone (1 g orally) in rheumatoid arthritis: A pharmacokinetic and clinical study
    • Needs CJ, Smith M, Boutagy J, et al. Comparison of methylprednisolone (1 g i.V.) with prednisolone (1 g orally) in rheumatoid arthritis: A pharmacokinetic and clinical study. J Rheumatol 1988;15:224-8
    • (1988) J Rheumatol , vol.15 , pp. 224-8
    • Needs, C.J.1    Smith, M.2    Boutagy, J.3
  • 70
    • 0020603011 scopus 로고
    • Systemic bioavailability and pharmacokinetics of methylprednisolone in patients with rheumatoid arthritis following 'high-dose' pulse administration
    • Narang PK, Wilder R, Chatterji DC, et al. Systemic bioavailability and pharmacokinetics of methylprednisolone in patients with rheumatoid arthritis following 'high-dose' pulse administration. Biopharm Drug Dispos 1983;4:233-48
    • (1983) Biopharm Drug Dispos , vol.4 , pp. 233-48
    • Narang, P.K.1    Wilder, R.2    Chatterji, D.C.3
  • 71
    • 84868696448 scopus 로고    scopus 로고
    • Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation
    • Novotna A, Pavek P, Dvorak Z. Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation. Eur J Pharm Sci 2012;47:842-7
    • (2012) Eur J Pharm Sci , vol.47 , pp. 842-7
    • Novotna, A.1    Pavek, P.2    Dvorak, Z.3
  • 72
    • 84894193127 scopus 로고    scopus 로고
    • DRUGDEX System [Internet database]. Greenwood Village CTHUp
    • DRUGDEX System [Internet database]. Greenwood Village CTHUp


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.