Effect of methylprednisolone on CYP3A4-mediated drug metabolism in vivo

European Journal of Clinical Pharmacology

Volumn 57, Issue 5-6, 2001, Pages 457-460

  Krisper, Peter ^a   Aschauer, Manuela ^a   Tiesenhausen, Kurt ^a   Leitner, Gerhard ^a   Holzer, Herwig ^a   Schneditz, Daniel ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

CYP3A4; Methylprednisolone; Triazolam

Indexed keywords

CYTOCHROME P450 3A4; METHYLPREDNISOLONE; TRIAZOLAM;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG CONCENTRATION; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; HUMAN; IN VIVO STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PSYCHOMOTOR ACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DRUG DETERMINATION; DRUG MEGADOSE; ENZYME INDUCTION; PHASE 3 CLINICAL TRIAL; PSYCHOMOTOR PERFORMANCE;

EID: 85017277289     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280100340     Document Type: Article

References (16)

1. Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes
2. Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes
3. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients
4. In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone
5. The effect of dexamethasone on the pharmacokinetics of triazolam
6. An evaluation of the effects of oral dexamethasone 2 mg and 5 mg once daily for 7 days on CYP3A4 activity
7. Pharmacokinetic drug interactions with cyclosporin (part II)
8. Clinically significant drug interactions with cyclosporin. An update
9. Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P4503A4
10. Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole
11. Triazolam is ineffective in patients taking rifampin
12. Simultaneous screening and quantitation of alpidem, zolpidem, buspirone and benzodiazepines by dual-channel gas chromatography using electron-capture and nitrogen-phosphorus detection after solid-phase extraction
13. Psychomotor function and psychoactive drugs
14. Plasma concentrations and effects of oral methylprednisolone are considerably increased by itraconazole
15. Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone
16. The effect of ingestion time interval on the interaction between itraconazole and triazolam